SwissTargetPrediction

Target Common Uniprot ChEMBL ID Target Class Probability* Known

name ID actives
(3D/2D)
Peroxisome proliferator- PPARD Q03181 CHEMBL3979 Nuclear 0.248387034018 0 / 7     
activated receptor delta receptor
Fatty acid binding FABP2 P12104 CHEMBL4879 Fatty acid 0.248387034018 0 / 1     
protein intestinal binding protein
family
Fatty acid binding FABP4 P15090 CHEMBL2083 Fatty acid 0.217345402545 2 / 3     
protein adipocyte binding protein
family
Peroxisome proliferator- PPARA Q07869 CHEMBL239 Nuclear 0.217345402545 27 / 9     
activated receptor receptor
alpha
Fatty acid binding FABP3 P05413 CHEMBL3344 Fatty acid 0.217345402545 1 / 5     
protein muscle binding protein
family
11-beta-hydroxysteroid HSD11B1 P28845 CHEMBL4235 Enzyme 0.217345402545 20 / 22     
dehydrogenase 1
Aldo-keto reductase AKR1B10 O60218 CHEMBL5983 Enzyme 0.176998752973 2 / 7     
family 1 member B10
Solute carrier family 22 SLC22A6 Q4U2R8 CHEMBL1641347 Electrochemical 0.146856850103 1 / 2     
member 6 (by transporter
homology)
Vitamin D receptor VDR P11473 CHEMBL1977 Nuclear 0.146856850103 0 / 2     
receptor
Bile acid receptor FXR NR1H4 Q96RI1 CHEMBL2047 Nuclear 0.146856850103 0 / 11     
receptor
DNA polymerase beta POLB P06746 CHEMBL2392 Enzyme 0.146856850103 0 / 5     
(by homology)
Dual specificity CDC25A P30304 CHEMBL3775 Phosphatase 0.146856850103 0 / 14     
phosphatase Cdc25A
G-protein coupled bile GPBAR1 Q8TDU6 CHEMBL5409 Family A G 0.146856850103 0 / 15     
acid receptor 1 protein-coupled
receptor
Fatty acid binding FABP5 Q01469 CHEMBL3674 Fatty acid 0.135105167765 1 / 2     
protein epidermal binding protein
family
Free fatty acid receptor FFAR1 O14842 CHEMBL4422 Family A G 0.114586695126 3 / 3     
1 protein-coupled
receptor
Histone lysine PHF8 Q9UPP1 CHEMBL1938212 Eraser 0.105843861316 0 / 1     
demethylase PHF8
Corticosteroid binding SERPINA6 P08185 CHEMBL2421 Secreted 0.105843861316 0 / 6     
globulin protein
Testis-specific SHBG P04278 CHEMBL3305 Secreted 0.105843861316 0 / 26     
androgen-binding protein
protein
Estradiol 17-beta- HSD17B3 P37058 CHEMBL4234 Enzyme 0.105843861316 0 / 11     
dehydrogenase 3
Glucose-6-phosphate 1- G6PD P11413 CHEMBL5347 Enzyme 0.105843861316 0 / 9     
dehydrogenase
GABA-B receptor (by GABBR1 Q9UBS5 CHEMBL2064 Family C G 0.105843861316 0 / 1     
homology) protein-coupled
 Target Common Uniprot ChEMBL ID Target Class Probability* Known
name ID actives
(3D/2D)
receptor
Lysine-specific KDM2A Q9Y2K7 CHEMBL1938210 Eraser 0.0849737018175 2 / 1     
demethylase 2A
Prostanoid FP receptor PTGFR P43088 CHEMBL1987 Family A G 0.0849737018175 0 / 1     
protein-coupled
receptor
Protein FNTA P49354 CHEMBL2094108 Enzyme 0.0849737018175 0 / 8     
farnesyltransferase FNTB P49356
Niemann-Pick C1-like NPC1L1 Q9UHC9 CHEMBL2027 Other 0.0849737018175 0 / 6     
protein 1 membrane
protein
Prostanoid EP2 PTGER2 P43116 CHEMBL1881 Family A G 0.0743164735672 2 / 5     
receptor protein-coupled
receptor
SUMO-activating SAE1 Q9UBE0 CHEMBL2095174 Enzyme 0.0649510872641 1 / 2     
enzyme UBA2 Q9UBT2
11-beta-hydroxysteroid HSD11B2 P80365 CHEMBL3746 Enzyme 0.0649510872641 0 / 3     
dehydrogenase 2
Androgen Receptor AR P10275 CHEMBL1871 Nuclear 0.0544879468076 1 / 33     
receptor
Cytochrome P450 19A1 CYP19A1 P11511 CHEMBL1978 Cytochrome 0.0443083186041 1 / 22     
P450
Aldose reductase (by AKR1B1 P15121 CHEMBL1900 Enzyme 0.0443083186041 37 / 0     
homology)
Plasminogen PLG P00747 CHEMBL1801 Protease 0.0443083186041 0 / 1     
Protein-tyrosine PTPN1 P18031 CHEMBL335 Phosphatase 0.0443083186041 0 / 27     
phosphatase 1B
Glutathione S- GSTK1 Q9Y2Q3 CHEMBL4491 Enzyme 0.0443083186041 0 / 1     
transferase kappa 1
Carbonic anhydrase II CA2 P00918 CHEMBL205 Lyase 0.033970689612 16 / 5     
Carbonic anhydrase I CA1 P00915 CHEMBL261 Lyase 0.033970689612 15 / 7     
CDC45-related protein CDC45 O75419 CHEMBL3040 Other nuclear 0.033970689612 0 / 1     
protein
Lysine-specific KDM5C P41229 CHEMBL2163176 Eraser 0.033970689612 1 / 1     
demethylase 5C
Cyclooxygenase-2 PTGS2 P35354 CHEMBL230 Oxidoreductase 0.033970689612 42 / 2     
UDP- UGT2B7 P16662 CHEMBL4370 Enzyme 0.033970689612 1 / 20     
glucuronosyltransferase
2B7
Hydroxyacid oxidase 1 HAO1 Q9UJM8 CHEMBL4229 Enzyme 0.0238327432783 2 / 1     
Voltage-gated calcium CACNA2D1 P54289 CHEMBL1919 Calcium 0.0238327432783 0 / 4     
channel alpha2/delta channel
subunit 1 auxiliary
subunit
alpha2delta
family
GABA A receptor GABRA2 P47869 CHEMBL2111413 Ligand-gated 0.0238327432783 1 / 2     
alpha-2/beta-2/ GABRB2 P47870 ion channel
gamma-2 GABRG2 P18507
G protein-coupled PTGDR2 Q9Y5Y4 CHEMBL5071 Family A G 0.0238327432783 38 / 0     
receptor 44 protein-coupled
receptor
 Target Common Uniprot ChEMBL ID Target Class Probability* Known
name ID actives
(3D/2D)
Metabotropic glutamate GRM5 P41594 CHEMBL3227 Family C G 0.0238327432783 0 / 4     
receptor 5 protein-coupled
receptor
Prostaglandin E PTGES O14684 CHEMBL5658 Enzyme 0.0238327432783 0 / 8     
synthase
Squalene synthetase FDFT1 P37268 CHEMBL3338 Enzyme 0.0238327432783 0 / 1     
(by homology)
Prostanoid DP receptor PTGDR Q13258 CHEMBL4427 Family A G 0.0 7 / 0     
protein-coupled
receptor
Solute carrier family 22 SLC22A12 Q96S37 CHEMBL6120 Electrochemical 0.0 23 / 0     
member 12 transporter
Leukotriene A4 LTA4H P09960 CHEMBL4618 Protease 0.0 1 / 1     
hydrolase
Prostanoid EP3 PTGER3 P43115 CHEMBL3710 Family A G 0.0 1 / 0     
receptor protein-coupled
receptor
Steroid 5-alpha- SRD5A1 P18405 CHEMBL1787 Oxidoreductase 0.0 7 / 0     
reductase 1
Monocarboxylate SLC16A1 P53985 CHEMBL4360 Electrochemical 0.0 9 / 0     
transporter 1 (by transporter
homology)
Interleukin-8 CXCL8 P10145 CHEMBL2157 Secreted 0.0 9 / 0     
protein
Palmitoleoyl-protein NOTUM Q6P988 CHEMBL3714531 Hydrolase 0.0 35 / 0     
carboxylesterase
NOTUM
Histone deacetylase 3 HDAC3 O15379 CHEMBL1829 Eraser 0.0 0 / 1     
HMG-CoA reductase HMGCR P04035 CHEMBL402 Oxidoreductase 0.0 0 / 21     
c-Jun N-terminal kinase MAPK10 P53779 CHEMBL2637 Kinase 0.0 2 / 0     
3
Glutamate FOLH1 Q04609 CHEMBL1892 Protease 0.0 2 / 10     
carboxypeptidase II
Acetylcholinesterase ACHE P22303 CHEMBL220 Hydrolase 0.0 1 / 2     
Kynurenine 3- KMO O15229 CHEMBL2145 Oxidoreductase 0.0 17 / 0     
monooxygenase (by
homology)
Anandamide FAAH O00519 CHEMBL2243 Enzyme 0.0 0 / 1     
amidohydrolase
Telomerase reverse TERT O14746 CHEMBL2916 Enzyme 0.0 0 / 1     
transcriptase
Betaine transporter SLC6A12 P48065 CHEMBL3715 Electrochemical 0.0 0 / 3     
transporter
Xaa-Pro dipeptidase PEPD P12955 CHEMBL4185 Protease 0.0 0 / 1     
Carnitine O- CPT1A P50416 CHEMBL1293194 Enzyme 0.0 0 / 4     
palmitoyltransferase 1,
liver isoform (by
homology)
Mast cell CPA3 P15088 CHEMBL2645 Protease 0.0 1 / 0     
carboxypeptidase A
D-amino-acid oxidase DAO P14920 CHEMBL5485 Enzyme 0.0 3 / 0     
Egl nine homolog 3 EGLN3 Q9H6Z9 CHEMBL5705 Enzyme 0.0 2 / 0     
 Target Common Uniprot ChEMBL ID Target Class Probability* Known
name ID actives
(3D/2D)
G-protein coupled GRK2 P25098 CHEMBL4079 Kinase 0.0 3 / 0     
receptor kinase 2
Transient receptor TRPM8 Q7Z2W7 CHEMBL1075319 Voltage-gated 0.0 0 / 1     
potential cation channel ion channel
subfamily M member 8
Glutamate receptor GRIK1 P39086 CHEMBL1918 Ligand-gated 0.0 0 / 5     
ionotropic kainate 1 ion channel
Glutamate receptor GRIK2 Q13002 CHEMBL3683 Ligand-gated 0.0 0 / 4     
ionotropic kainate 2 ion channel
Metabotropic glutamate GRM2 Q14416 CHEMBL5137 Family C G 0.0 0 / 18     
receptor 2 (by protein-coupled
homology) receptor
Acyl-CoA desaturase SCD O00767 CHEMBL5555 Enzyme 0.0 0 / 1     
Peroxisome proliferator- PPARG P37231 CHEMBL235 Nuclear 0.0 21 / 8     
activated receptor receptor
gamma
Cathepsin (B and K) CTSB P07858 CHEMBL4072 Protease 0.0 1 / 0     
Aldo-keto-reductase AKR1C3 P42330 CHEMBL4681 Enzyme 0.0 26 / 0     
family 1 member C3
Nuclear receptor NR4A1 P22736 CHEMBL1293229 Nuclear 0.0 4 / 0     
subfamily 4 group A receptor
member 1
C-C chemokine receptor CCR2 P41597 CHEMBL4015 Family A G 0.0 10 / 0     
type 2 protein-coupled
receptor
Carbonic anhydrase XII CA12 O43570 CHEMBL3242 Lyase 0.0 14 / 0     
Heat shock 70 kDa HSPA1A P0DMV8 CHEMBL5460 Other cytosolic 0.0 6 / 0     
protein 1 protein
Macrophage migration MIF P14174 CHEMBL2085 Enzyme 0.0 1 / 0     
inhibitory factor
Aldo-keto reductase AKR1C1 Q04828 CHEMBL5905 Enzyme 0.0 3 / 0     
family 1 member C1
Egl nine homolog 1 EGLN1 Q9GZT9 CHEMBL5697 Oxidoreductase 0.0 0 / 2     
Protein-tyrosine PTPN6 P29350 CHEMBL3166 Phosphatase 0.0 0 / 1     
phosphatase 1C
Aminopeptidase A ENPEP Q07075 CHEMBL3439 Protease 0.0 0 / 7     
T-cell protein-tyrosine PTPN2 P17706 CHEMBL3807 Phosphatase 0.0 0 / 13     
phosphatase
Excitatory amino acid SLC1A2 P43004 CHEMBL4973 Electrochemical 0.0 0 / 3     
transporter 2 transporter
Nuclear receptor NR1I3 Q14994 CHEMBL5503 Nuclear 0.0 0 / 2     
subfamily 1 group I receptor
member 3
Intercellular adhesion ITGAL P20701 CHEMBL2096661 Membrane 0.0 4 / 0     
molecule (ICAM-1), ICAM1 P05362 receptor
Integrin alpha-L/beta-2 ITGB2 P05107
3-phosphoinositide PDPK1 O15530 CHEMBL2534 Kinase 0.0 2 / 0     
dependent protein
kinase-1
Transthyretin TTR P02766 CHEMBL3194 Secreted 0.0 3 / 0     
protein
Replication protein A 70 RPA1 P27694 CHEMBL1764940 Unclassified 0.0 9 / 0     
 Target Common Uniprot ChEMBL ID Target Class Probability* Known
name ID actives
(3D/2D)
kDa DNA-binding protein
subunit
Thrombin F2 P00734 CHEMBL204 Protease 0.0 1 / 0     
Renin REN P00797 CHEMBL286 Protease 0.0 2 / 0     
Casein kinase II alpha CSNK2A1 P68400 CHEMBL3629 Kinase 0.0 6 / 0     
Heat shock protein HSP HSP90AA1 P07900 CHEMBL3880 Other cytosolic 0.0 1 / 0     
90-alpha protein
Casein kinase II alpha CSNK2A2 P19784 CHEMBL4070 Kinase 0.0 6 / 0     
(prime)
Receptor-type tyrosine- PTPRG P23470 CHEMBL4905 Phosphatase 0.0 3 / 0     
protein phosphatase
gamma