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Pathophysiology of Ugib

Age, gender, and race are non-modifiable risk factors for upper gastrointestinal bleeding, while long-term aspirin use and coffee intake are contributing and modifiable risk factors, respectively. These factors can elicit effects on cyclooxygenase, impair mucosal defenses to acid, disrupt the mucous barrier, cause epigastric pain and ulcers that burrow into the gastro-duodenal mucosa, thin arterial walls, and cause weakened walls to rupture, resulting in upper gastrointestinal bleeding that presents as melena, low hemoglobin levels, and symptoms like lightheadedness, weakness, and pale skin and conjunctiva.

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Chombe Jc
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279 views1 page

Pathophysiology of Ugib

Age, gender, and race are non-modifiable risk factors for upper gastrointestinal bleeding, while long-term aspirin use and coffee intake are contributing and modifiable risk factors, respectively. These factors can elicit effects on cyclooxygenase, impair mucosal defenses to acid, disrupt the mucous barrier, cause epigastric pain and ulcers that burrow into the gastro-duodenal mucosa, thin arterial walls, and cause weakened walls to rupture, resulting in upper gastrointestinal bleeding that presents as melena, low hemoglobin levels, and symptoms like lightheadedness, weakness, and pale skin and conjunctiva.

Uploaded by

Chombe Jc
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as DOC, PDF, TXT or read online on Scribd
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V.

Pathophysiology

NON MODIFIABLE FACTORS: CONTRIBUTING FACTORS: MODIFIABLE FACTORS:


Age, Gender and Race Aspirin intake for 5 years Coffee intake

Elicit their effects on the Cyclooxygenase

Impaired mucosal defense to acid

Disruption of mucous barrier

Epigastric pain Ulcer burrows deep into the gastro


duodenal mucosa

Thinning of the arterial walls

Weakened walls ruptured

UPPER GASTRO INTESTINAL


BLEEDING

Melena

Low Hemoglobin Level

Light headedness and Pallor, poor skin turgor


weakness and poor capillary refill

Pale Palpebral conjunctiva

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