DRUG STUDY

GENERIC GAME: MECHANISM OF ACTION: SIDE EFFECTS/ADVERSE REACTION NURSING RESPONSIBILITIES

Amoxicillin Kills bacteria by binding to
BRAND NAME: inactivating penicillin-binding proteins •Patients with mononucleosis shouldn’t
Amoxil, Moxatag, Trimox on the inner bacterial cell wall and CNS: Agitation, anxiety, behavior changes, receive amoxicillin because this class of
causing lysis. confusion, dizziness, insomnia, reversible drugs may cause an erythematous rash.
DRUG ILLUSTRATION: INDICATION: hyperactivity, seizures •Use drug cautiously in patients with
Treatment of a variety of infections
CV: Hypersensitivity vasculitis hepatic impairment. Monitor hepatic and
including; skin and skin structure
EENT: Black, hairy tongue; mucocutaneous renal function and CBC, as ordered, in
infections, Otitis media, sinusitu,
Respiratory tract infections, candidiasis; tooth discoloration patients on prolonged therapy. Also use
Genitourinary tract infections. GI: Diarrhea, diarrhea related to Clostridium cautiously in breastfeeding and elderly
difficile, elevated liver enzymes, hemorrhagic patients.
or pseudomembranous colitis, jaundice, •Expect to start therapy before culture and
hepatic dysfunction, nausea, vomiting sensitivity test results are known.
GU: Crystalluria, vaginal mycosis •Be aware that chewable tablets and
HEME: Agranulocytosis, anemia (including tablets for oral suspension contain
hemolytic anemia), eosinophilia, phenylalanine.
granulocytosis, leukopenia, •Don’t confuse amoxicillin tablets with
thrombocytopenia, thrombocytopenic amoxicillin tablets for oral suspension
purpura (DisperMox). They’re not interchangeable.
SKIN: Erythema multiforme, erythematous warning If allergic reaction occurs, stop
maculopapular rash, generalized amoxicillin immediately and provide
exanthematous pustulosis, Stevens-Johnson emergency care as indicated and ordered.
syndrome, toxic epidermal necrolysis, •Monitor patient closely for diarrhea, which
urticaria may indicate pseudomembranous colitis
Other: Allergic reaction, anaphylaxis, serum caused by Clostridium difficile. If diarrhea
sickness-like reaction (such as arthralgia, occurs, notify prescriber, expect to withhold
arthritis, fever, myalgia, rash, and urticaria) amoxicillin, and treat with fluids,
electrolytes, protein, and an antibiotic
effective against C. difficile.
 •Expect treatment that lasts at least 10
CLASSIFICATION: CONTRAINDICATION: days for hemolytic streptococci infections.
Antibiotic Contraindicated in History os severe •Monitor patient for superinfection. If it
DOSAGE/ROUTE/FREQUENCY Hypersensitivity to penicillin reaction occurs, expect to discontinue drug and
EAR, NOSE, AND THROAT INFECTIONS (anaphylaxis or Steven-Johnson provide treatment as ordered. patient
ADULT: Per Orem syndrome) to other beta-lactam teaching
Mild to moderate infections antibiotics, hypersensitivity to •Tell patient to refrigerate reconstituted
500 mg orally every 12 hours or 250 mg amoxicillin or its components. suspension and to shake well before each
orally every 8 hours for 10-14 days use. •When amoxicillin suspension is
Severe infections prescribed for a child, instruct parents to
875 mg orally every 12 hours or 500 mg place it directly on child’s tongue to
orally every 8 hours for 10-14 days. swallow. If this doesn’t work, tell parents to
mix dose of suspension with formula or cold
PEDIATRIC: Per Orem
drink (milk, fruit juice, ginger ale, water)
Mild to moderate infections and have child drink it immediately.
•Instruct patient using DisperMox tablets to
Under 3 months: 30 mg/kg/day orally place one tablet and about 2 teaspoonfuls
divided every 12 hours for 48-72 hours; for of water in a glass, drink entire mixture, add
less than 10 days for S pyogenes infections more water to the glass, and drink again to
ensure delivery of full dose.
Older than 3 months and under 40 kg: 25 •Tell patient to chew or crush chewable
mg/kg/day orally divided every 12 hours or tablets and not to swallow them whole.
20 mg/kg/day orally divided every 8 hours •To prevent infection from recurring, urge
patient to take amoxicillin for full length of
Over 40 kg: 500 mg orally every 12 hours or time prescribed, even if he feels better.
250 mg orally every 8 hours for 10-14 days •Teach patient to report adverse reactions
and notify prescriber if infection worsens or
Severe infections doesn’t improve after 72 hours.
•Urge patient to tell prescriber about
Under 3 months: 30 mg/kg/day orally diarrhea that’s severe or lasts longer than 3
divided every 12 hours for 48-72 hours; for days. Remind patient that watery or bloody
 stools can occur 2 or more months after
less than 10 days for S pyogenes infections antibiotic therapy and may be serious,
requiring prompt treatment.
Older than 3 months and less than 40 kg:
45 mg/kg/day orally divided every 12 hours
or 40 mg/kg/day orally divided every 8
hours

Over 40 kg: 875 mg orally every12 hours or

500 mg orally every 8 hours for 10-14 days

REFERENCE:

https://www.drugs.com/amoxicillin.html

https://www.pdr.net/drug-summary/Amoxicillin-Tablets-amoxicillin-2350

https://www.rxlist.com/consumer_amoxicillin_amoxil_moxatag_trimox/drugs-condition.htm