Practitioner’s Reference

Guide to
Dr. Hans A. Nieper’s
Nutritional Supplements

Copyright c 2002 Papillon Publishing Inc. All Rights Reserved

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LICENSED HEALTHCARE PRACTITIONERS ONLY. IT SHOULD BE USED IN
CONJUNCTION WITH OTHER SCIENTIFIC PUBLICATIONS REGARDING DR. NIEPER’S
DEVELOPMENT AND USE OF MINERAL TRANSPORTERS AS PART OF A HEALTHCARE
PROGRAM.
 PRACTICIONER’S
REFERENCE INDEX
Product Page
Nieperzyme W/Zinc ................................................................................ 2
Bromelain W/Papain ............................................................................... 4
Buffered C W/Ca-Mag-K Ascorbates ........................................................... 6
Carotavit W/Selenium charge sustained ......................................................... 10
Calcium Orotate ................................................................................ 12
GTF Chromium ................................................................................ 14
Calcium Arginate W/Aspartate ............................................................ 16
2AEP Calcium ................................................................................... 18
Calcium Aspartate ............................................................................ 23
L-Carnitine ........................................................................................ 26
Dionaea Muscipula .......................................................................... 30
E Complex ......................................................................................... 32
Lithium Orotate ................................................................................ 37
Lithium Arginate .............................................................................. 39
L-Lysine Orotate .............................................................................. 42
L-Glutathione .................................................................................... 45
Magnesium Orotate .......................................................................... 48
Magnesium Arginate W/Aspartate ....................................................... 51
2AEP Magnesium ............................................................................. 54
Pau d’Arco ......................................................................................... 57
Potassium Arginate ........................................................................... 60
Potassium Orotate ............................................................................. 62
Shark Cartilage ................................................................................. 64
Selenium............................................................................................. 66
Thiamine B-1 ..................................................................................... 73
Zinc Orotate ..................................................................................... 76
Zinc Arginate W/Aspartate .................................................................... 79
Zinc Aspartate .................................................................................. 81
K-Mg .................................................................................................. 84
Squalene and Buffered C .................................................................. 86
Membrane Complex ......................................................................... 90
Iridodial ............................................................................................. 93
1
Nieperzyme with zinc

Count Size: 100, 200 tablets

Each Capsule Contains:

Zinc aspartate 5mg
(1.5mg elemental zinc)
Bromelain (1800 mcu/gm) 50mg
Papain (1600 mcu/gm) 60mg
Pancreatin, 4x USP 90mg
Protease 560 USP units
Lipase 45 USP units
Amylase 560 USP units
Rutin 50mg
Trypsin 24mg
Chymotrypsin 1mg

Other Ingredients: Plasdone, Ac-Di-Sol, Lubritab, Emcocel,

Magnesium Stearate.

Dosage:
General Health and Well-being: As an addition to the daily diet, take
2 tablets with each meal, or as directed by a health care professional.

Dr. Nieper’s General Treatment Protocols:

Cardiac diseases: 2 tablets 3 times per day
Varicose veins: 2 tablets 3 times per day
Appetite loss: 1 tablet with each meal
Muscle rheumatoid complaints (spasms of neck, shoulder
and back: 10-20 tablets over 3-4 hours before bedtime.
70-80 tablets over first 24 hours after acute injury.

Technical Information:
Zinc aspartate is composed of zinc bonded to the amino acid aspartic acid. Zinc
depletion and deficiency can develop during physical or emotional stress,
especially if it is prolonged. Individuals who have had trauma or surgery will also
lose large amounts of zinc and vitamin C as the body mobilizes these nutrients in
order to repair itself. Zinc is the component of many enzymes and is needed to
activate these enzymes. Listing just a few of it’s actions, zinc is essential for
growth, wound healing, taste acuity, insulin activity, recovery from depression
and the mobilization of vitamin A.

2
The Food Enzyme formula with zinc aspartate designed by Dr. Nieper was
created to aid digestion, treat inflammation and support circulatory health. This
enzyme formula can assist healing in conditions as diverse as arthritis,
pancreatic insufficiency, autoimmune diseases and sports injuries. The
proteolytic enzymes in the formula break down harmful proteins that can inflame
joints and connective tissues. By reducing compounds that initiate inflammatory
responses the tissues are protected from damage. These enzymes are not only
active in the gastrointestinal tract aiding in the digestion of food; but, these
enzymes can also enter the circulation where they can also neutralize foreign
proteins that enter the bloodstream. When foreign proteins enter the blood
stream due to incomplete digestion they can trigger an immune response of
antibody production. These circulating protein- antibody complexes can deposit
in tissues creating a chain reaction of inflammation and immune system
dysfunction. In many inflammatory conditions these enzymes are as effective as
non-steroidal inflammatory drugs. This natural enzyme formula works to support
the body’s own repair processes. The reason zinc aspartate was combined in
this food enzyme formula formulated by Dr. Nieper is because zinc aspartate
increases the activity of intestinal enzymes called peptidases, which are
necessary for the absorption of amino acids and neutralization of food peptides.
Undigested protein peptides when absorbed into the blood stream can chronic
fatigue and autoimmune diseases. This product was developed by Dr. Nieper to
provide an affordable source of digestive enzymes.

Clinical Applications:
Dr. Nieper reported that food enzymes including amylase, chymotrypsin, lipase,
pancreatin, papain, protease, rutin and trypsin along with bromelain supplements
were effective in dissolving blood vessel clots and in cleaning artery deposits. Dr.
Nieper found these supplements to be very helpful in individuals with angina,
diabetes, inflammation, muscle spasms, cancers and pancreatic insufficiency.

References:
1. Nieper, Hans A., Eagle-Oden, G. S. and Alexander III, Arthur D.
“PREVENTING AND TREATING CARDIOVASCULAR DISEASE” The
Curious Man (1999): 72-73.
2. Nieper, Hans A. “EXAMPLE: Thrombosis” Dr. Nieper’s Revolution in
Technology Medicine and Society (May, 1985): 228.
3. Nieper, Hans A. “EXAMPLE: Arteriosclerosis” Dr. Nieper’s Revolution in
Technology Medicine and Society (May, 1985): 229.

3
BROMELAIN & PAPAIN

Count Size: 200 Tablets

Each Tablet Contains:
Bromelain (1800 mcu/gm) 200 mg
Papain (1600 mcu/gm) 33 mg

Total 233 mg
Papain is included in this formula as an additional source of proteolytic
enzymes.

Dosage:
Dr. Nieper’s General Treatment Protocols:
Cancer: 2 – 6 tablets per day between meals
Cardiac Diseases: 5 tablets per day
Radiation Therapy: 12 – 18 tablets per day
General Health and Well-being, and to assist in digestion of food: As an
addition to the daily diet, take 1-4 tablets after meals

Technical Information:
Bromelain is a complex enzyme from the root and stems of the plant “Ananas
comosus.” This enzyme complex consists of an entire group of distinct enzymes
and is obtained from pineapple roots. It can be obtained from the green, unripe
pineapple in large quantities.1 The body does not build up a resistance to
bromelain. An orthomolecular strategy for health promotion is to use the enzyme
extracts of pineapple and papaya.

Clinical Application:
Bromelain and papain are proteolytic enzymes. Proteolytic enzymes digest
proteins in the body. Naturally, one of its first noted benefits of these enzymes
was as a digestive aid. Bromelain is an enzyme that is effective not only in the
acid environment of the stomach, but also in the alkaline environment of the
intestine. It is considered a substitute for the enzymes pepsin and trypsin.

Bromelain has been proven by laboratory experimentation to appear in the blood

stream in its active form after ingestion of the enzyme. Bromelain’s protein
digesting action can dissolve blood clots and reduce blood cell clumping creating
more circulation through small blood vessels and more oxygen delivery to the
tissues. Bromelain may prove to be one of the most important nutrients a diabetic
can use to keep open their small blood vessels.

The Bromelain enzyme has the ability to break down certain internal substances,
which may cause infarction (prostaglandin E2 and thromboxane). In this way,
these risks factors of heart disease can be reduced. Also, researchers at the

4
substances that could reduce mucoid cell coats of tumors such as bromelain 3-6/day,
digestive enzymes 6-18/day and beta-carotene 200mg capsules of dried powder
2/day. He used calcium 2-AEP 500mg 4-6/day and squalene together to help repair
the structure of the cell membranes, which are mostly composed of lipids (fats). He
used squalene 500mg 4-6/day, taurine 500mg/day and lithium orotate 120mg 1-2/day
to reduce excessive sodium concentrations within tumor cells.

In cancer, Dr. Nieper found that bromelain unmasks the surface antigens of malignant
cells, thus allowing them to be recognized by the body’s lymphocytes and
macrophages (important components of the natural immune defense system).
“Cancer cells frequently display a membrane-antigen configuration that is very similar
to that of blood-type A, and therefore is not readily recognized by the immune system
of the blood type A individual. This is significant; in Germany, blood type A patients
represent 77 percent of the stomach cancer population. Something has to be done to
provide additional protection to these patients. In this specific case, a continuous
intake of bromelain can be very helpful.”2

Dr. Nieper reported that long-term use of bromelain could be useful in hypertension
and arthritis. Bromelain when taken in sufficient doses 3 to 4 times a day can reduce
platelet aggregation and the sludging of blood cells in the microcirculation. Dr. Nieper
began using bromelain in his clinic in the 1970’s and he found that its ability to break
up fibrin clots significantly reduced leg amputations in his patients with diabetes and
cardiovascular disease. Many dentists use bromelain to reduce swelling after dental
extractions and oral surgery.

References:
1
Nieper, Hans A. “EXAMPLE: Cancer” Dr. Nieper’s Revolution in Technology,
Medicine and Society (May, 1985): 248 - 249
2
Nieper, Hans A., Eagle-Oden, G. S. and Alexander III, Arthur D. “DEFINING
CANCER AND ITS CAUSES: Diet” The Curious Man (1999): 72 – 73, 97 - 98

5
Buffered C with Ca-Mg-K Ascorbates
Count Size: 50, 100 Tablets

Each Tablet Contains:

Vitamin C 446mg
Elemental calcium 21mg
Elemental magnesium 15mg
Elemental potassium 18mg
Total 500mg

Other ingredients: Plasdone, Emcocel, Lubritab, Ac-Di-Sol,

Magnesium Stearate

Dosage:
General Health and Well-being: As an addition to the daily diet, take 1
tablet twice a day with meals, or as directed by a health care
professional.

Dr. Nieper’s General Treatment Protocols:

Acne: 2 tablets two times per day
Adrenal Exhaustion and Stress: 2 tablets two times per day
Age Spots: 2 tablets two times per day
Alcoholism Nutritional Support: 2 tablets two times per day
Amyotrophic Lateral Sclerosis (ALS): 2 tablets two times per day
Anxiety: 2 tablets two times per day
Bone Enhancement: 2 tablets two times per day
Brusing: 2 tablets two times per day
Cancer Support: 2-4 tablets two times per day
Capillary Fragility: 2 tablets two times per day
Cardiac diseases: 2 tablets two times per day
Depression: 2 tablets two times per day
Diabetes: 2 tablets two times per day
Disc Problems: 2 tablets two times per day
Fibrocystic Breasts: 2 tablets two times per day
Heavy metal toxicity (Lead, Cadmium and Mercury): 2 tablets two times
per day
Hypotension: 2 tablets two times per day
Inflammation: 2 tablets two times per day
Multiple sclerosis: 2 tablets two times per day

6
Technical Information and clinical applications:
Dr.Albert Szent-Gyorgyi was awarded the Nobel Prize in 1937 for his discovery
of both flavonoids and vitamin C. He believed; that the requirements for vitamin
C vary enormously from individual to individual and that it is tragically naïve of
the medical profession to think of scurvy as being the only effect caused by a
deficiency of vitamin C. Dr. Szent-Gyorgyi believed scurvy to merely be the end
stage of a disease process (antioxidant deficiency), which manifests itself in
subtle symptoms routinely missed by physicians.1

The medical profession has historically had an institutional bias against the use
of nutrients and antioxidants in treating degenerative diseases, despite a
voluminous scientific and medical literature on the role antioxidants have in aging
and degeneration. At present, this is starting to change. Most experts agree that
these nutrients should come from food, mainly fruits and vegetables, but these
experts almost uniformly admit that Americans do not eat enough of them. Only
9% of adults consume 5 servings of fruits and vegetables daily.2 The vitamin C
intake from 5 servings of fresh fruits and vegetables is about 200 mg per day3,
however substantial segments of the U.S. population do not meet the RDA for
vitamin C.4

BIOCHEMICAL ROLES

Vitamin C has multiple biological effects probably more widespread than any
other nutrient.5 It is a cofactor of many enzymes and an antioxidant in addition
many of its effects are related to vitamin C's chemical properties and not from its
role as a vitamin.
Vitamin C is an essential component of enzymes involved in energy production in
the mitochondria, detoxification in the liver, collagen formation, cholesterol and
steroid metabolism and regeneration of vitamin E.6 The Vitamin C concentration
in the adrenal gland is extremely high, which implies that vitamin C plays an
important role in adrenal functions, being involved in cortisol synthesis.7 Vitamin
C is also a vital cofactor for bone formation.
Individual antioxidant nutrients play interconnected protective roles in
maintaining the entire antioxidant system. Long term marginal vitamin C intake
could affect the body's antioxidant defense system adversely; creating reduced
glutathione concentrations and increased susceptibility to oxidative damage.8
Vitamin C has a key role in protecting cells against oxidative damage. Vitamin E
in conjunction with vitamin C significantly protects cells from free radical
oxidation.9

VITAMIN C’s ROLE IN THE BODY:

The highest level of vitamin C in the body is found in the brain. Active uptake
mechanisms exist in the choroid plexus of the brain and blood brain barrier that
maintain intracellular levels in the brain at 16 to 25 times higher than blood
levels.10 Ascorbate levels in the brain are lowest during sleep and rise during

7
prolonged activity and stress.10 Vitamin C has potent antioxidant activity in both
the extra cellular and intracellular aqueous fluids. Vitamin C can scavenge
radicals before they reach membranes, such as erythrocyte membranes and LDL
cholesterol11, however in order to ensure penetration of vitamin C through the cell
membrane into the intracellular space C-Complete also includes lipid soluble
ascorbyl palmitate in the formula.
Regular supplement use has a strong impact on blood levels of vitamin C. The
literature suggests that the consumption of generous amounts of vitamin C in
foods or supplements creating higher than average serum levels of vitamin C
may provide some type of protection against chronic disease. Since increased
serum levels of vitamin C are desirable then supplements can play a role in
helping achieve this end.12

There are clear needs for the use of ascorbate in alcoholism and Parkinson's
disease. When vitamin C therapy is given in early Parkinson's disease it delays
the need to give L-DOPA by 2 years. Alcohol use also results in oxidative stress
in the brain, raising the level of dopamine metabolites and lowering brain
ascorbate levels.10

When neurological tissue becomes depleted of ascorbate, the sensitive neuronal

structures are more sensitive to free radical damage. For anyone seeking to
maintain healthy brain function through out their life, optimization and regular
intake of antioxidants is essential.

The white blood cells preferentially take up vitamin C13 and contain
concentrations 14 times higher than plasma in studies on the effects of
supplementation of vitamin C.14

Aging produces dramatic physiological changes that can affect the need for
several essential nutrients. The amount of oxidative damage the body incurs
increases as a person ages. In aging and in individuals with degenerative
diseases the need for antioxidants rises, since there is always an imbalance
between pro-oxidants and antioxidants.15
The dietary requirements to prevent deficiency and maintain apparent health in
young adults for some nutrients (antioxidants) may be considerably less than the
optimal amounts necessary to provide protection against degenerative disease.14
Vitamin C, vitamin E, and the carotenoids have all been reported to be critically
important nutrients for the prevention of cancer, heart disease and cataracts.16
“Vitamin C has excellent antioxidant properties. Many free radical reactions that
may initiate the cancer and cardiovascular disease are limited by the presence in
tissues and cells of adequate amounts of specific antioxidants, which include
vitamin C. Other antioxidants may increase the effectiveness of vitamin C in
lowering endogenous oxidative reactions.”6
There is increasing support among nutritionists for the concept that optimal
nutrition and optimal protection in fighting infection and chronic disease including
coronary heart disease and cancer involve higher than RDA amounts of vitamin

8
C and other antioxidants. Higher intake of these beneficial and protective
micronutrients appears to be perfectly safe.

References:
1. “ Mega-Nutrients: A Prescription For Total Health”, Newbold, H.L., 1975,
The Body Press, Los Angeles, California.
2. "Vitamin Supplements Win New Found Respect: Skeptics are Changing
Their Minds Over the Value of These Compounds", Kennedy, S.H.,
Modern Medicine, July 1992;60:118.
3. "Determination of Optimal Vitamin C Requirements in Humans", Levine,
M., et al, American Journal of Clinical Nutrition, 1995; 62 (Suppl.): 1347S-
56S.
4. “The Health Effects of Vitamin C Supplementation: A Review", Bendich
A., Langseth, L., Journal of the American College of Nutrition, 1995; 14(2):
124-136.
5. Biological Functions and Relation to Cancer", Henson, D. E., et al,
Journal of the National Cancer Institute, April 17, 1991; 83(8): 547-550.
6. "Vitamin C in Disease Prevention", Weisburger, J. H., Journal of the
American College of Nutrition, 199514(2): 109- 111.
7. "The Regulation of Steroid Hormone Metabolism Requires L- Ascorbic
Acid", Moser, Goralczyk R., et al, Beyond Deficiency: New Views on the
Function and Health Effects of Vitamins, New York Academy of Sciences,
February 9-12, 1992;P-25.
8. "Vitamin C Affects Other Aspects of Antioxidant Systems", The Nutrition
Report, April 1992; 10(4): 30/"Glutathione Blood Levels and Other Oxidant
Defense Indexes in Men Fed Diets Low in Vitamin C", Henning, S., et al,
Journal of Nutrition, 1991; 121:169-175.
9. "Ascorbic Acid and Oxidative Inactivation of Proteins", Stadtman, E. R.,
American Journal of Clinical Nutrition, 1991;54:1125S-8S.
10. "The Role of Ascorbate in Brain: Therapeutic Implications," Smythies, J.,
R., Journal of the Royal Society of Medicine, May 1996; 89(5): 241.
11. "Action of Ascorbic Acid as a Scavenger of Active and Stable Oxygen
Radicals," Niki, E., American Journal of Clinical Nutrition, 1991; 54:1119S-
24S.
12. “Use, Other Dietary and Demographic Variables, and Serum Vitamin C: In
NHANES II", Dickinson, V. A., et al, Journal of the American College of
Nutrition, 1994; 13(1): 22-34.
13. "Vitamin C: A New Look", Block, G., et al, Annals of Internal Medicine,
May 15, 1991; 114(10): 909-910.
14. "Nutrient Requirements of the Healthy Elderly - Should There Be Specific
RDAs?” Blumberg, J., Nutrition Reviews, August 1994; 52(8): S15-S18.
15. "Oxidative Stress, Caloric Restriction, and Aging," Sohal, R. S.,
Weindruch, R., Science, July 5, 1996; 273:59-63.
16. "Micronutrient Status and Aging," Tucker, K., Nutrition Reviews,
September,1995; (II) S9-S15.

9
CAROTAVITä
Beta Carotene with Selenium

Count Size: 100, 200 Capsules

Each Capsule Contains:

Beta Carotene 25,000 IU
(Pro vitamin A activity)
Selenium 5 mcg
(Amino acid chelate)
Total 200 mg

Dosage:
Dr. Nieper’s General Treatment Protocols:
Cancer: 1 capsule, 3 times per day (3 total per day)
General Health and Well-being: 1 to 2 capsules daily

Note: Should be taken with a small amount of fat, i.e. teaspoon of Linseed Oil or Dairy
Cream with each dosage.

Technical Information:
Beta-Carotene is derived from carrots and is a natural, non-toxic precursor to vitamin
A, i.e. the body will produce from Beta-Carotene the amount of Vitamin A it needs
without over-dose or excess build-up (toxicity). During the normal metabolism of Beta
Carotene, the inherent molecular electron donating properties, also referred to as the
“hopping charge,” are reduced by as much as 40%. This drop in the “hopping charge”
leads to a reduction in the antioxidant activity of the Beta-Carotene. However, the
introduction of selenium from amino acid chelates in the production of CAROTAVITä
at the appropriate stage during the manufacturing process has been shown to stabilize
the “hopping charge.” Thus the resultant combination measures and delivers a greater
electrical effect within the body. This extra hopping charge generates a strong affinity
for Beta-Carotene wherever needed within the body. Thus effective anti-oxidant
activity is greatly enhanced.

Clinical Application:
Beta-Carotene aids in the growth and repair of body tissues and helps maintain
smooth, soft skin. Internally, it helps protect the mucous membranes of the mouth,
nose, throat and lungs. The soft tissue and all linings of the digestive tract, kidneys
and bladder are also protected. It promotes the secretion of gastric juices necessary
for proper digestion of protein and assists in the building of strong bones and teeth, the
formation of blood and the maintenance of good eyesight. Beta-Carotene protects
epithelial tissue like the skin, the stomach and the lungs and greatly enhances the
production of RNA. In addition, there is increasing evidence that vitamin A, produced
naturally within the body from Beta-Carotene, is related to sexual development and
reproduction. It is also essential to the chemical process by which cholesterol is
converted into female estrogens and male androgens.

As an immune-enhancer, it is an important protective nutrient against cancer

development and for most cancer nutrient protocols. It was in 1971 that Dr. Nieper 10
introduced Beta-Carotene into his cancer support program. 1
“It has been shown that foods rich in vitamin A (from Beta-Carotene) guard against
chemical carcinogenesis - that is, the initial development of cancer due to toxic
chemicals.” 2

References:
1
Nieper, Hans A. “EXAMPLE: Cancer” Dr. Nieper’s Revolution in Technology,
Medicine and Society (May, 1985): 257
2
Nieper, Hans A., Eagle-Oden, G. S. and Alexander III, Arthur D. “DEFINING
CANCER AND ITS CAUSES: Diet” The Curious Man (1999): 89

11
Calcium Orotate

Count Size: 50, 100, 200 Tablets

Each Capsule Contains:

Calcium Orotate 500 mg

(51.8 mg elemental calcium)
Magnesium DL-Aspartate 50 mg
(4.2 mg elemental magnesium)
Magnesium Hydrogen Phosphate 62.5 mg
(8.7 mg elemental magnesium)
Total 612.5 mg

Dosage:
General Health and Well-being: As an addition to the daily diet, take 2 – 3
tablets with evening meal, or as directed by a health care professional.
Dr. Nieper’s General Treatment Protocols:

Arterial Spasms: 1 tablet twice a day

Arthritis: 1-2 tablets three times a day
Back Pain: 2 tablets twice a day
Bone Fractures: 2 tablets twice a day
Brusing: 2 tablets three times a day
Bursitis and tendonitis: 2 tablets twice a day
Capillary Fragility: 2-3 tablets twice a day
Carpal Tunnel Syndrome: 1 tablet twice a day
Chronic Inflammation of the Liver and Atrophied Liver: 1 tablet 3 times a
day, always to be combined with 1-2 tablets of 120 mg Lithium Orotate
Friedreich’s Ataxia (FA): 1 tablet 3 times a day
Inflammation: 1 tablet 3 times a day
Leg Cramps: 2 tablets in AM
Osteoporosis: 1-3 tablets 3 times a day
Psoriasis: 2 tablets twice a day
Thrombophlebitis: 1 tablet 3 times a day

Technical Information:
During Dr. Nieper’s preliminary work with ‘Electrolyte Carriers’ based on aspartic
acid, he discovered that orotic acid was also an appropriate ‘carrier’ molecule. It
was already known that orotic acid penetrates very easily into the cell and, as an
aromatic substance, it possess high chemical-complexing power enabling the
creation of stable mineral compounds (orotates). He found that the orotates pass
through the cell’s double-layered outer membrane and are decomposed for
utilization only by the inner components of the cell, such as the microsomes and
the mitochondria. Biochemist Arthur D. Alexander III, Ph.D., describes the
mitochondrial organelles as the cell’s “furnace” where sugars and fats are broken
down to produce cellular energy. Furthermore he reports that “the mineral

12
Orotates have the ability to transport nutrient substances into the cells, maintaining
healthy cell growth and averting damage to the mitochondria and other important
metabolic structures.

Clinical Application:
Dr. Nieper reports from his treatments of osteoporosis “the orotate carrier molecule
has great affinity for the bone cells, penetrating the interior of the bone cells while
transporting critically needed calcium to the depleted bone cells.” In addition, “clinical
trials and electron microscopic research (Nieper, Moenninghoff, 1971) indicate the
Orotates have specific affinity toward cells of the heart, blood vessels, blood brain
barrier and cartilage.”
Calcium Orotate is a premier calcium supplement for the discriminating consumer.
Calcium orotate is a mineral transporter where calcium is bound to orotic acid, a
natural component of whey. It is well absorbed with 70-90% of the compound entering
the blood stream in an intact state. This compound is attracted to bone, cartilage, liver,
brain and the circulatory system where the molecule can enter the cells of these
tissues releasing calcium inside the cell avoiding the hypercalcemia common to other
calcium supplements. It is the intracellular delivery of calcium that makes this mineral
transporter so powerful in the treatment of: bone and cartilage degeneration, bone
fractures, spinal pain, periodontal disease, muscle cramps, inflammation in the liver
and autoimmune diseases.

Clinical Uses of Calcium Orotate

1. For reduction of the side effects of cortisone.

2. When cartilage degeneration is present.
3. Strengthening of bones such as the hips.
4. For periodontal disease.
5. For muscle-cramping secondary to low calcium.
6. For individuals with asthma.

Calcium orotate should be considered in the following conditions:

1. Any decalcification disease (osteoporosis).
2. Bone fractures, especially of the spine.
3. Immune system dysfunctions and inflammation.
4. Cartilage problems caused by rheumatoid arthritis, effects of cortisone or birth
control pills.
5. Generalized bone pain.
6. Dorsal spine pain and slipped discs.
7. Hip degeneration (arthrosis)
8. For reclacifying bone metastases

Calcium orotate is useful instead of nonspecific calcium supplements, which create

hypercalcemia in the blood, but do not necessarily get into tissues that require
calcium.

Dosage and Administration with other Products

Calcium orotate may temporarily cause a heat reaction. A bad taste in the mouth may 13
occur if calcium is mixed with Magnesium orotate. They are best given in separate
GTF Chromium-Glucose Tolerance Factor
Count Size: 100, 200 tablets

Each Tablet Contains:

Chromium polynicotinate 200mcg
(contains 100% ChromeMate)

Other Ingredients: Calcium carbonate, Avicel, Ac-Di-Sol,

Magnesium Stearate.

Dosage:
General Health and Well-being: As an addition to the daily diet, take
1-2 tablets after each meal, or as directed by a health care
professional.
Dr. Nieper’s General Treatment Protocols:
Diabetes Type I: 1 tablet 3 times per day
Diabetes Type II: 1-2 tablets 3 times per day
Hypercholesterolemia: 1-2 tablets 3 times per day
Hypertriglyceridemia: 1-2 tablets 3 times per day
Fatigue: 1-2 tablets 3 times per day

Technical Information:
Chromium is an essential trace mineral being a cofactor in a number of
chromium dependent enzymes. These enzymes, which are involved in energy
production, glucose, fat, protein and cholesterol metabolism will not function
properly unless chromium is biologically available in the tissues. Dietary
chromium is found naturally in brewer’s yeast and organ meats, but most
individuals do not eat these foods.

The amount of chromium needed by health adults is between 50 to 200mcg per

day, however pregnant women, diabetics; individuals under chronic stress and
individuals who exercise regularly have higher chromium requirements.
Chromium is also lost in the processing of grains and sugar so individuals who
eat large quantities of processed foods are invariably chromium deficient.
Despite the important role biologically active chromium has in metabolism 9 out
of 10 adults do not consume the minimum amount. Many other factors are
involved in creating chromium deficiency besides inadequate dietary intake.
Strenuous exercise and chronic stress result in a significant increase of
chromium loss through the kidneys. Another major factor in creating chromium
deficiencies is that chromium assimilation from foods is as low as 1-2 %.

Chromium exists in two chemical states. One form, hexavalent chromium, is

used in industry and is very toxic. The only form that humans can use is the

14
Chromium picolinate is a common chromium supplement, but according to Dr
Mertz this form is less effective in potentiating insulin than ChromeMate.
Jeffery Bland, while working at the Linus Pauling Institute of Science and
Medicine, reported in 1986 that chromium polynicotinate was a significantly more
effective than inorganic chromium salts and yeast bound chromium in reducing
blood sugar levels and in increasing liver levels of chromium.
In 1991 Dr Robert Lefavi did a university study that showed that people taking
ChromeMate had a significant reduction in serum cholesterol/ HDL ratios,
compared to a placebo group, which showed no improvement.

Clinical Applications:

Chromium when given in the form of bioavailable mineral supplements like

ChromeMate can lower cholesterol in individuals with high cholesterol and
reduce blood sugars in diabetics. Chromium may have a role in muscle building
by increasing the anabolic effect of insulin in individuals involved in weight
resistance training. Chromium also increases fat burning and when combined
with niacin (Vitamin B3) it can increase energy and fatigue especially in diabetics
although nondiabetics also frequently experience energy enhancement. Dr.
Nieper recommended that chromium be used in diabetics to help stabilize blood
sugar levels.

References:
1. Nieper, Hans A. “EXAMPLE: Diabetes mellitus (diabetes)” Dr. Nieper’s
Revolution in Technology, Medicine and Society (May, 1985): 218 – 219.
2. Mertz W. Effects and metabolism of Glucose Tolerance Factor: Present
Knowledge in Nutrition. 36:365-372. The Nutrition Foundation,
Washington, D.C., 1976.
3. Toepfer EW. Chromium in foods in relation to biological activity. J Agr.
Food Chemistry, 21 (1) : 69-73, 1973.
4. Bland J, et al. The effect of chromium as Cr (III) chloride, yeast- bound
chromium and a nicotinate-Cr III complex on tissue uptake, glucose
tolerance, serum lipids and fetal development in rats, Linus Pauling
Institute of Science and Medicine, 1986.
5. Toepfer EW, et al. Preparation of chromium containing material of glucose
tolerance activity from brewer yeast extracts and by synthesis. J. Agr.
Food Chem. 25(1):162-166, 1977.
6. Hasten DL, Rome EP, Franks BD and Hegsted M. Effects of chromium
picolinate supplementation on beginning weight training students.
International Journal of Sports Nutrition, 2:343-350, 1992.
7. Lefavi R, et al. Lipid- lowering effect of a dietary nicotinic acid- chromium
(III) complex in male athletes. The FASEB journal 5(6): A 1645, 1991.

15
Calcium Arginate with Aspartate

Count Size: 50, 100, 200 tablets

Each Tablet Contains:

Calcium Arginate with Aspartate 500mg
(52mg elemental calcium)
(336mg arginate)(112mg aspartate)
Magnesium L-aspartate 50mg
(6.65mg elemental magnesium)
Magnesium Hydrogen Phosphate 62.5mg
(8.7mg elemental magnesium)
Total 612.5mg

Other Ingredients:
Duratex, Pure Food Glaze, Avicel, Covatol and Magnesium Stearate

Dosage:
General Health and Well-being: As an addition to the daily diet, take
1-2 tablets with each meal, or as directed by a health care
professional.

Dr. Nieper’s General Treatment Protocols:

Angina: 1 two times a day
Cartilage degeneration: 2 two times a day
Diabetes: The daily doses of calcium arginate in diabetes ranges from 2.5
grams to 3.5grams per day and the daily dose of magnesium arginate ranges
from 2grams to 2.5grams per day in divided doses. He found that more resistant
cases required the higher doses.
Nervousness: 2 two times a day
Joint stiffness: 2 two times a day
Muscle cramps: 2 two times a day
Osteoporosis: 2 three times a day

Technical Information:
Calcium arginate delivers calcium to the inner layer of the cell membrane and
into the cell cytoplasm.
Calcium arginate is a mineral transporter composed of calcium bound to the
alkaline amino acid arginine. Dr. Nieper and Dr. Franz Kohler developed a series
of mineral transporters called arginates in the 1960’s, but they were not brought
to the market until the late 1980’s. Dr. Nieper found during his research that

16
calcium and magnesium arginate improved glucose transport out of the blood
into the cells.
When an individual cannot transport glucose into the cells a condition called
diabetes develops. Clinicians divide diabetes into 2 groups. Type I diabetes is
caused by reduced or total cessation of insulin production. Many clinicians
believe that the insulin producing pancreatic beta cells in the islets of Langerhans
are damaged or destroyed by viral infections and autoimmune damage. Dr.
Robert Atkins has written that use of another Nieper mineral transporter calcium
AEP, when given early in this process, can have protective effects by preventing
damage to the insulin producing cells. Type II diabetes is a much more common
illness than Type I diabetes affecting 10-14 times as many individuals. In Type II
diabetes the main problem is not a lack of insulin production like in Type I
diabetes, but rather a failure of insulin to adequately transport glucose into the
body’s cells. Because the issue is poor glucose transport in Type II diabetes and
arginate mineral transporters can improve glucose transport independent of the
action of insulin Dr. Nieper realized that arginate mineral transporters could be an
effective nutritional support for diabetics. He told me during my visit with him in
Hanover, Germany in 1998 that this was one of the most exciting discoveries of
his career.
Throughout his career Dr. Nieper advocated for the use of non-toxic
orthomolecular approaches to disease. He believed that arginate mineral
transporters were an effective natural approach to improving glucose transport in
Type II diabetics therefore they met his criteria for non-toxic support of a chronic
condition.

Clinical Applications:
Dr. Nieper noted a number of fascinating effects with the use of arginates
including a reduction of spinal pain in arthritic patients and improved hearing in
patients with inner ear problems. When he investigated why individuals with
partial hearing loss responded to arginates, he determined that arginate mineral
transporters improved the entry of glucose into ear cells. This was an exciting
discovery for Dr. Nieper, since this finding led him to test arginate mineral
transporters in diabetes. Dr. Nieper found that magnesium arginate along with
calcium arginate with every meal could reduce blood sugar in many Type II
diabetics.
Calcium arginate has the ability to transport glucose across the cell membrane
making it an excellent choice in any form of glucose intolerance. The transport of
glucose across membranes is required for cell survival. Since, glucose molecules
do not diffuse rapidly through cell membranes, specific transporters are required.
Insulin, zinc, chromium and arginates are all involved in glucose transport.
Calcium arginate as a natural glucose transporter is helpful for patients with
defects in their natural glucose transport system especially individuals with Type
II diabetes and syndrome X. Dr. Nieper felt that mineral transporters such as
Calcium 2-AEP, Calcium arginate, Calcium aspartate and Calcium orotate are
also the best nutritional supplements to prevent bone and joint aging. Calcium
arginate is especially beneficial in nutritional support of cartilage disorders

17
CALCIUM 2-AEP – Vitamin Mi™ (Membrane Integrity Factor)

Count Size: 50,100,200 Capsules

Each Capsule Contains:
Calcim 2-AEP† 500 mg
(62.5 mg elemental Calcium)
†2-aminoethyl phosphoric acid, also called colamine phosphate,
or 2-aminoethyl esther of phosphoric acid, or 2-amino ethanol
phosphate
Total 500 mg

Dr. Nieper’s General Treatment Protocols:

*Multiple Sclerosis (MS): 4-7, 500 mg Capsules every day (always
accompany with K/Mg Aspartate in a ratio of 3 – Ca 2-AEP to 1 – K/Mg
Aspartate). Also, 3-4 days per week, increase dosage by an additional 9
Capsules per day along with current dosage in those instances where
intravenous 2-AEP is unavailable
Cancer Prevention or Reoccurrence: 3 – 500mg Capsules per day
(especially in colon and breast cancer)
*Cancer: 3-5, 500 mg Capsules per day
Fibrocystic Breasts: 3-5, 500 mg Capsules per day
Friedreich’s Ataxia (FA): 2 – 500 mg Capsules per day
*Amyotrophic Lateral Sclerosis (ALS) and Leucodystrophy: 3 – 500 mg
Capsules per day
Diabetes Type I: 1-3, 500 mg Capsules, 3 times per day. 3-9 Total per day.
(always accompany with K/Mg Aspartate in the ratio of 3 – Ca 2-AEP to 1 – K/Mg
Aspartate)
*Varicose Veins: 1-3, 500 mg Capsules per day
Osteoporosis: 6 – 500 mg Capsules per day
General Health and Well-being: 1-3 Capsules per day
* In Dr. Nieper’s General Treatment Protocols, he indicates that in the above
marked (*) conditions Membrane ComplexÔ (Calcium/Magnesium/Potassium 2-
AEP complex – 500 mg Capsules) may also be used in addition to the Calcium
2-AEP. However, in the treatment of Multiple Sclerosis, at least 2/3 of the total
dosage per week must be Calcium 2-AEP.

Technical Information:
In 1939-41, the world-famous biochemist, Erwin Chargaff wrote several reports
on 2-aminoethyl phosphoric acid (2-AEP), or in short colamine phosphate. He
identified it as an important partial component in the structure of the cell
membrane. In accordance with the cell membrane model of the Swiss scientist
Buchi, 2-AEP is integrated into the cell membrane in a way that it is localized on
the exterior surface of the cell membrane. Not only is 2-AEP a bio-chemical

18
Autoimmune Diseases
Colitis
Hepatitis (chronic and non cirrhotic)
Chronic Nephritis and associated Hypertension
Nephrosclerosis, Malignant, and associated fixed Hypertension
Myocarditis, Post-infarct Syndrome
Post-cardiotomy Syndrome
Multiple Sclerosis
Osteonecrosis
Rheumatic manifestations, including Rheumatoid Arthritis, Rheumatic Fever,
Sclerodermia
Chronic Inflammation
Allergic Diseases
Inflammatory Diseases
Hemorrhoids (suppositories)
Skin inflammatory diseases such as Dermatitis
Eye diseases
Eczema
Smooth Muscle Spasms
Gastritis
Bronchial (Asthma)
Lupus Erythematosus
Osteoporosis
Aging
Diabetes
Cancer
Progressive Muscle Dystrophy
Hypertension
Chronic Encephalitis
Spondylitis Osteoporosis
Interstitial Pulmonary Fibrosis
Myalgia
Breast Induration
Consolidation of Bone Fracture

During Dr. Nieper’s lecture at the convention at the famous Waldorf Astoria Hotel
Grand Ballroom in Manhattan, NY, in June 1987, he proposed to name these
discovered metabolic Colamine Phosphate salts (2-AEP), the cell’s “membrane-
integrity factor” or simply “Vitamin Mi.” It is obvious that 2-AEP is essential to
retain charges by lining calcium, magnesium and potassium, on the membrane
surface of the cells to build or rebuild cell walls. The resulting change is
extremely significant. The cell membranes can function like an electric
condenser, except that the areas continuing the charge do not consist of metal,
as they do in technology, but of biologically retained (bound) mineral linings.
“Colamine Phosphate salts (2-AEP), and Calcium 2-AEP in particular, are

19
membrane permeability, structural alteration and disturbances of important
metabolic and nerve pathways. For each of these disturbances there exist
agents which could improve or cure a large number of diseases at the cellular
level.” 2

In studies, Nieper found that Ca 2-AEP plays an important role in binding fatty
acids to following peptide chains in the cell membrane. The incorporation of
carrier molecules that transport active inorganic electrolytes (i.e. mineral ions)
through the cell membrane, depends on the peptide layer of the cell membrane.

Calcium 2-aminoethyl phosphoric acid (Ca 2-AEP) functions as an electrolyte

carrier. It also transports calcium into the cells. Calcium 2-AEP introduced into
the blood stream is directed from the blood stream toward the membrane and
intracellular space, especially when disturbances have produced cellular and
organ alterations.

In 1967-68, Dr. Nieper began publishing information on this substance in the

French journal, titled Agressologie. He refers to 2-AEP as “one of the most
important and effective mineral transport substances (he) has ever conceived.” 3

Calcium 2-AEP decreases the permeability of the cellular membrane to foreign

substances. Dr. Nieper believed that calcium 2-AEP increases membrane
integrity by sealing damaged membranes, thus protecting the healthy cell from
penetration by toxins, bacteria and viruses. The fact that 2-AEP mineral
compounds provide an immune-protective effect was demonstrated in extensive
electron microscopic research by Dr. Moenninghoff and his collaborators at the
University of Muenster, Germany in1971. 2 In 1971 - 72, Dr. Moenninghoff
provided evidence confirming how the cell membrane could be successfully
sealed with Calcium 2-AEP.

It is important to note that Dr. Nieper generally recommends simultaneous

administration of Ca 2-AEP with K/Mg (Potassium/Magnesium) Aspartate, for two
reasons: a) to avoid deficiency in Potassium or Magnesium especially when
administering high levels of Calcium, and b) to retain the optimum level of 2-AEP
at the cellular level. While 2-AEP transports to the outer cell membrane, the
Aspartate mineral carriers transport to the inner portion of the outer cell wall.
Therefore, the Aspartate and the 2-AEP create a ‘velcro-type’ effect, retaining the
minerals to the outer and inner surfaces of the cell membrane.

Clinical Application:
Multiple Sclerosis
In the 1960’s, the German Health Authority (called Bundesgesundheitampt,
which is the equivalent to the American National Institute of Health, the parent of
the U.S. FDA, or the Australian Ministry of Health, the parent of the TGA)
approved Calcium 2-AEP for use in Multiple Sclerosis.

20
25% die of bone fractures, and another 25% die of kidney failure. Dr. Nieper reports
“amazingly, I have seen only eight (8) cases of bone fractures and no situations of
kidney failure in my 3,500 patients on Calcium 2-AEP.” 3

In 1986, Dr. George Morrisette of the USA conducted a retrospective study of 300 MS
patients who had begun Calcium 2-AEP in Dr. Nieper’s Hannover, Germany clinic. His
study showed that 82% had positive benefits. “MS patients also feel warmer when
using Calcium 2-AEP.” 5 The most important part of Dr. Nieper’s nontoxic approach to
MS is an attempt to correct the chemical and electrical defects of the cell membrane
and restore nerve paths using the 2-AEP salts. (For a full review of Dr. Nieper’s
findings and approaches used in MS, see Chapter 8 of The Curious Man.)

Osteoporosis
On the basis of his observations with 2-AEP for MS patients, Dr. Nieper began using
Calcium 2-AEP in osteoporosis, not related to MS. Dr. Nieper believed that “the
energetic membrane impairment in osteoblasts and of the bone matrix tissues is the
true and deeper cause for decalcification diseases. It is well know that these ailments
are not under control. Therapy with conventional calcium salts fail as well as does
hormone therapy fail miserably, not speaking of the extremely risky fluoride therapy
which may increase the cancer and leukemia risk and threaten the heart muscle’s
integrity.” 5 Dr. Nieper reported that Calcium 2-AEP, together with Calcium Orotate
(mineral transporter to the intra-cellular organelles including the mitochondria), were
excellent supplements to use in osteoporosis and other related decalcification
diseases. He says the “results are striking.” 5 Calcium 2-AEP greatly improves the
condenser function of the bone-cell membranes, thus allowing them to function
healthily. Dr. Nieper believed that the combined use of calcium and magnesium
mineral transporters “dramatically reduces the risk of bone fractures.” 3 Furthermore,
surgeons in six major surgical centers (2 in the USA, 1 in Monte Carlo, and 3 in
Germany, reported finding “extremely solid bone when implanting new joints in
patients who had been taking Calcium 2-AEP and Calcium Orotate for at least four
years prior to their surgeries.” 6 So Calcium 2-AEP with Calcium Orotate apparently
increases bone density.3

In the USA alone, approximately 24 million people suffer from decalcification of the
bone system and 1.45 million experience spontaneous bone fractures every year. In
Dr. Nieper’s opinion, use of Calcium 2-AEP when combined with other mineral
transporters would be highly beneficial for bone decalcification. 1

Diabetes
During the late 1960s, Dr. Nieper noticed that patients with rather severe diabetes felt
better when treated with Calcium 2-AEP or the highly effective complex
(Calcium/Magnesium/Potassium 2-AEP). “Their overall metabolism improved,
tolerance to sugar increased, and their kidneys appeared to react favorably to
this treatment.” 3

The damage to the blood vessel and capillary systems due to Diabetes is easily
observed in the small vessels of the eye’s retina. In the USA, Diabetes is the second
most frequent cause of blindness. The condition is called diabetic retinopathy. “For
this reason it must be attempted to ‘guard’ the arteries of the retina from damage and
above all, to ‘seal’ them.” 4 He believed that this could be done with Calcium 2-AEP.
21
Likewise, 2-AEP may seal the pancreatic islet cells against immune aggression. 4
Furthermore, the function of the brain, particularly concerning intellectual ability, can
be seriously impaired by such diabetic damage to the small vessels, as well as to the
large carotid artery, which feeds the brain with oxygen-rich blood. Dr. Nieper reported
Calcium 2-AEP, in combination with Magnesium 2-AEP and Potassium 2-AEP (2-AEP
Membrane Complex) was the best supplement choice in addressing this issue. Dr.
Robert Atkins of New York also recommends Calcium 2-AEP in diabetes. 3

Asthma
In Asthma, there is a disturbance of the gas exchange on the membranes of the lung
alveole cells. Dr. Nieper recommended regular use of 2-AEP compounds to help
stabilize the membrane functions in the cells of the lung alveoli, so that the gas
exchange can recover and normalize.1

Cancer
All people, healthy or ill, can benefit from this reinforcement of the body’s
natural defenses at the cellular level. Dr. Nieper expresses his beliefs on the benefit
of 2-AEP in cancer in his book The Curious Man.3

References:
1
Nieper MD, Hans A. “The New Vitamin Mi” (Aug/Sept 1988 - translated from Raum &
Zeit, German Space & Time) Australasian Health & Healing (July 1996)
2
Alexander III, Ph.D., Arthur D. “CALCIUM 2-AEP: An Orthomolecular Adjunct to the
Treatment of Multiple Sclerosis, Diabetes and Asthma” (April, 1997)
3
Nieper, Hans A., Eagle-Oden, G. S. and Alexander III, Arthur D. “THE MINERAL
TRANSPORTERS” The Curious Man (1999): 62-65
4
Nieper, Hans A. “EXAMPLE: Diabetes Mellitus (diabetes)” Dr. Nieper’s Revolution in
Technology, Medicine and Society (May, 1985): 218
5
Nieper, Hans A. “Suppression of Cancer Development by Calcium Colamine
Phosphate and by Calcium-l-dl-Aspartate” (December, 1995) Townsend Letter for
Doctors & Patients
6
Alexander III, Ph.D., Arthur D. “Calcium 2-AEP & Calcium Orotate Found Essential
in the Prevention and Treatment of Osteoporosis” (June 1997)

22
Calcium aspartate 350mg tablets

Count Size: 50 and 100 Tablets

Each Tablet Contains:

Calcium DL-Aspartate 175mg

(22.8mg elemental calcium)
Calcium L-aspartate 175mg
(22.8mg elemental calcium)
Other Ingredients: Duratex, Pure Food Glaze, Plasdone, Avicel, Ac-Di-Sol,
Magnesium Carbonate, Compitrol, and Magnesium Stearate.

Dosage:

General Health and Well-being: As an addition to the daily diet, take 2 – 3

tablets with evening meal, or as directed by a health care professional.

Dr. Nieper’s General Treatment Protocols: **

Allergies: 2 tablets twice a day

Bone Loss: 2 tablets twice a day along with calcium orotate 612.5mg 2 twice a
day and calcium AEP 500mg 2 three times a day
Cancer Concern: 2 tablets twice a day along with calcium AEP 500mg 2 three
times a day and selenium 100mcg 2 a day
Fibrocystic Breasts: 2 tablets twice a day along with magnesium orotate
500mg 2 twice a day and calcium 2-AEP 500mg 2 twice a day
Heart support: 1 tablet twice a day
Inflammation Of Connective Tissue: 2 tablets two times a day
** (An occasional person may experience more awareness of heart
palpitations in which case use only one per day. These individuals
usually have significant imbalances of numerous minerals and should
have mineral testing and balancing of all mineral deficiencies.)

Technical Information:

Calcium aspartate is composed of calcium bonded to the amino acid aspartic

acid. Calcium aspartate is a highly absorbed mineral transporter with a majority
of the compound entering the blood stream in an intact state (1). This mineral
transporter does not cause significant blood elevations of calcium, since the
tissues rapidly take up the transporter. This acid resistant compound is best
swallowed whole. This calcium transporter can be beneficial for individuals

23
suffering from calcium deficiency. For severe calcium deficiencies a general
dosage is 2-3 tablets three times per day.

Calcium deficiency results not only from inefficient absorption, but also from
gastrointestinal, sweat and high renal losses. A significant variance in calcium
balance is a result of poor dietary intake, poor absorption, and daily
gastrointestinal, sweat and renal losses (2). In post menopausal women, calcium
absorption varies as much as 61 percent, and that 40 percent of women do not
absorb enough calcium to stay in positive calcium balance even with an intake of
800 mg daily (3). Another problem is that the high protein and high sodium diets
common in the United States increase calcium losses in the urine (4,5).
As menopause develops falling estrogen levels will have a negative influence on
calcium absorption and renal calcium conservation therefore calcium needs
characteristically increase during menopause (6). Because of the advent of
commercial agriculture low-calcium, high-phosphorus cereal grains have
replaced high-calcium vegetables in our diets with a corresponding drop in
calcium intake. In addition the level of calcium and other minerals in the soil
these crops are grown on have declined because of continual harvesting and the
failure to replace the minerals that are leached from the soil by the crops.

Calcium absorption averages between 25-50 percent of intake. However what we

are concerned with is not the gross intake, but the net calcium accumulation
which can be as low as only 4-8 percent because of renal, gastrointestinal, and
perspiration losses (7). The gastrointestinal system excretes about 150-250
mg/day of calcium via digestive secretions, the kidneys excrete 80-250 mg/day
and up to 50-1000 mg/day are lost in perspiration depending on the
environmental temperature. These are obligate losses that occur no matter the
level of dietary calcium intake (8). From a physiological point of view the daily
loss of calcium from the gut, kidneys and perspiration results in an inability to
hold on to calcium and along with absorption difficulties that arise with age,
illness and postmenopausal states negative calcium balances occur in a
significant percentage of the population (9).

Absorption is only one aspect determining the effectiveness of a calcium

supplement. Other factors include transport in the blood stream and bio-
utilization. Biological utilization refers to the process where a nutrient is used at a
cellular level. Calcium supplements that raise blood levels of calcium generally
create increased calcium excretion through the kidneys, but don’t necessarily
improve the calcium uptake by the tissues. It is because of this physiology that
mineral transporters such as calcium aspartate can be beneficial, since the
calcium is bound to the mineral transporter while in the blood stream and
significant amounts of calcium are not released until the transporter is taken up
by the target tissue, thus reducing the calcium loss through the kidneys. It was
Dr. Nieper’s opinion that these types of mineral supplements deliver more
bioavailable calcium to the cells and tissues.

24
Clinical Application:
Dr. Nieper reports that the aspartate carrier molecule is particularly attracted to
bone, liver, muscle and breast tissues; where it enter the cells releasing calcium
at the inner layer of the cell membrane activating numerous enzymes that are
bound to the membrane (10). Calcium aspartate is indicated for pregnancy,
lactation, menopausal difficulties, osteoporosis, allergies, hay fever, urticaria,
fibrocystic breast disease (11) and bone fractures.

References:
1. Nieper, Hans A., Eagle-Oden, G. S. and Alexander III, Arthur D. “THE
MINERAL TRANSPORTERS” The Curious Man (1999): 58 – 59
2. NIH Consensus Conference. Optimal calcium intake. NIH Consensus
Development Panel on Optimal Calcium Intake. JAMA 1994;272:1942-
1944.
3. Heaney R, Recker R. Distribution of calcium absorption in middle-aged
women. Am J Clin Nutr 1986;43:299-305.
4. Devine A, Criddle RA, Dick IM, et al. A longitudinal study of the effect of
sodium and calcium intakes on regional bone density in postmenopausal
women. Am J Clin Nutr 1995;62:740-745.
5. Spencer H, Kramer L, Osis D. Do protein and phosphorus cause calcium
loss? J Nutr 1988;118:657-660.
6. Heaney R. Nutrition and risk for osteoporosis. In: Marcus R, Feldman D,
Kelsey J, eds. Osteoporosis. San Diego, CA: Academic Press Inc.;
1996:498-499.
7. Nordin B, Need A, Morris H, et al. Evidence for a renal calcium leak in
postmenopausal women. J Clin Endocrinol Metab 1991;72:401-407.
8. Heaney RP, Recker RR. Determinants of endogenous fecal calcium in
healthy women. J Bone Miner Res 1994;9:1621-1627.
9. Matlovic V, Fontana D, Tominac C, et al. Factors that influence peak bone
mass formation: a study of calcium balance and the inheritance of bone
mass in adolescent females. Am J Clin Nutr 1990;52:878-888.
10. Alexander III, Ph.D., Arthur D. THE HEALTHY CELL: Its Structure and
Functions that are so Essential to Disease Prevention and Treatment
(June, 1997)
11. Nieper, Hans A. “EXAMPLE: Painful, Tissue-Like, Cystic Hardening of the
Mammary Gland” Dr. Nieper’s Revolution in Technology, Medicine and
Society (May, 1985): 251 – 252.

25
L-CARNITINE with B 1

Count Size: 200 Capsules

Each Capsule Contains:
L-Carnitine 250 mg
Vitamin B1 100 mg
Total 350 mg

Dr. Nieper’s General Treatment Protocols:

Cardiac Diseases: 1-2 capsules 3 times per day
Varicose Veins: 1-2 capsules 3 times per day
General Health and Well-being: As an addition to the daily diet, take one (1)
capsule twice a day with meals

Dr. Nieper “found that adding Vitamin B1 greatly enhances the effects of L-
carnitine.”2 Dr. Nieper formulated L-carnitine with Vitamin B 1 to increase the
overall beneficial effects of the L-carnitine within the bloodstream. His formula
utilizes only 100% pure pharmaceutical grade L-carnitine and does not contain
DL or synthetic D-carnitine. Allergic individuals or those suffering from sugar or
yeast intolerance may use Dr. Nieper’s formula.

Technical Information:
L-carnitine when first discovered in 1952 was named vitamin Bt, however later
research determined that the body could manufacture L-carnitine so it lost its
status as a vitamin. In order for the body to manufacture L-carnitine, sufficient
amounts of the amino acids lysine and methionine along with iron and vitamins
C, B3 and B6 must be available. Any individual with a deficiency of any of these
nutrients is at risk of developing carnitine deficiency. Carnitine is synthesized in
the liver, kidney in the brain. The skeletal muscles and the heart require a steady
supply of carnitine in order to utilize long chain fatty acids as a fuel source,
however these tissues can not manufacture carnitine. So carnitine must be
transported to these tissues from other organs by the bloodstream.

L-carnitine is an amino acid derivative that is the substrate for L-carnitine

acyltransferase enzymes. These enzymes require L-carnitine to carry long-chain
fatty acids into the mitochondria. Once in the mitochondria these fatty acids can
either be burned as fuel or used to manufacture a special phopholipid unique to
the mitochondrial inner membrane called cardiolipin. Clinicians have found that
cardiolipin levels fall as a person ages. This very important structural lipid is
necessary for anchoring a number of mitochondrial enzymes. The cells use both
L-carnitine and acetylcarnitine to restore the mitochondrial content of cardiolipin.
As in any component of the body when the structure is altered there is also a
corresponding loss of function. Dr. Nieper’s philosophical approach to nutritional
support of the body entails providing the body the structural nutritional
substances that it needs in order to maintain normal functions.

26
As scientists and nutritionists have studied L-carnitine it has become apparent
that conditional L-carnitine deficiency can develop. L-carnitine deficiency can
result due to reduced L-carnitine in the diet, reduced L-carnitine synthesis due to
lack of building blocks and excessive loss of L-carnitine due to urine losses when
toxins are present. L-carnitine is found in high concentrations in animal foods, but
not in plants this means vegetarians are more predisposed to L-carnitine
deficiency.

L-carnitine besides being required for the transport of fatty acids across the
mitochondrial membrane so that they can be burned for energy is also involved
in the transport of branch chain amino acids into skeletal muscles. L-carnitine
also has roles in moving acids and toxins out of the cells and out of the body
through the urine with some L-carnitine being lost in the process.

Because L-carnitine facilitates removal of organic acids from the mitochondria

excessive amounts of L-carnitine can be lost in the urine in individuals with
chronic acidosis. A little known role of L-carnitine is in detoxification of toxins.
Excessive amounts of both L-carnitine and the cellular antioxidant glutathione
can be lost in the urine in individuals with chemical toxicity. Psychiatrists and
neurologists commonly prescribe L-carnitine for seizure patients who take
valproic acid, since valproic acid can interfere with carnitine metabolism and
supplemental L-carnitine can help prevent the toxic side effects of this drug

Clinical Application:
Heart
Around 1960, the French Pharmacist, Renier, an associate of Dr. Nieper and
mutual friend of Dr. Henri Laborit of Paris, published an enlightening report on
the effects of carnitine, as an important amino acid that occurs and naturally
metabolizes fat in the heart.”1

As a result of L-carnitine being a fatty acid transporter, L-carnitine plays an

essential role in the heart cell’s ability to convert fat into energy. It is the
conductor of fats into the mitochondria where they are burned as fuel. This is
critical since the heart uses fatty acids, as a primary source of energy, unlike
other tissues, such as the brain that relies almost exclusively on glucose.
The heart’s use of fat as a source of energy prevents the heart with competing
with the brain for glucose. L-carnitine is an important agent in the nutritional
support of coronary artery disease reducing the occurrence of arrhythmias and
damaging effects of low oxygen. Magnesium has a synergistic action with L-
carnitine enhancing the hearts utilization of fats for energy. Any impairment in
cardiac energy production from fat predisposes the heart to dysfunction or even
heart muscle damage. The heart will normally store adequate amounts of
carnitine, but when the heart is subject to low oxygen states carnitine levels in
the heart rapidly fall. Clinical studies have shown that L-carnitine
supplementation can be beneficial in individuals with cardiovascular disease.

27
of cardiac infarction or heart muscle necrosis. This build up reduces the
necessary combustion of fat into energy until the heart fails completely.”1

In 1981, Dr. Nieper introduced and began routinely administering L-carnitine with
B1 along with magnesium orotate to his patients with heart disease. This
combination is an enhancement to use of magnesium orotate alone. Dr. Nieper
reported, “this combination maintains the functional health of the heart and
circulatory system.”2

According to Dr. Nieper, “L-carnitine has been shown to reduce cholesterol and
to be useful in the treatment of degeneration of the heart muscle and circulatory
system.” (Nieper Revolution in Technology, 1985). L-carnitine also helps the
body burn and thus lower levels of triglycerides in the blood stream.

Oral L-carnitine supplementation has multiple metabolic actions, besides fat

transport of long chained fatty acids into the mitochondria. L-carnitine improves
fat metabolism in the heart and muscles especially during low oxygen conditions,
improves exercise tolerance and angina in heart patients by working in
conjunction with magnesium in vaso-dilating coronary blood vessels and L-
carnitine reduces blood levels of triglycerides and cholesterol. L-carnitine also
improves sperm quality in infertile men.

Bromelain, L-carnitine, magnesium and potassium orotate work in conjunction

with each other. Dr. Nieper recommended 3-5 (500 mg tablets) of magnesium
orotate daily, 2 (175mg capsules) of potassium orotate with 3-6 tablets of
Bromelain spread out in 3 doses, best taken on an empty stomach, as long as it
does not cause gastric disturbance. If gastric disturbance occurs, give the
tablets with food. L-carnitine is effective in doses of 500mg to 1000mg taken two
or three times/day.

Diabetics may have particular need for L-carnitine since they have
impairment in fat metabolism and tend to have excessive levels of
triglycerides and cholesterol, which can be lowered with use of L-carnitine,
digestive enzymes, chromium and magnesium orotate. Recommended
dose of L-carnitine is 500-1000 mg twice a day.

Varicose veins, angina and other uses

Dr. Nieper used L-carnitine with B1 for obesity, varicose veins, diabetes,
reduction of cholesterol and abnormalities in the circulatory system.
L-carnitine is also an important nutrient for conditions such as congestive heart
failure and angina. Many people who suffer from Chronic Fatigue Syndrome
have low blood levels of L-carnitine. L-carnitine is reported to naturally enhance
sports performance and endurance.

In 1997, Richard N. Podell, M.D. wrote an article titled “Carnitine Treats Blocked
Leg Arteries,” published by Nutrition Science News. In this document he points

28
‘angina of the leg.’”3 Dr. Podell expands furthermore on the uses of L-Carnitine to also
include: “Epilepsy, Congestive Heart Failure, Angina, Cardiogenic Shock, improved
sperm quality among infertile men, Chronic Fatigue Syndrome and Alzheimer’s
disease” (see report for full details).3 Dr. Podell also informs readers that “L-Carnitine
is relatively safe at the usual adult treatment dose of up to 1 gram, three times daily.
However, people taking therapeutic doses of L-Carnitine certainly need to be under a
physician’s care.”3

References:
1
Nieper, Hans A. “EXAMPLE: Heart and Cardiac Infarction” Dr. Nieper’s Revolution in
Technology, Medicine and Society (May, 1985): 243
2
Nieper, Hans A., Eagle-Oden, G. S. and Alexander III, Arthur D. “AVAILABLE
AVENUES TO CARDIOVASCULAR HEALTH” The Curious Man (1999): 78 - 79
3
Podell, M.D., Richard N. “Carnitine Treats Blocked Leg Arteries” Nutrition Science
News (November, 1997 – Vol. 2)

29
DIONAEA MUSCIPULA (Venus Fly-Trap Extract)

Sizes: 32 milliliter
120 milliliter
500 milliliter
1 liter

Each Liquid Bottle Contains:

Dionaea Muscipula Concentrate 43%
Propylene Glycol (U.S.P.) 30%
Distilled Water 27%

Dr. Nieper’s Treatment Protocols:

Cancer: At least 30 – 40 drops, 4 to 5 times per day, sublingually (under the
tongue), before meals, wait 60 – 120 seconds and then swish with a small
amount of pure water and swallow. (Should be used in combination with
Iridodial, when available, taken 15 minutes apart.)
Herpes: Applied topically as needed. It is also recommended to take orally one
teaspoon, 1 – 3 times daily, with water.
Cold, Flu & Viral Infections: one teaspoon, 3 – 4 times daily, until symptoms
abate
General Health and Well-being: one teaspoon, 1 – 3 times daily, with water

Technical Information:
“Carnivorous plant extracts derived from the Venus Fly-Trap plant contain the
active enzymes endopeptidase and endonuclease. These are special gene-
eliminating substances.”1 Venus Fly-Trap plants excrete substances, which
extinguish the gene information of ingested insects because otherwise, the
absorbed gene information from the insect would possibly go in their own gene
system and change it. The carnivorous plant of the “Venus Fly-Trap” contains
about a dozen substances, such as plumbagin, droseron, and hydroxydroseron,
which extinguish open gene information. According to Dr. Nieper, the extract of
Venus Fly-Trap extinguishes genetic replication of malignant cells. These
substances are also useful in eliminating tissue damaged by radiation therapy;
while having no effect on normal cells.1 Venus Fly-Trap Extract is botanically
termed Dionaea Muscipula.

Dr. Nieper clarifies in his 1999 book, The Curious Man, “that cancer cells are not
alien invaders. They are normal cells that have undergone an abnormal
transformation, and as such, are not recognized by the body’s immune system as
foreign. Thus, the body permits their uncontrolled growth.”1

Dr. Nieper reported, “Dionaea Muscipula extinguishes cells which are

genetically impaired. Therefore, whatever is improperly programmed gets
discarded.”2 Furthermore, Dionaea Muscipula has no bearing on normal cells.

30
Dr. Nieper liked to use Dionaea Muscipula in Adenocarcinomas of the colon, Hodgkins
Disease, Melanoma, Leukemia, Chronic Lymphatic Leukemia and Lymphocytic
Immunoblastoma. Dr. Nieper said that patients should start use of Dionaea Muscipula
relatively early. With large tumors, a surgeon should surgically remove as much as
possible of visible tumors and continue Dionaea Muscipula.

Dionaea Muscipula “stimulates the freeing of debris from the tumour, which has to be
expelled.”2 Dr. Nieper also recommends Pau D’Arco tea or capsules to be used to
cleanse the body of this debris.

Dr. Nieper found that there are no negative effects at all from using Dionaea
Muscipula. One could use Dionaea for 20 years if they wanted to.2 Since this
substance is completely non-toxic, there is no maximum dosage. Dr. Nieper
maintained that basically the more Dionaea ingested by the patient, the more helpful it
will be.

Dr. Nieper believed that Dionaea Muscipula was a good choice for cancer as well
as herpes type viruses. 3 Morton Walker, D.P.M. lists a number of conditions where
clinicians have used Dionaea Muscipula, “most forms of cancer, neurodermitis,
ulcerative colitis, Crohn’s disease, multiple sclerosis, all types of herpes
infections, primary chronic polyarthritis, and almost any immune deficiency
state. 4

Dr. Helmut Keller, M.D. uses Dionaea Muscipula in “most types of solid cancer tumors
and a variety of other noncancerous degenerative diseases”5 (See journal articles,
Parts I & II, for full details of clinical applications by Dr. Keller, documented by Morton
Walker, D.P.M.).

References:
1
Nieper, Hans A., Eagle-Oden, G. S. and Alexander III, Arthur D. “The History of
Chemotherapy” The Curious Man (1999): 36, 103, 105
2
Nieper, Hans A. “Dionaea Muscipula (Venus Fly-Trap) Therapy” - Excerpt from
Lecture at the Health by Choice Conference, Atlanta, Georgia (April, 1984)
3
Nieper, Hans A. “Modern Medical Cancer Therapy Following the Decline of Toxic
Chemotherapy” Townsend Letter for Doctors & Patients (November, 1996)
4
Walker, D.P.M., Morton “Medical Journalist Report of Innovative Biologics: The
Carnivora Cure for Cancer, AIDS & Other Pathologies” New Horizon’s Newsletter
(1992)
5
Walker, D.P.M., Morton “The Carnivora Cure for Cancer, AIDS & Other Pathologies –
Part II” New Horizons Newsletter (1992)

31
E Complex 615mg capsules

Count Size: 50, 100 Capsules

Each Capsule Contains:
Vitamin E 200IU
(As d-alpha tocopherol succinate and mixed natural tocopherols)
Magnesium 50mg
(As magnesium arginate contains 3.25mg elemental magnesium)
selenium aminoate 50mcg

Other ingredients:

Endurol™ 5000mcg
(Consisting of: Octacosanol, Tricontanol, Tetracosanol, and
Hexacosanol)
Organic Wheat Sprouts 100mg

Vitamin E is an antioxidant that can protect cell membranes and protect cells
from destruction by aiding in cellular respiration in both cardiac and skeletal
muscles.

Selenium is included in the formula to activate the antioxidant enzyme

glutathione peroxidase, which aids in the destruction of free radicals. Selenium
has critically important roles in the immune system and in protecting the
pacemaker system of the heart.

Magnesium arginate assists in cardiovascular protection by mobilizing

cholesterol deposits in the walls of arteries.
Endurol is a combination of octacosanol and other polyalcohols. These nutrients
assist cells in utilizing oxygen.

Organic wheat sprouts are a whole food complex that supports the body’s
production of the antioxidant enzymes superoxide dismutase, catalase,
glutathione peroxidase and methionine reductase.

Dosage:
General Health and Well-being: As an addition to the daily diet, take 1
capsule twice a day with meals, or as directed by a health care
professional.

Dr. Nieper’s General Treatment Protocols:

Alcoholism Nutritional Support: 1 capsule 2 times per day
Age spots: 1 capsule 2 times per day

32
Cancer: 1-2 capsules 2 times per day
Cardiac diseases: 1-2 capsules 2 times per day
Chemical Toxicity: 1-2 capsule 2 times per day
Chronic Viral or Autoimmune Liver Inflammation: 1-2 capsules 2 times
per day
Diabetes: 1-2 capsules 2 times per day
Heavy metal toxicity (Lead, Cadmium and Mercury): 1-2 capsules 2
times per day
Multiple sclerosis: 1-2 capsules 2 times per day

Technical Information and clinical applications:

Vitamin E is an oil-soluble vitamin that is naturally present in the oils of wheat

germ and many other plant seeds. It is present in lesser amounts in leafy
vegetables and other plants. In animal tissues vitamin E is generally
concentrated in fatty tissues and organs such as the heart and liver. Vitamin E
was not universally accepted as essential for human health until about 1966 with
the RDA established in 1968. Natural source vitamin E d-alpha tocopherol and
mixed tocopherols used in many supplements is derived from vegetable oil.
Vitamin E is considered an essential nutrient because the body cannot
manufacture its own vitamin E and therefore vitamin E must be obtained from
foods and/or supplements.

Research has shown that food alone cannot provide optimal amounts of vitamin
E, especially in individuals who are at risk for cardiovascular and other
degenerative diseases. The high amounts of vitamin E found in supplements,
often 100 to 1200 IU per day, are not obtainable from eating food. Almost all the
clinical studies of vitamin E shows that hundreds of units per day are required to
achieve positive effects—an amount easily obtained with supplements, but not
with food.

A natural food source of vitamin E is olive oil. Olive oil contains about 26 mg-
30mg of vitamin E per cup (one milligram of vitamin E is close to one IU.)
Unfortunately, most individuals cannot consume enough olive oil (13-26 cups of
olive oil daily) to obtain the quantity of E that is preventive of cardiovascular
disease probably 400 IU to 800 IU daily, which means that extra vitamin E
supplementation is necessary.
Vitamin E occurs naturally in several forms of 'tocopherols' with alpha, beta,
gamma and delta being the most important forms, but alpha tocopherol and
gamma tocopherols are the major forms, which have biological activity. The
natural forms of vitamin E are all d-stereoisomers. Vitamin E is absorbed in
the small intestine with the aid of bile salts and pancreatic enzymes. After
vitamin E is absorbed, it is transported in the blood stream to the tissues where it

33
is taken up by the membranes of cells. After oral ingestion of d-alpha tocopherol
red blood cell membrane levels significantly increase.

The antioxidant activity of vitamin E protects the polyunsaturated fatty acids in

cell membranes from oxidation and so protects cell membranes from destruction
by free oxygen radicals. Vitamin E has specific binding sites on cell membranes
especially the d-alpha tocopherol form with less preference for the other forms.
When d-alpha tocopherol is given orally the liver takes up a significant amount
where it is incorporated into very low-density lipoproteins (VLDL). When VLDL is
subsequently broken down into low density lipoprotein (LDL-bad cholesterol) and
high density lipoprotein (HDL-good cholesterol) these lipoproteins play critical
roles in the transport of vitamin E to the various issues of the body. It may be
considered that LDL and HDL are transport agents of vitamin E.

Tocopherol succinate and tocopherol acetate are esters of vitamin E. These are
the forms of vitamin E that typically are used in vitamin E supplements because
of they have greater stability in the presence of oxygen than unesterified free
tocopherols. These forms have good shelf life are used in supplements so that
vitamin E does not decompose prior to use.

Once tocopherol succinate and tocopherol acetate are ingested pancreatic

enzymes in the small intestine break down the molecules facilitating absorption
of the unesterefied tocopherol form.

Functions of vitamin E

The primary functions of Vitamin E are protective. Vitamin E works in conjunction

with the mineral selenium. These nutrients are involved in the control and
elimination of peroxide free radicals from the body. Vitamin E and selenium are
major anti-oxidant nutrients that protect biological molecules and cell membranes
from oxidative damage. When oxidative damage occurs to the membranes of
cells, cells lose their ability to regulate mineral movement into and out of their
interior. Since control of mineral concentrations inside of cells is critical for all
cellular functions, vitamin E, selenium and other antioxidants must be maintained
at physiologic levels to ensure proper mineral activity and normal cell
functions. Low vitamin E and selenium intake and tissue levels have been
associated with an increased risk of developing rheumatoid arthritis as well as
numerous other degenerative conditions especially coronary artery disease.

It is important to recognize the fact that while vitamin E is a potent antioxidant it

does not work in isolation and is most effective when other antioxidants are
present. Dr. Nieper recognized that other antioxidants such as beta carotene,
lycopene, lipoic acid, glutathione, vitamin C and the mineral selenium have
synergistic antioxidant effects. One of the major failings of research studies on
the effects of antioxidants is the failure to recognize antioxidant synergism and

34
the role of antioxidant cascades. Research studies on vitamin E antioxidant
effects will be skewed if participants have low levels of other antioxidants.

Vitamin E has been found to have an anti-inflammatory effect in blood vessels,

particularly in diabetics. Vitamin E in doses of 800-1200 IU reduces the
production of inflammatory cytokines particularly interleukin-6—a cytokine that
tells the liver to make C-reactive protein (CRP). CRP, a marker of inflammation,
is reduced by vitamin E and selenium supplementation. Research has shown
that inflammatory cytokines and CRP are involved in the process of
atherosclerosis and are elevated in individuals who suffer strokes and heart
attacks.

Many individuals especially smokers and diabetics are prone to atherosclerosis.

In atherosclerosis oxidized fats accumulate in plaques in the major arteries of the
body. Vitamin E protects against the development of vascular blockages by
reducing: the blood levels of LDL-cholesterol and triglycerides, the oxidation of
LDL, inflammation of the artery lining and the oxidation of platelet membranes,
which predisposes to the formation of blood clots. The result of this combination
of effects by vitamin E reduces the propensity for plaque formation. When vitamin
E is taken before meals along with vitamin C blood flow is maintained in the
tissues along with improved oxygenation, which reduces the feeling of lethargy
many people experience after eating.

Vitamin E maintains cell membrane integrity, prostaglandin biosynthesis,

reproductive function in both males and females and it is involved in blood
coagulation, wound healing and immune competency.

Vitamin E strengthens the walls of blood vessels and protects the delicate
membranes of red blood cells and other cells from destructive free radicals.
Individuals who are deficient in vitamin E frequently have anemia and red blood
cells that are more fragile causing them to break more easily and release their
hemoglobin.

Vitamin E helps prevent blood clots and has been used by doctors in numerous
conditions ranging from sterility, muscular dystrophy and heart conditions.

Vitamin E can protect the brain from free radical attack and may be helpful in
individuals suffering from Parkinson’s disease, Alzheimer’s and tardive
dyskinesia in slowing the progression of these conditions.

A deficiency of vitamin E may lead to a rupture of red blood cells, premature

aging, depression, loss of memory, cataracts, male infertility, and degenerative
changes in the heart, muscles, nerves, skin and circulatory system. People who
eat diets high in unsaturated fat have increased vitamin E requirements.

35
Vitamin E is actually a group of naturally occurring and synthetic compounds with
the most biologically active being d-alpha tocopherol, which has over two times
the biological activity than synthetic dl-alpha tocopherol. D-alpha tocopherol has
significantly more biological activity than dl-alpha tocopherol and since the alpha-
tocopherol form of vitamin E is the form best utilized by the body, the best
supplements contain predominantly d-alpha-tocopherol along with a mixture of
other natural tocopherols. Vitamin E is sold in natural and synthetic versions. A
supplement containing natural vitamin E is will have the letter "d" in front of the
word “alpha”. Synthetic versions of vitamin E will have the letters "dl" in front of
the word “alpha”.

While d-alpha tocopherol may be the most important form of vitamin E, other
natural tocopherols also have biological benefits. The other naturally occurring d-
stereoisomers that exhibit vitamin E activity are beta, delta, and gamma-
tocopherol. These different forms of vitamin E have different bioactivity than the
d-alpha tocopherol form. For example, gamma tocopherol is more potent than
alpha tocopherol in increasing the activity of the antioxidant enzyme superoxide
dismutase (SOD) and in increasing the body’s production of nitric oxide (NO) by
increasing the activity of the enzyme nitric oxide synthase, which produces NO.
Because the body needs several natural tocopherols, supplements that contain a
spectrum of natural tocopherols are superior to versions that only contain d-alpha
tocopherol or synthetic forms of vitamin E.

Numerous clinical studies have demonstrated that vitamin E plays a protective

role against the development and progression of Coronary Artery Disease (CAD).
The anti-atherosclerotic property of vitamin E is associated with: a reduction in
low density lipoprotein (LDL) peroxidation, a decrease in insulin resistance,
decreased blood sugar in diabetics, decreased fasting insulin levels and an
improved plasma lipid profile in diabetic patients.

Aging individuals and especially type 2 diabetics generally have insulin

resistance and hyperinsulinemia (high serum insulin levels). High circulating
insulin levels have been found to have a strong relationship to the development
and progression of (CAD). Therefore any nutritional approach that can improve
cellular insulin resistance and reduce high blood sugar levels can be beneficial in
individuals at risk for heart disease. Dr. Nieper found that a combination of
vitamin E along with vitamin C, selenium, zinc mineral transporters, chromium
GTF, calcium arginate and magnesium arginate were beneficial in diabetics and
in individuals with or at risk for CAD. Use of vitamin E along with these
supplements may be beneficial in decreasing: free radical production, fasting
insulin levels, serum triglycerides and total LDL cholesterol.

A number of studies have reported that oral intake of 400 to 800 IU of natural
vitamin E per day reduces the risk of heart attacks. However, some double-blind
trials have found either limited benefit, or no benefit at all from vitamin E
supplementation when supplements containing synthetic vitamin E were used.

36
LITHIUM OROTATE

Count Size: 200 Tablets

Each Capsule Contains:
Micro Vortex Enteric Coated
Lithium Orotate 120 mg
(4.6 mg elemental lithium)
Total 120 mg

Dr. Nieper’s General Treatment Protocols:

Chronic Inflammation of the Liver and Atrophied Liver: 1 – 120 mg Tablet per
day. Should always be combined with 500 mg of Calcium Orotate per day.
Migraine Headaches: 2 – 3, 120 mg Tablets per day, or as needed (non-toxic).
Should always accompany L-Taurine – 120 mg, or as needed, in equal dosage to
Lithium Orotate.
Depression, Bi-Polar Disorder, Alcoholism (Beer Alcoholism in particular),
Convulsive Diseases (Epilepsy): 3 – 4, 120 mg Tablets per day.
General Health and Well-being: As an addition to the daily diet, take 1 – 120 mg
Tablet twice a day with meals.

Avoid using lithium orotate while using diuretcis, since excessive sodium loss may
occur. In general lithium compounds should not be used during the first 4 months of
pregnancy.

Technical Information:
Lithium Orotate is completely non-toxic and lithium is not released in significant
amounts from the transporter in the blood stream. It is not until the compound has
entered the cells that lithium is released. Therefore, it is not necessary to monitor the
blood serum levels, which is necessary when administering Lithium Carbonate, for
example. Lithium Orotate furthermore, does not trigger the harmful side effects that
normally occur with high doses of Lithium Carbonate, Sulfate, Acetate, or Citrate.1

Dr. Nieper reports regular examinations of blood serum levels are not necessary
because there is not a significant increase in the blood’s lithium content when Lithium
Orotate is used as a mineral supplement. Muscular tremors (fibrillation) as well as
disorderly effects on the thyroid usually do not occur with this lithium mineral
supplement unless very high amounts are used (over 8/day, which is much higher than
recommended doses). The formation of ‘goiter’ is avoided, as are undesirable
disturbances in the body’s water balance.2

Lithium Orotate preferentially attracts toward certain tissues such as: connective
structure of the brain, such as the brain blood barrier and the glia cells; the cells of the
heart’s pacemaker and the heart’s stimulus conduction system; and the bone marrow
cells. With orotic acid as the carrier, “it is thus possible to improve the specific effect of
Lithium nearly 20 fold.”2

During Dr. Nieper’s preliminary work with Dr. Franz Kohler on specific cellular
electrolyte carriers, he considered the possibility that Orotic Acid might be an
appropriate carrier molecule. Later, “clinical trials and electron microscopic research 37
(Nieper, Moenninghoff, 1971) indicate that the Orotates have specific affinity toward
cells of the heart, blood vessels, blood brain barrier and cartilage.”3 Orotic Acid
penetrates very easily into the cell and, as an aromatic substance, its salts possess
high chemical-complexing power. Dr. Nieper found that the Orotates pass through the
cell’s double-layered outer membrane and are decomposed for utilisation only by the
inner components of the cell, such as the microsomes and the mitochondria.1
Biochemist and Scientific Consultant, Arthur D. Alexander III, Ph.D., describes the
mitochondrial organelles as the cell’s “furnace” which break down sugars and fats to
produce cellular energy.

Lithium Orotate is a molecular compound of one elemental Lithium and one Orotic
Acid molecule, all micro vortex enteric coated to protect the fragile mono-valent bond
during passage through the stomache acids when administered orally.

Clinical Application:
Clinical conditions that warrant supplementation with Lithium orotate include manic
and depressive states, childhood epilepsy, alcoholism, tension headaches, migraine
headaches, thyroid hormone overproduction and low production of white blood cells.2
Dr. Nieper recommended lithium orotate was used along with taurine 500mg/day and
squalene 500mg 4-6 softgels/day to reduce sodium accumulation in cells.

Dr. Nieper always combined Lithium Orotate with Calcium Orotate in individuals with
chronic liver inflammation. He reported favorable responses with this combination of
mineral transporters in viral hepatitis and cirrhosis.2

Lithium Orotate is Dr. Nieper’s primary suggestion for depression and bipolar disorder,
as well as migraine and frequently recurring headaches.1

References:
1. Nieper, Hans A., Eagle-Oden, G. S. and Alexander III, Arthur D. “THE
OROTATES: LITHIUM OROTATE” The Curious Man (1999): 58 – 59.
2. Nieper, Hans A. “EXAMPLE: Chronic Inflammation of the Liver and Atrophied
Liver; Lithium Orotate” Dr. Nieper’s Revolution in Technology, Medicine and
Society (May, 1985): 224 – 226.
3. Alexander III, Ph.D., Arthur D. THE HEALTHY CELL: Its Structure and
Functions that are so Essential to Disease Prevention and Treatment (June,
1997)

38
Lithium arginate

Count Size: 100 and 200 Tablets

Each Tablet Contains:
Micro Vortex Enteric Coated Granules of
Lithium arginate with aspartate 120 mg
(4.3 mg elemental lithium)
(86.9mg arginate) (28.8mg aspartate)
(Other ingredients: Magnesium carbonate, Avicel, Duratex, Pure
Food Glaze, Compitrol, Ac-Di-Sol, Plasdone and Magnesium
Stearate)
Total 120 mg

Dr. Nieper’s General Treatment Protocols:

Cirrhosis: Lithium arginate 120 mg 1 tablet per day combine with Zinc aspartate
40mg 2 twice/day, Selenium 100mcg 1 twice/day, Calcium AEP 1 three
times/day, Magnesium orotate 500mg 1 twice/day
Glaucoma: Lithium arginate 120mg 1 three times/day, 2-AEP complex 500mg 2
twice/day
Gout: Lithium arginate 120mg 1/day, Lysine orotate 600mg 2 twice/day, Folic
acid 400mcg 3 twice/day
Depression: Lithium arginate 120mg 1-3/day

Technical Information:
Lithium arginate is a nutritional supplement of the trace element lithium combined
with the mineral transporters arginine and aspartic acid. Because such a small
amount of lithium is given, it is not necessary to monitor the blood serum levels,
which is necessary when administering the drug form of lithium such as lithium
carbonate. Lithium arginate furthermore, does not trigger the harmful side effects
that normally occur with high doses of lithium carbonate, acetate, or citrate.1

Dr. Nieper reports that supplementation with either lithium arginate or lithium
orotate, in recommended doses, does not significant the lithium content of the
blood so regular examinations of blood lithium levels are not necessary. When
taken in recommended doses muscular tremors, diarrhea and disorderly effects
on thyroid function do not occur.2

Lithium mineral transporters preferentially are attracted toward the connective

structures of the brain, such as the brain blood barrier and the glia cells; the cells
of the heart’s pacemaker conduction system; and the bone marrow cells. With
mineral transporters as the carrier for lithium, “it is thus possible to improve the
specific effect of lithium nearly 20 fold.”2

Clinical Application:

39
Psychiatrists have been actively using lithium compounds for decades in
psychiatric patients. The most common drug forms of lithium are lithium
carbonate and lithium citrate, which are mineral salts. In these preparations the
lithium is removed from the compound in the process of digestion and free lithium
ions are absorbed into the blood stream. In order to establish a therapeutic dose
of lithium salts, psychiatrists are trained to measure lithium levels in the blood
serum. The monitoring of lithium levels and patient response to lithium combines
both the science and art of medicine. With scientific testing, doctors try to
establish therapeutic levels of lithium in the blood stream while attempting to
avoid lithium toxicity, which is often manifested by a variety of symptoms such as
diarrhea, excessive thirst, excessive urination and tremors. Scientific studies
have shown that there is a very narrow range between the blood level where
lithium salts exert therapeutic effects and the level at which they exert toxic
effects. Long-term lithium salts can damage the kidneys and the thyroid so
psychiatrists attempt to maintain the blood level of lithium within a very narrow
therapeutic range to avoid both the acute and chronic side effects of lithium.
Unfortunately, some individuals will exhibit symptoms of lithium toxicity even
when they have very low lithium levels. Recognition of such a phenomenon
entails the art of medicine and clinical experience where a good doctor learns to
pay attention to the patient’s response and symptoms instead of the lab report,
which may show a therapeutic or even low blood level of lithium.

Lithium mineral transporters such as lithium arginate and lithium orotate are
different types of lithium compounds than lithium carbonate or lithium citrate.
When a lithium mineral transporter is used about 80% of the lithium is still bound
to the transporter while the compound is in the blood stream. These compounds
only release significant amounts of free lithium after the transporter carries the
lithium into the cells. Free lithium is then released inside the cells when metabolic
processes utilize the transport agent. With lithium mineral transporters, the
clinical effects are not related to the actual amount of lithium in the blood, but
rather by tissue delivery. So investigation of blood levels of lithium has little
correlation with the effect of lithium mineral transporters.

These form of lithium supplements have a high affinity for particular tissues and
by maintaining control of lithium release till the transporter enters the tissues only
a small amount of lithium is needed in order to achieve biological effects.
These mineral transporters contain much lower doses of elemental lithium than
drug versions of lithium such as lithium citrate or lithium carbonate. It is important
to recognize that even though these nutritional supplements contain only small
amounts of elemental lithium some individuals may be very sensitive to any
amount of lithium and may only need one per day. If an individual is sensitive
they may develop temporary weakness, which is resolved by lowering the dose
or using the product every other day. Lithium also plays an important role in the
production of blood cells in the bone marrow and stimulates the production of
new nerve cells in the brain.

40
References:
1. Nieper, Hans A., Eagle-Oden, G. S. and Alexander III, Arthur D. “THE
OROTATES: LITHIUM OROTATE” The Curious Man (1999): 58 – 59.
2. Nieper, Hans A. “EXAMPLE: Chronic Inflammation of the Liver and
Atrophied Liver; Lithium Orotate” Dr. Nieper’s Revolution in Technology,
Medicine and Society (May, 1985): 224 - 226

41
L-Lysine Orotate
Count Size: 50 Capsules

Each Capsule Contains:

L-Lysine orotate 600mg
(L-Lysine 300mg)
(Orotic acid 300mg)

Other Ingredients:
Magnesium Stearate

Dosage:
Dr. Nieper’s General Treatment Protocols:
**Note: Lysine should always be taken only on an empty stomach
Acne: 3 capsules 2 times a day
Amyotrophic Lateral Sclerosis (ALS): 3-4 capsules 4 times a day
Arthritis: 2-3 capsules 2 times a day
Bone loss and fracture repair: 3 capsules a day
Canker sores and fever blisters: 2-3 capsules 2 times a day
Dandruff: 2 capsules 2 times a day
Gout: 2 capsules 2 times a day
Herpes infections: 2 capsules 2 times a day
Hypercholesterolemia and Hypertriglyceridemia: 2 capsules 2 times a
day
Leg cramps: 2 before bedtime
Psoriasis: 1-2 capsules 3 times a day
Wound healing: 2 capsules 2 times a day

Technical Information and clinical applications:

Lysine orotate supplementation is one of the best nutritional options available for
individuals with herpes simplex virus infections. The amino acids arginine and
lysine both have a role in healing of bone fractures. The action of these amino
acids have multiple roles including increasing calcium absorption in the small
intestine, increasing collagen synthesis, increasing growth hormone secretion
and in activation of the bone forming cells called osteoblasts. Because lysine has
an important role in helping the body absorb and conserve calcium an excellent
bone support approach is to combine lysine orotate 2 to 3 capsules twice a day
on an empty stomach with calcium orotate, calcium AEP, vitamin C and zinc
aspartate. Lysine orotate may also increase kidney excretion of uric acid, making
it a helpful supplement for individuals with gout.

42
Lysine orotate is a good nutritional supplement to use in individuals with elevated
cholesterol. Lysine orotate may be useful in helping reduce lipid deposits in the
artery walls, which keeps artery walls flexible lessening the susceptibility to high
blood pressure. Dr. Mathias Rath first began working with the double Nobel Prize
winner Linus Pauling in the early 1990’s on nutritional support of cardiovascular
disease. Dr. Rath currently recommends high doses of vitamin C, bioflavinoids
and lysine for individuals with cardiovascular disease. Vitamin C products are
available that already include a broad spectrum of bioflavinoids.

Lysine is a precursor of the derivative amino acid carnitine, however the

conversion from lysine into carnitine requires that vitamin C be present as a
biocatalyst. It is evident from the chemistry that combining lysine and vitamin c
can be advantageous.

According to Irwin Stone, Ph.D. most animals, except humans, primates, trout,
guinea pigs and the Indian fruit-eating bat, manufacture vitamin C. Animals
manufacture vitamin C in their liver in amounts proportional to body weight.
According to two-time Nobel Prize winner Linus Pauling, for an adult male, this is
about 10 or 12 grams (12,000 mg) a day. Rath and Pauling in a 1991 paper
theorized that lipoprotein A is found in high levels primarily in the blood of
mammals that are unable to synthesize ascorbate (vitamin C). These two doctors
have proposed that lipoprotein A is used by the body to repair damage to
arteries. Arteries are constantly under mechanical stress and are continually
undergoing repair. To repair arteries properly, the body must continually produce
a protein called collagen. To properly form collagen, the body needs a continual
supply of vitamin C, bioflavinoids and the amino acids lysine and proline. When
adequate vitamin C, bioflavinoids and these amino acids are available collagen is
manufactured as a repair substance for stress damaged arteries. When
inadequate amounts of vitamin C are available, the inability to produce sufficient
collagen to repair damaged artery walls causes the body to use other repair
substances to patch the arteries. When adequate vitamin C is not available Rath
and Pauling have postulated that lipoprotein A is able to serve as a patch for
damaged arteries. Unfortunately over time this repair process may result in
obstruction of arteries and compromise of blood flow. When such a process
occurs in the coronary arteries blockages and heart attacks can occur. Both
vitamin C and vitamin B3 can lower lipoprotein A levels in the blood.

According to Linus Pauling it is lipoprotein A that is deposited in plaques on the

walls of arteries, not just LDL-cholesterol. High levels of lipoprotein A in the blood
will result in the deposition of plaques and the development of atherosclerosis.
Lipoprotein A binds to the amino acid lysine, which is present in the proteins
composing artery walls. Both Linus Pauling and Mathius Rath have promoted the
idea that if the blood contains high levels of the amino acid lysine then the blood
lysine will compete with artery wall lysine for binding of lipoprotein A in effect
drawing lipoprotein A away from the artery walls. This competition will reduce the
amount of lipoprotein A that is available to bind to the artery walls and will even

43
work to pull it loose and remove some of the lipoprotein A found in
atherosclerotic plaques. Lysine is also a circulating inhibitor of lipoprotein A.
Physiologically lipoprotein A inhibits plasmin-induced proteolysis (enzymatic
protein digestion). The proteolytic effect of plasmin is a tool used by white blood
cells in moving through the tissues and is also involved in increasing vascular
permeability. Vitamin C deficiency can lead too excessive vascular permeability,
which can lead to tissue hemorrhages in individuals suffering from severe vitamin
C deficiency. By inhibiting enzymatic degradation of proteins, lipoprotein A serves
an important function in repairing the fragile leaking blood vessels that occur in
individuals low in vitamin C.

References:
1. Flodin NW. The metabolic roles, pharmacology, and toxicology of lysine. J
Am Coll Nutr 1997; 16(1): 7—21.
2. Griffith RS, Walsh DE, Myrmel KH, et al. Success of L-lysine therapy in
frequently recurrent herpes simplex infection. Treatment and prophylaxis.
Dermatologica. 1987;175:183–190.
3. Pauling L. Case report: Lysine/ascorbate-related amelioration of angina
pectoris. J of Ortho Med 1991;6:3-4.
4. Rath M, Pauling L. Lipoprotein (a) is a surrogate for ascorbate. Pro Nat
Acad Sci 1990;87:6204-6207.
5. Rath M, Pauling L. Immunological evidence for the accumulation of
lipoproptein(a) in the atherosclerotic lesion of the hypoascorbemic guinea
pig. Proc Natl Acad Sci 1990; 87: 9388-9390.
6. Rath M, Pauling L. Solution to the puzzle of human cardiovascular
disease. Its primary cause is ascorbate deficiency, leading to deposition of
lipoprotein(a) and fibrinogen/fibrin in the vascular wall. J Ortho Med
1991;6:125-134.
7. Rath M, Pauling L. Plasmin-induced proteolysis and the role of
apoprotein(a), lysine, and synthetic lysine analogs. J Ortho Med
1995;7(1).
8. Stone I. Vitamin C: The Healing Factor Against Disease. New York:
Grosset and Dunlap, 1972.

44
L-Glutathione 100mg tablets
Count Size: 100 tablets

Each Tablet Contains:

L-Glutathione (reduced form)

Other Ingredients: Lemon Powder, Solka Floc, Tricalcium Phosphate,

Maltodextrin, Lubritab, Plasdone, and Magnesium Stearate.

Dosage:
Dr. Nieper’s General Treatment Protocols:
General recommendation: take one tablet twice a day
Cancer: 1-2 tablets 2 times per day
Cardiac diseases: 1-2 tablets 2 times per day
Chemical Toxicity: 1-2 tablets 2 times per day
Chronic Viral or Autoimmune Liver Inflammation: 1-2 tablets 2 times per
day

Technical Information and clinical applications:

Glutathione (GSH) is a naturally occurring cellular tripeptide composed of the
amino acids cysteine, glutamic acid, and glycine. When combined together in this
form, these amino acids provide the cells with an essential compound that is a
critical part of the body's natural defense system. Glutathione is an important
cellular antioxidant that protects cells against oxidative stress and has a critical
role in cellular detoxification.

All the cells of the body contain glutathione in high concentrations. In its role as
an antioxidant glutathione is a component of the intracellular antioxidant
enzymes glutathione peroxidase and glutathione reductase. In order for these
enzymes to protect cells against damage from free radical scavengers these
antioxidants require a continuing supply of reduced glutathione as well as
adequate cellular concentrations of vitamin E and the mineral selenium. When
reduced glutathione neutralizes free radicals it is converted to an inactive
oxidized form. Selenium is needed to activate glutathione peroxidase, which
recycles cellular glutathione from its oxidized form back to its active reduced
form. Vitamin E works in conjunction with the mineral selenium and circulating
and cellular reduced glutathione. All of these nutrients are required for the control
and elimination of peroxide free radicals from the body.

Oral glutathione has several benefits as a dietary supplement. While some is

broken down in the digestive system, a significant amount is effectively absorbed
resulting in higher blood levels of glutathione. In the blood stream glutathione is
able to neutralize lipid peroxide free radicals. In addition oral glutathione

45
supplements support intestinal detoxification of dietary peroxides. Oral
glutathione also provides as a readily available source of cysteine, since it is
more water-soluble than cysteine and it is not toxic even in large doses. The
disadvantage of oral glutathione as a dietary supplement is that it does not
appear to readily cross cell membranes directly increasing cellular glutathione
levels. Thus, oral glutathione’s ability to increase intracellular levels of glutathione
most likely depends on its role as a physiological source of cysteine, not as a
direct source of glutathione.

Enhancement of cellular glutathione levels

Cellular glutathione levels decline with age, chemical toxicity, heavy metal
toxicity, viral infections and with low dietary intake of the amino acids cysteine
and/or methionine. Ingestion of food or dietary supplements containing the sulfur
amino acids cysteine and methionine or the supplement N-acetylcysteine (NAC)
can provide substrate material for glutathione synthesis. However, because the
amino acid cysteine is relatively toxic in higher amounts, N-acetylcysteine
supplements are a preferred alternative choice for supporting the body's natural
cellular glutathione production.

An NAC oral supplement is different from an oral glutathione supplement in that

NAC can be transported across the cell membrane into the cell where it
promotes the intra cellular synthesis of glutathione. Glutathione levels in the body
are most effectively enhanced by a combination approach; using reduced L-
Glutathione as a oral supplement to provide increased circulatory antioxidant
activity and including NAC supplements 250-500mg 3 times/day as an additional
dietary cysteine source and precursor of intracellular glutathione production.

When doctors try to increase antioxidant levels they run into problems trying to
increase cellular glutathione levels. Cellular levels of selenium, vitamin E and
vitamin C can be elevated by increased simply by increasing intake by using
dietary or supplemental sources, but cellular glutathione is only produced in the
body. Fortunately there is an answer. Use of whey protein 1-2 scoops/day, lipoic
acid 50-100mg 3 times/day and N-acetyl cysteine (NAC) supplements can cause
the cells to produce more glutathione and oral reduced glutathione
supplementation 1-2 100mg tablets 3 times/day can increase circulating
glutathione levels.

References:
1. Meister A. New developments in glutathione metabolism and their
potential application in therapy. Hepatology 1984; 4(4):739-742.
2. Meister A. New aspects of glutathione biochemistry and transport:
selective alteration of glutathione metabolism. Fed Proc 1984;
43(15):3031-3042.

46
1. Staal F, Ela S, Roederer M, et al. Glutathione deficiency and human
immunodeficiency virus infection. Lancet 1992;339:909-912.
2. Vallis KA. Glutathione deficiency and radiosensitivity in AIDS patients.
Lancet 1991;337:918-9.
3. Williamson J, Boettcher B, Meister A. Intracellular cysteine delivery
system that protects against toxicity by promoting glutathione synthesis.
Proc Natl Acad Sci 1982;79:6246-6249.

47
Magnesium Orotate
Count Size: 50, 100, 200 tablets

Each Tablet Contains:

Magnesium Orotate 500mg
(31mg elemental magnesium)

Other Ingredients:
Duratex, Pure Food Glaze, Avicel and Magnesium Stearate

Dosage:
General Health and Well-being: As an addition to the daily diet, take 1-2
tablets with each meal, or as directed by a health care professional.

Dr. Nieper’s General Treatment Protocols:

Allergies: 1 tablet 3 times per day
Arthritis: 1-2 tablets 3 times per day
Asthma and Emphysema: 1 tablet 3 times per day
Bone Enhancement: 1-3 tablets per day
Bursitis and tendonitis: 1 tablet 2-3 times per day
Cardiac disease: 1-2 tablets 3 times per day
Chronic Pancreatitis: 1 tablet 3 times per day
Cirrhosis: 1 tablet 2-3 times per day
Diabetes: 1 tablet 3 times per day
Erectile Dysfunction: 2 tablets 2 times per day
Fatigue: 1 tablet 2-3 times per day
Fibrocystic Breasts: 2 tablets 2 times per day
Hypercholesterolemia and Hypertriglyceridemia: 2 tablets 2 times per day
Hyperthyroidism: 1 tablet 3 times per day
Hypokalemia: 1 tablet 3 times per day
Insomnia: 2-4 tablets at bedtime
Leg Cramps: 2-4 tablets at bedtime
Migraines: 1-2 tablets 3 times per day
Muscle Spasms After Trauma Head Neck Back: 2 tablets 2 times per day

Technical Information:
Magnesium is the second most abundant intracellular mineral. Over 300
enzymes in the body require magnesium. Virtually all of the magnesium of the
body is located within the cells (about 99%) with only 1% being present in the
bloodstream. Magnesium is involved in virtually all the energetic processes in the
body. Magnesium has critical roles in cardiovascular function, bone metabolism,

48
body. Magnesium has critical roles in cardiovascular function, bone metabolism,
nerve conduction and muscular contraction. Without adequate cellular levels of
magnesium energy production and synthesis of proteins, DNA and RNA are
impaired.

Magnesium orotate is a mineral transporter where magnesium is bound orotic

acid a natural component of whey. Dr. Hans Nieper used this mineral transporter
in thousands of patients who suffered from hypertension, angina, heart attacks,
kidney stones and elevated cholesterol. This compound has very high absorption
and it passes intact through the small intestine into the blood stream. Orotates
have particular affinity for bone, cartilage, liver, brain, heart, lungs and circulatory
tissues. Due to its ready absorption by the lining of blood vessels, magnesium
orotate will activate enzymes in the vessel walls mobilizing deposits of
cholesterol. The magnesium will also relax the smooth muscle of arteries. Both of
these processes will increase the elasticity of blood vessels so over time
magnesium orotate can help reduce hypertension. Long term use of this mineral
transporter along with bromelain, other proteolytic enzymes and potassium-
magnesium aspartate can clean artery walls. Dr. Nieper used to call this his pipe
cleaner cocktail. Magnesium not only plays a role in energy production, but it is
also needed for protein synthesis and for the activation of alkaline phosphatase
the enzyme required for production of hydroxyapatite the calcium crystal that
creates bone hardness.

Clinical Applications:
One of the most important functions of magnesium orotate is its enhancement
fatty acid metabolism by heart muscle. The heart obtains up to half its energy
from the metabolism of fatty acids unlike skeletal muscles, which rely more on
glucose. Selenium, chromium, L-carnitine, vitamin E, lithium orotate, magnesium
orotate and magnesium-potassium aspartate all support the ability of the heart to
metabolize fatty acids. By supporting cardiac energy production magnesium
orotate can be helpful in angina and in recovery from heart attacks. Dr. Nieper
also used magnesium orotate to decrease kidney stones, reduce heavy
menstrual flow, reduce the odor of perspiration, reduce bowel odor and improve
digestive disorders.

References:
1. Nieper, Hans A., Eagle-Oden, G. S. and Alexander III, Arthur D.
“PREVENTING AND TREATING CARDIOVASCULAR DISEASE” The
Curious Man (1999): 60-62, 72-73.
2. Nieper, Hans A. “EXAMPLE: Diabetes Mellitus (diabetes)” Dr. Nieper’s
Revolution in Technology Medicine and Society (May, 1985): 218-219.
3. Nieper, Hans A. “EXAMPLE: Arteriosclerosis” Dr. Nieper’s Revolution in
Technology Medicine and Society (May, 1985): 229.
4. Nieper, Hans A. “EXAMPLE: Heart and Cardiac Infarction” Dr. Nieper’s
Revolution in Technology Medicine and Society (May, 1985): 237-241.

49
1. Nieper, Hans A. “EXAMPLE: Heart Therapy in combination with
Magnesium, Selenium and Strong Enzymes” Dr. Nieper’s Revolution in
Technology Medicine and Society (May, 1985): 241-243.

50
Magnesium Arginate with Aspartate

Count Size: 50, 100, 200 tablets

Each Tablet Contains:

Magnesium Arginate-Aspartate 500mg
(32.5mg elemental magnesium)
(351mg arginate)
(116.5mg aspartate)

Other Ingredients:
Avicel, Plasdone, Lubritab, Syloid and Magnesium Stearate

Dosage:
General Health and Well-being: As an addition to the daily diet, take
1-2 tablets with each meal, or as directed by a health care
professional.

Dr. Nieper’s General Treatment Protocols:

Age Spots: 1 two times a day
Anorexia and Bulimia: 1 two times a day
Anxiety: 2-3 two times a day
Attention Deficit Disorder: 1 two times a day
Carpal Tunnel Syndrome: 1 two times a day
Chemical Toxicity: 2 two times a day
Diabetes: 2-3 three times a day
Hearing Loss: 2 two times a day
Heavy metal toxicity (Lead, Cadmium and Mercury): 1 two times a day
Memory Loss: 2 two times a day

Technical Information:
Magnesium is the second most abundant intracellular mineral. Over 300
enzymes in the body require magnesium. Virtually all of the magnesium of the
body is located within the cells (about 99%) with only 1% being present in the
bloodstream. Magnesium is involved in virtually all the energetic processes in the
body. Magnesium has critical roles in cardiovascular function, bone metabolism,
nerve conduction and muscular contraction. Without adequate cellular levels of
magnesium energy production and synthesis of proteins, DNA and RNA are
impaired.
Magnesium arginate is a mineral transporter composed of magnesium bound to
the amino acid arginine. Arginine is an alkaline amino acid. Dr. Nieper and Dr.
Franz Kohler developed a series of mineral transporters called arginates in the

51
1960’s, but they were not brought to the market until the late 1980’s. This
magnesium transporter along with magnesium orotate activates magnesium
dependent enzymes in blood vessel walls mobilizing deposits of cholesterol. Dr.
Hans Nieper thought these magnesium mineral transporters were very effective
mineral carriers for individuals suffering from arteriosclerosis and
atheroscleroisis. Magnesium and calcium arginate also improve glucose
transport out of the blood into the cells. When an individual cannot transport
glucose into the cells a condition called diabetes develops.

Clinicians divide diabetes into 2 groups. Type I diabetes is caused by reduced or

total cessation of insulin production. Many clinicians believe that the insulin
producing pancreatic beta cells in the islets of Langerhans are damaged or
destroyed by viral infections and autoimmune damage. Dr. Robert Atkins has
written that use of another Nieper mineral transporter calcium AEP, when given
early in this process, can have protective effects by preventing damage to the
insulin producing cells. Type II diabetes is a much more common illness than
Type I diabetes affecting 10-14 times as many individuals. In Type II diabetes the
main problem is not a lack of insulin production like in Type I diabetes, but rather
a failure of insulin to adequately transport glucose into the body’s cells. Because
the issue is poor glucose transport in Type II diabetes and arginate mineral
transporters can improve glucose transport independent of the action of insulin
Dr. Nieper realized that arginate mineral transporters could be an effective
nutritional support for diabetics. He told me during my visit with him in Hanover,
Germany in 1998 that this was one of the most exciting discoveries of his career.
Throughout his career Dr. Nieper advocated for the use of non-toxic
orthomolecular approaches to disease. He believed that arginate mineral
transporters were an effective natural approach to improving glucose transport in
Type II diabetics therefore they met his criteria for non-toxic support of a chronic
condition.

Clinical Applications:
Dr. Nieper noted a number of fascinating effects with the use of arginates
including a reduction of spinal pain in arthritic patients and improved hearing in
patients with inner ear problems. When he investigated why individuals with
partial hearing loss responded to arginates, he determined that arginate mineral
transporters improved the entry of glucose into ear cells. This was an exciting
discovery for Dr. Nieper, since this finding led him to test arginate mineral
transporters in diabetes. Dr. Nieper found that magnesium arginate along with
calcium arginate with every meal could reduce blood sugar in many Type II
diabetics. Magnesium arginate also has a major role in any condition where
there is impairment in glucose transport into the cells such as diabetes and
Syndrome X. In order to get the maximum benefit from magnesium use 50 mg of
vitamin B6, which has a synergistic action with magnesium. Magnesium arginate
also has a synergistic action with L-carnitine enhancing the hearts utilization of
fats for energy. Any impairment in cardiac energy production from fat

52
predisposes the heart to dysfunction or even muscle necrosis, so supporting
cardiac fat metabolism is important in nutritional support of heart disease.

References:
1. Nieper, Hans A., Eagle-Oden, G. S. and Alexander III, Arthur D.
“PREVENTING AND TREATING CARDIOVASCULAR DISEASE” The
Curious Man (1999): 60-62, 72-73.
2. Nieper, Hans A. “EXAMPLE: Diabetes Mellitus (diabetes)” Dr. Nieper’s
Revolution in Technology Medicine and Society (May, 1985): 218-219.
3. Nieper, Hans A. “EXAMPLE: Arteriosclerosis” Dr. Nieper’s Revolution in
Technology Medicine and Society (May, 1985): 229.
4. Nieper, Hans A. “EXAMPLE: Heart and Cardiac Infarction” Dr. Nieper’s
Revolution in Technology Medicine and Society (May, 1985): 237-241.
5. Nieper, Hans A. “EXAMPLE: Heart Therapy in combination with
Magnesium, Selenium and Strong Enzymes” Dr. Nieper’s Revolution in
Technology Medicine and Society (May, 1985): 241-243.

53
2-AEP Magnesium
Count Size: 50, 100, 200 capsules

Each Capsule Contains:

2-AEP magnesium 500mg
(62.5mg of elemental magnesium)
Other Ingredients: Duratex, Pure Food Glaze.

Dosage:
General Health and Well-being: As an addition to the daily diet, take
1 capsule twice a day or as directed by a health care professional.

Dr. Nieper’s General Treatment Protocols:

Diabetes Type I: 1-2 capsules 3 times per day
Diabetes Type II: 1-2 capsules 3 times per day
Fatigue: 1-2 capsules 3 times per day
Angina: 1-2 capsules 2 times per day
Multiple Sclerosis: 1-2 capsules 3 times per day
Asthma: 3 capsules three times per day
Magnesium deficiency: 2-3 capsules three times per day

Technical Information:
AEP, also known as membrane integrity factor, aminoethanol phosphate or
colamine phosphate is a natural constituent of the cell membrane making it an
effective substance in repairing the membranes of cells. AEP is a lipid mineral
complex, making it a mineral transporter. AEP is basically a patch (a biological
cell membrane sealant that binds to and acts as a sealant for the outer surface of
the cell membrane. Dr. Nieper advocated the use of AEP mineral transporters for
any condition associated with damage to the cell membranes because he
believed that if you have a hole in a brick wall you fix it with bricks.

AEP has a unique role in the history of biochemical nutrition in that it corrects
structural cellular membrane abnormalities that arise in a number of conditions
returning the cell to a state of normal function. AEP mineral transporters enhance
normal membrane activity by acting as a cell sealant yet allows passage of
nutrients into the cell while concurrently excluding intrusion of toxins into the cell.
Electronmicrograph studies done in 1971 showed that AEP protects cells from
penetration by aggressive substances such as viruses and toxins without
interfering with nutrient transport.
AEP mineral transporters by restoring membrane structure assist the cells in
maintaining their charge allowing for proper production of cellular and tissue
electro-magnetic fields. In addition to the sealing effect, AEP is a particularly
effective mineral transport agent.

54
2-AEP calcium has usefulness in a variety of conditions since it is an effective
calcium transport agent that also repairs damaged membranes. The calcium
transport utility of AEP is demonstrated by Dr. Nieper's treatment of more than
2200 multiple sclerosis cases by 1993 with only 2 patients suffering kidney failure
or bone fractures. This is almost unheard of in this large a population of multiple
sclerosis patients, since bone fractures and kidney disease are relatively
common occurrences with severe forms of the disease. It was Dr Nieper's belief
that multiple sclerosis is a "generalized disease of the cell membrane system."
Dr. Nieper believed medicine must include the findings of physics as well as
chemistry. When it is understood that cells function as electromagnetic as well as
chemical units, then it makes sense to treat disease by trying to maintain cell
membrane integrity, cell membrane charge and cell membrane conduction.
Cancer patents are treated with AEP mineral transporters because AEP
reestablishes the natural electrical charge of the cell. This helps as a preventive
aid because cancer alters the normal electrical charge of the cell. Dr. Nieper first
reported in the February 1993 Townsend Letter, that multiple sclerosis patients
treated with AEP mineral transporters for many years had a significantly lower
rate of development of cancer than untreated multiple sclerosis patients. He also
reported a reduction in colon polyps and colon cancer. Dr. Nieper believed the
anti-cancer impact of AEP mineral transporters was far-reaching when compared
to any form of chemotherapy or even natural products such as beta-carotene or
herbs.
Normalizing the electrical charge of the cell also assists the urinary tract in
reducing bacterial adhesion to the mucosal lining. Patients with fibrocystic breast
disease have reported reduction in pain when given Calcium AEP. The premier
use of AEP has been in early cases of multiple sclerosis where up to 82% of
individuals who use AEP mineral transporters in nutritional support have noted
improvement in strength and reduction of symptoms.
Clinical Applications:
Dr. Nieper used AEP mineral transporters (2-AEP calcium, 2-AEP magnesium
and 2-AEP complex) to treat multiple sclerosis, lupus (SLE,) colitis, asthma,
pulmonary fibrosis, myocarditis, gastritis, reduce urinary tract infections,
nephritis, amyotrophic lateral sclerosis (ALS) and to support bone regeneration.
AEP mineral transporters help the skin maintain its youthful appearance, tissue
elasticity and maintenance of skeletal structure by reducing bone calcium loss
making it an important anti-aging supplement.
2-AEP magnesium can improve membrane function in the cells of the lung alveoli
supporting gas exchange. The normalization of gas exchange reduces CO2
induced respiratory acidosis, constriction of lung airways in asthmatics which
helps reduce tissue hypoxia. 2-AEP magnesium, by supporting the structure of
lung membranes, can also help reduce cell death leading to emphysema and
fibrosis.
Dr. Nieper used all of the AEP mineral transporters in his treatment of multiple
sclerosis. He used both oral and intravenous forms of AEP. In 1998, when Dr.
Nieper was asked if multiple sclerosis patients could respond on just the oral

55
form of AEP mineral transporters, his response was yes if they take a high
enough dosage. For patients with multiple sclerosis recommended dosages are:
2-AEP calcium 6-12 capsules per day
2-AEP magnesium 3-6 capsules per day
2-AEP complex 3-6 capsules per day
Patients with spasticity or stiffness often do well when the proportion of 2-AEP
magnesium is increased compared to the amount of 2-AEP calcium.

References:
1. Nieper, Hans A., Eagle-Oden, G. S. and Alexander III, Arthur D. “The
Mineral Transporters” The Curious Man (1999): 57, 61-62.
2. Nieper, Hans A. “EXAMPLE: Multiple Sclerosis” Dr. Nieper’s Revolution in
Technology, Medicine and Society (May, 1985): 219 – 223.

56
PAU D’ARCO
10 times Concentrate

Count Size: 100 Capsules

Each Capsule Contains:

Pau D’Arco
Organic Ipe Roxo/Lapacho
(10 times concentrate) 600 mg

Dosage:
Dr. Nieper’s General Treatment Protocols:
Cancer: Take 1 – 2, 600 mg capsules (may open to make into tea), up to 4
times per day
Radiation & Chemo Therapies: Take 1 – 2, 600 mg capsules, up to 4 times
per day
General Health and Well-being: As an addition to the daily diet, take 1 – 2
capsules twice a day with meals or as directed by your health care professional

Technical Information:
Pau D’Arco is the Portuguese name of a particular tree found in the rainforests of
Brazil. Today the locals call this tree “Lapacho,” but it is also known by the tribal
names of "Ipe Roxo" or "Taheebo.” These trees are a part of the Bignoniaceae
family, of which the Teak tree also belongs. Extracts from the inner lining of this
certain type of tree bark have been used for hundreds of years for its many
medicinal properties.

Dr. Hans A. Nieper’s meticulous formula of Pau D’Arco has been painstakingly
researched and sourced in South America, to use only the extracts of
Bignoniaceae that are “insect-eating (carnivore) and grow in an ozone-rich
atmosphere.”1 Extracts from non-carnivore Bignoniaceae are not as effective.1
Furthermore, Dr. Nieper’s formula is made from only the inner lining of organic
Lapacho (Pau D’Arco) tree bark. It is this inner lining (or phloem) which
contains nutrients within the cambium layer, where all the new cells are
produced – the “life” of the tree. Other parts of the tree have no known
medical value. Dr. Nieper’s formula utilizes an extraction process that
concentrates this particular inner layer to 10 times its natural strength, thereby
maximizing clinical results.

Pau D’Arco has been used for hundreds of years throughout South America for
its powerful anti-fungal and immune building properties. It is known to nourish
and stimulate the body’s defense system, helping the body to protect itself
against pathogenic organisms and assisting in the body’s elimination of
wastes.

57
many kinds of cancer and for all kinds of infections in the medical
establishments throughout Brazil.2

Dr. Hans Nieper incorporated Pau D’Arco in his cancer recommendations. He

reported that this bark extract “exerts a remarkable effect (on malignant cells).1

In the United States, this incredible extract from Brazil has attracted considerable
attention.1 Many reports have appeared in medical and health journals regarding
this powerful natural substance.
Pau D’Arco is used in hospitals in South America in a wide variety of patients
because of its analgesic, antiinflammatory, antioxidant, anitbacterial , anti fungal
and antiviral properties. Dr. Nieper believed one of Pau D’Arco’s main actions
was to assist the body in defending itself to resist disease. 3

A common report throughout early and current empirical and clinical studies with
Pau D’Arco in cancer is the consistent observation that this tree extract reduces
many of the common side effects from orthodox treatments, such as pain,
hair loss and immune dysfunctions.2

Dr. Nieper often combined this tree extract with Dionaea Muscipula and Irododial.
As Dionaea and Irododial attacks genetically impaired and/or cancerous cells,
debris and dead cells may be left in the body. Pau D’Arco has a powerful
detoxification function to expel this debris.

Pau D’Arco is non-toxic. The most consistent reported ‘side effect’ is that some
people experience nausea when the extract is first used. This is due to the
purging/cleansing effect. Once the poisons and/or toxins are cleansed from the
body, the nausea goes away.

The extract of this particular bark has many beneficial active substances,
including Lapachol. Dr. Nieper has documented that “Lapachol is a chemical
relative of the well-known anticancer remedy Daunorubicin.”1 However, Dr.
Mowry reports, and most natural therapists/herbalist would agree, that “no
isolated component of lapacho (Pau D’Arco) comes anywhere close to being
equal in effectiveness to the combined activity of all constituents in the whole
herb.” 2

Dr. Mowry documents many of the effects of Pau D’Arco that “have been
validated by modern research: 2
Laxative effect: pleasant and moderate loosening of the bowels that leads to
greater regularity without any unpleasant side effects such as diarrhea.
Cancer support: Pau D’Arco improves immune function and stimulates the
production of red blood cells in the bone marrow, thereby improving the oxygen-
carrying capacity of the blood.
Anti-oxidant effect: In vitro trials show inhibition of free radicals and
inflammatory leukotrienes. This property might underlie the usefulness of Pau

58
Antimicrobial/anti-parisiticidal effects: Pau D’Arco may be useful in infections
associated with gram positive and acid-fast bacteria, yeasts, fungi, viruses and several
kinds of parasites.
Anti-fungal effect: Pau D’Arco is an excellent supplement choice for Candida or
yeast infections. Many doctors recommend soaking toe and fingernail fungi infections
in lapacho (Pau D’Arco) tea daily for a couple of weeks.
Anti-inflammatory effect: when applied intra-vaginally via gauze tampons soaked in
the extract, and renewed every 24 hours, Pau D’Arco is helpful for inflammation of the
cervix and vagina resulting variously from candida albicans, trichomonas vaginalis,
chemical and mechanical irritations. The anti-inflammatory effect might also account
for its observed tendency to reduce the pain, inflammation and other symptoms of
arthritis.

References:
1
Nieper, Hans A. “EXAMPLE: Cancer” Dr. Nieper’s Revolution in Technology,
Medicine and Society (May, 1985): 277
2
Mowry, Dr. Purple Lapacho: Ancient Herb, Modern Miracle – Complete 13 page
article may be obtained from: Wisdom of the Ancients, 640 S. Perry Ln. #2, Tempe, AZ
85281 USA
3
Today’s Herbal Health, Third Edition, Woodland Publishing: 137

59
Potassium Arginate 200mg

Count Size: 100, 200 tablets

Each Tablet Contains:
Potassium Arginate 200mg
(27.4mg elemental potassium)

Other Ingredients: Duratex, Pure Food Glaze, Avicel, Magnesium

Stearate

Dosage:
General Health and Well-being: As an addition to the daily diet, take
1-2 tablets twice a day with meals, or as directed by a health care
professional
Anorexia and Bulimia: 1 tablet two times per day
Arthritis: 1-2 tablets two times per day
Attention Deficit Disorder: 1 tablet two times per day
Chronic Fatigue: 2 tablets two times per day

Caution: Dr. Nieper recommends using potassium mineral transporters with

caution in individuals who have cardiac palpitations.

Technical
Arginates are mineral transporters where a mineral is bound to the amino acid
arginine. Arginine is an alkaline amino acid, which consists of one imino and two
amino groups. In the late 1980’s when the FDA forbade imports of orotates Dr.
Nieper began promoting arginates as a substitute. Dr. Nieper helped develop
several forms of arginates including potassium arginate, magnesium arginate,
calcium arginate, zinc arginate and lithium arginate. Arginate mineral transporters
are able to penetrate the cell membrane and deliver minerals into the cytoplasm
of the cell. In the process of metabolism, of the arginine component of the
transporter, the minerals are released inside the cell.

Potassium is the most abundant intracellular mineral with 98 to 99% found inside
of the cells. Potassium is an essential mineral with the average intake between 2
to 4 grams a day and it is found in high concentrations in citrus fruits, bananas,
green vegetables, dairy, grains, and coffee. Individuals, who ingest diuretics,
have diarrhea and vomiting and who consume excessive amounts of sugar and
alcohol are at greater risk of potassium deficiency. Potassium is required for
carbohydrate and protein metabolism, acid-base balance, nerve conduction and
cardiac conduction.

60
Symptoms of potassium deficiency include, but are not limited to: weakness,
fatigue, constipation, fluid accumulation, acid-base disturbances, depression,
numerous metabolic disturbances and muscle cramps.

Clinical
Potassium mineral transporters such as potassium arginate and potassium-
magnesium aspartate can be useful in supporting metabolism both in heart
muscle and skeletal muscles. Both potassium arginate and potassium orotate are
helpful in cellular potassium replacement in individuals suffering from potassium
loss due to diarrhea, vomiting, malabsorption, sweating, heavy use of diuretics
and prolonged stress. These potassium mineral transporters can be helpful in
individuals with high blood pressure and arthritis.

References:
1. Nieper HA. Experimental Bases and Clinical Use of Electrolyte Carrier
Compounds. Ärztl Forsch. 15:510-514 (1961).
2. Nieper, Hans A., Eagle-Oden, G. S. and Alexander III, Arthur D. “The
Mineral Transporters” The Curious Man (1999): 57, 61-62.

61
Potassium Orotate
Count Size: 100, 200 tablets
Each Capsule Contains:
Potassium Orotate 175mg
(35mg elemental potassium)

Other Ingredients: Duratex, Pure Food Glaze, Avicel, Cab-O-Sil.

Dosage:
General Health and Well-being: As an addition to the daily diet, take
1 capsule twice a day or as directed by a health care professional.

Dr. Nieper’s General Treatment Protocols: **

Diabetes Type I: 1 capsule 3 times per day
Diabetes Type II: 1 capsule 3 times per day
Fatigue: 1-2 capsules 3 times per day
Angina: 1-2 capsules 2 times per day
Hypoglycemia: 2 capsules 2 times per day
Muscle weakness: 2 capsules 2 times per day
Potassium deficiency: 2-3 capsules 2 times per day
** (Potassium orotate should be avoided or used cautiously in
individuals with heart palpitations)

Technical Information:
Potassium is the most abundant intracellular mineral with 98 to 99% found inside
of the cells. Potassium is an essential mineral with the average intake between 2
to 4 grams a day and it is found in high concentrations in citrus fruits, bananas,
green vegetables, dairy, grains, and coffee. Individuals, who ingest diuretics,
have diarrhea and vomiting and who consume excessive amounts of sugar and
alcohol are at greater risk of potassium deficiency.
Potassium is required for carbohydrate and protein metabolism, acid-base
balance, nerve conduction and cardiac conduction.
Symptoms of potassium deficiency include, but are not limited to: weakness,
fatigue, constipation, fluid accumulation, acid-base disturbances, depression,
numerous metabolic disturbances and muscle cramps.

Orotic acid is an organic molecule found in milk whey and it is typically

synthesized in the body from the amino acid aspartic acid. Orotic acid has a
number of functions in the body. It is involved in the pentose pathway in the
breakdown of sugar. It is integrated into the RNA and DNA molecules and it
forms a strong bond with a number of inorganic minerals, including potassium,
magnesium, calcium, zinc, iron and lithium. Orotates are stable as they pass

62
through the GI system are more efficiently absorbed than inorganic mineral salts
and have excellent cell penetration.

It is the body's bioutilization of the orotic acid that brings it into preeminence as a
mineral transporter. This molecule will completely pass through the cell
membrane, both outer and inner layers, where it is taken up by the cell
organelles. In the process of the orotic acid being metabolized, the mineral is
released inside the cell.

Potassium orotate is a mineral transporter where potassium is bound to orotic

acid. Potassium orotate delivers potassium through the cell membrane and into
the cell. Dr. Hans Nieper believed this was the most effective potassium
transporter for delivering potassium into the cell. The intracellular uptake of
potassium helps stabilizes cellular acidity and energy production helps correct
glucose metabolism (sugar is a potassium antagonist) and improves low
potassium levels in diabetics. Potassium orotate also supports collagen
synthesis.

Clinical Applications:
“Through tests done on hamsters, Dr. Kohler and I demonstrated that potassium
orotate, like potassium aspartate, could prevent spontaneous heart-tissue
destruction. It has since been used extensively both as a preventative agent of
heart muscle degradation and as the most effective potassium transporter to cell
plasma. Ninety percent of the potassium found in the human body is inside the
cells. Potassium orotate penetrates the cell membrane and delivers required
potassium to the cell, where it is utilized to maintain the fluid (plasma) pressure
(1).”

Potassium orotate can be very beneficial in supporting the metabolic functions of

the heart and in prevention of cell damage in low oxygen states by helping
restore normal sodium-potassium cellular balance. Potassium orotate provides
entry of potassium into the cells even in low oxygen states. Potassium orotate
also has an affinity for the pacemaker tissue of the heart. Dr. Nieper used
potassium orotate for nutritional support in individuals suffering from cardiac
problems such as slow pulse, heart attacks, angina, atrial fibrillation and irregular
heart beats (2). Some individuals will experience palpitations if they have
significant mineral imbalances. These individuals should have mineral testing
and have all of their minerals balanced.

References:

1. Nieper, Hans A., Eagle-Oden, G. S. and Alexander III, Arthur D. “The

Mineral Transporters” The Curious Man (1999): 57, 61-62.
2. Nieper, Hans A. “EXAMPLE: Heart andac
Cardi
Infarction
Dr. Nieper’s
Revolution gy,
in Technolo
Medicine and
(May,
Society
1985):
– 241.
237

63
Shark Cartilage 500mg capsules
Count Size: 50, 100 capsules

Each Capsule Contains:

Shark Cartilage Powder
(As shark fin)

Other Ingredients: Dicalcium Syloid, Magnesium Stearate

Dosage:
General Health and Well-being: As an addition to the daily diet, take
2 capsule three times a day with meals, or as directed by a health
care
Arthritis: 3 capsules 3 times a day
Cancer: 3-5 capsules 3 times a day

Technical Information and Clinical Applications:

Shark cartilage has been used for thousands of years in the orient as a functional
food. Shark cartilage is a structural material for the joints, since shark cartilage
contains large amounts of calcium (16-24%), phosphorus (8%) and chondroitin.
Dr. Nieper recommended shark cartilage as a daily dietary supplement to provide
nutritional support to the connective tissue and to help reduce tissue
inflammation. Many doctors also recommend use of shark cartilage because it
contains mucopolysaccharides, which are dietary nutrients useful for bolstering
the immune system. It has been reported that shark cartilage has active
components that inhibit the development of new blood vessels, which is why
many individuals use shark cartilage as a dietary supplement in cancer and
diabetic retinopathy.

Shark cartilage contains a wide range of nutrients that are necessary to promote
joint and skeletal repair and reduce inflammation in body tissues. Shark cartilage
also has been clinically used to reduce inflammation and pain, and decrease
general wear and tear on joints. Shark Cartilage supplementation is also widely
used in people suffering from a number of inflammatory and degenerative
diseases as an adjunct in the treatment of lower back and joint pains. In acute
joint injuries many patients may experience a reduction in pain and swelling and
a marked increase in the range of limb motion.

The calcium and phosphorus contained within cartilage is readily absorbed and
available for use by the human body. In addition, the complex carbohydrates and
proteins constitute important potential building blocks for bone and the
mucopolysaccharides also stimulate the immune system. Shark cartilage has
been described as an ideal "protomorphogenic" supplement for bone and joint

64
health. Many people now use cartilage extracts such as glucosamine and
chondroitin to promote of skeletal health. However, complete preparation of
100% pure shark cartilage may be more beneficial than extracts of cartilage
because it is a more holistic approach and it may be more cost effective than
extracts alone.

References:

1. Nieper, Hans A., Eagle-Oden, G. S. and Alexander III, Arthur D. The Curious
Man (1999)

65
Selenium
Count Size: 100 and 200 Tablets
Each Tablet Contains:
Selenium amino acid complexed 100mcg

Other Ingredients: Plasdone, Ac-Di-Sol, Magnesium Carbonate,

Avicel, Magnesium Stearate, Compritol.

Dosage:
General Health and Well-being: As an addition to the daily diet, take 1
tablet twice a day with meals, or as directed by a health care
professional.

Dr. Nieper’s General Treatment Protocols:

Alcoholism Nutritional Support: 1 tablet 2 times per day
Age spots: 1 tablet 2 times per day
Cancer: 1 tablet 2 times per day
Cardiac diseases: 1 tablet 2 times per day
Chemical Toxicity: 1 tablet 2 times per day
Chronic Viral or Autoimmune Liver Inflammation: 1 tablet 2 times per day
Cirrhosis: 1 tablet 2 times per day
Hypothyroidism: 1 tablet 2 times per day
Multiple sclerosis: 1 tablet 2 times per day
Thymus Support: 1 tablet 2 times per day
Toxic Hepatitis: 1 tablet 2 times per day

Technical Information and clinical applications:

A Swedish scientist Jons J. Berzelius discovered selenium in 1817, but selenium
was not recognized as an essential nutrient until 1957. Selenium is an essential
trace mineral, which has a number of important biochemical roles in the body.
Selenium’s chemical, physical and biological characteristics are similar to the
element sulfur. Selenium is required for the proper activity of certain proteins and
antioxidant enzymes and is absolutely needed for the production of the amino
acid selenocysteine. Because the body cannot manufacture selenium, it must be
acquired from dietary sources.

World wide the major dietary source of selenium comes from plant foods,
however the amount of selenium in soil, which varies by region and country,
determines the amount of selenium in the plant foods that are grown in that soil.
Selenium may also be obtained from the meat of animals that graze or eat grains
grown on selenium rich soils. Other good dietary sources of selenium are Brazil
nuts and walnuts. Certain areas in the USA such as northern Nebraska and the

66
Dakotas have high soil levels of selenium. On the other hand, there are areas in
China, Russia, northern Europe and Africa that have very low soil levels of
selenium and selenium deficiency is often found in people who live in those
regions. Epidemiological studies have shown that individuals who are selenium
deficient due to ingestion of food low in selenium are prone to a number of
disease-related conditions especially cancer and cardiovascular disease. The
body primarily concentrates selenium in the liver, kidney, pancreas, muscles,
heart and spleen. When selenium deficiency arises metabolic functions of these
organs can be compromised.

Selenium has numerous biological roles in the body. It functions synergistically

with dietary antioxidants particularly vitamin E. Selenium also works
synergistically with other minerals particularly zinc. Selenium and zinc have
important roles in protecting the body against heavy metal toxicity from mercury,
cadmium, lead, arsenic and sliver. Selenium supports cardiovascular health and
appears to reduce cancer risk and mortality particularly for prostate, breast, lung,
lymph and colorectal cancers. Selenium also has anti-viral effects. Dr. Nieper
frequently recommended selenium for patients with viral conditions, cancer and
cardiovascular disease. From a cardiovascular perspective individuals deficient
in selenium have increased risk of developing platelet stickiness, blood clots,
atherosclerosis, heart attacks and cardiac rhythm disturbances.

Selenium deficiency can arise in individuals with intestinal disease and

intestinal malabsorption or from inadequate dietary intake. The best-known
condition associated with selenium deficiency is called Keshan disease, which
was first identified in areas of China where the soils are very low in selenium.
Keshan disease causes heart enlargement and poor heart function. Keshan
disease was the first selenium-deficiency disease identified in humans.

It was subsequently found that use of selenium supplements could prevent this
disease. On further investigation Chinese doctors discovered that individuals
suffering from this condition frequently had severe coxsackie viral infections in
their hearts. Many researchers now believe that selenium deficiency sets up
cellular conditions where rather benign viruses can transmute into more
aggressive forms. It is likely that this is an example of a more general
phenomenon that shows that deficiencies of essential minerals especially
selenium and zinc increase the severity of viral infections.

Selenium deficiency may impair thyroid function, since a selenium

dependent enzyme is required for synthesis of thyroid hormone. In fact both
selenium and zinc are both required for normal thyroid hormone function. Thyroid
hormone is one of the major anabolic hormones that regulates metabolism.
Selenium is specifically needed for the conversion of thyroxine T4 to the active
T3 form of thyroid hormone. The conversion of T4 to T3 depends on a selenium-
requiring enzyme iodothyronine deiodinase. Human growth hormone, which
requires zinc for its production, is also known to stimulate conversion of T4 to T3

67
by increasing the activity of this selenium dependent deiodinase enzyme. This
enzyme reaction is much more effective when adequate levels of selenium are
present in the thyroid and is impaired when mercury is present in the thyroid.
Mercury is a specific antagonist of both selenium and zinc. Mercury accumulates
in both the pituitary and the thyroid and mercury’s ability to impair growth
hormone production and thyroid hormone activity is at least partially related to
mercury’s ability to interfere with the biological activity of these two minerals.
Thus both selenium and zinc have important roles in reducing the toxicity and
metabolic disruption of the heavy metal mercury.

The prostate and semen contain fairly large amounts of zinc and selenium, these
minerals are essential for normal function of the prostate and for sperm
production. Selenium, zinc and the amino acid arginine are needed for the
formation of sperm in males. Sperm require significant amounts of vitamin E,
selenium, zinc and arginine and a deficiency of any of these nutrients can lead to
male infertility.

Adequate levels of vitamin E, selenium and zinc are also necessary for proper
function of the immune system. Without vitamin E, selenium and zinc T-cells, B-
cells and macrophages do not function properly. Deficiencies of vitamin E and
these minerals reduce the ability of immune system to kill cancers, control viral
replication and to produce and regulate cytokines. Vitamin E and these minerals
also have significant roles in improving the cell membrane receptor activity of a
variety of hormones and cytokines. Numerous studies have shown that
individuals infected by a variety of viruses have poorer immune responses and
worse outcomes when deficiencies are present in vitamin E, zinc or selenium.
Plasma and tissue levels of vitamin E, selenium and zinc are significantly related
to total lymphocyte counts, viral progression, carcinostatic activity and cancer
risk. Tissue levels of vitamin E, selenium and zinc are consistently lower in
individuals who develop cancer and in individuals with actively progressing HIV
infections. In fact the risk of mortality from HIV is much worse in individuals who
are deficient in vitamin E, zinc, selenium and other essential minerals. When the
body lacks vitamin E, vitamin C, vitamin A, selenium, zinc and trace minerals
cellular antioxidant defenses are damaged and immune cells are rapidly
destroyed by free radical induced production of lipid peroxides. Research has
shown that individuals with HIV and many other viruses will accumulate oxidized
lipids, which may contribute to immune system dysfunction

An immense body of scientific evidence has accumulated that demonstrates the

role of oxidative stress in stimulating viral replication in HIV infections and
hepatitis inducing viral infections, cancerous transformation and the development
of numerous degenerative diseases most particularly atherosclerosis, diabetes
and arthritis. It is also known that that adequate antioxidant activity and certain
vitamins and essential minerals can inhibit these processes. It is critically
important for any individual who suffers from any of these conditions to maintain
a spectrum of antioxidants in their diet and adequate tissue concentrations of all

68
essential minerals and exogenous and endogenous antioxidants. Unfortunately,
medical professionals generally overlook the need to assure that their patients
have these antioxidants as well as adequate tissue concentrations and sufficient
dietary intake of all essential minerals and vitamins as well as the other
essential nutrients required for human health.

What are free radicals?

Free radicals are extremely reactive molecules that contain at least one unpaired
electron in their outer orbital shell. Free radicals are naturally produced by
chemical reactions in the body and toxins and radiation to which the body is
exposed. Unless these damaging chemicals are neutralized by antioxidants
these reactive molecules will steal electrons from cellular molecules creating a
chain reaction of destruction. The tissue reactions created by free radicals are
now thought to be involved in premature aging, cancer, atherosclerosis, arthritis,
immune disorders and other degenerative diseases.

When energy is produced in the mitochondria of cells up some of the oxygen is

converted to a variety of free radicals such as superoxide (O2-), hydrogen
peroxide (H2O2) and hydroxyl (OH-) radicals. Unless adequate amounts of
cellular and extracellular antioxidants are available these free radicals will begin
to damage cellular structures such as the cell membranes, the mitochondria, the
nucleic acids of DNA and cellular proteins impairing the ability of the cells to
repair themselves and reproduce.

When cell membranes are damaged by free radicals their ability to hold an
electrical charge (capacitance) and their ability to transport minerals and other
nutrients is disrupted. When mitochondria are damaged the cells ability to make
energy is impaired. When the genetic code is damaged cells cannot reproduce
normal cells. Free radicals also cause lipid peroxidation (oxidative stress), which
can result in lowering HDL cholesterol and damage to the cell membranes lining
blood vessels. When the delicate membranes lining blood vessels are damaged
an inflammatory process may result which leads to thickening of blood vessels
and arterial plaque.

Selenium itself is not an antioxidant yet it is a critical component of several

antioxidant enzymes. Selenium activates the enzyme glutathione peroxidase,
which recycles the water-soluble cellular antioxidant glutathione. Glutathione
peroxidase along with vitamin E is necessary to control the harmful process of
lipid peroxidation (a form of oxidative stress). Uncontrolled lipid peroxidation
results in cell membrane destruction and can result in irreparable cell damage
leading to cell death. Selenium also is needed as a cofactor of the enzyme
thioredoxin reductase, which recycles vitamin C a water-soluble antioxidant,
which in turn recharges vitamin E, the body’s primary fat-soluble antioxidant. In
addition selenium has a separate synergistic potentiation of vitamin E. Selenium
thus has an important role in preventing the cellular damage from free radicals by
promoting antioxidant activity.

69
The body uses dietary antioxidants such as vitamin E, vitamin C, vitamin A and
selenium along with a number of internally generated (endogenous) cellular and
extracellular enzymatic antioxidants (catalase, superoxide dismutase (SOD) and
glutathione peroxidase) to defend itself against free radicals.

Recycling Antioxidants
Dr. Lester Packer is a world famous antioxidant researcher who has studied
vitamin E and exercise-induced free radical production. Dr. Packer believes that
lipoic acid and other antioxidants interact in a complex recycling process in the
body. It was Dr. Packer who first discovered how vitamin E is "recycled" by
vitamin C in the body.

Vitamin E is a lipid-soluble antioxidant that neutralizes free radicals (lipid peroxyl

radicals and lipid alkoxyl radicals) that form in fatty (lipid) tissues and
membranes. Vitamin E first absorbs the excess unpaired electrons from free
radical molecules and becomes oxidized in the process becoming a free radical
itself, though less reactive than the original free radicals. Vitamin C is now
needed to react with the free radical oxidized form of vitamin E converting it back
to its natural bioactive form of reduced vitamin E.
The newly regenerated vitamin E molecule has now reacquired antioxidant
capability, but this mechanism leaves behind a new free radical in the form of
oxidized vitamin C (a semiascorbyl radical). The recycling process continues with
glutathione regenerating reduced vitamin C from oxidized vitamin C. Glutathione,
the cell’s primary antioxidant is now oxidized and it is recycled back to its
reduced biologically active form by the cellular antioxidant coenzyme NADPH
and the selenium dependent enzyme glutathione peroxidase. From this
discussion it is apparent that vitamins E, C, selenium and glutathione work in
conjunction with each other to deactivate and prevent free radicals from causing
oxidative damage in the body. The limiting factors in this process are the
availability of selenium and glutathione.
Despite understanding the antioxidant regeneration cycle, when doctors try to
increase antioxidant levels they run into problems trying to increase cellular
glutathione levels. Cellular levels of selenium, vitamin E and vitamin C can be
elevated by increased simply by increasing intake by using dietary or
supplemental sources, but cellular glutathione is only produced in the body.
Fortunately there is an answer. Use of whey protein, lipoic acid and N-acetyl
cysteine (NAC) supplements can cause the cells to produce more glutathione
and oral reduced glutathione supplementation 1-2 100mg tablets 3 times/day can
increase circulating glutathione levels.

In summary selenium deficiency increases the risk of cardiovascular disease,

cancer, arthritis and the mortality in AIDS. Inadequate selenium levels are
associated with an increased risk of viral infections. Selenium has been
extensively researched in viral disease. Virus infected patients characteristically
are extremely deficient in both selenium and glutathione. The recommended
dietary selenium intake for adults is 55mcg per day. It is generally safe to take

70
selenium supplements between 100-400mcg per day. The Institute of Medicine
has set the upper intake level for selenium at 400 micrograms per day for adults
to prevent the risk of developing selenium toxicity. Although some doctors who
treat AIDS patients with documented selenium deficiency will often use higher
amounts for short periods of time to bring tissue levels up faster. In general,
selenium should not be used in doses higher than 400mcg/day without a doctor’s
supervision.

References:
Bai J, Wu S, Ge K, et al. The combined effect of selenium deficiency and viral
infection on the myocardium of mice. Acta Acad Med Sin 1980; 2: 29-31.

Beck MA, Shi Q, Morris VC, Levander OA: Rapid genomic evolution of a non-
virulent Coxsackievirus B3 in selenium-deficient mice results in selection of
identical virulent isolates. Nature Med 1995; 1:433-436.

Clark LC, Cantor K, Allaway WH. Selenium in forage crops cancer mortality in
US counties. Arch Environ Health 1991; 46:37-42.

Clark LC, Combs GF Jr, Turnbull BW, et al. Effects of selenium supplementation
for cancer prevention in patients with carcinoma of the skin. JAMA 1996;
276(24):1957-1963.

Clark LC, Dalkin B, et al. Decreased incidence of prostrate cancer with selenium
supplementation: result of a double-blind cancer prevention trial. Brit J Urol
1998;81:730-734.

Constans J, Pellegrin JL, Sergeant C, et al. Serum selenium predicts outcome in

HIV infection. J AIDS Human Retrovirol 1995;10:392.

Dworkin BM, Rosenthal WS, Wormser GP, et al. Abnormalities of blood selenium
and glutathione peroxidase activity in parients with acquired immunodeficiency
syndrome and AIDS-related complex. Biol Trace Elem Res 1988; 15: 167-177.

Horvathe PM, Clement LP. Synergistic effect of vitamin E and selenium in

chemoprevention of mammary carcinogenesis. Canc Res 1983;43:5335-5341.

Kiremidjian-Schumacher L, Roy M, Wishe HI, et al: Regulation of cellular immune

response by selenium. Biol Trace Elem Res 1992; 33: 23-35.

Meydani M. Modulation of the platelet thromboxane A2 and aortic prostacyclin

synthesis by dietary selenium and vitamin E. Biol trace Elem Res 1995;33:79-86.

National Research Council: Recommended Dietary Allowances, 10th ed.,

National Academy of Sciences; Washington D.C., 1989.

71
Rayman MP. Dietary selenium: time to act (editorial). British Medical J 1997; 314:
387.

Salonen JT, Alfthan G, Huttunen JK, et al. Association between cardiovascular

death and myocardial infarction and serum selenium in a matched pair
longitudinal study. Lancet 1982;July24:175-179.

Sandstrom PA, Tebbey PW, Van Cleave S, Buttke TM. Lipid hydroperoxides
induce apoptosis in T cells displaying a HIV-associated glutathione peroxide
deficiency. J Biol Chem 1994; 269: 798-801.

Schrauzer GN, Sacher J. Selenium in the maintenance and therapy of HIV-

infected patients. Chem-Biol Interact 1994; 91: 199-205.

Schrauzer GN, White DA, et al. Cancer mortality correlation studies. III.
Statistical associations with dietary selenium intakes. Bioinorg Chem 1977;7:23-
24.

Turner RJ, Finch JM. Selenium and the immune response. Proc Nutr Soc 1991;
50: 275-285.

Yu SY, Chu YJ, et al. Regional variation of mortality and its relation to selenium
levels in China. Biol Trace Elem F 1985;21-29.

72
Thiamine 100mg Tablet
Count Size: 50 and 100 Tablets
Each Tablet Contains:
Thiamine Mononitrate 100mg
Other Ingredients: Emcocel, Maltodextrin, Magnesium Stearate,
Syloid.

Dosage:
General Health and Well-being: As an addition to the daily diet, take 1
tablet twice a day with meals, or as directed by a health care
professional.

Dr. Nieper’s General Treatment Protocols:

Alcoholism Nutritional Support: 1 tablet 2 times per day
Cancer: 1 tablet 3 times per day
Cardiac diseases: 1 tablet 2 times per day
Multiple sclerosis: 1-2 tablets 2 times per day

Technical Information and clinical applications:

Vitamin B1 is also known as thiamine. Food sources of thiamine include brewer’s
yeast, wheat germ, pork, whole grains and legumes. Thiamine is destroyed when
the pH of food is above 8.0, which happens when food processors add sodium
bicarbonate to vegetables to maintain their green color. Thiamine is also
destroyed by high temperatures and is removed when whole grains are
processed. Once it is absorbed thiamine is carried by the blood to the liver where
it is rapidly converted to its active coenzyme forms. Thiamine is concentrated in
skeletal muscles, heart, liver, kidneys and the brain. Thiamine is a water soluble
B-vitamin that is poorly stored so it must be continually supplied by the diet.
Today, many countries fortify rice and other cereal grains to replace the nutrients
lost in processing to prevent frank thiamine deficiency.

The major biologically active form of thiamine is thiamine pyrophosphate (TPP).

Thiamine is converted in the brain and liver to its active form, thiamin
pyrophosphate by the enzyme thiamin diphosphotransferase. Thiamine in its
active TPP form has a number major roles at the cellular level. TPP is a required
cofactor for cellular enzymes that convert pyruvate to acetyl CoA and alpha-
ketoglutarate to succinyl CoA as well as the transketolase enzymes of the
pentose phosphate pathway. A deficiency in thiamine intake or thiamine enzyme
activity leads to a severe reduction in the capacity of cells to generate energy
and metabolize carbohydrates. Thiamine also has roles in nerve conduction and
in maintaining normal membrane functions.

Thiamine does not operate in isolation in fact all known TPP dependent enzymes
also require a divalent mineral, usually magnesium. In addition, one of the major

73
 enzyme complexes that utilize thiamine, pyruvate dehydrogenase, also requires
lipoic acid and coenzyme forms of vitamin B2 (riboflavin) and vitamin B3 (niacin).
It is the interconnectedness of nutrients, as represented by this example that
makes it critical that all essential nutrients be maintained at physiological levels
for optimal health. The failure to maintain adequate tissue levels of all essential
nutrients is one of the fundamental causes of disease and premature aging. This
fact was well known to Dr. Nieper and is one of the reasons why he stressed the
need for his patients to eat nutrient balanced diets.

The energy powerhouses of the cells, the mitochondria, have a set of connected
enzymes called the Krebs cycle, which extract energy from fuel molecules. TPP
is the coenzyme for two of the enzyme reactions of the Krebs cycle. It is
therefore necessary that thiamine, riboflavin, niacin, magnesium and lipoic acid
be present in the cells in order for proper creation of energy. Other minerals and
vitamins are also involved in energy production, but this section is primarily
concerned with nutrients that operate in conjunction with thiamine.

Lipoic acid, which is synthesized in the liver, is a required cofactor for certain
enzyme reactions involving thiamine. Individuals with liver disease often show
signs of B1 deficiency because of deficient synthesis of lipoic acid. Because
magnesium has to be present inside of cells for proper energy production, Dr.
Nieper developed magnesium mineral transporters to assure adequate cellular
delivery and availability of magnesium.

A number of clinical studies have shown that thiamine is marginally deficient in

numerous people. Marginal thiamine deficiency manifests itself in symptoms
such as fatigue, irritability and lack of concentration, loss of appetite, nervous
irritability, insomnia, loss of weight; vague aches and pains, depression,
constipation, heart and gastrointestinal problems. Individuals who are pregnant,
actively exercising, regularly drinking, eating a high carbohydrate diet of
processed foods or have gastrointestinal diseases are more likely to have
thiamine deficiency.
Thiamine deficiency is the one vitamin deficiency known to practically all
medical professionals. When thiamine is reviewed in medical training doctors are
taught about two main thiamine deficiency conditions. The first is beriberi, which
historically was present in individuals who consumed polished rice as a major
component of their diet. When rice and other grains are processed a significant
amount of chromium, magnesium, zinc and B-complex vitamins are lost in the
processing. Most countries now fortify rice and other cereal grains with a few
vitamins to replace the nutrients lost in processing. When I was a kid I thought
that these types of food had to be better than natural whole grains because I
thought fortification made them better. Unfortunately, all that is lost is not
replaced so a diet high in processed foods will over the long-term results in a
multitude of nutrient deficiencies. Beriberi can result in damage to the nervous
system creating a condition known as polyneuropathy. Beriberi can also create

74
muscle wasting, weakness, edema, memory loss and heart failure. The second
thiamine deficiency disease taught in medical schools is Wernicke-Korsakoff
syndrome. This condition is usually found in alcoholics who replace food with
alcohol. Over a period of time because of reduced thiamine intake, malabsorption
and increased thiamine utilization in the metabolism of alcohol alcoholics can
develop vitamin B1 deficiency. The symptoms of Wernicke-Korsakoff syndrome
include confusion, memory impairment, cognitive dysfunctions, paralysis of eye
muscles, nystagmus (rhythmical oscillation of the eyes), psychosis and
confabulation.

References:
Easton, C. J., & Bauer, L. O. (1997). Beneficial effects of thiamine on
recognition memory and P300 in abstinent cocaine-dependent patients.
Psychiatry Res, 70(3), 165-74.

Passwater RA. Lipoic Acid: The Metabolic Antioxidant, New Canaan, Conn.,
Keats Publishing, 1995.

75
Zinc Orotate
Count Size: 100, 200 tablets
Each Tablet Contains:
Zinc orotate 60mg
(9.45mg of elemental zinc)

Other Ingredients: Duratex, Pure Food Glaze, Plasdone, Ac-Di-Sol,

Magnesium Carbonate, Magnesium Stearate, Compritol and Avicel.

Dosage:
General Health and Well-being: As an addition to the daily diet, take
1-2 tablets twice a day with meals, or as directed by a health care
professional.

Dr. Nieper’s General Treatment Protocols:

Anorexia and Bulimia: 1 tablet 2 times per day
Bursitis and tendonitis: 1 tablet 2 times per day
Carpal Tunnel Syndrome: 1 tablet a day
Chemical Toxicity: 1 tablet 2 times per day
Diabetes Type I: 1 tablet 2 times per day
Diabetes Type II: 1 tablet 2 times per day
Candidiasis: 1 tablet 2 times per day
Bone support: 1 tablet 2 times per day
Immune support: 1-2 tablets 2 times per day

Technical Information:

Zinc orotate is a mineral transporter where zinc is bound to orotic acid, a natural
component of whey. Zinc orotate stabilizes cell membranes and improves
immune function by stimulating thymulin synthesis, which activates the thymus
gland to increase T-cell production. Zinc also activates T-cell enzymes, which are
needed for active cell mediated immune function making it useful in conditions
due to bacterial and viral infections.
Zinc is required by hundreds of enzymes in the body. These enzymes are
involved in many vital functions such as: stabilization of membranes, protein
synthesis, DNA/RNA synthesis, collagen synthesis, wound healing, immunity,
digestion, carbohydrate metabolism, free radical scavenging, alcohol
metabolism, taste, insulin production and activity, vision, vitamin A metabolism
and bone formation. Despite the critical role in human nutrition and the fact that
up to two thirds of Americans consume less than the RDA minimum for zinc
(15mg in adults), zinc deficiencies are almost never checked for during medical
evaluations. Zinc is critically important in the health of pregnant women, growing

76
evaluations. Zinc is critically important in the health of pregnant women, growing
children, the elderly, and people with allergies, immune dysfunctions and chronic
diseases. A number of well recognized medical conditions can lead to zinc
deficiency including alcoholic and non-alcoholic liver disease, chronic renal
disease, sickle cell anemia, Crohn’s disease, pancreatic insufficiency and celiac
disease among others. Body zinc levels fall when an individual is stressed or has
suffered some type of trauma. The amino acid histidine can enhance absorption
and tissue uptake of zinc.
Most of the zinc in the body is concentrated in the bones, muscles and skin,
however significant amounts are also found in the prostate, retina, endocrine
glands and the brain.
When the body is deficient in zinc:
1. it cannot properly metabolize fats, carbohydrates, alcohol, vitamin A and
proteins;
2. blood sugar levels may rise due to impairment in the action of insulin;
3. increased absorption of toxic metals occurs;
4. amino acid levels rise in the urine because the body cannot utilize the
amino acids to make proteins. So the body disposes of unused amino
acids as waste. This is an important point since urine amino acid tests can
be misread as showing that the body has excess amino acids when in
reality the body cannot use the amino acids that it needs. I recommend
that tissue zinc levels be checked when urine amino acid tests are
performed or that the person be given supplementation with zinc
transporters for several weeks prior to the test to increase tissue levels of
zinc.
5. the body cannot convert linoleic acid to gamma-linolenic acid. This is
important because an individual can suffer from the symptoms of a fatty
acid deficiency despite taking fatty acids. The issue then is improper fatty
acid metabolism not a lack of intake;
6. skin problems, visual difficulties, loss of taste, reduced wound healing,
fatigue, dyslexia, memory impairment, depression, allergies and immune
dysfunctions can occur.
7. zinc may also play a specific role in some cases of dementia. A lack of
brain zinc may be associated with neural cell dysfunction, since almost all
of the enzymes involved with the replication, repair and transcription of
DNA are zinc metalloenzymes. If toxic metals such as aluminium replace
zinc or there is a loss of incorporation of zinc into neuronal enzymes
because of aging or illness associated with damage to cell membrane and
cell transport mechanisms, then a loss of enzyme activity occurs, protein
synthesis is interfered with and genetic errors begin to multiply eventually
leading to death of brain cells. I believe understanding of the problems of
toxic metal accumulation and the decline of cellular transport of minerals
in aging is applicable not only in this example, but in all conditions
associated with aging and dysfunction of cell membranes. For what does it
matter if you take a mineral supplement if it cannot get the minerals into
the cells where they are needed? It is my understanding of these

77
 1. problems that has prompted me to focus on the nutritionally supportive
roles of mineral transporters.

Zinc is a necessary mineral for normal osteoblastic activity, for the production of
collagen, chondroitin sulfate, and for the activity of the zinc dependent enzyme
alkaline phosphatase (1). Alkaline phosphatase is an enzyme secreted by
osteoblasts when they are actively depositing calcium salts. Adequate dietary
zinc is also required by the body in order to secrete Insulin-like growth factor 1
(IGF-1), which is a critical regulator of bone formation, remodeling, and calcium
homeostasis (2,3). IGF-1 levels and other critical growth factors decrease when
zinc levels are low.

Clinical Applications:
Zinc aspartate, zinc arginate and zinc orotate were used by Dr. Nieper to assist
the body in dealing with glucose intolerance in both Type I and Type II diabetics
(4,5). Zinc arginate, zinc aspartate and zinc orotate are excellent zinc
supplements if you have a child with growth delay or if you have diabetes, joint
pain (6), Crohn’s disease, ulcerative colitis, celiac disease, infertility, kidney
disease, liver disease, ulcers, alcoholism, vitamin A deficiency, night blindness,
hearing impairment, loss of taste, loss of smell, poor wound healing, stretch
marks, skin conditions, hair loss, white spots in the finger nails, finger nail ridges,
brittle nails, diarrhea, malabsorption, anemia, Anorexia Nervosa, appetite loss,
bulimia, memory problems, irritability, paranoia, attention deficit disorder and
depression or if you are recovering from surgery, burns, trauma or fractures.
These transporters are also useful for individuals who might develop zinc
deficiency from medications especially diuretics, steroids, birth control pills, for
women with menstrual abnormalities and for men with prostate conditions.

References:
1. Calhoun NR, Smith JC, Becker KL. The role of zinc in bone metabolism.
Orthopedics 1974;103:212-234.
2. 2. Canalis E, Centrella M, McCarthy TL. The role of insulin-like growth
factors in bone remodeling. In Cohn DV, Gennari C. Tashjian AH, eds.
Calcium Regulating Hormones and Bone Metabolism: Basic and Clinical
Aspects. Amsterdam: Elsevier Science;1992:258-265.
3. 3. Devine A, Rosen C, Mohan S, et al. Effects of zinc and other nutritional
factors on insulin-like growth factor 1 and insulin-like growth factor binding
proteins in postmenopausal women. Am J Clin Nutr 1998;68:200-206.
4. 4. Nieper, Hans A. “EXAMPLE: Diabetes mellitus (diabetes)” Dr. Nieper’s
Revolution in Technology, Medicine and Society (May, 1985): 218 – 219.
5. 5. Nieper, Hans A., Eagle-Oden, G. S. and Alexander III, Arthur D. “The
Mineral Transporters” The Curious Man (1999): 57, 61-62.
6. 6. Nieper, Hans A. “EXAMPLE: Rheumatism, Arthritis and Deformation of
Joints” Dr. Nieper’s Revolution in Technology Medicine and Society (May,
1985): 232-235.

78
Zinc Arginate
Count Size: 100, 200 tablets
Each Tablet Contains:
Zinc Arginate 60mg
(11.3mg elemental zinc)

Other Ingredients: Duratex, Pure Food Glaze, Plasdone, Ac-Di-Sol,

Magnesium Carbonate, Magnesium Stearate, Compritol and Avicel.

Dosage:
General Health and Well-being: As an addition to the daily diet, take
1-2 tablets twice a day with meals, or as directed by a health care
professional.

Dr. Nieper’s General Treatment Protocols:

Backache: 1 tablet 2 times a day
Candidiasis: 1 tablet 2 times a day
Diabetes Type I: 1 tablet 3 times a day
Diabetes Type II: 1 tablets 3 times a day
Infertility in men: 2 tablets two times a day
Immune enhancement: 2 tablets two times/day
Prostate cancer: 2 tablets three times a day**
Prostatitis: 2 tablets 2-3 times a day
** New research has shown the benefits of zinc in the arginate from in
prostate cancer

Technical Information:

Zinc arginate is a mineral transporter where zinc is bound to the amino acid
arginine. Along with calcium and magnesium arginates it is effective in stabilizing
blood glucose levels. Insulin synthesis in the pancreas is enhanced by actively
transported zinc.
The transport of glucose across membranes is required for cell survival. Since,
glucose molecules do not diffuse rapidly through cell membranes, specific
transporters are required. Insulin is the best-known glucose transport facilitator.
Arginates are another type of natural glucose transporter. Dr. Nieper discovered
that arginates are molecular glucose receptors that can self-assemble. Natural
transporters may prove therapeutic for patients with defects in glucose utilization.
Zinc arginate, aspartate and orotate assist the body in insulin production making
it useful in individuals, who have elevated blood sugar levels (1). Insulin

79
synthesis is enhanced by actively transported zinc. Diabetics who are zinc
deficient may have increased insulin production with actively transported zinc.

Clinical Applications:
Zinc aspartate, zinc arginate and zinc orotate were used by Dr. Nieper to assist
the body in dealing with glucose intolerance in both Type I and Type II diabetics
(1,2). Zinc arginate, zinc aspartate and zinc orotate are excellent zinc
supplements if you have a child with growth delay or if you have diabetes, joint
pain (3), Crohn’s disease, ulcerative colitis, celiac disease, infertility, kidney
disease, liver disease, ulcers, alcoholism, vitamin A deficiency, night blindness,
hearing impairment, loss of taste, loss of smell poor wound healing, stretch
marks, skin conditions, hair loss, white spots in the finger nails, finger nail ridges,
brittle nails, diarrhea, malabsorption, anemia, Anorexia Nervosa, appetite loss,
bulimia, memory problems, irritability, paranoia, attention deficit disorder and
depression or if you are recovering from surgery, burns, trauma or fractures.
These transporters are also useful for individuals who might develop zinc
deficiency from medications especially diuretics, steroids, birth control pills, for
women with menstrual abnormalities and for men with prostate conditions.

References:
1. Nieper, Hans A. “EXAMPLE: Diabetes mellitus (diabetes)” Dr. Nieper’s
Revolution in Technology, Medicine and Society (May, 1985): 218 – 219.
2. Nieper, Hans A., Eagle-Oden, G. S. and Alexander III, Arthur D. “The
Mineral Transporters” The Curious Man (1999): 57, 61-62.
3. Nieper, Hans A. “EXAMPLE: Rheumatism, Arthritis and Deformation of
Joints” Dr. Nieper’s Revolution in Technology Medicine and Society (May,
1985): 232-235.

80
Zinc Aspartate
Count Size: 100 tablets

Each Tablet Contains:

Zinc Aspartate 40mg
(12mg elemental zinc)

Other Ingredients: Maltodextrin, Avicel, Ac-Di-Sol and Magnesium

Stearate.

Dosage:
General Health and Well-being: As an addition to the daily diet, take
1-2 tablets twice a day with meals, or as directed by a health care
professional.

Dr. Nieper’s General Treatment Protocols:

Acne: 2 tablets 2 times a day
Adrenal exhaustion and stress: 2 tablets 2 times a day
Age spots: 2 tablets 2 times a day
Alcoholism nutritional support: 2 tablets 2 times a day
Anemia: 2 tablets 2 times a day
Anorexia and Bulimia: 1 tablet 2 times per day
Anxiety: 1 tablet 2 times per day
Attention Deficit Disorder: 1 tablet 2 times per day
Bone support and fractures 1 tablet 2 times per day
Canker Sores and Fever Blisters: 2 tablets 2 times a day
Cataracts: 1 tablet 2 times per day
Chronic Fatigue: 2 tablets 2 times a day
Cirrhosis: 2 tablets 2 times a day
Dandruff: 2 tablets 2 times a day
Dermatitis: 2 tablets 2 times a day
Diabetes: 1-2 tablets 2 times per day
Hearing Loss: 2 tablets 2 times a day
Heavy metal toxicity (Lead, Cadmium and Mercury): 2 tablets 2 times a day
Hepatitis toxic cause (DO NOT USE IN VIRAL HEPATITIS) 2 tablets 2
times a day
Herpes Infections: 2 tablets 2 times a day
Immune support 1-2 tablets 2 times per day
Memory support 1 tablet 2 times per day

81
Prostate conditions 2 tablets 2 times a day
Thymus Support: 2 tablets 2 times a day

Technical Information:
Zinc aspartate is composed of zinc bonded to the amino acid aspartic acid. Zinc
depletion and deficiency can develop during physical or emotional stress,
especially if it is prolonged. Individuals who have had trauma or surgery will also
use and lose large amounts of zinc, lysine, glutamine and vitamin C as the body
mobilizes these nutrients in order to repair itself. Zinc is the component of many
enzymes and is needed to activate these enzymes. Listing just a few of it’s
actions, zinc is essential for growth, wound healing, taste acuity, insulin activity,
recovery from depression and the mobilization of vitamin A. Zinc Aspartate
assists the body in insulin production making it useful in individuals, who have
elevated blood sugar levels. Diabetics who are zinc deficient have increased
insulin production with actively transported zinc. Zinc aspartate, zinc arginate and
zinc orotate all can help glucose intolerance in diabetics. Zinc aspartate 2 to 4
tablets per day can be beneficial in any person who is subjected to daily life
existence. Dr. Hans Nieper found that combining zinc aspartate with magnesium
orotate inhibited the replication of many viruses.

Zinc aspartate, arginate and orotate assist the body in insulin production making
it useful in individuals, who have elevated blood sugar levels (1). Insulin
synthesis is enhanced by actively transported zinc. Diabetics who are zinc
deficient may have increased insulin production with actively transported zinc.

Clinical Applications:
Zinc aspartate, zinc arginate and zinc orotate were used by Dr. Nieper to assist
the body in dealing with glucose intolerance in both Type I and Type II diabetics.
In discussing cartilage damage in inflammatory arthritis Dr. Nieper noted that the
degree of cartilage damage of the joint surfaces was not always directly related
to the degree of inflammation. He believed other causes were also operating in
causing cartilage damage. He found that many of his patients with rheumatoid
arthritis had significant zinc deficiencies. He felt that zinc mineral transporters
could be very helpful in these patients. In fact he noted that morning stiffness
would frequently decrease when patients took zinc aspartate.
“In Germany, zinc aspartate is accepted and routinely offered as a mineral
supplement for the enhancement of the immune defense system. It activates the
thymus gland and the formation of T-lymphocytes, which are important elements
of immune system. Finally, zinc aspartate seems to increase the body’s
production of insulin, which makes a valuable contribution to the treatment of
diabetes (2).”

References:

82
1. Nieper, Hans A. “EXAMPLE: Diabetes mellitus (diabetes)” Dr. Nieper’s
Revolution in Technology, Medicine and Society (May, 1985): 218 – 219.
2. Nieper, Hans A., Eagle-Oden, G. S. and Alexander III, Arthur D. “The
Mineral Transporters” The Curious Man (1999): 57, 61-62.
3. Nieper, Hans A. “EXAMPLE: Rheumatism, Arthritis and Deformation of
Joints” Dr. Nieper’s Revolution in Technology Medicine and Society (May,
1985): 232-235.

83
K-Mg

Count Size: 100, 200 tablets

Each Tablet Contains:

Potassium-magnesium aspartate 500mg

Other Ingredients: Plasdone, Ac-Di-Sol, Solka Floc, Magnesium

Stearate, Explotab

Dosage:
General Health and Well-being: As an addition to the daily diet, take
1-2 tablets twice a day with meals, or as directed by a health care
professional.
Dr. Nieper’s General Treatment Protocols:
Adrenal exhaustion and stress: 2 tablets 2 times a day
Alcoholism and drug abuse nutritional support: 2 tablets 2 times a day
Amyotrophic lateral sclerosis (ALS): 2 tablets 2 times a day
Angina: 2 tablets 2 times a day
Anxiety: 2 tablets 2 times a day
Arterial Spasms: 2 tablets 2 times a day
Asthma And Emphysema: 2 tablets 2 times a day
Chronic Fatigue: 2 tablets 3 times a day
Diabetes: 2 tablets 2 times a day
Fibromyalgia: 2 tablets 3 times a day
Hepatitis toxic or viral: 2 tablets 2 times a day
Hypertension: 2 or 3 tablets 2 times a day
Multiple sclerosis: 2 tablets 2 times a day

Technical Information:
Magnesium-Potassium aspartate is a mineral transporter where magnesium is
bound to two molecules of the amino acid aspartic acid. Aspartic acid is a
nonessential amino acid that is very important in detoxification of ammonia, and
in cellular energy production in the mitochondria. This type of mineral transporter
efficiently carries magnesium and potassium to virtually all the cells of the body;
but liver, muscle, heart, breast and glandular tissue have the best uptake. Since
this compound is absorbed intact through the cells of the small intestine, the
whole compound enters into the blood stream. Upon uptake by the target cells
the mineral is released inside the cell membrane activating membrane bound
magnesium dependent enzymes. Studies show magnesium-potassium aspartate
increases ATP formation in the cells especially the skeletal muscles and the

84
heart. The mineral is freed when the aspartic acid is incorporated into essential
cellular metabolic processes. This mineral supplement is effective in relaxing
skeletal muscles and the smooth muscles of the blood vessels, biliary tract,
gastrointestinal tract, and the bronchial tree. Since this mineral transporter
activates the enzymes involved in energy production, it can improve metabolism
in the liver, muscles and the heart, especially in individuals with cardiovascular
disease who have poor oxygen perfusion.

Clinical Applications:
Magnesium mineral transporters such as potassium-magnesium aspartate,
magnesium arginate and magnesium orotate can be useful in supporting
metabolism both in heart muscle and in the conducting system of the heart.
These magnesium mineral transporters can be helpful in individuals with high
blood pressure. By activating the formation of high-energy phosphates in side of
cells, especially ATP, potassium-magnesium aspartate helps increase the cells
energy pool therefore overcoming muscular fatigue. Potassium-magnesium
aspartate helps support glucose metabolism in diabetics, increases liver
detoxification of ammonia and assists cardiac and skeletal muscle energy
production in low oxygen conditions. Many athletes have found that use of Dr.
Nieper’s magnesium mineral transporters improves their muscular performance,
stamina and aerobic capacity.

References:
1. Nieper HA. Experimental Bases and Clinical Use of Electrolyte Carrier
Compounds. Ärztl Forsch. 15:510-514 (1961).
2. Nieper HA, Blumberger K. The Effectiveness of Electrolyte Carrier
Compounds on Myocardial Metabolism, Illustrated by Magnesium and
Potassium Aspartate, Ärztl. Forsch. 15:305-309 (1961).
3. Nieper, Hans A. “EXAMPLE: Diabetes mellitus (diabetes)” Dr. Nieper’s
Revolution in Technology, Medicine and Society (May, 1985): 218 – 219.
4. Nieper, Hans A., Eagle-Oden, G. S. and Alexander III, Arthur D. “The
Mineral Transporters” The Curious Man (1999): 57, 61-62.

85
SQUALENE & BUFFERED C
A Combination Approach

I. Squalene Count Size: 200 Softgels

Each Softgel Contains:
Squalene (Shark Liver Oil) 500 mg
Vitamin E (d-alpha Tocopherol U.S.P.) 20 IU
Gelatin, U.S.P. 158 mg
Glycerin, U.S.P. 75 mg
Purified Water, U.S.P. 17 mg

II. Buffered C Count Sizes: 200 Tablets

100 Tablets
Each Tablet Contains:
Vitamin C 500 mg
Calcium ascorbate 40%
Magnesium ascorbate 40%
Potassium ascorbate 20%

Dr. Nieper’s Treatment Protocols:

Cancer: 4 – 8, 500 mg Squalene softgels in combination with 2 – 4, 500 mg
Buffered C tablets per day
Multiple Sclerosis: 2-4, 500 mg Squalene softgels in combination with 2-4,
500 mg Buffered C tablet per day
Arthritis: 6 – 500 mg Squalene softgels preferably taken with 3-4, 500 mg
Buffered C tablets per day
General Health and Well-being: As an addition to the daily diet, take 1
Squalene softgel three times a day, preferably taken with Buffered C, or as
directed by a health care professional

Technical Information:
Squalene is a “triterpenoid hydrocarbon found in shark oil.”1 Sharks are “able to
recycle back into the sea the high-sodium concentration through the Squalene in
their livers.”2 Squalene represents about 70% of the oil in the shark’s liver.

Dr. Hans Nieper’s clinical formula calls for deep-sea sharks, which live in cold
water depths below 3,000 feet. These particular sharks have “energetic or highly
active livers.”2 Dr. Nieper’s premium quality formula is made with 99.5% pure
Squalene. In addition to achieving fame as an active oncologist, medical doctor
and clinical researcher for almost 50 years, Dr. Nieper was also acclaimed as a
Tachyon/Field Space Physicist. Dr. Nieper insisted on the using of the most pure
Squalene with the most energetic properties from the deep Southern Ocean
water sharks off the coast of New Zealand.

86
component to further facilitate the normal “potassium/sodium pump effect.” The
potassium is a necessary, required component to pump the sodium from the
cancer cells (later discussed).

Furthermore, the ratio between Squalene and Buffered C ascorbates for oral
application was found to be particularly sensitive for optimal assimilation and
effectiveness. Too much ascorbate or excessive Squalene and the effectiveness
of both active ingredients was diminished. Simultaneous administration was
found to be an absolute must.

Thus, Dr. Nieper’s particular products combination provides a) the energetic

properties and quality of raw ingredients, plus b) the exacting ratio of material
components, which causes his formulation to be the most powerful facilitator to
activate the DHEA production and the body’s other mechanisms to ward off
and/or fight serious disease conditions.

Clinical Application:
CANCER
“The cancer cell pumps sodium into itself, which is observed only very rarely
within a normal cell body.” 2 Removing sodium from the cancer cell causes it to
“lose much of its vitality, dry out and more readily fall prey to the body’s
defences.”2 Thus, Squalene is a “desodification” substance, which
eliminates sodium from cancer cells. In sharks for example, “no cancer cell is
able to survive due to the constant ‘desodification,’ it would become depleted of
sodium and lose its vitality.”2 This “desodification” function is an important part of
Dr. Nieper’s cancer protocol.

As cancer cells absorb sodium, they “develop an electrical behavior which is

outside the sphere of the body’s defense capabilities.”2 During the process of
cancer genesis, the cell loses the calcium lining of its inner membranes, along
with a loss of magnesium and potassium. “The profuse amount of sodium in the
cancerous cell destroys the electrical condenser function of the cell membrane
and ultimately disables the normal functions of the cell.”3

Dr. Nieper demonstrates that “Squalene combined with Buffered C is also an

excellent gene-repair substance. This combination of ingredients helps the
organism to develop defence factors against both malignant cells and
herpes-type viruses.”3 Squalene and Buffered C stimulate the body to
increase its production of the carcinogen-blocking hormone DHEA and the
enzyme, cholinesterase. DHEA (dehydroepiandrosterone) is a steroid secreted
largely by the suprarenal gland. “This steroid increases the level of the enzyme
cholinesterase. The higher the level of cholinesterase, the greater the degree of
cancer regression.”3

The cancer cell “secretes blister-like elements, usually called “oncogenic

agents…These elements leave the cancer cell, replicate in the blood stream, and

87
Dr. Nieper reported most young people have enough DHEA in their blood, but the
DHEA level in the blood stream declines with age. Although there are companies that
produce synthetic DHEA, Dr. Nieper believed a far better and more natural method
was “turning on the DHEA production of the body itself.”2 This is accomplished
through a daily intake of Squalene and Buffered C. All individuals are different, and it
may therefore take up to several weeks for the body’s production of DHEA to increase
by this natural, non-toxic means.

DHEA paralyses the enzyme, glucose-6-phosphate-dehydrogenase, which contributes

to the aggressiveness of a cancer cell. Furthermore, DHEA may play a role in
reducing the transformation of normal cells into cancer cells, caused by cancer
generating viruses.2 In a Swiss study with mice, where more than 90% of them were
prone to contract breast cancer due to genetic inheritance, when their DHEA levels
were increased, the occurrence of breast cancer was reduced in most cases.2

DHEA only ‘paralyzes’ cancer cells, greatly reducing their vitality. In addition, lymph
cells, other white blood cells and substances such as Dionaea Muscipula and Iridodial
are still required, in order to overcome the paralyzed cells.2

Tumosterons are genetic repair substances naturally ejected from lymph cells that
have attached themselves to a tumour cell. “By penetrating into the nucleus of a
cancer cell, they are able to switch off or reverse the genetic information of
malignancy.” 3 A combination of Squalene, Buffered C and Vitamin D2
(ergocalciferol) together, increase the lymph cells’ production of tumosterons in
the body.2,3,4

Dr. Nieper makes an important observation in his book, Revolution in Technology,

Medicine and Society, that “all species which are seemingly resistant against viruses
and cancer, like insects and sharks, also convert important quantities of Tachyon
energy into bio-electrical energy – about 70-90% of the energy released by
sharks…the conversion principle seems to be the Squalene itself.”2 It is well reported
from studies of olive oil, which contains only about 2% of Squalene, that it exhibits an
extremely powerful Kirlian-effect. Furthermore, this seems to indicate that Squalene
is able to strongly enhance the polarization of cell membranes, restoring the
cancer cell’s electrostatic ‘order’ and enhance the potential for defensive cells
such as the lymph cells, to dock onto cancerous cells.2

MULTIPLE SCLEROSIS
Squalene combined with Buffered C is part of Dr. Nieper’s highly successful Multiple
Sclerosis protocol. Patients who use Calcium 2-AEP, Squalene and Buffered C
report feeling warmer, particularly in their extremities, no longer experiencing
the characteristic MS chills.3

HERPES & FEMALE CERVICAL CANAL

In addition, Squalene plus Buffered C is extremely valuable in nutritional
approach to herpes infections, herpes manifestations and high risk irregularities
in the female cervical canal.5

88
References:
1
Stedman, Thomas Lathrop, Stedman’s Medical Dictionary 26th Edition, Williams &
Wilkins (1995): 1659
2
Nieper, Hans A. “EXAMPLE: Cancer” Dr. Nieper’s Revolution in Technology,
Medicine and Society (May, 1985): 252 – 280
3
Nieper, Hans A., Eagle-Oden, G. S. and Alexander III, Arthur D. “Gene-Repairing and
Gene-Extinguishing Substances” The Curious Man (1999): 105 – 106, 109 – 111
4
Nieper, Hans A. “Modern Medical Cancer Therapy Following the Decline of Toxic
Chemotherapy” Townsend Letter for Doctors & Patients (November, 1996)
5
Nieper, Hans A. “Genetic Repair Including ‘IRIDODIAL’ An Insect Derived Genetic
Repair Factor of Important Antimalignant Effect” Raum & Zeit (German Magazine,
Space & Time) (1990)

Additional Reading:
Nieper, Hans A. “The Treatment of Multiple Sclerosis” A. Keith Brewer International
Science Library

89
Membrane Complex

Count Size: 50, 100 and 200 Capsules

Each Capsule Contains: 500mg
Calcium 2-AEP 200mg
(25mg elemental calcium)
Magnesium 2-AEP 200mg
(16 elemental magnesium)
Potassium 2-AEP 100mg
(21.5mg elemental potassium)

Other Ingredients: Duratex, Avicel, Cab-O-Sil, Magnesium Stearate,

Pure Food Glaze

Dr. Nieper’s General Treatment Protocols:

Multiple Sclerosis (MS): 1-2 Capsules three times/day along with calcium
2-AEP and magnesium 2-AEP
Anxiety: 1-2 Capsules three times/day
Amyotrophic Lateral Sclerosis (ALS) and Leucodystrophy: 1
Capsule three times/day or use calcium 2-AEP
Attention Deficit Disorder: 1-2 capsules three times/day
Capillary Fragility: 2 Capsules three times/day or may use calcium 2-AEP
Celiac and Crohn’s: 2 Capsules three times/day or may use calcium 2-
AEP
Depression: 2 Capsules three times/day
Diabetes: 2-3 Capsules three times/day or may use calcium 2-AEP 6-9 total
per day. (if you use calcium 2-AEP always accompany with K/Mg Aspartate in
the ratio of 3 – Ca 2-AEP to 1 – K/Mg Aspartate)
Leg cramps: 2 Capsules three times/day
Varicose Veins: 1-2 Capsules three times/ day or may use calcium 2-AEP
Osteoporosis: 2 Capsules three times/per day or may use calcium 2-AEP
General Health and Well-being: 1-3 Capsules per day

In Dr. Nieper’s General Treatment Protocols, he indicates that some conditions

may be treated with Membrane Complex (also known as
Calcium/Magnesium/Potassium 2-AEP complex) in addition to the Calcium 2-
AEP. However, in the treatment of Multiple Sclerosis, at least 2/3 of the total
dosage per week must be Calcium 2-AEP.

Technical Information:

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2-AEP complex also called colamine phosphate complex, 2-aminoethanol
phosphate or in Europe 2-ethylamino phosphate is a mineral supplement where
the minerals calcium, magnesium and potassium are bonded to a lipid 2-
aminoethanol phosphate. 2-aminoethanol phosphate is a natural component of
all cell membranes. Because this lipid substance forms stable complexes with
the minerals calcium, magnesium and potassium, it is an effective mineral
transport agent. 2-AEP effectively delivers these minerals to the surface of cell
membranes. Despite use in Europe for nearly four decades this type of cell
membrane mineral supplement is virtually unknown in the United States. During
a June 1987 lecture at the famous Waldorf Astoria Hotel Grand Ballroom in
Manhattan, Dr. Nieper proposed to name the colamine phosphate salts (2-AEP),
“cell membrane-integrity factor” or simply “Vitamin Mi.” It is obvious that 2-AEP is
essential to retain charges by lining calcium, magnesium and potassium, on the
membrane surface of the cells to repair cell membranes and normalize cell
membrane capacitance function.

Healthy cell membranes function as biological capacitors. In electronics a

capacitor is a device that stores electrical charges. In the body the membranes of
cells have many functions, but one of the most important is in maintaining
different mineral concentrations inside of the cell as compared to the outside of
the cell. In the process of establishing separate mineral concentrations on the
inside and the outside of cells the cell membrane accumulates an electrical
charge. In order for a healthy membrane charge to accumulate, the cell
membrane must have the proper types of fats in the membrane and the right
minerals in the right locations. All of the 2-AEP mineral transporters (calcium 2-
AEP, magnesium 2-AEP and 2-AEP complex) play dual roles both as mineral
carriers and as cell membrane repair materials. 2-AEP mineral transporters such
as 2-AEP complex bind to the outer membranes of cells where they act as a
biological membrane sealant. Cell membranes are composed of a double layer of
lipid molecules with interspersed molecules of protein. Because nutrients go
through the protein structures not the lipid component of the cell membrane when
AEP seals the lipid component it does not affect nutrient transport into the cell.
When the AEP is incorporated into the cell membrane the minerals are released.
This combined action enhances the capacitance of cell membranes. Cells that
are injured or turning cancerous have a lower than normal cell membrane charge
(capacitance). When cell membranes have a normal charge they assist the cells
of the body in resisting toxins, viral penetration and free radical damage. A
healthy charge on cell membranes also is needed for DNA activation.

2-AEP complex is manufactured with the individual granules enterically coated by

a microvortex process, which makes the granules resistant to gastric breakdown.
The intact compound is delivered into the small intestine where the enteric
coating is dissolved by the alkaline juices of the small intestine. The 2-AEP
mineral-lipid complex remains intact through the digestive process so that the
complete compound can be absorbed into the blood stream still maintaining its
mineral transport properties.

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Clinical Application:

Overall 2-AEP complex enhance cellular membrane structure and cellular

bioenergetics. Conditions where 2-AEP complex may be useful are: multiple
sclerosis, osteoporosis, anxiety, asthma, diabetes, pulmonary diseases,
autoimmune diseases, inflammatory conditions, kidney disease and aging. Dr.
Nieper discovered that diabetics were particularly benefited with AEP mineral
transporters whether used individually as calcium 2-AEP, magnesium 2-AEP or
as part of a highly effective complex (Calcium/Magnesium/Potassium 2-AEP).

References:
1. Nieper, Hans A. “EXAMPLE: Diabetes Mellitus (diabetes)” Dr. Nieper’s
Revolution in Technology Medicine and Society (May, 1985): 218-219.
2. Nieper, Hans A., Eagle-Oden, G. S. and Alexander III, Arthur D. “The
Mineral Transporters” The Curious Man (1999): 57, 61-62.
3. Nieper MD, Hans A. “The New Vitamin Mi” (Aug/Sept 1988 - translated
from Raum & Zeit, German Space & Time) Australasian Health & Healing
(July 1996)
4. Alexander III, Ph.D., Arthur D. “Calcium 2-AEP & Calcium Orotate Found
Essential in the Prevention and Treatment of Osteoporosis” (June 1997)
5. Alexander III, Ph.D., Arthur D. THE HEALTHY CELL: Its Structure and
Functions that are so Essential to Disease Prevention and Treatment
(June, 1997)

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IRIDODIAL (Ant Extract)

Sizes: 32 milliliter
120 milliliter

Each Liquid Bottle Contains:

Iridodial (Proprietary Blend)

Dr. Nieper’s Treatment Protocols:

Cancer: At least 30 – 40 drops, 4 to 5 times per day, sublingually (under the tongue),
before meals. Wait 60 – 120 seconds and then swish with a small amount of pure water
and swallow. (Should be used in combination with Dionaea Muscipula, taken 15
minutes apart.)
General Health and Well-being: As an addition to the daily diet, take 20 – 40 drops, 1 –
5 times per day, with water before meals

Technical Information:
Iridodials are a primary source of dialdehydes, which “are extremely powerful genetic-
repair factors.”1
Dialdehydes are “lipid soluble agents that can penetrate the lipid membranes of the
outer cells of large tumours.”1 Dr. Peter Thies of Germany first described the anti-
malignant, genetic-repair properties of Iridodials in 1985.

Insects, ants in particular are “the most effective producers of gene repair substances.”2
Insects are phylogenetically extremely old. Their ability to conserve and safeguard their
gene system is superb. Similar to sharks, they “hardly ever develop tumours. They are
able to host unbelievable amounts of viruses in their organism, without showing ill
effects. Yet insects have no immune system, phylogenesis only equipped them with a
repair principle…called Iridodial.”2

Iridodial is extremely “similar to the activated dialdehyde, called didrovaltrate.”2 “It is

apparent that aldehydic iridoides (Iridodial) from insects inhibit viruses.”3 These gene-
repairing Iridodials “inactivate the ‘undesired’ information (from an infecting virus) to the
cellular genome. Such ‘undesired’ information may often otherwise result in the
conversion of a normal cell into a cancerous cell.”3 Gene-repair therapy “represents in
many ways, an imitation of the cancer defense of our body.”3

Clinical Application:
According to Dr. Nieper, “Iridodial “supplementation should be applied immediately after
the first discovery of, or operation on, a malignant tumour. This is mandatory. Any
waiting game is fundamentally wrong.”3

In 1985, Dr. Didier of Gifhorn, Germany first reported pulmonary tumor regression by
use of Iridodial. Dr. Hans Nieper believed that Iridodial and Dionaea Muscipula
outdistance most other substances for use in cancer.1 Dr. Nieper reported that his first
choice in his nontoxic approach to cancer were the combined use of the extract
of Venus Fly-Trap (Dionaea Muscipula) and the ant extract (Iridodial)”2
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Dr. Nieper states that a pre-requisite to the combined effectiveness of Iridodial and
Dionaea Muscipula is that the tumors have not grown beyond a certain size. Large
tumors do not respond as well as small tumors1, 2
Iridodial is “completely free of any side effects, completely non-toxic and can be
administered without complication in early and suspected stages of the disease for an
unlimited time.”2 “There is no longer any doubt about its high clinical value. In Dr.
Nieper’s latest book, The Curious Man, released in 1999, he states: “Never, in forty
years of treating cancer, have I experienced more positive results than I have with
the Iridodials.”1

References:
1
Nieper, Hans A., Eagle-Oden, G. S. and Alexander III, Arthur D. “The History of
Chemotherapy” The Curious Man (1999): 107-108
2
Nieper, Hans A. “Genetic Repair Including ‘IRIDODIAL’ An Insect Derived Genetic
Repair Factor of Important Antimalignant Effect” Raum & Zeit (German Magazine,
Space & Time) (1990)
3
Nieper, Hans A. “Reaction to Many Questions, Politics and News Regarding Policies of
Cancer Treatment” Dr. Nieper’s Revolution in Technology, Medicine and Society (May,
1985): 277-279

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