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Preface: Encyclopedia (Marshall Sittig, Noyes Publications, Westwood

This document is the preface to the Third Edition of the Pharmaceutical Manufacturing Encyclopedia. It contains descriptions of 2266 pharmaceuticals marketed in America and other countries. Information on 1295 pharmaceuticals comes from the Second Edition, while information on 971 additional pharmaceuticals approved by the FDA since 1986 are also included. The Encyclopedia comprises 4 volumes in alphabetical order. The preface describes the information sources used to identify manufacturing processes, patents, and other data for the drugs listed.

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190 views4 pages

Preface: Encyclopedia (Marshall Sittig, Noyes Publications, Westwood

This document is the preface to the Third Edition of the Pharmaceutical Manufacturing Encyclopedia. It contains descriptions of 2266 pharmaceuticals marketed in America and other countries. Information on 1295 pharmaceuticals comes from the Second Edition, while information on 971 additional pharmaceuticals approved by the FDA since 1986 are also included. The Encyclopedia comprises 4 volumes in alphabetical order. The preface describes the information sources used to identify manufacturing processes, patents, and other data for the drugs listed.

Uploaded by

Julcon Avanceña Araiz
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PDF, TXT or read online on Scribd
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Preface

The Third Edition of Pharmaceutical Manufacturing


Encyclopedia contains descriptions of manufacturing processes,
structural formulas, trade names, therapeutic functions, and other
information on 2266 pharmaceuticals now being marketed as
trade-named products in America and many other countries.
Information on 1295 pharmaceuticals has been taken from the
Second Edition of the Pharmaceutical Manufacturing
Encyclopedia (Marshall Sittig, Noyes Publications, Westwood,
New Jersey, USA, 1986). Information on 971 additional
pharmaceuticals, including those approved by the U.S. Food and
Drug Administration (FDA) since 1986, are included in the
Encyclopedia as well.

The Encyclopedia comprises 4 volumes:


Volume 1: A through B
Volume 2: C through G
Volume 3: H through P
Volume 4: Q through Z, and the Raw Materials and Trade
Names Indexes.

The pharmaceuticals are listed in alphabetical order.

INFORMATION SOURCES USED

For the Second Edition, a variety of sources were used to identify


the patents associated with particular commercial products and to
serve as a source of process information. The sources included the
following:

Merck Index: followed by a citation of the entry number in the


Tenth (1983) Edition.1
vi

DFU: The periodical publication, Drugs of the Future,3 published


by Prous Science.
DOT: The periodical publication, Drugs of Today,4 published by
Prous Science.
Kleeman & Engel: The encyclopedic German work,
Pharmazeutische Werkstoffe,5 second revised edition published in
1982.
OCDS: The 3-volume reference series, The Organic Chemistry of
Drug Synthesis.7
In addition, sources of pharmacological data and comparative
information on trade names used in various countries were
obtained from:
REM: Remington's Pharmaceutical Sciences.9
Nonproprietary Name Index: The nonproprietary name index
published by Paul de Haen.11
I.N.: The biannual Swiss publication, Index Nominum.12
PDR: The guide to commercially available U.S. drugs, the
Physicians' Desk Reference.13

For the Third Edition, a number of new and updated sources


were used, including the latest edition of The Merck Index.2
Extensive use has been made of the US, British, German, and
world patent literature with regard to the process information.
In addition, a variety of sources were used to identify the patents
associated with particular commercial products and to serve as a
source of process information. These include the encyclopedic
German work Pharmazeutische Wirkstoffe (4th edition), edited by
A. Kleeman and J. Engel,6 and the 6-volume reference series on
the Organic Chemistry of Drug Synthesis by Daniel Lednicer8 and
references [10] through [14] below.
vii

In addition to the patent-derived process information, references to


major pharmaceutical reference works where additional
information can be obtained on synthesis methods and the
pharmacology of the individual products are also cited under each
drug entry.

Pharmacological data and comparative information on trade names


used in various countries were obtained from Organic-Chemical
Drugs and Their Synonyms, 8th ed., by M. Negwer and H.-G.
Scharnow. 15

July 2006
References
1. Windholz, M., editor, The Merck Index, 10th ed. Rahway, NJ: Merck
& Co., Inc. (1983).
2. Smith, Ann, et al., The Merck Index: An Encyclopedia of Chemicals,
Drugs, & Biologicals, 13th ed. Rahway, NJ: Merck & Co., Inc.
(2001).
3. Prous, J.R., editor, Drugs of the Future, Vol. 30. Barcelona, Spain:
Prous Science Publishers (2005)
4. Prous, J.R., editor. Drugs of Today, Vol. 41. Barcelona, Spain: Prous
Science Publishers (2005)
5. Kleeman, A. and Engel, J., Pharmazeutische Werkstoffe: Synthesen,
Patente, Anwendugen, Stuttgart, Germany: Georg Thieme Verlag,
(1982).
6. Kleeman A., Engel J. Pharmazeutische Wirkstoffe. English:
Pharmaceutical substances: syntheses, patents, applications, 4th ed.
Stuttgart, Germany: Georg Thieme Verlag, (2001).
7. Lednicer, D., and Mitscher, L., The Organic Chemistry of Drug
Synthesis, New York: John Wiley and Sons. Vol. 1 (1977); Vol. 2
(1980); Vol. 3 (1984); Vol. 4 (1990).
8. Lednicer, D., The Organic Chemistry of Drug Synthesis, New York:
John Wiley and Sons. Vol. 4 (1990); Vol. 5 (1994); Vol. 6 (1998).
viii

9. Philadelphia College of Pharmacy and Science, Remington's


Pharmaceutical Sciences, 17th ed. Easton, PA: Mack Publishing Co.
(1985).
10. Alfonso R. Gennaro, editor. Remington: The Science and Practice of
Pharmacy (Remington's Pharmaceutical Sciences), 20th ed. New
York: Lippincott Williams & Wilkins (2000).
11. Paul de Haen International, Inc., Nonproprietary Name Index, 15th
ed. Englewood, CO: Paul de Haen International, Inc. (1984).
12. H.P. Jasperson et al., editors. Index Nominum, Zurich, Switzerland:
Swiss Pharmaceutical Society (1984).
13. Barnhart, E.R., editor, Physicians' Desk Reference, 40th ed. Oradell,
NJ: Medical Economics Co., Inc. (1986).
14. Physicians Desk Reference, 55th ed. Oradell, NJ: Medical
Economics Co., Inc. (2001).
15. Negwer, M., and Scharnow, H.-G., Organic-Chemical Drugs and
Their Synonyms, 8th ed. New York: John Wiley and Sons (2001).

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