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BIOC441

This document provides course details for Biochemical Engineering, including: 1. The course description covers principles of chemical engineering applied to bioprocesses, kinetics, bioreactor design, fermentation, and modern bioprocess technologies. 2. The scope and objective is to introduce basic biochemical engineering and bioprocess technology concepts to students from various disciplines. 3. The course plan lists topics such as applied biocatalysis, metabolic stoichiometry, upstream and downstream processing, fermentation, and product recovery that will be covered over the semester according to the textbook and reference book chapters.

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49 views3 pages

BIOC441

This document provides course details for Biochemical Engineering, including: 1. The course description covers principles of chemical engineering applied to bioprocesses, kinetics, bioreactor design, fermentation, and modern bioprocess technologies. 2. The scope and objective is to introduce basic biochemical engineering and bioprocess technology concepts to students from various disciplines. 3. The course plan lists topics such as applied biocatalysis, metabolic stoichiometry, upstream and downstream processing, fermentation, and product recovery that will be covered over the semester according to the textbook and reference book chapters.

Uploaded by

aman_sasan
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© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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You are on page 1/ 3

BIRLA INSTITUTE OF TECHNOLOGY AND SCIENCE, PILANI

INSTRUCTION DIVISION

Course Handout (Part II)


In addition to part-I (General Handout for all courses appended to the timetable) this
portion gives further specific details regarding the course.
Course No. : BIO C441/CHE C421/CHEM C441/PHA C441
Course Title : BIOCHEMICAL ENGINEERING

1. COURSE DESCRIPTION: Principles of Chemical Engineering applied to


Bioprocesses; Kinetic Models for growth, substrate utilization and product formation;
biological reaction engineering kinetics and applied enzyme catalysis in homogeneous
and heterogeneous systems, Immobilized biocatalyst technology, Bioreactor design and
operation, Fermentation, Upstream and Downstream processing, Novel Bioreactor
configurations, Transport phenomena in Bioprocesses, Bioprocess instrumentation &
control, Bioprocess optimization & scale up, Modern bioseparation technologies,
Industrial protein purification techniques, industrial biochemicals, enzymes,
biopharmaceuticals, bioprocess economics & feasibility studies.

2. SCOPE & OBJECTIVE:


This course introduces the basic aspects of biochemical engineering and bioprocess
technology and their commercial implications to the students from various disciplines.

3. BOOKS
A. Text Book:
“Biochemical Engineering Fundamentals” by J. E. Bailey & D. F. Ollis (1987) 2 nd Ed
McGraw Hill International Edition.
B. Reference Book:
“Bioprocess Engineering Principles” by P. M. Doran, (1995) Academic Press.

4. COURSE PLAN: TB: Text Book RB: Reference Book

Lec.# Learning Objectives Topics to be covered Chapter #


For Microbiological aspects The structure of cells and Important cell types. 1 (TB)
Self
Study Chemicals of life Lipids, Polysaccharides, Nucleotides, Proteins etc. 2 (TB)

1
1. Applied Biocatalysis Reaction mechanisms, Comparison with chemical Chap # 3, 4 (TB)
2. in homogeneous and catalysis, Michaelis-Menten and Briggs-Haldane
3. heterogeneous systems kinetic models and parameter evaluation, Enzyme Chap#11,12(RB)
4. Inhibition kinetic models and their Implications in
5. elucidating reaction mechanisms and drug design.
6. Physico-chemical factors influencing Enzyme
7. activity. Enzyme deactivation and kinetic models.
8. Immobilized Enzyme Technology: Immobilized
9. enzyme kinetics; analysis of external and intra-
10. particle mass transfer; Immobilized Enzyme
11. Reactors – Various Configurations; Biosensors.
12. Commercial production and applications.
13. Metabolic Stoichiometry C-metabolism, Aerobic & anaerobic Respiration, Chap# 5 (TB)
14. & Energetics Stochiometry of growth and product formation. Chap# 4 (RB)

15. A Complete Bioprocess: Isolation of pure culture, Strain improvement by Chap# 6 (TB)
16. STEP-I: mutation, protoplast fusion & r-DNA techniques.
17. Upstream Processing Media formulation & preparation, Media & Air Chap# 7, 9 (TB)
18. Sterilization: Batch & Continuous, Death Kinetics
19. Seed culture development: Growth kinetic studies. Chap#11,13(RB)

20. STEP-II: Ideal & non-ideal bioreactors, Modes of reactor


21. Fermentation: operations: Batch, Fed-batch & Continuous.
22. Bioreactor Design and Biomass growth, Substrate Uptake and Product
23. Operation formation: Mass & Heat Balances, Structured and Chap # 7–9 (TB)
24. unstructured models, Bioreactor design &
25. configurations, Mass & Heat Transfer in gassed Chap#12,13(RB)
26. reactors, Immobilized enzyme & cell reactor
27. systems, Animal cell culture strategies.

28. STEP-III: Bioprocess Instrumentation & Control, Classical Chap# 10 (TB)


29. Process Optimization and Statistical Optimization of Bioprocesses, Chap# 3 (RB)
30. Control & Scale-up. Process Scale-up Criteria & Correlations. Chap# 8 (TB)
31. STEP – IV Unit Operations: Filtration (Micro, Cross-flow Chap # 11 (TB)
32. Product Recovery, and Ultra) and Centrifugation (High-speed, Chap # 10 (RB)
33. Concentration and Continuous and Ultra), Cell disruption methods.
34. Purification Operations Precipitation, coagulation, Flocculation,
35. Solvent /Aqueous 2-phase extractions, Dialysis,
36. Electro-dialysis, Reverse osmosis, Ultrafiltration,
37. SDS-PAGE, HPLC & Column Chromatography:
38. Gel Filtration, Ion Exchange, Affinity & HIC etc.
39. Drying, Crystallization, Formulation, Packaging
40. Examples of complete commercial bioprocesses.
41. Bioprocess Economics Bioprocess Economics and Feasibility Studies. Chap# 12 (TB)

2
5. Evaluation Scheme:
Component Duration Marks Date & Time Venue Remarks
Test – I 50 min 20 Closed Book
Test – II 50 min 20 Open Book
Comp. Exam 3 hours 35 Closed Book
Seminar + Report 15
Surprise Quiz 10 Closed Book
Total 100 Mid Sem: 45 + End Sem: 55
6. Make-up will not usually be granted.
7. Chamber Consultation Hour: To be announced in the class
8. Notices: To be displayed on the Bioscience Notice Board

Instructor-in-Charge
BIO C441/CHE C421/CHEM C441/PHA C441

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