SIGMA-ALDRICH

MATERIAL SAFETY DATA SHEET

Date Printed: 03/03/2004

Date Updated: 09/02/2002
Version 1.2

Section 1 - Product and Company Information

Product Name 1,3,5-TRIOXANE, 99+%

Product Number T81108
Brand ALDRICH

Company Sigma-Aldrich
Street Address 3050 Spruce Street
City, State, Zip, Country SAINT LOUIS MO 63103 US
Technical Phone: 314 771 5765
Emergency Phone: 414 273 3850 Ext. 5996
Fax: 800 325 5052

Section 2 - Composition/Information on Ingredient

Substance Name CAS # SARA 313

1,3,5-TRIOXANE 110-88-3 No

Formula C3H6O3
Synonyms Triformol * Trioxan * Trioxane * sym-Trioxane *
1,3,5-Trioxane * Trioxymethylene
RTECS Number: YK0350000

Section 3 - Hazards Identification

EMERGENCY OVERVIEW
Flammable. Harmful.
Harmful if swallowed.

HMIS RATING
HEALTH: 1
FLAMMABILITY: 2
REACTIVITY: 1

NFPA RATING
HEALTH: 1
FLAMMABILITY: 2
REACTIVITY: 1

For additional information on toxicity, please refer to Section 11.

Section 4 - First Aid Measures

ORAL EXPOSURE
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.

INHALATION EXPOSURE
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.

DERMAL EXPOSURE
In case of skin contact, flush with copious amounts of water for
 at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.

EYE EXPOSURE
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.

Section 5 - Fire Fighting Measures

FLAMMABLE HAZARDS
Flammable Hazards: Yes

EXPLOSION HAZARDS
Container explosion can occur under fire conditions. In advanced
or massive fires the area should be evacuated and the fire
should be fought from a remote explosion-resistant location.

EXPLOSION DATA
Dust Potential: This material, like most materials in powder
form, is capable of creating a dust explosion.

CONDITIONS OF FLAMMABILITY
Under fire conditions, material may decompose to form flammable
and/or explosive mixtures in air.

FLASH POINT
113 °F 45 °C Method: closed cup

EXPLOSION LIMITS
Lower: 3.6 % Upper: 29 %

AUTOIGNITION TEMP
414 °C

FLAMMABILITY
N/A

EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.

FIREFIGHTING
Protective Equipment: Wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s): Flammable solid. Emits toxic fumes under
fire conditions.

Section 6 - Accidental Release Measures

PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL

Evacuate area. Shut off all sources of ignition.

PROCEDURE(S) OF PERSONAL PRECAUTION(S)

Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.

METHODS FOR CLEANING UP

Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.

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Section 7 - Handling and Storage

HANDLING
User Exposure: Do not breathe dust. Avoid contact with eyes,
skin, and clothing. Avoid prolonged or repeated exposure.

STORAGE
Suitable: Keep container closed. Keep away from heat, sparks,
and open flame.

SPECIAL REQUIREMENTS
Moisture sensitive.

Section 8 - Exposure Controls / PPE

ENGINEERING CONTROLS
Safety shower and eye bath. Use nonsparking tools. Mechanical
exhaust required.

PERSONAL PROTECTIVE EQUIPMENT

Respiratory: Government approved respirator.
Hand: Compatible chemical-resistant gloves.
Eye: Chemical safety goggles.

GENERAL HYGIENE MEASURES

Wash thoroughly after handling. Wash contaminated clothing before
reuse.

SPECIAL PRECAUTIONS
1,3,5-Trioxane releases formaldehyde when heated to body
temperature. Due to this, oral exposures should be treated the
same as a formaldehyde exposure.

EXPOSURE LIMITS
Country Source Type Value
Poland NDS 15 MG/M3
Poland NDSCh 75 MG/M3
Poland NDSP -

Section 9 - Physical/Chemical Properties

Appearance Color: Colorless

Form: Crystals

Property Value At Temperature or Pressure

Molecular Weight 90.08 AMU

pH N/A
BP/BP Range 112 - 115 °C
MP/MP Range 59 °C
Freezing Point N/A
Vapor Pressure N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
SG/Density 1.17 g/cm3 65 °C
Bulk Density N/A
Odor Threshold N/A
Volatile% N/A
VOC Content N/A
Water Content N/A
Solvent Content N/A
Evaporation Rate N/A

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Viscosity N/A
Surface Tension N/A
Partition Coefficient N/A
Decomposition Temp. N/A
Flash Point 113 °F 45 °C Method: closed cup
Explosion Limits Lower: 3.6 %
Upper: 29 %
Flammability N/A
Autoignition Temp 414 °C
Refractive Index N/A
Optical Rotation N/A
Miscellaneous Data N/A
Solubility Solubility in Water:Soluble.
Other Solvents: EASILY SOLUBLE IN ALCOHOL
KETONES, ETHER, ACETONE OR

N/A = not available

Section 10 - Stability and Reactivity

STABILITY
Stable: Stable.
Conditions to Avoid: Moisture
Materials to Avoid: Strong oxidizing agents.

HAZARDOUS DECOMPOSITION PRODUCTS

Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.

HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur

Section 11 - Toxicological Information

ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: May be harmful if inhaled. Material may be
irritating to mucous membranes and upper respiratory tract.
Ingestion: Harmful if swallowed.

SIGNS AND SYMPTOMS OF EXPOSURE

Symptoms of exposure may include burning sensation, coughing,
wheezing, laryngitis, shortness of breath, headache, nausea, and
vomiting. To the best of our knowledge, the chemical, physical,
and toxicological properties have not been thoroughly
investigated.

CHRONIC EXPOSURE - MUTAGEN

Species: Rat
Route: Intraperitoneal
Dose: 425 MG/KG
Mutation test: DNA damage

CHRONIC EXPOSURE - REPRODUCTIVE HAZARD

Species: Rat
Dose: 14 GM/KG
Route of Application: Oral
Exposure Time: (7-20D PREG)
Result: Maternal Effects: Other effects. Effects on Embryo or

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 Fetus: Fetotoxicity (except death, e.g., stunted fetus). Effects
on Embryo or Fetus: Fetal death.

Section 12 - Ecological Information

ACUTE ECOTOXICITY TESTS

Test Type: EC50 Daphnia

Species: Daphnia magna
Time: 24 h
Value: 15,683 - 21,823 mg/l

Test Type: LC50 Fish

Species: Cyprinodon variegatus (Sheepshead minnow)
Time: 96 h
Value: 13,198 - 20,254 mg/l

Section 13 - Disposal Considerations

APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION

Contact a licensed professional waste disposal service to dispose
of this material. Burn in a chemical incinerator equipped with an
afterburner and scrubber but exert extra care in igniting as this
material is highly flammable. Observe all federal, state, and
local environmental regulations.

Section 14 - Transport Information

DOT
Proper Shipping Name: Flammable solids, organic, n.o.s.
UN#: 1325
Class: 4.1
Packing Group: Packing Group II
Hazard Label: Flammable solid
PIH: Not PIH

IATA
Proper Shipping Name: Flammable solid, organic, n.o.s.
IATA UN Number: 1325
Hazard Class: 4.1
Packing Group: II

Section 15 - Regulatory Information

EU DIRECTIVES CLASSIFICATION
Symbol of Danger: Xn
Indication of Danger: Harmful.
R: 22
Risk Statements: Harmful if swallowed.
S: 24/25
Safety Statements: Avoid contact with skin and eyes.

US CLASSIFICATION AND LABEL TEXT

Indication of Danger: Flammable. Harmful.
Risk Statements: Harmful if swallowed.
Safety Statements: Keep container tightly closed. Keep away from
sources of ignition - no smoking. In case of contact with eyes,
rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.

UNITED STATES REGULATORY INFORMATION

SARA LISTED: No

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 TSCA INVENTORY ITEM: Yes

CANADA REGULATORY INFORMATION

WHMIS Classification: This product has been classified in
accordance with the hazard criteria of the CPR, and the MSDS
contains all the information required by the CPR.
DSL: Yes
NDSL: No

Section 16 - Other Information

DISCLAIMER
For R&D use only. Not for drug, household or other uses.

WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2004 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.

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