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Organic Chemistry II Course Outline

This document outlines the course plan for Organic Chemistry II. It includes 5 chapters covering topics such as aromatic compounds, amines, carbonyl compounds, oxidation-reduction reactions, and an introduction to biomolecules. The course will be delivered through lectures, group discussions, and presentations and assessed through continuous assignments and a final exam.

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Eshet Shumet
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80 views2 pages

Organic Chemistry II Course Outline

This document outlines the course plan for Organic Chemistry II. It includes 5 chapters covering topics such as aromatic compounds, amines, carbonyl compounds, oxidation-reduction reactions, and an introduction to biomolecules. The course will be delivered through lectures, group discussions, and presentations and assessed through continuous assignments and a final exam.

Uploaded by

Eshet Shumet
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
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Addis Ababa Science and Technology University

College of Applied Sciences


Department of Industrial Chemistry
Course Plan of Organic Chemistry II
Course Name: Organic Chemistry II; Course Code: InCh2402; Cr.Hr: 3
Prerequisite: InCh2401 Semester (Acc. Year): II (2020/21);
Name of Instructor: Mesfin Getachew (Ph.D.)

Synopsis: This course designed to make students aware of organic reactions in detail and depth. It
will elaborate chemistry of aromatic, amine, carbonyl compounds, carboxylic acid, and oxidation–
reduction reactions. In addition, biological molecules such as carbohydrates, amino acids, peptides,
lipid, and nucleic acids are introduced to address basic concepts about natural product chemistry.

Course Contents
Chapter 1: The Chemistry of Aromatic Compounds
1.1 Aromaticity 1.2 Properties of Benzene and its Derivatives
1.3 Heterocyclic Aromatic Compounds
1.4 Aromatic Substitution Reactions & their Mechanism:
1.4.1 Halogenation 1.4.2 Nitration 1.4.3 Alkylation 1.4.4 Acylation 1.4.5 Sulphonation
1.4.6 Directing Effects of Substituents
1.4.7 Examples of Electrophilic Aromatic Substitution Rxns
1.4.8 Representative Rxns of (pyrrole, furane, thiophen and pyridine)
1.5 Nucleophilic Aromatic Substitution Reactions
1.5.1 Reactions of Aryl halides
1.5.2 Mechanisms of Nucleophilic Aromatic Substitution Rxns
1.6 Reactions of Aromatic Side Chains
1.6.1 Oxidation & Substitution of Alkyl Side Chains
1.6.2 Reduction of Nitro Groups & Aryl Ketones
1.6.3 Conversion of Halogens to Organometallic Reagents
1.6.4 Hydrolysis and Fusion of Sulphonic Acids
1.6.5 Modifying the Influence of Strong Activating Groups
1.6.6 Diazotization of Primary Aromatic Amines & their Usefulness in Synthesis of Aromatic
Derivatives

Chapter 2: Amines
2.1 Nomenclature & Structure 2.2 Properties of Amines: Physical and chemical
2.3 Basicity of Nitrogen Compounds 2.4 Acidity of Nitrogen Compounds
2.5 Reactions of Amines 2.6 Electrophilic Substitution at Nitrogen
0 0 0
2.7 Preparation of 1 , 2 & 3 Amines 2.8 Reactions with Nitrous Acid
2.9 Reactions of Aryl Diazonium Intermediates 2.10 Elimination Reactions of Amines
Chapter 3: Reactions of Carbonyl Compounds
3.1 Addition Reactions
3.1.1 Hydrates 3.1.2 Hemiacetals 3.1.3 Cyanohydrins 3.1.4 Carbinolamines
3.1.5 Addition of Grignard Reagents 3.1.6 Addition of Hydrogen
3.1.7 Hydride Additions (lithium aluminum hydride and sodium borohydride)
3.2 Addition Elimination Reactions
3.2.1 Imines and related compounds 3.2.2 Wittig reaction 3.2.3 Acetals
3.2.4 Ester hydrolysis and formation 3.2.5 Reactions of acid chlorides
3.2.6 Reactions of acid anhydrides 3.2.7 Reactions of amides
3.2.8 Reductions of acid derivatives
3.3 Enolization-Ketonization reactions
3.3.1 Haloform Reaction of Methyl Ketones 3.3.2 Alkylations at the α-Carbon
3.3.3 Aldol and Related Condensation reactions

Chapter 4: Oxidation–Reduction reactions


4.1. Oxidation Reactions
4.1.1 Alcohols 4.1.2 Aldehydes 4.1.3 Multiple Bonds
4.2. Reduction Reaction
4.2.1 Catalytic Hydrogenation 4.2.2 Hydride Reduction 4.2.3 Dissolving metal reduction

Chapter 5: Introduction to Chemistry of Biomolecules


5.1 Carbohydrates
5.1.1 Glucose 5.1.2 Structure & Configuration of Glucose
5.1.3 Anomeric forms of Monosaccharides 5.1.4 Glycosides
5.1.5 Disaccharides 5.1.6 Polysaccharides
5.2 Lipids
5.2.1 Fatty Acids 5.2.2 Fats & Oils 5.2.3 Waxes 5.2.4 Phospholipids
5.2.5 Prostaglandins 5.2.6 Terpenes 5.2.7 Steroids
5.3 Proteins and Amino Acids
5.3.1 α-Amino Acids 5.3.2 Reactions of Amino Acids 5.3.3 Synthesis of Amino Acids
5.3.4 Peptides and Proteins 5.3.5 Primary, Secondary & Tertiary Structure of Proteins
5.3.6 Peptide Synthesis
5.4 Nucleic Acids: Introduction to the chemistry of Nucleic Acids (Structure and Chemistry)

Mode of Delivery: Lecture; Group Discussion; Presentation


Mode of Assessments: Continuous Assessment (Assignment, Quizzes; Tests = 50%) and
Final exam (50%)
Text Book and References
1. Carey F., Giuliano, R. M. Allison, N.T., Bane Tuttle S.B. (2020) Organic Chemistry;
Publisher: New York, NY : McGraw-Hill Education,
2. Graham T. S. organic Chemistry 2017), JOHN WILEY & Sons,
3. McMurry, J., Simanek, E. (2018) Fundamentals of Organic Chemistry , Belmont:
Thomson: rooks/Cole.

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