Line List MPP SRU Column-1(Stream-I)- P&ID IPA from BUP MLR and IPA+EA MLR from Venla

Phase Fluid Density Flow rate Flow rate Area Line size Line Size Pressure
Line No Fluid (solid/Liq/Gas) (kg/m3) Line From Line To (kg/hr) (m3/hr) required required (mm) selected (NB) drop MOC Remarks
(mm2)
PID No.: Case-1 Column-1

Toluene+TBA ML's Liquid 867 T-10 K-01 8670 10.00 1389 42.06 50 - SS-304

Gas 2.23 K-01 C-01 1380 619 17191 147.98 150 - SS-304
Vapour line
Gas 2.23 C-01 HE-01 276 124 3438 66.18 80 - SS-304

Nitrogen Gas 1.25 N2 Header K-01 -- 0.005 0.1 0.42 25 - SS-304

Reflux line Liquid 826 P-12/P-13 C-01 1150 1.4 193 15.69 50 - SS-304

CT Water Utility for HE-01 CT-water 1000 CSW Header HE-01 67843 68 9423 109.56 150 - MS

Chilled Water Utility for HE-01 Chilled Water 1000 CHWS Header HE-01 46513 47 6460 90.72 100 - MS

Chilled Water Utilty for HE-02 Chilled Water 1000 CHWS Header HE-02 13569 14 1885 49.00 80 - MS

Bottom Line Viscous Liquid 1100-1500 K-01 Spent Tank-1 5000 5 631.31 28.36 40 - SS-304

CT water Liquid 1000 CWS Header K-01 Jacket 37500 38 5208.33 81.45 80 - MS

Steam Vapour 2 LPS Header K-01 516 258 2866.67 60.43 80 MS

CIP Liquid 900-1000 CIP tank K-01 15000 14 1893.94 49.12 50 MS

Vacuum Line Vapour 0.7-1.2 Vacuum Trap FT-02 336 280 2592.59 57.47 80 SS-304

Transfer line Liquid 826 T-02 and T-11 T-03 and T-12 4300 5 723.03 30.35 40 SS-304

Transfer line Liquid 826 T-02 and T-11 T-10 and T-01 4300 5 723.03 30.35 40 SS-304

CT Water Liquid 1000 Utility Header K-01 12048.37 12 1673.38 46.17 50 MS

Re-circulation line Liquid 826 T-02, T-11, T-03 2891 4 486.11 24.88 25 SS-304
and T-12

Fraction Collection Line -1 Liquid 826 HE-01 and HE- Reflux Drum-01 1374 2 231.03 17.16 40 SS-304
02

Fraction Collection Line -2 Liquid 826 Reflux drum T-02 and T-11 1374 2 231.03 17.16 40 SS-304

CIP solution Liquid 1000-1100 CIP Tank K-01 15000 14 1893.94 49.12 50 MS

Reactor SRV vent Gas 700-900 K-01 Dump Tank 80X100 MS

Nitrogen plant and Compressed air main header lines

Phase Fluid Density Line From Flow rate Flow rate Area Line size Line Size Pressure
Line No Fluid Line To required MOC Remarks
(solid/Liq/Gas) (kg/m3) (kg/hr) (m3/hr) required (mm) selected (NB) drop
(m2)
Nitrogen Gas N2 supply line SRU 100 0.00 48.57 50 SS304

Compressed Air Gas Air supply SRU 100 0.00 48.57 50 SS304
Utility Header Lines
Area
Line No Fluid Phase Fluid Density Line From Line To Flow rate Flow rate required Line size Line Size Pressure MOC Remarks
(solid/Liq/Gas) (kg/m3) (kg/hr) (m3/hr) (m2) required (mm) selected (NB) drop
CHW Supply and return line Liquid 1000 Utility SRU 80 0.01 118.97 150 MS
headers
RT Water supply and return line Liquid 1000 Utility SRU 350 0.05 248.85 250 MS
headers
RO Water Supply to the plant Liquid 1000 RO Plant SRU 5 0.00 29.74 40 SS-316
Line List MPP SRU Reactor-1 P&ID
Phase Fluid Density Flow rate Flow rate Area Line size Line Size Pressure
Line No Fluid (solid/Liq/Gas) (kg/m3) Line From Line To (kg/hr) (m3/hr) required required (mm) selected (NB) drop MOC Remarks
(mm2)
PID No.: Case-2 Reactor

6.3 KL New
Toluene MLR Liquid 826 MLR Tank Reactor-1 4130 5.00 694 29.74 40 - MSPTFE

Gas 3 Reactor-1 HE-01 482 161 4462 75.40 100 - MSPTFE

Vapour line
Gas 3 HE-01 outlet HE-02 outlet 96 32 892 33.72 50 - MSPTFE

Nitrogen Gas 1.25 N2 supply line Batch Kettle-1 -- 0.005 0.1 0.42 25 - SS-304

Distillate
Reflux line Liquid 826 HE-02 Collection Tank 161 0.2 27 5.87 40 - MSPTFE

CT Water Utility for HE-01 CT-water 999 CT Water HE-01 25000 25 3476 66.54 80 - MS
Header

Chilled Water Utilty for HE-02 Chilled Water 1000 Chilled water HE-02 2410 2 335 20.65 50 - MS
Header

Bottom Line Viscous Liquid 1100-1500 Reactor-1 Spent Tank- 5000 5 631.31 28.36 40 - MSPTFE

CT water Liquid 1000 Utility Reactor-1 18000 18 2500.00 56.43 80 - MS

Steam Vapour 2 Utility Reactor-1 241 120 1338.71 41.30 40 MS

CIP Liquid 900-1000 Utility Reactor-1 15000 14 1893.94 49.12 50 MS

Vacuum Line Vapour 0.7-1.2 Vacuum Trap Inprocess Tank- 336 280 2592.59 57.47 80 SS-304
1

Transfer line Liquid 826 Inprocess Tank- Recovered 4300 5 723.03 30.35 40 SS-304
1 Tank-1

Re-circulation line Liquid 826 Inprocess tank- Inprocess Tank- 2891 4 486.11 24.88 25 SS-304
1 1

Fraction Collection Line -1 Liquid 826 HE-01 and HE- Distillate 161 0.2 27.01 5.87 40 MSPTFE
02 Collection Tank

Fraction Collection Line -2 Liquid 826 Distillate In process 160.644915 0 27.01 5.87 40 SS-304
Collection Tank Tank-1
CIP solution Liquid 1000-1100 CIP Tank Equipment 15000 14 1893.94 49.12 50 MS

Reactor SRV vent Gas 700-900 Reactor-1 Dump Tank 80X100 MS

Nitrogen plant and Compressed air main header lines

Area
Line No Fluid Phase Fluid Density Line From Line To Flow rate Flow rate required Line size Line Size Pressure MOC Remarks
(solid/Liq/Gas) (kg/m3) (kg/hr) (m3/hr) required (mm) selected (NB) drop
(m2)
Nitrogen Gas N2 supply line SRU 50 0.00 34.34 50 SS304

Compressed Air Gas Air supply SRU 50 0.00 34.34 50 SS304

Utility Header Lines
Area
Line No Fluid Phase Fluid Density Line From Line To Flow rate Flow rate required Line size Line Size Pressure MOC Remarks
(solid/Liq/Gas) (kg/m3) (kg/hr) (m3/hr) (m2) required (mm) selected (NB) drop
CHW Supply and return line Liquid 1000 Utility SRU 80 0.01 118.97 150 MS
headers
RT Water supply and return line Liquid 1000 Utility SRU 350 0.05 248.85 250 MS
headers
RO Water Supply to the plant Liquid 1000 RO Plant SRU 5 0.00 29.74 40 SS-316
 STEAM

Working Heating Surface Overall Heat

SL. No. Tag No. MOC transfer
Capacity (Lts) area, m2
Coefficient, U
kCal/hr.m2.°C

1 Reactor MSGL 6300 16.10 150.00

STEAM COOLING WATER CHILLED WATER

Overall
Heat
Heat Load Heat load for
transfer Water
Heat Load Steam Heat Load for Water flow condenser CHWS
Coefficie flow
(Kcal/hr) (Kg/hr) (Kcal/hr) condenser m³/hr when in (m³/hr)
nt, U m³/hr
Secondary
kCal/hr.
m2.°C

48193.47 94.50 175.00 ### 20.34 48193.47 9.69 9638.69 2.41

43.74862 m3/hr
481.93474 486.0957 mm2 2825.339 mm2 1345.39964 mm2 334.689 mm2
Kg/hr 24.88434 50 NB 59.99299 80 NB 41.3990929 80 NB 20.64837 40 NB
TCE-5986A : Dr. Reddy's Laboratories Ltd. Date: 01-07-2010
Specification of Utilities
LPS
Sat. temp. 130 °C
Density 2.16 Kg/m3
Latent heat 2132 kJ/Kg
510.00 kCal/Kg

Overall Heat transfer Coefficient (U) Values (kCal/hr.m2.°C)

UTILITY MSGL Reactor Toluene CW

Steam 225 Toluene Vapour 110.60
Hot Water 200 Tolune Liquid 110.60
Cooling Water 175 Delta T1 73.60
Chilled Water 150 Delta T2 78.60
LMTD 76.07

LMTD
Utility I/L Temp (K) O/L Temp (K) Inlet temp oC Return temp °C Delta T
Low pressure Steam 403.00 403.00 130.00 130.00 0.00
( Kg/cm2.g)
Hot Water 358.00 353.00 85.00 80.00 5.00
Cooling Water 305.00 310.00 32.00 37.00 5.00
Chilled Water 280.00 284.00 7.00 11.00 4.00

STEAM COOLING WATER CHILLED WATER

DT1 DT2 LMTD(°K) DT1(°C) DT2(°C) LMTD(°C) DT1(°C) DT2(°C) LMTD(°C)
Toluene 70.00 20.00 39.91 98.00 8.00 35.92 38.00 14.00 24.04
TCE-5986A : Dr. Reddy's Laboratories Ltd. Date: 01-07-2010
ASPEN SIMULATION SUMMARY

Selected dia. 500 mm

No.of stages 40
Packed height 10 m

1. IPA-MLR: Bupropion

Dia as per Steady state

Description stages Packing type Feedrate (kg/h)
sizing (m)

Cut-1 1.0 40 Mellapak 500 Y

Cut-2 0.6 40 Mellapak 500 Y 2000
Cut-3 0.9 40 Mellapak 500 Y

2. IPA MLR Venlafaxine

Dia as per Steady state

Description stages Packing type Feedrate (kg/h)
sizing (m)

Cut-1 0.9 40 Mellapak 500 Y

Cut-2 1.0 40 Mellapak 500 Y 2000
Cut-3 0.9 40 Mellapak 500 Y

Pressure drop = 10 mm hg(Total)-10 m

Designed in continuos and suggested to increase recovery if feed does not have solid
3. Methanol MLR-Quetiapine

Dia as per Steady state

Description stages Packing type Feedrate (kg/h)
sizing (m)

Cut-1 1.300 40 Mellapak 500 Y

2000
Cut-2 1.000 40 Mellapak 500 Y

Pressure drop = 10 mm hg(Total)-10 m

Designed in continuos and suggested if feed does not have solid content. Separation difficult
4. Ethyl acetate MLR-Venlafaxine

Dia as per Steady state

Description stages Packing type Feedrate (kg/h)
sizing (m)

Cut-1 1.3 40 Mellapak 500 Y

Cut-2 0.7 40 Mellapak 500 Y 2000
Cut-2 0.7 40 Mellapak 500 Y

Pressure drop = 10 mm hg(Total)-10 m

Separation difficult. Batch recommended
5. DMF+water-Valacyclovir
 Dia as per Steady state
Description stages Pressure (in bar) Packing type
sizing (m)

Cut-1 0.75 40 0.3 Mellapak 500 Y

Cut-2 0.85 40 0.3 Mellapak 500 Y

delta P = 10 mmHg
Designed in continuos and suggested to increase recovery if feed does not have solid
6. TBA

Dia as per Steady state

Description stages Pressure (in bar) Packing type
sizing (m)

Cut-1 1.16 40 1.01325 Mellapak 500 Y

Distillate rate Selected Distillate rate (kg/h) for Reboiler
RR Time (in h)
(kg/h) dia selected dia duty(Kcal/h)

448 8.5 112.00 4.0 881399.086

119.5 10 0.5 98.76 1.2 236252.668
1374 2 424.07 3.2 673495.451

8.5

Distillate rate Selected Distillate rate (kg/h) for Reboiler

RR Time (in h)
(kg/h) dia selected dia duty(Kcal/h)

418 10 129.01 3.2 747682

400 12.5 0.5 100.00 4.0 851645
1175 2.5 362.65 3.2 662875
10.5

Distillate rate Selected Distillate rate (kg/h) for Reboiler

RR Time (in h)
(kg/h) dia selected dia duty(Kcal/h)

687.9 10 101.76 6.8 1885521.65

0.5
1284 2 321.00 4.0 1000791.23
10.8

Distillate rate Selected Distillate rate (kg/h) for Reboiler

RR Time (in h)
(kg/h) dia selected dia duty(Kcal/h)

40 145 5.92 6.8 1142779.77

305 8 0.5 155.61 2.0 253922.275
1590 1 811.22 2.0 279292.561
8.7
Feedrate Distillate Distillate rate (kg/h)
RR Selected dia Time (in h)
(kg/h) rate (kg/h) for selected dia

367 3 163.11 2.3

2000 0.5
1595 0.5 551.90 2.9

5.1

Feedrate Distillate Distillate rate (kg/h)

RR Selected dia Time (in h)
(kg/h) rate (kg/h) for selected dia

2000 1719 5 0.5 319.37 5.4

5.4
Condenser Reboiler Condenser
duty(Kcal/h) duty(Kcal/h) duty(Kcal/h)

803419.301 220350 200855

236190.24 195250 195199
673495.241 207869 207869

220349.77 207868.90

Condenser Reboiler Condenser

duty(Kcal/h) duty(Kcal/h) duty(Kcal/h)

672120 230766 207444

851664 212911 212916
662875 204591 204591
230766.05 212916.00

Condenser Reboiler Condenser

duty(Kcal/h) duty(Kcal/h) duty(Kcal/h)

1834478.74 278923 271373

1000791.25 250198 250198
278923.32 271372.59

Condenser Reboiler Condenser

duty(Kcal/h) duty(Kcal/h) duty(Kcal/h)

1099822.82 169050 162696

253903.636 129552 129543
279292.535 142496 142496
169050.26 162695.68
Reboiler Condenser Reboiler Condenser
duty(Kcal/h) duty(Kcal/h) duty(Kcal/h) duty(Kcal/h)

349588.1286 270420.05232 155373 120187

334997.12916 334995.62796 115916 115915

155372.50 120186.69

Reboiler Condenser Reboiler Condenser

duty(Kcal/h) duty(Kcal/h) duty(Kcal/h) duty(Kcal/h)

1027125.99 1001410.26 190830 186053

190830.48 186052.74
DMF+Water stream IPA MLR -Venla stream

Liquid flow (Kg/h) Vapour flow (Kg/h) Liquid flow (Kg/h)

Cuts Summary Cuts Summary
Min Max Min Max Min
Cut-1 191.3 810.0 866.0 1090.1 Cut-1 580.7
Cut-2 203.1 808.4 866.0 1093.6 Cut-2 571.3
Cut-3 444.0
Ethyl acetate stream
Methanol MLR
Liquid flow (Kg/h) Vapour flow (Kg/h)
Cuts Summary
Min Max Min Max Liquid flow (Kg/h)
Cuts Summary
Cut-1 764.2 784.1 837.6 1138.6 Min
Cut-2 769.8 996.5 837.6 1147.3 Cut-1 532.2
Cut-3 575.6 899.2 837.6 1150.1 Cut-2 381.3

IPA MLR -BUP stream Overall Summary

Liquid flow (Kg/h) Vapour flow (Kg/h) Liquid flow (Kg/h)

Cuts Summary Description
Min Max Min Max Min
Cut-1 612.7 777.1 846.2 920.5 Overall 191.3
Cut-2 616.0 806.4 846.2 926.6 Density 857
Cut-3 613.9 797.4 846.2 936.6 0.223242
distributor flow

Reflux pump
Reflux pump flow required 1150
density 829
Flowrate 1.4
Flowrate selected 2
Liquid flow (Kg/h) Vapour flow (Kg/h)
Max Min Max
702.4 625.9 651.1
665.5 623.3 651.1
641.1 623.3 651.1

Liquid flow (Kg/h) Vapour flow (Kg/h)

Max Min Max
632.8 576.0 596.0
613.5 573.0 593.7

Liquid flow (Kg/h) Vapour flow (Kg/h) 0.143258

Max Min Max 0.19625
996.5 573.0 1150.1 1.493318
829 2.23 f-Factor 1.09
1.20 m3/h 515.73
0.36 m3/h

kg/h

m3/h
m3/h
 Condenser load Reboiler Load
Stream
(Kcal/h) (Kcal/h)
DMF+Water 120186.7 155372.5

TBA stream 186052.7 190830.5

Ethyl acetate MLR 162695.7 169050.3

IPA MLR-BUP 207868.9 220349.8

IPA MLR-Venla 212916.0 230766.0

Methanol MLR 271372.6 278923.3

Max loads 271372.6 278923.3

516.52466852948
Condenser ASPEN Summary
Stream Cuts Heat Load (Kcal/h) Area (m2) Overdesign

Cut-1 320936 18.1

Methanol MLR
Cut-2 294644 18.1

Cut-1 318563 12.4

IPA MLR-Venla Cut-2 308543 12.6

Cut-3 306901 14.4

Cut-1

Cut-2

Cut-3