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Biopharmaceutics Question Bank

This document contains 25 multiple choice questions related to the topics of bio-pharmaceutics, pharmacokinetics, drug absorption, and drug disposition. The questions cover concepts such as bioavailability, drug distribution, transport mechanisms, drug clearance, pharmacokinetic modeling, and in vitro dissolution testing. This bank of questions appears to be for a third year Bachelor of Pharmacy exam focusing on these essential pharmacokinetics and biopharmaceutics topics.

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Riya Patani
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570 views3 pages

Biopharmaceutics Question Bank

This document contains 25 multiple choice questions related to the topics of bio-pharmaceutics, pharmacokinetics, drug absorption, and drug disposition. The questions cover concepts such as bioavailability, drug distribution, transport mechanisms, drug clearance, pharmacokinetic modeling, and in vitro dissolution testing. This bank of questions appears to be for a third year Bachelor of Pharmacy exam focusing on these essential pharmacokinetics and biopharmaceutics topics.

Uploaded by

Riya Patani
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
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(Bio-pharmaceutics & Pharmacokinetics Question Bank SEM-VI)

THIRD YEAR B.PHARM (SEM-VI) CBCS SYLLABUS


Q.1 ………..is defined as rate and extent of drug absorption.
a. Bioavailability b. Bioequivalence
c. drug disposition d. absorption
Q.2. The movement of drug from one compartment to other compartment is referred as…
a. Bioavailability b. drug distribution
c. drug disposition d. absorption
Q.3. Passive transport process involve all except….…
a. Passive difussion b. Pore transport
c. ion-pair transport d. Antiport
Q.4. Facillated diffusion is also known as…..
a. Active difussion b. mediated diffusion
c. ion-pair transport d. Symport
Q.5. …….. is active transport process
a. Persorption b. Pinocytosis
c. Phagocytosis d. ion-pair transport
Q.6. BCS Class III have….
a. Low solubility & Low permeability
b. High solubility & low permeability
c. Low Solubility & High permeability
d. High solubility & high permeability
Q.7. Equation for zero order half life is………
a. t1/2= 0.5 A0/k0 b. t1/2= 2A0/k0
c. t1/2= 1.5 A0/k0 d. t1/2= 0.693 A0/k0
Q.8. Equation for first order half life is………
a. t1/2= 0.5 A0/k0 b. t1/2= 2A0/k0
c. t1/2= 1.5 A0/k0 d. t1/2= 0.693/k
Q.9. In cell uptake studies use of peristaltic pump is required for……….
a. Single pass perfusion b. Everted Sac Technique
c. Doluisio method d. Everted Ring Technique
Q.10. Blood brain barrier consist of specialized cells except……
a. Astrocytes b. Endoblasts
c. Pericytes d. Endothelial cells
Q.11. Formula for volume of distribution is………
a. Vd= C/X b. Vd= X/C
c. Vd= Ke/X d. Vd= Ke/C
Q.12. Resident time for large intestine is……
a. 2 hrs b. 6-12 hrs
c. 4 hrs d. 3 hrs
Q.13. Intestinal transit time for Duodenum is…….
a. 0.5 to 1 hrs b. 3 to 6 hrs
c. 2 hrs d. 5 minute
Q.14. Majority of drug that binds to extravascular tissues, the order of binding is
a. Liver>Kidney>Lung>Muscles b. Lung>Liver>Kidney>Muscles
c. Liver> Lung >Kidney >Muscles d. Liver>Kidney> Muscles>Lung
Q.15. Which of this is not phase II reaction
a. Acetylation b. Methylation
c. Hydrolysis of esters d. Conjugation of glucoronic acid
Q.16. Clearance is defined as the ration of…….
a. Elimination rate/Plasma drug Concentration
b. Plasma drug Concentration/ Elimination rate
c. Vd/AUC d. AUC/Vd
Q.17. The beginning of pharmacological response is called as….
a. Onset time b. Duration of action
c. Onset of action d. Intensity of action
Q.18. Which of this is model independent approach of pharmacokinetics….
a. Mammillary model b. Perfusion model
c. Distributed parameter model d. Noncompartmental analysis

Q.19. Absorption rate constant can be calculated by ….


a. Method of residuals b. Sigma minus method
c. Model independent method d. Noncompartmental analysis
Q.20. First order pharmacokinetic model equation is ….
a. LogC= LogC0- KEt/2.303 b. LogC= LogC0- KE/2.303
c. LogX= LogC0- KEt/2.303 d. LogC0= LogC- 2.303/KEt
Q.21. Bioavailability is generally in the order of……
a. Oral> Parenteral>Rectal>Topical b. Parenteral>Oral> Topical> Rectal
c. Oral>Parenteral>Topical >Rectal d. Parenteral>Oral>Rectal>Topical \
Q.22. Flow through cell belongs to which type of USP appratus ….
a. USP type 1 b. USP type 2
c. USP type 4 d. USP type 3
Q.23. ..is used for molecular inclusion complexation for solubility enhancement of drugs
a. Sodium Lauryl suphate b. Cyclodextrine
c. CMC d. HPMC
Q.24. IV bolus dose of 200 mg given by IV. Following one compartment kinetics described
by equation C= e-0.91t. Claculate ClT, Vd.
a. 0.0173 ml/min, 1.44 ml b. 0.0273 ml/min, 2.5 ml
c. 0.0785 ml/min, 3.22ml d. 0.0673 ml/min, 4.44 ml
Q.25. IV bolus dose of 25mg given by IV. Following one compartment kinetics having half
life is 36 hrs and volume of distribution is 27000 lt. Claculate ClT, C0.
a. 8640 ml/min, 0.00092 mg/lit b. 5220 ml/min, 0.92 mg/lit
c. 8520 ml/min, 0.92 mg/lit d. 5220 ml/min, 0.092 mg/lit

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