Scribd
Upload
112 views15 pages

Chorionic Villus Sampling: Ashique Palliyal 09M2385

Chorionic villus sampling (CVS) is a prenatal test performed early in pregnancy to screen for genetic defects in the developing baby. It involves removing a small sample of chorionic villi from the placenta using either a transcervical or transabdominal approach. The sample is tested for chromosomal abnormalities and genetic disorders. CVS can be performed earlier than amniocentesis, between 10-12 weeks of pregnancy. It provides results within 2 weeks and carries a small risk of miscarriage.

Uploaded by

Sanjay Kumar Sanju
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
112 views15 pages

Chorionic Villus Sampling: Ashique Palliyal 09M2385

Chorionic villus sampling (CVS) is a prenatal test performed early in pregnancy to screen for genetic defects in the developing baby. It involves removing a small sample of chorionic villi from the placenta using either a transcervical or transabdominal approach. The sample is tested for chromosomal abnormalities and genetic disorders. CVS can be performed earlier than amniocentesis, between 10-12 weeks of pregnancy. It provides results within 2 weeks and carries a small risk of miscarriage.

Uploaded by

Sanjay Kumar Sanju
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
You are on page 1/ 15

CHORIONIC VILLUS

SAMPLING
Ashique Palliyal
09M2385
CHORIONIC VILLI
• Chorionic villi are villi that sprout from the chorion in
order to give a maximum area of contact with the
maternal blood.

• Embryonic blood is carried to the villi by the branches of


the umbilical arteries, and after circulating through the
capillaries of the villi, is returned to the embryo by the
umbilical veins.

• Thus, the villi are part of the border between maternal


and fetal blood during pregnancy.
• Villi cells have the same genetic makeup
as the growing fetus so it is easy to analyze
and identify genetic & chromosomal
abnormalities
Chorionic Villus Sampling (CVS)
• Chorionic villus sampling (CVS) is the
removal of a small piece of chorionic
villi (placenta) from the uterus during
early pregnancy to screen the baby for
genetic defects.

• In 1983 an Italian biologist named


Giuseppe Simoni discovered it.
INDICATIONS
 Abnormal first trimester screen results

 Increased nuchal translucency or other abnormal ultrasound


findings

 Family history of a chromosomal abnormality or other genetic


disorder

 Parents are known carriers for a genetic disorder

 Advanced maternal age (maternal age above 35).


AMA is associated with increase risk of Down's syndrome
risk is 1:400.
PROCEDURE
• Two ways 1. Transcervical
2. Transabdominal

• Preparation of the patient

• An abdominal ultrasound is performed to determine the


position of the uterus, the size of the gestational sac, and
the position of the placenta within the uterus.
vulva, vagina, cervix, and abdomen are cleaned with an
antiseptic.
TRANSCERVICAL
It is performed by inserting a thin plastic tube through vagina
& cervix to reach placenta with the help of ultrasound guided
images
• 10 weeks to 12 weeks
TRANSABDOMINAL
• It is performed by inserting a needle through the abdomen
utreus to reach placenta with the help of ultrasound guided
images
• 10 weeks to term
• Sample collected are sent to lab for direct preparation
and culture in special fluids

• The sample is used to study the DNA , chromosomes, and


certain signs (called chemical markers) of disease in the
developing baby.

• It can be done sooner than amniocentesis, about 10 to


12 weeks after last menstrual period.

• Test results take about 2 weeks.


RESULTS

• Normal Results
A normal result means there are no signs of any
genetic defects.

• Abnormal Results
• Down syndrome
• Hemoglobinopathies- sickle cell anemia
• Tay-Sachs disease
• sex linked disorders – muscular dystrophy
More than 200 gentic disorder can be identified
• Flase positive – placental mosaics
maternal cell contamination

• It does not detect


Neural tube defects
Rh incompatibility
Congenital defects

• It is also useful in determining paternity of a child prior to


delivery
Risks
• Miscarriage 1:100

• Infection

• Spotting

• Cramping and pain at puncture point

• Bleeding

• Rupture of membrane

• Limb reduction defects (LRD) when performed at <9 weeks


CONTRAINDICATIONS
• Women who
• Have an active infection(STD)

• Carrying twins

• Have experinced vaginal bleeding during pregnancy

• Having uterine fibroids

• Having tilted utreus


THANK YOU

You might also like

pFad - Phonifier reborn

Pfad - The Proxy pFad of © 2024 Garber Painting. All rights reserved.

Note: This service is not intended for secure transactions such as banking, social media, email, or purchasing. Use at your own risk. We assume no liability whatsoever for broken pages.


Alternative Proxies:

Alternative Proxy

pFad Proxy

pFad v3 Proxy

pFad v4 Proxy