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Bohlmann-Rahtz Pyridine Synthesis PDF

The document describes the Bohlmann-Rahtz pyridine synthesis, a chemical reaction that produces pyridine derivatives. The synthesis involves reacting an amide with acetic anhydride to form an imide, which then undergoes a cyclodehydration reaction to form the pyridine product by removing a water molecule. Various substituents can be placed on the pyridine ring at different positions through this multi-step synthesis process.

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Abdullah Sabry Azzam
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140 views1 page

Bohlmann-Rahtz Pyridine Synthesis PDF

The document describes the Bohlmann-Rahtz pyridine synthesis, a chemical reaction that produces pyridine derivatives. The synthesis involves reacting an amide with acetic anhydride to form an imide, which then undergoes a cyclodehydration reaction to form the pyridine product by removing a water molecule. Various substituents can be placed on the pyridine ring at different positions through this multi-step synthesis process.

Uploaded by

Abdullah Sabry Azzam
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
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Evan J.

Weinberg

Bohlmann-Rahtz Pyridine Synthesis

R2

O O
NH4 OAc

N R3 R4
R1 O

R2

H
H
O O
O O H NH3
OAc

R3 R4
R3 R4 R1 O

R2 O R2 O

NH3
R3 R3
-H2O

O R4 O R4
O R1 HN R1

-H2O

R2 O

TM

R3

R1 N R4

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