MULTIPLE CHOICE QUESTIONS

1. Medicinal chemistry is a science whose roots are interlinked with

A. Chemistry and Biology

B. Chemistry and Physics

C Téchnology and Biology

D. None of above

2 Morphine was isolated from opium by-

B. Davy

A. Serjuner

D. Emil Fischer

C. Knorr

3. Aspirin introduced by ____in 1889

A. Dreser's

B. Emil Fischer and Mering

C. Barger and Dale

D. None of above

4. Human micro dosing studies conducted in clinical phase?

A. Phase 0

B. Phase I

C. Phase II

D. Phase III

5. MTD is

A. Maximum targeted dose

B. Minimum tolerated ddose

C. Minimum targeted dose

D. Maximum tolerated dose

6. Single ascending dose studies are done in..

A. Phase Ib

B. Phase la

C. Phase I

D. Phase Ila

7. NDA is.

A. New Drug Application

B. New Drug approval

C. Noval Drug Admistration

D.: New Drug agenda

8. Phase IV trial is also known

A. Base of clinical trial

B. Multiple ascending dose era

C. Post marketing Surveillance

9. Precision Medicine is an emerging approach depend on-

A. Genomic study of individual

B. Diagnostic process of individual

C Diseases conditions

D. None of above

10. First hormone epinephrine synthesized in o Year.

A. 1903

B. 1904

C. 1909
D. 1889

11. Who is founder of modem medicine?

A. Hippocartes

B. Clark

C Charak

D. Henry's

12. How many main family of GPCRs?

A.5

B.6

C.7

D.4

13. Which of the following reactions is catalyzed by the enayme adenylate cyclase?

A. Conversion of ATP to cyclic AMP

B. Conversion of cyclic AMP to AMP

C. Conversion of cycic AMP to ATP

D. Conversion of AMP to cyclic AMP

14. Oxadiazole ring contains

A. 1 Nitrogen/Oxygen

B. 20xygen/ Nitrogen

C. 2 Nitrogen/Sulphur

D. 2 Nitrogen/Oxygen

15. The hetroaromatic radical is called

A. Anthryl
B. Naphthyl

C. Phenanthryl

D. Dibenzyl

MULTIPLE CHOICE QUESTIONS

1. The most important physicochemical properties affecting drug action

A. Partition coefficient

B. Chemical bonding

C. Adid base properties

D. Surface activity .

E. Chelation

F. Solubility

2. In 0SAR, study of medicinal chemistry Q stands for

B. Quantitative

A. Qualitative

D.Quantam

C. Both

3.Dimercaprol is a chelating agent used in the treatment of

B. Lead poisoning

A. Arsenic poisoning

D. Vanadium poisoning

C Iron poisoning

4. The non-polar compound dispersed.

A. By forming hydrogen bonding

B. By interacting with lipid

C By forming drug receptor complex

D. by forming hydrophilic bond

5. pka is a parameter which indicates the

A. Strength of drug as acid base reaction in water

B. Aqueous phase in phosphate buffer

C Hydrophilic and lyphophilic character

D. All of the above

6. 85% of drugs are ionizied which pH

B. 7-12

A. 2-5

D. Neutral

C 1.5-8

. 7. Bioisoterism is the process of

A. Replacement similar group

B. Replacement similar valence group

CReplacement similar mass no. group

D. Addition of group having different mass no.

8. A drug like phenytoin & barbiturate when pka is larger than 7 is

B. unionised at pH

A. lonised at all pH

D. Unionised at pH 6

C. lonised at pH8

9. A drug where pka is 7& unionised at all pH it is-

B. Very weak acidic

A. Weak acidic

D. Very weak basic

C. Weak basic

10. Dissolution & pka helps in drug-

B. dissociation & transportation

A. ionization & solubility

D. None of these

C. Dissociation & solubility

11. Bioisosteres are similar in their-

B. Chemical character

A. Physical character

D. Biochemical character

C. Both character a & b

12.Which of the following is not a bivalent?

B. CS

A. Co

D. SH

C. CC

13. A molecule having 3 chiral centre carbon it have

B. 9 set of enantiomers

A. 4 set of diasters

D. 9 set of diasters

C. 6 set of monomers

14. The 3D structure elucidation is done by process-

B. FTIR

A. IR
D. d.MS

C. NMR

15. Which of the following is odd one regarding drug-receptor interaction-

B. Electrostatic

A. Hydrogen bonding

D. Dipole- induced dipole interaction

C Weak Wander wall Rorce

16.Which of the following is a fastest receptor

B. lon- gated

A. Enzyme linked

D. Nuclear

C. GPCR

17. Which of the following is not an optically isomer

B. Epimers

A. Enantiomers

D. Meso

C. Disasters

18. Enantiomer has a higher affinity to receptor are called-

B. Diastomer

A. Eudismic

D. None of these

C. Eutomer

19. Which type of hydrogen bonding present when hydrogen bonding occurs bebween

molecules?

B. Intermolecular
A. Intramolecular

D. None of them

C A&Bboth

20. Which compound is capable of forming a ring structure with metal atomo?

B. Chelates

A. Ligands

D. All of the above

C Surfactants

ANSWERS

[ , 12:20 pm] . MULTIPLE CHOICE QUESTIONS

1. Which of the followíng statements is the dosest description of Phase I metabolism?

A. Reactions which add a polar molecule to a functional group already present.on a drug

or one of its metabolites

B. Reactions which occur in the blood supply.

C Reactions which add a polar functional group to a drug

D. Reactions which occur in the gut wall.

2. Which of the following statements is the dosest description of Phase I metabolism?

A. Reactions which add a polar molecule to a functional group already present om a drug

or one of its metabolites.

B.Reactions which occur in the blood supply.

c. Reactions which add a polar functional group to a drug

D. Reactions which occur in the gut wall.

3. Which of the following enzymes is not involved in catalyzing Phase I melabolic reaction?

A. Flavin-containing monooxygenases

B. Oxidation of alkyl groups

C Glucuronyltransferase

D. Estetases

4. Which of the following reactions is not a Phase I metabolic transformation?

A. Reduction of ketones

B. Conjugation to alcohols

C. Monoamine oxidases

D. Esterhydrolysis

5. Which of the following groups is least susceptible to cytochrome P450 enzymes?

A. Terminal methyl groups

B. Epoxide grbup

C. Benzylic carbon atoms

D. Quaternary carbon atoms

6. Alkenes and aromatic groups can be metabolised to diols. Which enzymes are involved?

A. Cytochrome P450 enzymes

B. Both of the above

C Neither of the above

D. Alylic carbons

7. Solubility ofa drug in polar solvents and Non-polar solvents depends upon-

A. Chemical struchure

B. Particle size

D. All of above

C. Crystal form

8. Higher will be the diffusion of the drug across the membrane if

A. Higher value of partition-coefficient

B. Low value of partition-coefficient

C Higher water soluble

D. None of above

A Text Book of M

[ , 12:24 pm] . 9. Diazepam gets metabolised into Hydroxydiazepam is example of

A. Oxidation at allylic carbon atom

B. Oxidation at the carbon alpha to carbonyl and imino group

C. Oxidation at benaylic carbon atom

D. Aromatic and Side chain Hydroxylation

10. ________Reaction is most common in drugs having ester or amide funètiónal groups

B. Reduction

A. Oxidative reactions

D. Phase I

C. Hydrolysis

11. UDPGA means..

A. Urane diphospho -a- D glueuronic acid

B. Uridine diphospho -a-D glucuronic acid

C Uridine diphospho-D glucuronic acid

D. Uric diphospho-a- D glucuronic acid

12. What is the site of first-pass metabolism before molecules reach systemic circulation?

B. Throat

A. Kidney

D. Intestine

C. Liver

E. Urinary tract
13. What plays a major role in extra-hepatic metabolism and contains CYP3A4 isozyme and P-
glycoprotein?

B. Throat

A. Kidney

D. Intestine

C. Liver

E. Urinary tract

14. What test uses microsomal extracts from the ER for in-vitro drug metabolism studies?

B. Biochemical tests

A. Ames test

D. Polymorphisms

C. Serology

E. None of the above

15. Which of the following are protein components of the cytochrome P450 system?

B. NADH-CYP450 reductase

A. Heme protein CYP450o

D. A and B

C. NADPH-CYP450 reductase

E. A and CC

16. What is not a xenobiotic

B. Drugs

A. Plant toxins

D. Environmental pollutants

CSteroids

E. Carcinogens
17. What cytochrome P450 isozyme is most abundantly expressed in the human liver and

intestines7

B. CYP3A4

A. CYPIA1

D. CYP2D6

C.CYP2c9

E. CYP2E1

[ , 12:26 pm] . 18. Which of the following is an antiarrhythmic drug that is a calcium channel blocker?

A. Lidocaine

B. Nitroglycerin

C. Nifedipine

D. Codeine

E. Nabumetone

19. What drug should not be given to a patient that is a poor CYP2D6 metabolizer?

A. Codeine

B. Lidocaine

C. Nifedipine

D. Nitroglyoerin

B. Nabumetone

20. What injectionis administered directly into systemic cireulation causing apid distribution?

A. Intramuscular

B. Intravenous

CIntracerebral

D. Intraspinal

E. Subcutaneous

21. Where is Protonsil converted to Sulfanilamide?

A. Liver

B. Gut

C. Kidney

D. Colon

E. None of the above

[ , 12:31 pm] . MULTIPLE CHOICE QUESTIONS

Which of the following substance is the first precursor of ADRENALINE formatipn?

b) DOPA

a) Tyrosine

d Non-adrenaline

c)Dopamine

Which of the following is activated by sympathetic system

b) Sweat gland

Heart

Hairs stimulation

d) All of these

Which of the following drug is not used as an appetite suppressant:

b) Phenteramine

a) Fenfluramine

d)Adrenaline

Amphetamine

The catechol ring contains (4O) groups on which position?

b)Third and fourth

a) Second and third

d)Second and fourth

c) First and second

Which of the following adrenergic drug belongs to category of vasoconstrictos?

b) lsoprenaline

a) Metaraminol

d) Naphazoline

c)Amrinone

Nephridine is a synonym of which of the following drug?

b) Isoprenaline

a) Adrenaline

d)Non-adrenaline

Naphazoline

Which of the following drug belongs to the category of exogenous catecholamine

b De utam'ne

a) Dopamine

d) Adrenaline

c. Salbutamol

Which of the following is the selective antagonist of al receptors?

b) Yohimbine

a) Prazosin

d) Clonidine

c. Rauwolscine

[ , 12:33 pm] . Which of the following is not a cardiac stimulant?

b) Dobutamine

a) Adrenaline

d Salmeterol
Isoprenaline

Which of the following is not a dual acting adrenergic agonist?

b) Amphetamine

a) Ephedrine

d) Adrenaline

)Mephenteramine

Which of the following is not a dosage form of ADRENALINE?

b) Dilute injection

a) Eye drop

d) None of the above

c)Trans dermal patch

Which of the following is a synonym of dopamine?

b)Domanin

a) Domin

dVeratrole

Dopastat

What does COMT stands for?

a) Catechol-o-methyl-transferase

b) Catecho-oxy-methyl-transferase

c)Catecholamine-o-methyl-transferase

d) Catecholamine-oxy-methyl-transferase

In which of the following drug is not an example of direct acting adrenergic agonist.

b Phenylephrine

a) Xylometazoline
d) Tyramine

c)Methoxamine

In which of the following drug is used for raising blood pressure.

b) Adrenaine

a)Isoprenaline

Naphazoline

c)Noradrenaline

In which drug is not used for suppressing the appetite.

b) Benzidrine

a) Fenfluramine

d) Phenteramine

Phenylephrine

In which of the following is not a Bronchodilators.

b) Adrenaline

a) Terbutaline

d) Isoprenaline

c) Dobutamine

In which of the following is a CNS stimulant.

b) Methamphetamine

a) Naphazoline

Phenylephrine

c Sibutramine

Epherine alkaloid is obtained from

b) Ephedra vulgaris
a) Ephedra sinica

d) Ephedra Intermedia

Ephedra fragilies

In which of the following drugs that produced both.cardic stimulant and vasoconstriction.

b bilbutanol

a) Mephentermine

d) Dobutamine

c)Isoxsuprine

In which of the following is not a substrate for MA0 or COMT.

b) Isoxsuprine

a) Methoxamine

d) Dobutamine

Mephentermine

[ , 12:36 pm] . In which of the following is not a Noradrenergic agents.

b)Sibutramine

a) Phentermine

d)Diethylpropion

d Mazindol

In which of the following drug is reduce food seeking behaviour by enhancing serotonerg!

transmition in the Hypothalamus.

b) Sibutramine

a) Fenfluramine

c Mazindo

d) Diethylpropion

In which of the following is a selective af agonist, has negligible action.

b) Methoxamine

a) Mazindol

d) Phenylephrine

c)Amphetamine

In which of the following is stereoisomers of ephedrine.

b)Isoxsuprine

a) Pseudophedrine

d) Methoxamine

c) Mephentermine

In which of the following is selective ßl agonist which no- action.

b) Dobutamine

a) Dopamine

d) Methoxamine

c)Ephedrine

In which of the following is not a selective a2 stimulants.

b) Ritodrive

a) Salbutamol

dMethoxamine

c)Salmeterol

Which Type Of Receptor in Bronchial Smooth Muscle

B. betal subtype

A. alphal subtype

D. beta2 subtype

C. alpha2 subtype
Which of the following is pressor agent

B. isoprenaline

A. adrenaline

D. esoprenaline

C. ephedrine.

Beta2 receptors are predominently found in

MAPK is s

A. mitrogen activated protein kinase

B. mitogen activated proton kinase

C mitogen áctivated protein kinase

D. mitrogen activated proton kinase

[ , 12:38 pm] . Book of Medicinal Chemistry-

Tyramine is a type of agonist

B. indirect acting

A. Direct acting

D. none of these

C dual acting

Metraminol is used for.?

B. as central stimulant

A. raising blood pressure

C for their inotropic action oh heart

D. as a smooth muscdle relaxant

Which drug used in allergic reaction

B. Isosuprine

A. Naphazoline.

D. Ephedrine
C. Dopamine.

Which of the following is noncatecholamines

B. isoprenaline

A. dobutamine.

D. adrenaline

Csalbutamol

Dopamine comes under the categorie

B. noncatecholemines

A. catecholamines

C both

D. none

DOMA is

B. diahydroxy mandelic acid

A, dihydroxy mandelic acid

D. dihydroxy mandolic acid

C. decahydroxy mandelic acid

[ , 3:35 pm] . MULTIPLE CHOICE QUESTIONS

Adrenergic blocking agent prevents the response of adrenergic drug at which

adrenergic receptor.

B. Alpha

A. Beta

D. none of these

C. both of these

Which one is an irreversible antagonist that binds covalently to a adienergic

receptor.

B. Prazosin,

A. Atenolo

D. Phenoxybenzamine

C.Carvedial

Almost all the adrenergic blocking agent are shows which type of interaetion

with adrenergic receptor.

B. competitive antagonist

A. Non competitive antagonist

D. Competitive agonist

C. Non competitive agonist

Seletive , antagonist drugs are used to act on which part

A. Kidney

B. Brain

D. Respiratory system

C. Heart

Selective B, antagonist drugs are used to act on which part.

B. Brain

A. kidney

D. Respiratory system

C. Heart

A, mediated vasodilation called

B. Roynauds syndrome

A.Coronary atherosclerosis

D. Dale vasomotor reversal

C. Mydriasis

Blockade of a, receptor inhibits vasoconstriction induced by

B. Exogenous catecholamines

A. Endogenous catecholamines

D. none of these

C. Both of these

Phenoxybenzaime inhibits the uptake of.

B. catecholamines

A. Histamine

D. Carvedial

C. Prazosin

Phenetolamine and tolazoline äre competitive adernergic antagonist and block

the receptor fo.

A.2 HT

B. 3 HT

D.4 HT

C.5HT

Synonyms of prazosin

B. Alfazosin, Prazoptess

A. Minipress, Alfazosin

D. None of these

C. Minipress, Prazopress

[ , 3:40 pm] . In Propranolol the aromatic ring and its substitute is the primary determint of

which activity

A. alpha 1 antagonistic
B. alpha 2 antagonistic

C. beta 1 antagonistic

D. beta 2 antagonistic

How much carbon chains are essențlal for activity of propranolol.

B. 2 carbon chain

A. lcarbon chain

D. 4 carbon chain

C. 3 carbon chain

B blockers are structurally similar to..

B. B antagonist

A. a agonist

D.B agonist

C. a antagonist

Characteristics of Atenolol

A. beta 1 selective drug with low lipid solubility

B. beta 1 non selective drug with low lipid solubility

C. beta 1non selectiye drug with high lipid solubility

D. beta 1selective drug with high lipid solubility

We can synthesis the Atenolol from.

A. 2-4-hydroxyphenyD acetic acid

B.p hydroxyphenyl acetamide

C. both of these

D. none of thęse

Propanolol is prepared by condensing

A. alpha naphthol and epichlorhydrin

B. alpha naphthol and chloro propanolol

C. phenol and epichlorhydrin

D. chloro naphthol and propanolol

Prazocin belongs to the class of

A. pyridyl quinoxaline

B. piprazinyl quinazoline

C. pyridyl quinazoline

D. piprazinyl quinoxaline

[ , 3:44 pm] . Which of the followirng is a clinical use for a muscarinic agonist ?

A. Treatment of myásthenia gravis

B. "Swifting off the gastrointestinal tract prior to sungery

c "switing on the urinary trad after surgery

D. ncreasing heart muscde adtivity in certain heart defects

Acetylcholine can exist in how many number of conformation?

B.3

A. 2

D. 4synplanar, synclinal, anticlinal ánd antiplanar)

C5

Why the quaternary ammonium group is essential for inrinsic activity of acetylcholine?

A. beciise it acts as electron donor

B. because it act as electron aaeptor

Cbecause of its 2ction as a detecting 8group

D. None of the above

On substitution of methyl group on quaternary ammonium with amine group, which

amine group shows more activity ?

B. Secondary

A Primary

D. None of above

C. Tertiary

Which group of Ach contributes to the binding of compound to the muscarinic receptor?

B.methy group

A. ammonium group

D. Al of above

C. Ester group

Effects of cholinergic nerve stimulation are called

B Parasympathiomimetic

A. Sympathetic

D. B&CBoth

c Cholinerc

Replacement of methyl group by ethyl group or large alkyl groups cause ?

A Increacse in activity of compound B.Decrease in activity of compound

D. No change

C Inactivation of compound

Ester of arotmatic or higher molecular weight acids possess-

B Cholinergic antagonist activity

A Cholinergic agonist activily

D. Anticholinergic antagonist activity

c Anticholinergic agonist activity

[ , 3:46 pm] . In etiylene bidge lncorporation of betasubstitution leads to reduction of

B. Nicotinic activity

A. Muscarinic activity

C No change

D. All of above

Placement of alpha-substitution in choline moiety results in-

A. Decrease in nicotinic activty

B. Decrease in muscarinic activity

C Increase in nicotinic activity

D. both a and b

Replacement of ester group with ether or ketone produce-

A. Chemically Unstable Compound

B. Chemicaly Stable Compound

C. No Change

D. None of The Above

The nicotinic action at autonomie ganglia are blocked by

B. Atropine

A. Hemicholinium

C Hexamethonium

D. Tubocurarine

Choline is synthesised

B. not by itself

A. by itself in liver

C not in iver

D. none of above
What short of receptor is the nicotinic receptor

A. Gprotein coupled receptor

B. kinase linked receptor

D. an ion channel

C an intracellular receptor

Muscarinic sub receptors are .. ypes

A. 3

B.4

C.5

D. 2

Which of the following statement is wrong about Ach

B. Soluble in water and alcohol

A. Hygroscopic in nature

C Induce mitosis

D. Used in cataract surgery

Which of one is wrong statement about methacholine

A. Treat Reynaud's syndrome

B. Treat glucoma

C Insoluble in water

D. Soluble in alcohol and chloroform

Ach agonist drug having IUPAC 2 (Acetoxy-N, N, N-trimethyl propan-1-aminium

B.Bethanechol

A. Methacholine

C Carbachol

D. Pilocarpine
[ , 3:49 pm] . Tetrahydrofuran ring comes in the structure of o drug..

B. Bethanechol

A. Methacholine

D. Pilocarpine

C Carbacho

Physostigmine Salicylate is an example one of following class-

A. Reversible Cholinesterase inhibitors

B. Irreversible Cholinesterase Inhibitors

C. Direct acting Ach agonist

D. None of above

Drug having IUPAC 3HDimethylamino carbonyloxykl-metiyl pyddinium bxojnide is-

A Pyridostigmine

B. Edrophonium

CNeostigmine

D. Tacrine

Drug is used as insectiside in agrieulture-

A. Parathion

B. Edrophonium

C Neostigmine

D. Tacrine

IUPAC name of Pralidoxime chloride is-

A. 2-4(Hydroxyamino)methyl-1-methyl pyridine-1-ium chloride

B.Ethyl-(3-hydroxyphenylDdimethyl-ammonium chioride

C 3-(Dimethylamino carbony)oxy 1-methyl pyridinium chloride

D. 2 (AcetoxyN, N, N-trimethyl propan-1-aminium chloride

Bethanechol chloride given by which route of administration

B. Intravenous

A. Intramuscular

C. Subcutaneous

D. None of the above

Which is the selective agonist, for nicotinie receptor

B. Tubocurarine

A. Nicotine

D. Carbachol

C. Hexamethonium

Location of Moreceptor is

A. Autonomic ganglia

B.Heart

C.Visceral smooth muscle

D. None of the aboye

Indirectly acting Chollinergie drugs are

A. Neostigmine

B. Physostigmine

C. Edroyhonium

D. All of these

[ , 3:53 pm] . MULTIPLE CHOICE QUESTIONS

Effect of Atropine on CNS

b) Low dose strong stimulation

a)Low dose - mild stimulation

c) High dose depress

d) High dose mild stimulation

Effeet of Hyoscine on CNS

b) High dose excitation

a) Low dose depressant

d) Both A and B

c) High dose drowsiness

Nature of Atropine sulphate is

b)Basic

a) Acidic

d None of these

c)Neutral

Hyoscine is more potent on

b) Heart

a) Eye

d) Both A and C

c) Secretory gland

True about Hyoscine

a) Less potent and longer acting than àtropine

b)More potent and short acting than atropine

c)Less potent and short acting than atropine

d) More potent and longer acting than atropine

T half of atropine is

b) 8 to 12 hours

a) 5 to 6 hours
d) 3 to 4 hours

d 1 to 2 hours

How much amount of atropine metabolized in liver

b) 50%

a) 100%

d) 30%

c) 80%

Topical instillation of atropine causes

b)Abolition of light reflex

a) Mydriasis

d) All of these

c) Cycloplegia

[ , 3:56 pm] . Selective M1 Antagonist if

b) Atropine

a) Pirenzpine

d)Humatropine

c) Hyoscine

Which of the following is not an anti- cholinergic drag-

b) Cyclopentolate

a) Tropicamide

d) Homatropine

c) Neostigmine

Which of the following is ganglionic blocking agents-

b)Curare alkaloids

a) Hexamethnium
d) All of these

c) Pancuronium bromide

Atropine are

a) Freely soluble in alcohol

b)Well soluble in water

d) Both A and B

cInsoluble in water

Synonym of homatropine

b)Bentyl

a) Michol

d) Mesbentyl

c) Isopto

The taste of Dicyclomine HCI is-

b)Aromatic

a) Sweet

d)Pungent

c) Bitter

Tropicamide contain which amine group-

b) Secondary amine

a) Primary amine

d Contain no amine group

Tertiary amine

Which of the following is the levorotatory isomer of atropine?

b) Hyoscyamine
a) Hyoscine

d) none of the above

e)Tropine

What is the other name for scolpolamine?

b) Hyoscyamine

a) Pseudotropine

c) Tropine

d) Hyoscine

Out of the following which one is the corect option for the composition of racemic mixture

of atropine?

b)+and Hyoscyaimine

a)Tropine and tropic acid

d) +and-Scopine

c) and-Hyoscyamine

Which of the following isn't an example of amino alcohol drug?

b) Trihexylphenidyl

a) Procyclidine HCI

d) Dicycloamine

c) Biperiden

[ , 4:00 pm] . Which of the following isn't a solanaceous alkaloid?

a) Scopolaminec

b) Cyclopentolate

Homatropine

d lpratropium bromide

Which group according to SAR of anti-cholinergics doesn't possess antagonist action?

a)OH group

b) Carboxy amide group

c)ester group

d) Heterocyclic ring

Ipratropium bromide causes:

a) Bronchioconstriction

b)Bronchiodilation

c) No effect on bronchioles

d) first a)then (b)

Which of the following is used to induce cycloplegiaand mydriasis?

a)Cyclopentolate

b) Tropicamide

c) Atenolol

d) Both (a) & (b)

Which of the following drug is a purine derivative contatining drug?

a) Tolterodine

b) Procyclidine

c) Cyclopentolate

d) Scopolamine

Which of the following are common adverse effects of anti-cholinergics?

a) Bradycardia, dementia

b)Headache, Dizziness

c) Diarrhoea, Sedation

d) Dry mouth, constipation

Which of the following is a therapeutic use of anticholinergic drug?

a) Treatment of Parkinson

b) Dilate pupil

c)Treatment of epilepsy

d) All the above

Which replacement in general structure of anti-cholinergics drug makes it useful in case

of peptide ulcer patient?

a) Replacement of Nfrom tertiary to quartenary

b) Change in R, R R,

c) Length of alkyi chain

d) None'of the above

[ , 4:03 pm] . Which of the following anticholinergic is mainly used in treatment of pain caused by

muscle injuries like strain and sprain?

a) Tropicamide

b) Orphenadrine citrate

d) All the above

c) Solifenacin

Which of the following is antiçholinergic'bronchodilator?

a)Cyclopentolate

b) Glycopyrrolate

c) Tiotropine

d) All the albove

Which of the following anti cholinergie drug is used to treat overactive bladder wiih

increase urination frequency?

a) Solifenacin and Darifenacin

b) Cycopentolate and dicyloamine

c) Atropine and scopolamine

d) Tiotropine and glycopyrolate

[ , 4:04 pm] . MULTIPLE CHOICE QUESTIONS

Hypnotics should

a) Decrease consciousness for sleep without lingering effect

b) No potential for decreasing respiration even at high dose

c)No addiction, tolerance

d) All of above

Normal adult enters through which stage of sleep

b) REM

a) NREM

d) None of above.

Lakefulness

Which stage of sleep has following characteristics Low voltage, fast EEG, high muscle

activity and numerous REMs

b)Wakefulness

a) NREM

d) Both a) &

)REM

What is the proportion of different stages of sleep in normal adult?

a) 75-809%NREM & 20-25% REM

b) 15-20%REM & 80-85%NREM

c)15-20%NREM & 80-85% Wakefulness

d) 75-80% REM &20-25% Wakefulness

What is the effect of adenosine on sleep?

a) Produces CNS stimulant action

b) Produces hypnotic effect by stimulation of A, receptors

c) Produces hypnotic effect by inhibition of A, receptors

d) None of above.

[ , 4:08 pm] . Which neurotransmitter is known aş antiwaking agent i

b) Noradienaline .

a) Dopamine .

d) Both a) & b)

c) Serotonin

Which substance among the following are safer for treatment of insomnia?.

b) TCA

a) Barbiturates

d)Both a) & c)

c) Benzodiazepines

What is mechanism of action of barbiturates?

a) Enhancing GABA inhibition by influencing conductance at Chloride channel by binding

with a & B subunit

b) By binding to A, receptor

Through GPCR

d) None of above.

Which change in thiopental structure make it able to cross BBB fastly & suitable for iv.

administration?

a)Substitution of halogen at N,

b) Presence of large alkyl chain

Replacement of =O by -S at C-2 position

d) Both a)& c)

Which of following drugs show polymorphism?

a) Lorazepam & alprazolam

b) Zolpidem & zaleplon

c)Chloral hydrate & diazepam

d) Phenobarbitone & pentobarbitone

Which of following sedative and hypnotic is used in status epilepticus?

b) Secobarbitol

a) Diazepam

Paraldehyde

Zopiclone

Which of the following sedative and hypnotic excreted in urine in form of glucuronides?

b)Barbiturates

a) Benzodiazepines

d)Carbamates

c) Non-benzodiazepines

Which change in structure of benzodiazepines result in their rapid conjugation with

glucuronic acid?

a) Introduction of carbonyl grp at position 3 are polar, increase hydrophilicity

b) Reduction of-C-O at c2

c)Presence of electron withdrawing grp at position7

d) None of above.

What is the effect of hypnotics on REM?

a) Increase duration and intensity of REM

b) N effect

d Reduce duration and intensity of REM.

d) None of above.

[ , 4:10 pm] . 5,5-diethyl barbituric acid is a common name of

b) barbitone

a) Phenytoin

d) Procaine

c)Tropane

barbituric acid is prepared by condensation of

a) malonic acid and urea

b) diethyl malonate and urea

malonic acid and methyl urea

d) diethyl malonate and methyl urea

In barbiturates hypnotic activity inereases with lipid solubility until the number of carbon

atoms for both substituents at C6 is between

b) 4 and 6

a) 6 and 10

d) None of above

c)10&16

Sedative action of barbiturates is due to substituents at C5.is due to

b steric efect

a) high lipophilicity of groups at C5

d) isosteric effect

d Metal complex formation

Condensation of ethyl phenyl malonate with urea give

b) thiobarbitone

a) pentobarbitone

d) barbitone

) phenobarbitone

2-amino 5-chlorobenzophenone is the starting material for synthesis of

b) diazepam

a) nitrazepam

none of above

c) chlorazepam

246-trioxo hexahydto pyrimidine is IUPAC name of

b) barbituric acid

a) barbitone

d none of above

c)methabarbitone

[ , 4:12 pm] . MULTIPLE CHOICE QUESTIONS

Antipsychotics drugs also known as

B. CNS Stimulants

A: CNS depressants

D. antidepressant drug

C. neuroleptic drugs

Antipsychotic drugs have a significantly stronger effect on the CNS, antagonists of ...

B. Serotonin

A. GABA

D. 5HT

C. Dopamine
Which one is example of Atypical Antipsychotic Agents

B. Risperidone

A. Chlorpromazine

D. Perphenazine

C. Haloperidol

...is example of dihydroindolones derivatives

B. Risperidone

A. Molindone HCI

D. Perphenazine

C. Haloperidol

.is example of Piperazine derivatives

B. Risperidone

A. Fluphenazine

D. thioridazine

C Haloperidol

6Which type of Phenothiaziue is inactive but has good lipophilicity for brain penetration?

B. Unsubstituted

A. Aromatic

D. Aliphatic

C Substituted

The linear alkyl chain linker between the core ring and the terminal amino ring must

thave three methylene units ie. -CH-CH-CH Reduction in these carbon number causes.

B. Increases the activity.

A. Reduces the activity

D: None of above

C. Unchanged the activity

3-(10H- Phenothiazin-10-yi-N, N-di-methyl propan-1-amiņe hydrochloride is IUPAC name

of

B. Chlorpromazine Hydrochloride

A. Promazine Hydrochloride

D. Piperacetazine Hydrochloridę

C Thioridazine Hydrochloride

IUPAC name of Clozapine is.

A. 8-Chloro-6-(4-methyl piprazin-1-yD benzo [6] [1,4) benzoxazepine

B. 8-chloro-11-4-methyk-piprazin-1-y) 5H-dibenzo bcl I14 diazepine

C. (RS)-10-2-(1-Methyl-2-piperidyl) ethyll-2-methyl thiophenothiazine.

D. 8-Chloro-6-(4-methyl piprazin-1-y) benzo {61 [14] benzoxazepine

Which drug used in treatment of schizophrenia, who are unresponsive and intolerant to

other antipsychotic drugs

B. Clozapine

A. Molindone Hydrochloide

D. Promazine

C. Thioridazine

[ , 4:51 pm] . 11. The drug which act by blocking dopamine receptor especially D, receptor is

B. Loxapine Sucinate

A. Prochlorperazine Maleate

D.Haloperidol

C Clozapine

[ , 6:12 pm] . MULTIPLE CHOICE QUESTIONS

Epilepsy is a disorder of-

B. Heart

A. Brain

C.Kidney

D. Hair

Seizures are the . .that take place as a result of pathologic processes

both inside and outside the brain.

B. Involuntary muscle contractions

A, Voluntary muscle conractions

D. None of above

C Involuntary neurons contractions

Anticonvulsant drugs inhibits seizures by potentiating of synaptic inhibition through an

action on the . TeCeptor.

B. GABA

A. 5T

D. Serotonin

C. Epinephrine

HNCH CHCH_COOH chemical fornhula of-

B. aamino propionie acid

A. a amino butyric acid

D. Amino pentoie acid

C GABA

Simple Partial Seizures also known as-

A. With Impairment of Consciousness B. B.Without Impairment of Consciousness

D. None of above ,
C. Complex Partial Seizures

Loss of consciousness and blinking of eyelid or jerking of the entire body for 30 seconds

are the symptoms of-

A:Clonic Seizures

B. Tonic Seizures

D. Absence (Petitmal) Seizures

C. Grand mal

Hydantoin is a basically

B. Imidazolidine-2,5-dione

A. Imidazolidine-2,3-dione

D. Imidazolidine-24dione

c Imidazolidine-2,2-dione

In Hydantoins which position at phenyl or other aromatic. substituent is important for

activity

B. C4

A. C5

D.C

C C3

[ , 6:16 pm] . MULTIPLE CHOICE QUESTIONS

The given TUPAC name 2-chloro-1, 1,2-triffuoroethyl-difluoromethyl ether is of,

b) Isoflurane

a) Enflurane

d) Halothane

c) Sevoflurane
The given TUPAC name 2-Bromo-2-Chloro-1, 1, 1-triluoroethane is of

b) Isoflurane

a)Enflurane

c)Sevoflurane

d) Halothane

Cyclopropane belongs to .category

b) Halogenated Carbons

a) Gases

d) Dissociative

c) Ethers

The IUPAC name of Methohexital Sodium is-

a) 5-allyl-1-methyk5-(1-methyl-2-pentyny) barbituric acid

b) 5-allyl-2-methyl-3-(1-methyl-2-pentyny) barbituric acid

5-allyl4-methy-1-(1-methyl-2-pentyny) barbituric acid

d 5-allyl-3-methyk5-(1-methy-2-pentyny) barbituric acid

1-Butrynyl Magnesium Bromide is the starting precusor for the synthesis of .

a) Thiopental

a) Ketamine

b) Diazepam

c) Methohexital Sodium

Which of the inhalation analgesic is recommended' in obstetrical procedure?

b) Halothanes

aNitrous oxide

c) Methoxyflurane

d) Isoflurane
Which of these anesthetics is selective antagonist of NMDA receptor?

a) Ketamine

b) Thiopental

Diazepam

d)Methohexital Sodium

Which of these anesthesia is not recommended in case of children

b) Halothane

(a)Desflurane

(d) Enflurane

(c) Sevoflurane

Which of the following is considered as best and safe general anesthetics?

a) Halothane

b)Ethers

(d) Hydrocarbons

( Nitrous Oxide or Gas

Why is ethanol used during the preparation of chloroform ?

(a) To prevent the formation of poisonous carbonyl chloride

b) To prevent toxicity

(c)To prevent hepatotoxicity

d) For sedative effect

[ , 6:20 pm] . Nitrous oxide produces unconsciousness by blocking the following receptors

b) H2 receptor

(a) NMDA

c) GABA, receptor

d) D2 receptor
Which color is chosen to paint the cylinder containing Nitrous oxide

b) Green

(a) Blue

d) Yellow

(e)Red

Choose the correct arrangement of stages of Anesthesia.

(a) Delirium, surgical, medullary paralysis, analgesia

b) Analgesia, delirium, surgical, medullary paralysis

c) Medullary paralysis, surgical, delirium, analgesia

(d)Surgical, medullary paralysis, delirium, analgesia

Which of the following is not an inhalation anesthetic?

b) Methoxyflurane

(a) Barbiturate

(d) Chloroform

(c) Nitrous oxide

Which of the following is not an I.V. anesthetics?

b) Thiopental

(a) Ketamine

() Desflurane

() Diazepam

Which of the following has the ultrashort action as general anaesthetics?

(b) Nitrous oxide

(a) Halothane

(D Ketamine
() Thiopental

General anesthetics are administered by.

b) Inhalation

(a) IV.

d)IV.&Inhalation

(c) Rectal

Inhalation anaesthetic first reach to

6) Alveoli space

(a) Brain

(d) D Lungs

c) Blood

Anaesthetics effect produce by Drugs are

(b) Reversible

(a) Irreversible

() Non competitive

(c) Competitive

Methoxyflurane is employed for

b) Analgesic

(a) Cardiac

D) Hepatitis

(c) Diabetes

First organie agent discovered as general anesthetie is

(b) Chloroform

(a) Diethyl ether

d) Vinyl Chloride Halogenated A

(c) Nitrous oxide

Which is more imitating to airway as compare to other Halogenated Hydrocarbón & ethes?

(b) Sevoflurane

(a) Desflurane

d) Enflurane

(c) Isoflurane

[ , 6:22 pm] . Which one is known as Laughing gas?

b) Cyclopropane

(a) Nitrous oxide

(d) Cyclohexane

c) Chloroform

Laughing gas cylinder is painted with which color

(b) Red

(a) Yellow

d) Green

c) Blue

When intravenously anaesthetic administered parentally than what type of effect they

produce?

b) Unconsciousness

(a) Antianxiety

d) Calm.

c) Respiratory depression

Intravenous drug are mainly belonging to category

b) Barbiturate
(a) NSAIDS

d) Benzodiazepine

(c) Diuretic

Which barbiturates are employed as intravenous änaesthetic

b) Thiopentone

(a) Methohexitone

(c)Enflurane

(d) Halothane

Ketamine is contraindicated in patient that are suffering with

b CVS disease

(a) CNS disease

d) CVS&Hypertension

(c) Parkinsonism

Which receptor is 1° target for general anaesthetic

(b) GABA

(a) GABA A

(c)GABA B

(a) GABA C

Agent of choice in cardiac surgery for anacsthesia is

b)Enflurane

(a) NO

(d) Halothane

(c)Isoflurane

Agent used for dissociative anaesthesia is-

(b) Halothane

(a) Fentanyl

(d) Ketamine

c) Etomidate

All of the following anaesthetic agents depress respiration system except

(b) Sevoflurane

a) Nitrous oide

( Desflurane

(c) Halothane

[ , 6:25 pm] . MULTIPLE CHOICE QUESTION=

Which one is not an Opiolds receptor

B. Kappa

A. mu

D. Gamma

C. Delta

Morphine is ..........and penetrates the blood brain barrier relatively slowly

B. Hydrophobic

A. Hydrophilic

D. Less water soluble

C Lipophilic

Which position of morphine is important for analgesic activity after binding

B. 2 position

A. 3 position

D. 8 position
C. 4 position

Acetylation or methylation of morphine produces-

B. Methadone

A. Codeine

D. Ethyl morphine

c Heroin

Location of ê receptor in brain is

B. Cortex

A. Hypothalamus

D. laninae M and IV of the cortex

C.olfactory bulbs

.is metabolised by 3 and 6-glucuronide conjugation reaction.

The drug- n

B. Morphine Sulphate

A. Pentazocine HC1

D. Naloxcne Hydrochloride

C Loperamide Hydrochloride

Penazoicine drug is an example of . ategory.

B. Methadone derivatives

A. Benzomorphanan

D. Opioids antagonists

C Phenylpiperidine derivatives

idrug, which is highly addictive and is twice

Acetylation of morphine produces.

as active as morphine.

B. Methadone

A. Diamorphine

D. Ethyl morphine

C Heroin

What type of activity is in compound obtained if the double bond is present at position 7

and 8 is removed ?

A. Compounds with increased duration of action and reduced activity

B. Compounds with reduced duration of action and increased activity

C. Compounds with increased duratior of act on and increasel activity

D. Compounds with reduced duratión of action and reduced activity

[ , 6:28 pm] . Narcotic and Non-Narcotic Analgesics

Introduction of -OH group at C-14 gives potent compounds. i.e oxymorphone and

oxycodone has increased potency because -OH group provides........... binding

B. an additional covalent bonding

A. an additional H-bonding

D: Pi-Pi bonding

C an additional ionic bonding

Which drug activates i receptos and pfoduces analgesia, respiratory depression?

B. Morphine Sulphate

A. Pentazocine

D. Loperamide Hydrochloride

C Levorphanol Tartarate

-3-hydroaxy-N-methyl-morphinan TUPAC name of ... drug&

B. Morphine
A. Pentazocine

D. Loperamide

C. Levorphanol

2-Chloro-1-dimethylaminopropane is intermediate precursor for the synthesis of-

B. Methadone

A. Pentazocine

D. Loperamide

C Levorphanol

The IUPAC name of Fentamyl Citrate is-

A. 4-14-Chlorophenyl)-4-hydroxypiperidinej-N, N-dimethyl-2, 2-diphenyl butyramide

B.1-Benzy-3-dimethylamino-2-methyl-1-phenyl propy propionate hydrochloride

C. N-Phenyl-N-11-2-phenylethylpiperidine-4-yll propanamide-2-hydroxy- 1, 2,3-propane

tricarboxylate

D. Dimethyl (1-methyl4-oxo-33-diphenylhexy)-amine

Which drug is ê, agonist?

B. Morphine Sulphate

A. Pentazocine

D. Loperamide Hydrochloride

C. Codeine

The morphirie is less effective when given by .. oute

B. IV

A. Orally

C. IM

D. SC
How mány carbon present in morphine structure?

B. .17

A. 14

D. 18

C. 16

[ , 6:30 pm] . MULTIPLE CHOICE QUESTIONS

Which drug is used as an antidote in overdose of clonidine?

B. Morphine Sulphate

A. Pentazocine HCI

D. Naloxone Hydrochloride

C. Loperamide Hydrochloride

Drugs used in the treatment of alcohol addiction are-

B. Narcotic agonists

A. Narcotic Antagönists

D. Anticholinergics

C. CNS stimulants

In which year Martin and Gilbert postulated about three subspecies of opioid

receptors?

D. 1975

C. 1966

B. 1977

A. 1988

Choose (the) pure narcotic antagonistks:

D) codeine

C) naltrexone
A) pentazocine

B) naloxone

E) nallorphine

Least addiction/abuse liability:

B) oxycodone

A) hydromorphone

D) codeine

nalbuphine

E) methadone

[ , 6:47 pm] . MULTIPLE QUESTIONS

NSAIDs act by-

By competitively inhibiting cyclooxygenase (prostaglandin synthase), the enzyme that

catalyse the synthesis of cyclic endo peroxides which synthesize prostalgandins.

b) By selective inhibiton of CcOx-1 ike ketoprofen, indomethacin

By selective inhibition of COx-2 like Rofecoxib, celecoxb

d) All of the above

Most common side effects of NSAIDs is

b) Headache

c)Gastrointestinal disturbances

a) A and b both

d) Vomiting

Blood clotting or platelets aggregation get disturbed by NSAIDs due to decireasing the

production of

b) Uric acid

a) Cloting factors
d) Thromboxane A,

Cydo oxygenase

NSAIDs prolong gestation period by inhibition of which of the following prostáglandin in

uterus

b) PGR,

a) PGE,

. d) All of the above

PGD,

Aspirin is

b p-aminophenol derivatives

a) Salicylic acid derivative

d Anthranilic adid derivatives

pyrazolidinedione derivatives

Which of the following is not as selective COX-2 inhibitor

b) Rofecoxib

a) Celecoxib

d) Aspirin

Valedocoxdb

Salicylates are useful in treatment of

b) Gouty arthritis

a Osteoarthritis

d)b&cboth

Rheumatoid arthritis

[ , 6:53 pm] . Placement of the phenolic hydroxy group may abolish the activity of salicylates type of

NSAIDs when substituition occur at

b) At Metaposition
a) At Paraposition

d) a&b both

c) At Orthoposition

Substitution of aromatic ring at 5th position of salicylic acid derivatives type of NSAIDs

increases which of the following activity

b) Antipyretic activity

a) Analgesic activity

d) All of the above

c) Anti-inflammatory activity

Other name of aspirin is-

b) Bufferin

a) Emipirin

d) All of the above

Acetyl salicylic acid

Salsalate is

b) Trimer of salicylic acid

a) Dimer of salicylic acid

None of the above

Sulphasalazine is used in treatnment of-

b) Crohn's lititis

a) Peptic ulcer

d)B&C both

Ulcerative dotitis

Which of the following derivatives lack anti-inflammatory effects

b) p-aminophenol derivatives

a)Salicylic acid derivatives

d) Anthranilic acid, derivatives

c)Pyrazolidinedione derivatives

Anti inflammatory activity of pyrazolidine diones type of NSAIDs decreases by decreas-

ing or eliminating the acidic proton at position no.

b) 2nd

a) 1st

d) a &b both

c) 4th

PG (Prostaglandin) is naturally occuring fatty acid derivative of-

b) 25-C cyclopentáno

a) 20-C cyclopentano

d) 35-C cyclopnetano

c30-C cycdopentano

2-phenyl thio ethyl group substitutíon in pyrazolidinedione produces anti gout activity

when substitution occur at

b) 2nd position

1st position

d) 1st and 2nd position

4th position

[ , 6:57 pm] . Why don't you want to give NSAID to pregnant women, especially in the third trimester

(A)t causes spinabifelia in the uterus.

(B)It causes excess bleeding during delivery.

C) It causes prolongation of gesiation or delayed spontaneous labor.

D)B&C both
The alkyl group attached to N- atom of indole acetic acid derivatives type of NSAID

shows increase in anti-inflammatory activity in order

(B) FH> alkyl CHCH,

(A) CHCH alyl > H

D) Alkyl CHCH

(C) OCHCHLH> allyl

Which drug used in the treatment of gout is highly bound to plasma proteins-

B) Allopurino

(A)Sulfinpyrazone

(D)buprofen

(OProbencid

Which drug listed below is the only non acid NSAID

() Ketoprofen

(AJCelecoxib

(DIndomethacin

CONabumetone

21. Which of the following moiety is essential for the activity of Anthranilic acid derivatives

types of NSAIDs

CB)-0

(A)-NH

D)-S0,

C-CH,

Other name of Analgin is-

E) Nalangin
(AMetanizol

DAll of the above

(Dipyrone

Which of the following class of NSAIDs is charácterized by long acting and very potent

anti-inflammatory activity

3B) Oxicams

CAJSalicylate acid derivatives

Dp-Aminophenol derivatives

(CMiscellaneous

Replacement of the indole ring system of the indomethacin by pyrrole ring produces the

Pyrole acetic acid

(B)Tolematin

(AZomipirac

D)Meloxicam

CKetorolac

Which of the following drúg is semi selective COX inhibitor-

B) Aspirin

(A Celecoxib

(D Diclofenac

(C Ibuprofen

[ , 6:58 pm] . Which of the following drug produces an intermediate which is a toxic imetabolite

CB) Paracetamol

(A)lbuprofen

(D)Diclofenac

CAspirin
If the acidity of pyrazolidine derivative type of NSAID is enhanced too much then anti-

inflammatory activity will.

) Decrease

(A)Increase

DNone of the above

C)Remains same

Paracetamol prodaces anitipyretic effect by acting on-

(B) Thalamus

(AHypothalamus

D)Cerebral cortex

(C)Mid brain

IUPAC name of Diclofenac is

(A)2-02,6-Dichloroanilinephenylaceticacid

(B)2-(p-isobutyl pheny)aceticacid

C) 23-phenoxyphenyl)lpropionicacid

(D) 2-42,5Dichloroaniline)phenylaceticacid

Most common side effects of NSADs is

(B Headache

(AGastrointestinal disturbancès

(D)A and b both

C) Vomiting

Aspirin is

B)p-amino phenol derivatives

(A)Salicylic acid derivative

D)Anthranilic acid derivatives

CPyzazolidinedione derivatives

Substitution of aromatic ring at 5h position of salicylic acid derivatives type of NSAID

increases which of the following activity-

CB) Antipyretic activity

(A)Analgesic activity

tD)All of the above

(C)Anti-inflammatóry activity

Fenamate is

(B) Selective cox-2 inhibitor

(A)Anthranilic acid derivative

sigD)Salicylic acid derivative

C)oxicam derivative

One of the following is synthesized by using Ullmann Condensation reagton-

B)Salicylic acid derivative

Oxicem derivative

C)Anthranilic acid derivative DiSelective cox-2 inhibitor

[ , 7:04 pm] . One of the following is not a Fyrazolidine derivative drug

(B) oxyphenbutazone

A)phenylbutazone

D) phenacetin

(C)sulphinpyrazone

Which isomer of Sulindac drug showed more potent anti-inflammatory activity

(B) E-isomer

A)Z-isomer

D)all of the above

C) none of the above

IUPAC name of Mefenamic acid is

(A)2-42,3-Dimethylphenylamino)benzoic acid

B) sodium 3-26-dichloro-3-methylphenylaminojbenzoate

244-isobutyl phenyD propionie acid

D)2-13-phenoxy phemy) ethanone

Which one is synonym of Ibuprofen-

B) Nalton

(A)Motrin

(D)clinoril

C)Zomax

Which functional group is important for increasing the activity of Anthranilic acide:

derivative

(B) O

(A)S

(D)None of the above

(CONH

IUPAC name of Indomethacin-

(A)2-(4isobulyl phenyl propionic acid

B) 1-p-chlorobenzoyD-5-methoxy indole-3-acetic acid

C) 2-3-phenoxy phemy) ethanone

(D)2423-Dimethylphenylaminobenzoic acid

NSADS primarily promoted as an analgesic, not as an anti-inflammatory agent

B) Naproxen
(A) Ibuprofen

D) Sulindac

C) Ketorolac

Other name of Oxyphenbutazone drug

(B) tandearil

(A)oxaril

D)both a &b

C) metacin

Which of the following drug water soluble

B) Oxyphenbutäzone

(A) Phenylbutazone

D) Naproxent

C) buprofen

[ , 7:05 pm] . Anti-inflammatory Agents

Indole acetic acid derivative type of NSAIDS will have max. activity when 5th position

substituted by

(B) N(CH3);

(A) OCH3

(D) H

(C) CH3

Which drug is used in dysmenorrhea

(B) mefenamic acid

(A)fenamate

Doxyphenbutazone

C)indomethacin
Which of the following is the precursor for phenylbutazone drug-

B) diethyl butyl malonate

(A) diethyimalonate

D) all of the above

C) butylmalonyl chloride

[ , 7:08 pm] . Multiple Choice Questions (MCQs)

1. Aspirin introduced by

--in 1889

B. Emil Fischer and Mering

A. Dreser's.

C. Barger and Dale.

D. Non of Above.

2. Bioisosteres are similar in their-

B. Chemical Character.

A. Physical Character.

C. Both Character a & b.

D. Biochemical Character.

3. Which of the following reaction is not a Phase I metabolic transformation?

A. Reduction of ketones.

B. Conjugation of alcohols.

D. Esterhydrolysis.

C. Monoamine oxidases.

4. --------reaction is most common in drugs having ester or amide functional groups

B. Reduction.

A. Oxidative reactions.

D. Phase I.
C. Hydrolysis.

5. Which of the following adrenergic drug belongs to category of vasoconstrictors?

A. Metaraminol.

B. Isoprenaline.

D. Naphazoline.

C. Amrinone.

6. Which type of Receptor in Bronchial Smoth Muscle.

B. Beta 1 subtype.

A. Alpha 1 subtype.

D. Beta 2 subtype.

C. Alpha 2 subtype

7. Prazocin belongs to the class of

A. Pyridyl quinoxaline.

B. Piprazinyl quinazoline.

C. Pyridyl quinazoline

D. Piprazinyl quinoxaline

8. In Propranolol the aromatic ring and its substitute is the primary determing of

which activity.

B. Alpha 2 antagonistic.

A. Alpha 1 antagonistic.

D. Beta 2 antagonistic.

C. Beta 1 antagonistic.

9. Ach agonist drug having IUPAC 2(Acetoxy)-N, N, N-urimethyl propan-1-aminium

B. Bethanechol.
A. Methacholine.

D. Pilocarpine.

C. Carbachol.

[ , 7:09 pm] . 10. IUPAC name of Pralidoxime chloride is-

A. 2-1(Hydroxyamino)methyl]-1-methyl pyridine-1-ium chloride.

B. Ethyl-(3-hydroxyhynyl)dimethyl-ammonium chloride.

C. 3-[(Dimethylamino carbonyl)oxyl-1-methyl pyridinium chloride.

D. 2 (Acetoxy)-N, N, N-trimethyl propan-1-aminium chloride.

11. Tropicamide contain which amine group-

B. Secondary amine.

A. Primary amine.

D. Contain no amine group.

C. Tertiary amine.

12. Which replacement is general structure of anti-cholinergic drug make it useful in case of

peptide ulcer patient?

A. Replacement of N from tertiary to quaternary.

B. Change in R1, R2, R3.

C. Length of alkyl chain.

D. None of the above.

13. One of the following is not a triazolobenzodiazepine derivative

B. Triazolam.

A. Alprazolam.

D. Estazolam.

C. Midazolam.

14. Blood levels of neuroleptics are useful to check the following:

B. Therapeutic levels.

A. Toxicability.

D. All of he above.

C. Resistace.

15. The Mechanism of action of Carbamazepine appears to be similar to that of:

B. Sodium valproate.

A. Benzodiazepines.

D. Ethosuximide.

C. Phenytoin.

16. The anesthetic agent, which is an inhibitor of NMDA glutamate receptors is:

B. Halothane.

A. Thiopental.

D. Sevoflurane.

C. Ketamine.

17. Which COX enzyme are aspirin, indomethacin, and sulindac more selective for?

B. COX-2.

A. COX-1.

C. They are equally selective for cOX-1& COx-2.

18. Most current opioid analgesics act at this opioid receptor subtype

B. Delta.

A. Kappa.

D. Mu.

C. Epsilon

19. Drug associated with the hepatic/renal toxic metabolite: N-acetyl-p-benzoquinone.

B. Meclofenamate.

A. Diclofenac.

D. Acetaminophen.

C. Indomethacin.

20. What can be done to prevent GI side effect of NSAIDs?

A. Co-administration of NSAID with PPI. B. Enteric coated tablets.

D. All of the above.

C. Prescribe CINODs instead.

[ , 7:11 pm] . 1. Gaseous and volatile drugs and their metabolites are excreted through

b) Lungs

a) Skin

d) Saliva

c) Billiary route

2. Major site of drug metabolism is

b) Liver

a) Lung

c)Skin

d) Gastrointestinal tract

3. Conversion of alcohols to aldehydes is metabolic reaction.

a) Oxidation

b) Reduction

c)Hydrolysis

d) Conjugation

4. Enzyme used for glucuronic acid conjugation is

a) Glutathione S-transferase
b) UDP-Glucuronyltransferase

c)SAM

d) PAPS

5. Henderson-Hesselbalch equation is used to determine

_of drug.

b) Solubility

a) Partition Coefficient

) % ionization

d) pH

6. % ionisation of drug depend upon

a) pKa of the drug

b) pH of the body fluid

c)Partition coefficient of drug

d) Both a. and b.

7. Beta 2 receptors are found in

a) Heart

b) Bronchi

c) Adipose tissue

d) Skeletal muscles.

8. Muscarinic receptors are.

. receptor.

a) Nuclear

b) G-protein Coupled

c)Enzyme

d) Ligand gated lon Chanel.

9. Which of the drug is direct acting sympathomimetic agent?

a) Phenylephrine

b) Pseudoephedrine

c) Propylhexedrine

d) Ephedrine

10. Which of the drug is alpha adrenergic blocker?

a) Propranolol

b) Metibranolol

c) Atenolol

d) Tolazoline

11. Acetylcholine on hydrolysis gives..

a) Serine and acetic acid

b) Choline and carbamic acid

c) Acetic acid and serine

d) Choline and acetic acid

12. Acetylcholine is biosynthesized from.

a) L-Cysteine

b) L-Codeine

)L-Serine

d) L-Cholic acid

13. Chlordiazepoxide, a psychotherapeutic agent belongs to class of

a) Carbamates

b) Propanediol

c) Benzodiazepine

d) Phenothiazine.
14. Hypnotics are.

a) Strong depressant of CNS

b) Strong stimulant of CNS

c) Mild depressant of CNSs

d) Mild stimulant of CNS

15. Chemical name 5-ehtyl,5-phenyl barbituric acid belong to

a) Hexobarbital

b) Phenobarbital

)Pentobarbital

d) Secobarbital

16. Which one of the following receptor is block by Neuroleptic agent?

a) Cholinergic

b) Adrenergic

) GABA

d) Dopaminergic

17. Which of the Anticholinergic agent useful as a spasmolytic drug?

a) Pyridostigmine

b) Dicyclomine

c) Tropicamide

d) Glycopyrrolate

18. Phenobarbital is orally administered in the treatment of

a) Grand mal epilepsy

b) Petit mal epilepsy

)Jackson epilepsy
d) Psychomotor epilepsy

19. Which of the following barbiturate derivative acts as anticonvulsant agent?

a) Hexobarbital

b) Phenobarbital

)Pentobarbital

d) Secobarbital

20. Which of the following drug is acts as Cholinergic Blocking agent?

b) Neostigmine

a) Physostigmine

d) Dicyclomine

c)Pyridostigmine