How Coronavirus (COVID-19) is treated

with TCM in China

By

John Chen
Pharm.D., Ph.D., O.M.D., L.Ac.

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 How Coronavirus (COVID-19) is
treated with TCM in China Biology

John K. Chen, Ph.D., Pharm.D., O.M.D., L.Ac. • Coronavirus is an RNA virus

Lori Hsu, MTOM, MS • SARS-CoV causes SARS.
Michael Norris, L.Ac., C.H. • SARS-CoV-2 causes Covid-19.
Debra Nash-Galpern, L.Ac.
• 96% genome identity
R b t Ch
Robert Chu, OME
Lorraine Wilcox, L.Ac.
Donna Chow, L.Ac., DiplOM
Special thanks to Drs. Chen Juan, Huang Di, Wang
Shi Qi, Cai Xiang, Tang Ying and several other doctors
who wish to remain “anonymous.” • Report of the WHO-China Joint Mission on Coronavirus Disease (COVID-19) 16-24
February 2020.
• https://emcrit.org/ibcc/covid19/?fbclid=IwAR31Xy-
vkhL39xSWNAqkx3fECRR2yQLVbyWD2EOOoDG7FYv2WXqdQm7Lu_U#biology

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Shall not be copied, duplicated, or distributed in any format or be used for teaching without prior written consent from Lotus Institute of Integrative Medicine

Clinical Manifestation Pathophysiology

• Incubation: 2-14 days • Cytokine storm: The coronavirus causes

• Resp s/sx: fever, dry cough, sneezing, runny uncontrolled / dysfunctional immune response,
nose, sputum production, nasal congestion, leading to an overproduction of immune cells and
shortness of breath, lethargy, muscle pain, their signaling molecules, resulting in a cytokine
headache and dehydration. storm with a flood of immune cells into the lung.
• GI s/sx: 5-10% of patients can present initially • S/Sx include: severe inflammatory disease,
with diarrhea or nausea, before fever and shortness of breath, inflammation of the airway,
dyspnea and finally acute respiratory distress syndrome
• Wang, et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China.
and multiple organ failure.
JAMA. Published online February 7, 2020. doi:10.1001/jama.2020.1585 • https://www.the-scientist.com/news-opinion/why-some-covid-19-cases-are-worse-than-others-67160

Pathophysiology Biopsy

• In addition to hyper-inflammatory injury, • “Edema, proteinaceous exudate, focal

the lung suffers physical injuries (diffuse reactive hyperplasia of pneumocytes with
alveolar damage, including hyaline patchy inflammatory cellular infiltration, and
membranes) and physiological multinucleated giant cells
cells. Fibroblastic
compromises (wheezing, shortness of plugs were noted in airspaces.”
breath, etc).

• Xu Z, et al. Pathological findings of COVID-19 associated with acute respiratory distress syndrome. • Xiao, Shu-Yuan. Pulmonary Pathology of Early COVID-19 Pneumonia Identified Retrospectively in Two Patients With Lung Cancer, The
https://www.thelancet.com/action/showPdf?pii=S2213-2600%2820%2930076-X ASCO Post. 3/12/2020. https://ascopost.com/news/march-2020/pulmonary-pathology-of-early-covid-19-pneumonia-identified-
retrospectively-in-two-patients-with-lung-cancer/

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 WM Diagnosis WM Diagnosis

• Signs and symptoms evaluation • Lymphopenia is common, seen in ~80% of

• Nasopharyngeal swab patients.
• Chest x-ray and CT scan • Mild thrombocytopenia is common (but
platelets
l t l t are rarely
l <100).
100) Lower
L platelet
l t l t
count is a poor prognostic sign.

• Guan W et al. Clinical Characteristics of Coronavirus Disease 2019 in China. The New England Journal of Medicine. February 28, 2020.
• Ruan Q et al. Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China. Intensive
Care Med https://doi.org/10.1007/s00134-020-05991-x

WM Treatment WM Treatment

• Acetaminophen, aspirin, ibuprofen • Convalescent

• Antiviral: remdesivir, lopinavir, ritonavir. plasma
• Chloroquine • Convalescent
• Steroids sera
• Immunosuppressant
• Ventilator
• ECMO
Johns Hopkins University.
https://hub.jhu.edu/2020/03/13/covid-19-antibody-sera-arturo-casadevall/

WM Treatment Prognosis

• “Vaccine for Covid-19 • Up to 70% of people get Covid-19.

won’t be deployed for at • Most patients have mild illness. They don’t require
least 1 to 1.5 years.” medical attention and aren't counted.
– March 3, 2020 • The vast majority of infected patients (e.g.
>80%)
80%) don't
d 't gett significantly
i ifi tl ill and
d don't
d 't require
i
hospitalization.
• Individuals under 18 years of age make up only 2.4% of
all reported cases.
• Individuals over 60 years of age, with pre-existing health
Anthony S. Fauci, M.D.,
Director of NAID (National Institute of Allergy and Infectious Diseases)
conditions, have the highest risks.

Report of the WHO-China Joint Mission on Coronavirus Disease (COVID-19) 16-24 February 2020.
https://www.businessinsider.com/coronavirus-covid-19-angela-merkel-bundestag-infection-19-2020-3

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 Prognosis Prognosis

• Among hospitalized patients: ~10-20% of • Patients who survive the initial phases of the
patients are admitted to ICU. illness may still require prolonged ventilator
support (due to pulmonary fibrosis).
• ~3-10% require intubation.
• As the epidemic progresses, an issue which may
• ~2-5% die. arise is a large volume of patients unable to wean
from mechanical ventilation.

• Guan et al. Clinical Characteristics of Coronavirus Disease 2019 in China. The New England Journal of Medicine.
https://www.nejm.org/doi/pdf/10.1056/NEJMoa2002032?articleTools=true • Zhang, W. Imaging changes of severe COVID-19 pneumonia in advanced stage. Intensive Care Med (2020). https://doi.org/10.1007/s00134-
020-05990-y

TCM and Epidemic Diseases 张仲景 Zhāng Zhòng-Jĭng, 150-219 CE

• There have been over • Shang Han 伤寒

320 large-scale (Cold-Induced Disorders)
epidemics in China – Taiyang
between Eastern Han – Yangming
g g
and Qing Dynasty – Shaoyang
(approximately 2,000 – Taiyin
years). – Shaoyin
– Jueyin

叶桂 Yè Guì, 1666-1745 TCM Pattern Differentiation

• Wen Bing 温病 • Taiyang • Wei (defensive) level

(Warm Disease): • Yangming • Qi (energy) level
– wei (defensive) level
• Shaoyang • Ying (nutritive) level
– qi (energy) level
• Taiyin • Xue (blood) level
– ying (nutritive) level
– xue (blood) level • Shaoyin
• Jueyin

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 TCM Diagnosis TCM Diagnosis

• Early S/Sx: Fever, dry • Taiyang • Lymphopenia is • Qi deficiency

cough, sneezing, – Wind-heat common, seen in
runny nose, nasal – Wind-cold ~80% of patients.
congestion, shortness • Mild thrombocytopenia • Blood deficiency
of breath, lethargy, is common.
muscle pain,
headache and • Wei (defensive) level
dehydration.

•Guan W et al. Clinical Characteristics of Coronavirus Disease 2019 in China. The New England Journal of Medicine.
February 28, 2020.
•Ruan Q et al. Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients
from Wuhan, China. Intensive Care Med https://doi.org/10.1007/s00134-020-05991-x

TCM Diagnosis TCM Diagnosis

• S/Sx: severe • Yangming • “Edema, proteinaceous • Damp and phlegm in

inflammatory disease, exudate, focal reactive the Lung
shortness of breath, hyperplasia of – Lung heat, with
inflammation of the pneumocytes with – Lung
g cold,, with
airway • Qi (energy) level patchy
t h iinflammatory
fl t
cellular infiltration, and
multinucleated giant
cells. Fibroblastic plugs
were noted in
airspaces.”

TCM Diagnosis TCM Diagnosis

• S/Sx: cytokine storm • Shaoyang • In addition to hyper- • Lung yin deficiency

leading to acute • Taiyin inflammatory injury, the • Lung qi deficiency
respiratory distress lung suffers physical
• Shaoyin injuries (diffuse alveolar
syndrome and multiple
organ failure. • Jueyin d
damage, iincluding
l di h hyaline
li
membranes) and
physiological compromises
• Ying (nutritive) level
(wheezing, shortness of
• Xue (blood) level breath, etc).

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 TCM Diagnosis TCM and Covid-19

• Patients who survive • Lung yin deficiency • More than 85% of all
the initial phases of • Lung qi deficiency patients with
the illness may still coronavirus,
require prolonged approximately 60,000
ventilator support (due people, received herbal
to pulmonary fibrosis). treatment along with
western medicine
treatments, as of late
February 2020.

• Ministry of Science and Technology, China.

Hubei Provincial Hospital Wuhan Union Hospital Guidance for Covid-19

• Hubei Provincial Hospital of TCM
Prevention Phase Prevention
– Prevention Phase: 预防期
Early Phase Wind-Heat Invading the Exterior Medical Observation Period
Syndrome – Early Phase: 流感期
Pneumonia Phase Damp Warmth in Early Phase Clinical Treatment Period – Pneumonia
P i Ph
Phase: 肺炎期
Damp Heat Obstructing the Lung
Syndrome
– Recovery Phase: 恢复期
Epidemic Toxins Blocking the Lung
Closed Interior and Abandoned
Exterior

Recovery Phase Insufficiency of qi and yin, Deficiency Recovery Period

of Lung and Spleen. 湖北省中医院新型冠状病毒感染的肺炎中医药防治协定方（第一版）

Prevention Phase: 预防期

• Prevention Phase: 预防期 • Huang Qi 黄芪 (Radix Astragali) 15g
• Early Phase: 流感期 • Bai Zhu 炒白术 (Rhizoma Atractylodis Macrocephalae),
– Wind-Cold Invading the Exterior 风寒袭表证 dry fried 10g
– Toxic Heat Attacking the Lung 热毒袭肺证
– Dampp Cold in the Lungg 濕寒鬱肺
• Fang Feng 防风 (Radix Saposhnikoviae) 10g
• Pneumonia Phase: 肺炎期 • Mian Ma Guan Zhong 绵马贯众 (Rhizoma Dryopteridis
– Shaoyang Syndrome with Damp 少阳夹湿证 Crassirhizomatis) 10g
– Damp Heat Afflicting the Lung 湿热郁肺证 • Jin Yin Hua 金银花 (Flos Lonicerae Japonicae) 10g
– Toxic Stagnation Obstructing the Lung 毒瘀壅肺证
• Chen Pi 陈皮 (Pericarpium Citri Reticulatae) 6g
– Closed Interior and Abandoned Exterior Syndrome 内闭外脱证
• Pei Lan 佩兰 (Herba Eupatorii) 10g
• Recovery Phase: 恢复期
• 湖北省中医院新型冠状病毒感染的肺炎中医药防治协定方（第一版）

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 Prevention Phase: 预防期 Early Phase: 流感期

• Bilateral Zusanli (ST 36), Qihai (CV 6), • Wind-Cold Invading Exterior 风寒袭表证
Zhongwan (CV 12) • Toxic Heat Attacking the Lung 热毒袭肺证
– Moxa Zusanli (ST 36) on both sides for 15 • Damp Cold in the Lung 濕寒鬱肺
minutes Moxa Qihai (CV 6) or Zhongwan (CV
minutes.
12) for 10 minutes. (alternating from treatment
to treatment).
– Twice a day, once in the afternoon and once at
night.

Early Phase: Early Phase:

- Wind-Cold Invading the Exterior - Wind-Cold Invading the Exterior
• S/Sx: Onset of fever (mostly low-grade fever), ‧葛根汤或柴葛解肌汤
aversion to cold, chills, headache, ticklish throat,
• Ge Gen Tang (Kudzu Decoction) or Chai
soreness of muscles of limbs, no sweat or night
sweats. Ge Jie Ji Tang (Bupleurum and Kudzu
• Exam: Lung CT negative. Tongue is pale,
D
Decoction
ti tto R
Release
l th
the M
Muscle
l LLayer))
coating is white and thin. Floating pulse
• Treatment: Expel Wind, Release the Exterior;
Clear Heat, Detoxify

Early Phase: Early Phase:

- Wind-Cold Invading the Exterior - Toxic Heat Attacking the Lung
• Ge Gen 葛根 (Radix Puerariae Lobatae) 15g • S/Sx: Fever, aversion to cold, sore and dry
• Ma Huang 麻黄 (Herba Ephedrae) 10g throat, dry cough, scanty sputum, sore and
• Gui Zhi 桂枝 (Ramulus Cinnamomi) 6g painful muscles in the limbs, weakness,
• Bai Shao 白芍 (Radix Paeoniae Alba) 15g headache
• Sheng Jiang 生姜 (Rhizoma
(Rhi oma Zingiberis Recens) 10g • Exam:
E CT scan reveals
l both
b th llungs tto h
have
• Gan Cao 生甘草 (Radix et Rhizoma Glycyrrhizae) 10g scattered ground-glass opacity (GGO). Tip and
• Da Zao 大枣 (Fructus Jujubae) 10g sides of the tongue are red; thin white or yellow
• Jin Yin Hua 金银花 (Flos Lonicerae Japonicae) 20g tongue coating. Floating and rapid pulse.
– with headache, add Bai Zhi 白芷 (Radix Angelicae Dahuricae) 15g • Treatment: Expel Wind, Release the Exterior;
– with dry or ticklish throat, add She Gan 射干 (Rhizoma
Belamcandae) 15g Clear Heat, Detoxify

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 Early Phase: Early Phase:
- Toxic Heat Attacking the Lung - Toxic Heat Attacking the Lung
‧银翘散加清瘟败毒散加减 • Jin Yin Hua 金银花 (Flos Lonicerae Japonicae) 10g
• Lian Qiao 连翘 (Fructus Forsythiae) 10g
• Yin Qiao San (Honeysuckle and Forsythia • Jing Jie 荆芥 (Herba Schizonepetae) 10g
Powder) and Qing Wen Bai Du San (Clear • Niu Bang Zi 牛蒡子 (Fructus Arctii) 10g
E id i and
Epidemics dO
Overcome P Pathogenic
th i • Bo He 薄荷 (Herba Menthae) 10g
Influences Powder), modified • Gan Cao 生甘草 (Radix et Rhizoma Glycyrrhizae) 10g
• Dan Zhu Ye 淡竹叶 (Herba Lophatheri) 10g
• Lu Gen 芦根 (Rhizoma Phragmitis) 15g
• Huang Lian 黄连 (Rhizoma Coptidis) 6g

Early Phase: Early Phase:

- Damp Cold in the Lung - Damp Cold in the Lung
• S/Sx : Aversion to cold, fever or absence of • Cang Zhu 蒼朮 (Rhizoma Atractylodis) 15g
fever, dry cough, dry throat, fatigue, • Chen Pi 陳皮 (Pericarpium Citri Reticulatae) 10g
• Hou Po 厚樸 (Cortex Magnoliae Officinalis) 10g
weakness, chest stuffiness, epigastric
• Huo Xiang 藿香(Herba Pogostemonis) 10g
distention nausea,
distention, nausea diarrhea
diarrhea. • Cao Guo 草果 (Fructus Tsaoko) 6g
• Exam: Pale tongue, white greasy coating, • Ma Huang 生麻黃 (Herba Ephedrae) 6g
slippery pulse. • Qiang Huo 羌活 (Rhizoma et Radix Notopterygii) 10g
• Treatment: Expel Wind, Release the • Sheng Jiang 生薑 (Rhizoma Zingiberis Recens) 10g
• Bing Lang 檳榔 (Semen Arecae) 10g
Exterior; Dispel Damp Cold

Early Phase: Pneumonia Phase: 肺炎期

• Bilateral Hegu (LI 4), Taichong (LR 3), • Shaoyang Syndrome w/ Damp 少阳夹湿证
Zusanli (ST 36), Shenque (CV 8) • Damp Heat Afflicting the Lung 湿热郁肺证
– Moxa Hegu (LI 4) and Taichong (LR 3) • Toxic Stagnation Obst the Lung 毒瘀壅肺证
bilaterally for 15 minutes
minutes. Moxa Zusanli (ST
36) bilaterally for 10 minutes. Moxa Shenque • Closed Interior / Abandoned Exterior
(CV 8) with a moxa box for 15 minutes. Syndrome 内闭外脱证
– Twice a day, once in the morning and once in
the afternoon.

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Shall not be copied, duplicated, or distributed in any format or be used for teaching without prior written consent from Lotus Institute of Integrative Medicine. 7
 Pneumonia Phase: Pneumonia Phase:
- Shaoyang Syndrome with Damp - Shaoyang Syndrome with Damp
• S/Sx : Fever, which is more pronounced in the afternoon, ‧小柴胡汤合三仁汤或甘露消毒丹
alternating chills with fever, cough, absence of wheezing,
bitter taste in the mouth, dry mouth, chest stuffiness, • Xiao Chai Hu Tang (Minor Bupleurum
stifling sensation, chest and hypochondriac fullness and
distention, irritability, nausea or vomiting, no appetite, Decoction) with San Ren Tang (Three-Nut
weakness.
k Similar
Si il tto th the b
beginning
i i stage
t off pneumonia.
i D
Decoction)
ti ) or Gan
G Lu L Xiao
Xi Du D (Sweet
D Dan (S t
• Exam: CT scan reveals both lungs to have multiple Dew Special Pill to Eliminate Toxins)
scattered or large pieces of ground-glass opacity (GGO).
Slightly red tongue, thick and greasy, white or yellow
coating, slippery, rapid pulse.
• Treatment: Harmonize Shaoyang Syndrome, Clear
Damp-Heat

Pneumonia Phase: Pneumonia Phase:

- Shaoyang Syndrome with Damp - Damp Heat Afflicting the Lung
• Chai Hu 柴胡 (Radix Bupleuri) 24g • S/Sx: Low-grade fever or absence of fever, dry cough,
• Huang Qin 黄芩 (Radix Scutellariae) 9g scanty sputum, dry and sore throat, fatigue, weakness,
• Sheng Jiang 生姜 (Rhizoma Zingiberis Recens) 10g poor appetite, chest stuffiness, epigastric distention,
• Fa Ban Xia 法夏 (Rhizoma Pinelliae) 12g nausea or vomiting, loose stool.
• u Xing
Ku e 杏仁 (Se
g Ren (Semen
e Armeniacae
e acae Amarum)
a u ) 15g
5g • Exam: CT scan reveals both lungs to have multiple
• Bai Dou Kou 白豆蔻 (Fructus Amomi Rotundus) 10g scattered or large pieces of ground-glass opacity (GGO).
• Yi Yi Ren 薏苡仁 (Semen Coicis) 30g Pale or pink, puffy tongue with teeth marks. White or
• Dan Zhu Ye 竹叶 (Herba Lophatheri) 15g greasy white coating. Soft or slippery pulse.
• Hua Shi 滑石 (Talcum) 15g
• Treatment: Transform Dampness, Detoxify; Disperse the
• Tu Fu Ling 土茯苓 (Rhizoma Smilacis Glabrae) 30g
Lungs and Expel Pathogens
• Gan Cao 生甘草 (Radix et Rhizoma Glycyrrhizae) 10g

Pneumonia Phase: Pneumonia Phase:

- Damp Heat Afflicting the Lung - Damp Heat Afflicting the Lung
• Ma Huang 麻黄 (Herba Ephedrae) 10g
‧麻杏薏甘汤、小陷胸汤、草果知母汤
• Ku Xing Ren 杏仁 (Semen Armeniacae Amarum) 10g
• Ma Xing Yi Gan Tang (Ephedra, Apricot • Yi Yi Ren 薏苡仁 (Semen Coicis) 30g
Kernel, Coicis, and Licorice Decoction), • Huang Lian 黄连 (Rhizoma Coptidis) 6g
• a Ban
Fa a Xiaa 法夏 ((Rhizoma
o a Pinelliae)
e ae) 10g
0g
Xi Xian
Xiao Xi Xiong
Xi T
Tang (Mi
(Minor Sinking
Si ki into
i t • Gua Lou Pi 瓜蒌皮 (Pericarpium Trichosanthis) 10g
the Chest Decoction) and Cao Guo Zhi Mu • Cao Guo 草果 (Fructus Tsaoko) 10g
Tang (Tsaoko and Anemarrhena • Zhi Mu 知母 (Rhizoma Anemarrhenae) 10g
• Yu Xing Cao 鱼腥草 (Herba Houttuyniae) 15g
Decoction) • Gan Cao 生甘草 (Radix et Rhizoma Glycyrrhizae) 10g
• Bai Dou Kou 白豆蔻 (Fructus Amomi Rotundus) 9g

Lotus Institute of Integrative Medicine, PO Box 92493, City of Industry, CA 91715

Tel: 626-780-7182 • Fax: 626-363-9751 • Website: www.eLotus.org • Email: info@eLotus.org
Shall not be copied, duplicated, or distributed in any format or be used for teaching without prior written consent from Lotus Institute of Integrative Medicine. 8
 Pneumonia Phase: Pneumonia Phase:
- Toxic Stagnation Obstructing the Lung - Toxic Stagnation Obstructing the Lung
• S/Sx Cough, stifling sensation, stuffiness and distention ‧白虎汤加人参汤合四土汤
in the chest, asthma and wheezing that worsens with
exertion, accelerated respiration, thirst, irritability, reddish • Bai Hu Jia Ren Shen Tang (White Tiger
yellow urine. plus Ginseng Decoction) with Si Tu Tang
• Exam: CT scan reveals both lungs to have multiple (F
(Four Wild D
Decoction)
ti )
scattered or large pieces of ground-glass opacity (GGO).
Fibrotic changes of the lung are also visible. Dark purplish
tongue, yellow dry tongue coating or thick and greasy
yellow coating, rapid, slippery pulse.
• Treatment: Detoxify, Arrest Wheezing; Transform Blood
Stasis and Open Collaterals

Pneumonia Phase: Pneumonia Phase:

- Toxic Stagnation Obstructing the Lung - Closed Interior / Abandoned Exterior Syndrome
• Shi Gao 石膏 (Gypsum Fibrosum) 30g
• Zhi Mu 知母 (Rhizoma Anemarrhenae) 10g
• S/Sx: Mental incoherence, irritability, burning or
• Shan Yao 山药 (Rhizoma Dioscoreae) 15g heat sensation in the chest and abdomen, cold
• Xi Yang Shen 西洋参 (Radix Panacis Quinquefolii) 5g extremities, accelerated respiration and need for
• Tu Fu Ling 土茯苓 (Rhizoma Smilacis Glabrae) 30g
• g土大黄 ((Radix Rumicis Obtusifolii)) 10g
Tu Da Huang土大黄 g assisted breathing, scarlet purple tongue, dry
• Tu Bei Mu 土贝母 (Rhizoma Bolbostemmatis) 10g yellow or yellowish brown coating, floating,
• Tu Niu Xi 土牛膝 (Rhizoma Achyranthes Sylvestris) 10g
• Tu Bie Chong 土鳖 (Eupolyphaga seu Steleophaga) 10g
forceful pulse that is empty in the deep level, or
• Su Mu 苏木 (Lignum Sappan) 10g rootless.
• Ju Luo 橘络 (Vascular Citri Reticulatae) 15g
• Lai Fu Zi 莱菔子 (Semen Raphani) 20g • Treatment: Open the Closed, Consolidate the
• Ting Li Zi 葶苈子(Semen Descurainiae seu Lepidii) 15g Abandoned, Detoxify, Rescue Reversal
• Si Gua Luo 丝瓜络 (Retinervus Luffae Fructus) 30g

Pneumonia Phase: Pneumonia Phase:

- Closed Interior / Abandoned Exterior Syndrome - Closed Interior / Abandoned Exterior Syndrome
‧四逆加人参汤、送服安宫牛黄丸、紫雪散 • Ren Shen 人参 (Radix et Rhizoma Ginseng) 10g
• Si Ni Jia Ren Shen Tang (Frigid Extremities • Fu Zi 制附子(Radix Aconiti Lateralis Praeparata)
10g
Decoction plus Ginseng), taken with An
G
Gong Ni Huang
Niu H W (Calm
Wan (C l ththe P
Palace
l Pill • Serve with An Gong Niu Huang Wan (Calm the
Palace Pill with Cattle Gallstone) and Zi Xue San
with Cattle Gallstone) and Zi Xue San
(Purple Snow Powder).
(Purple Snow Powder)

Lotus Institute of Integrative Medicine, PO Box 92493, City of Industry, CA 91715

Tel: 626-780-7182 • Fax: 626-363-9751 • Website: www.eLotus.org • Email: info@eLotus.org
Shall not be copied, duplicated, or distributed in any format or be used for teaching without prior written consent from Lotus Institute of Integrative Medicine. 9
 Recovery Phase: 恢复期 Recovery Phase: 恢复期

• S/Sx: Absence of fever, dry cough, chest ‧沙参麦门冬汤

stuffiness, shortness of breath, shortness of
• Sha Shen Mai Dong Tang (Glehnia and
breath upon exertion, dry mouth, weakness.
Ophiopogonis Decoction)
• Exam: CT reveals inflammation begins to
subside as well as pulmonary interstitial changes.
Pale red tongue, thick or greasy coating, thread,
rapid pulse.
• Treatment: Tonify Qi, Nourish Yin, Tonify Lung
and Open the Collaterals

Recovery Phase:恢复期 Recovery Phase:恢复期

• Sha Shen 沙参 (Radix Glehniae seu Adenophorae) 15g
• Mai Dong 麦冬 (Radix Ophiopogonis) 15g
• Bilateral Dazhui (GV 14), Geshu (BL 17),
• Wu Wei Zi 五味子(Fructus Schisandrae Chinensis) 15g Feishu (BL 13), Zusanli (ST 36) or Kongzui
• Ren Shen 人参 (Radix et Rhizoma Ginseng) 12g
• Lai Fu Zi 莱菔子 (Semen Raphani) 15g
(LU 6).
• Si G L 丝瓜络 (Retinervus
Gua Luo (R i L
Luffae
ff F Fructus)) 1
15g – Moxa
Mo a all points for 15 min
minutes.
tes
• Ju Luo 橘络 (Vascular Citri Reticulatae) 15g
• Zi Su Zi 苏子(Fructus Perillae) 12g
– Once a day.
• Zhe Bei Mu 浙贝 (Bulbus Fritillariae Thunbergii) 12g
• Ku Xing Ren 杏仁 (Semen Armeniacae Amarum) 12g
• Huang Qin 黄芩 (Radix Scutellariae) 15g
• Gan Cao 生甘草 (Radix et Rhizoma Glycyrrhizae) 10g

Wuhan Union Hospital 武汉协和医院

• Prevention 预防
• Wind-Heat Invading the Exterior Syndrome 风熱袭表证
• Damp Warmth in Early Phase 濕溫初期
• Damp Heat Obstructing the Lung Syndrome 濕熱壅肺証
• Epidemic Toxins Blocking the Lung 疫毒闭肺证
• Closed Interior and Abandoned Exterior 内闭外脱
• Insufficiency of qi and yin, Deficiency of Lung and Spleen.
气阴不足，肺脾两虚

武汉协和医院关于“新冠”中医防治方案（第三版） 武汉协和医院关于“新冠”中医防治方案（第三版）

Lotus Institute of Integrative Medicine, PO Box 92493, City of Industry, CA 91715

Tel: 626-780-7182 • Fax: 626-363-9751 • Website: www.eLotus.org • Email: info@eLotus.org
Shall not be copied, duplicated, or distributed in any format or be used for teaching without prior written consent from Lotus Institute of Integrative Medicine. 10
 Wind-Heat Invading Exterior Syndrome
Prevention 预防 风熱袭表证
• Huang Qi 生黄芪 (Radix Astragali) 12g
• Bai Zhu 白术 (Rhizoma Atractylodis Macrocephalae) 9g • S/sx: headache, sore throat, cough, thick
• Fang Feng 防风 (Radix Saposhnikoviae) 6g tongue coating, red tongue tip
• Bei Sha Shen 北沙参 (Radix Glehniae) 10g
• Mian Ma Guan Zhong 贯众 (Rhizoma Dryopteridis Crassirhizomatis) 10g
• Qiao 连翘 ((Fructus Forsythiae)
Lian Q y ) 10g
g
• Yu Xing Cao 鱼腥草 (Herba Houttuyniae) 15g
• Jie Geng 桔梗 (Radix Platycodonis) 10g
• Gan Cao 甘草 (Radix et Rhizoma Glycyrrhizae) 5g
• Cang Zhu 苍术 (Rhizoma Atractylodis) 10g
• Yi Yi Ren 薏苡仁 (Semen Coicis) 30g
• Guang Huo Xiang 藿香 (Herba Pogostemonis) 5g
• Fu Shen 茯神 (Poria Paradicis) 15g

Wind-Heat Invading Exterior Syndrome

Damp Warmth in Early Phase 濕溫初期
风熱袭表证
• Jin Yin Hua 金银花 (Flos Lonicerae • Xuan Shen 玄参 (Radix Scrophulariae)
Japonicae) 15g 15g • S/sx: muscle aches and pain, poor
• Lian Qiao 连翘 (Fructus Forsythiae) 10g • She Gan 射干 (Rhizoma Belamcandae)
10g
appetite, low grade fever, thick tongue
• Bo He 薄荷 (Herba Menthae) 5g
• Niu Bang Zi 牛蒡子 (Fructus Arctii) 10g • Fang Feng 防风 (Radix Saposhnikoviae) coating
• Ban Xia 法半夏 (Rhizoma Pinelliae) 10g 10g
• Chai Hu 柴胡 (Radix Bupleuri) 10g • Ku Xing Ren 苦杏仁 (Semen
Armeniacae Amarum) 10g
• Huang Qin 黄芩 (Radix Scutellariae)
10g • Qiang Huo 羌活 (Rhizoma et Radix
Notopterygii) 10g
• Ban Lan Gen 板蓝根 (Radix Isatidis)
15g • Cang Zhu 苍术 (Rhizoma Atractylodis)
10g
• Jie Geng 桔梗 (Radix Platycodonis) 10g
• Dou Kou 蔻仁 (Fructus Amomi
• Gan Cao 甘草 (Radix et Rhizoma Rotundus) 6g
Glycyrrhizae) 6g

Damp Heat Obstructing Lung Syndrome

Damp Warmth in Early Phase 濕溫初期
濕熱壅肺証
• Jin Yin Hua 金银花 (Flos Lonicerae • Ku Xing Ren 杏仁 (Semen Armeniacae
Japonicae) 25g Amarum) 10g • S/sx: dry cough, shortness of breath
• Lian Qiao 连翘 (Fructus Forsythiae) 15g • Guang Huo Xiang 藿香 (Herba
• Sheng Ma 升麻 (Rhizoma Cimicifugae) 25g Pogostemonis) 10g
• Dang Gui 当归 (Radix Angelicae Sinensis) • Hou Po 厚朴 (Cortex Magnoliae
15g Officinalis) 6g
• Ban Xia 法半夏 (Rhizoma
( Pinelliae)) 10g • She Gan 射干 (Rhizoma Belamcandae)
• Ju Hong 橘红 (Exocarpium Citri Rubrum) 10g
10g • Zhi Qiao 枳壳 (Fructus Aurantii) 10g
• Fu Ling 茯苓 (Poria) 15g • Zhu Ru 竹茹 (Caulis Bambusae in Taenia)
• Cang Zhu 苍术 (Rhizoma Atractylodis) 15g 10g
• Da Fu Pi 大腹皮 (Pericarpium Arecae) 15g • Ma Huang 炙麻黄 (Herba Ephedrae),
honey-baked 6g
• Chai Hu 柴胡 (Radix Bupleuri) 10g
• Hong Jing Tian 红景天 (Radix et Rhizoma
• Huang Qin 黄芩 (Radix Scutellariae) 15g Rhodiolae Crenulatae) 10g

Lotus Institute of Integrative Medicine, PO Box 92493, City of Industry, CA 91715

Tel: 626-780-7182 • Fax: 626-363-9751 • Website: www.eLotus.org • Email: info@eLotus.org
Shall not be copied, duplicated, or distributed in any format or be used for teaching without prior written consent from Lotus Institute of Integrative Medicine. 11
 Damp Heat Obstructing Lung Syndrome Epidemic Toxins Blocking the Lung
濕熱壅肺証 疫毒闭肺证
• Sang Bai Pi 桑白皮 (Cortex Mori) 15g • Chai Hu 柴胡 (Radix Bupleuri) 10g
• Chuan Bei Mu 川贝 (Bulbus Fritillariae Cirrhosae) • Huang Qin 黄芩 (Radix Scutellariae) 15g • S/sx: fever, severe breathing difficulties,
10g
• Bai Bu 百部 (Radix Stemonae) 10g
•
•
Hou Po 厚朴 (Cortex Magnoliae Officinalis) 10g
Hong Jing Tian 红景天 (Radix et Rhizoma wheezing, severe hypoxemia, dark red
• Yu Xing Cao 鱼腥草 (Herba Houttuyniae) 30g Rhodiolae Crenulatae) 15g
• Lian Qiao 连翘 (Fructus Forsythiae) 15g • Sheng Ma 升麻 (Rhizoma Cimicifugae) 30g tongue, thick tongue coating
• Bai Jiang Cao 败酱草 (Herba cum Radice • Dang Gui 当归 (Radix Angelicae Sinensis) 25g
Patriniae) 15g • Bing Lang 槟榔 (Semen Arecae) 10g
• Yi Yi Ren 薏苡仁 (Semen Coicis) 15g • Cao Guo 草果 (Fructus Tsaoko) 6g
• Mai Dong 麦冬 (Radix Ophiopogonis) 15g • Zhi Mu 知母 (Rhizoma Anemarrhenae) 10g
• Lu Gen 芦根 (Rhizoma Phragmitis) 25g • Bai Shao 芍药 (Radix Paeoniae Alba) 10g
• Dong Gua Zi 冬瓜仁 (Semen Benincasae) 10g • Chao San Xian 炒三仙: Shen Qu (Massa
• Jie Geng 桔梗 (Radix Platycodonis) 10g Medicata Fermentata), Shan Zha (Fructus
• Ku Xing Ren 苦杏仁 (Semen Armeniacae Amarum) Crataegi) and Mai Ya (Fructus Hordei
10g Germinatus), blend & dry-fry together 20g

Epidemic Toxins Blocking the Lung Closed Interior and Abandoned Exterior
疫毒闭肺证 内闭外脱
• Ting Li Zi 葶苈子 (Semen Descurainiae • Cang Zhu 苍术 (Rhizoma Atractylodis) 15g
seu Lepidii) 15g • Jie Geng 桔梗 (Radix Platycodonis) 10g • S/sx: high fever, delirium, restlessness,
• Ma Huang 炙麻黄 (Herba Ephedrae),
honey-fried 10g • Jiang Huang 姜黄 (Rhizoma Curcumae
Longae) 10g
irritability, burning sensations in the chest
• Sheng Ma 升麻 (Rhizoma Cimicifugae)
30g • Chan Tui 蝉蜕 (Periostracum Cicadae) 6g and abdomen, cold hands and feet, hurried
• Dang Gui 当归 (Radix Angelicae Sinensis) • Jiang Can 僵蚕 (Bombyx Batryticatus) 10g
25g • Da Huang 熟大黃 (Radix et Rhizoma breathing ECMO needed.
breathing, needed
• Lu Gen 芦根 (Rhizoma Phragmitis) 25g Rhei), cooked 6g
• Yi Yi Ren 薏米仁 (Semen Coicis) 30g • Yu Xing Cao 鱼腥草 (Herba Houttuyniae)
• Dong Gua Zi 冬瓜仁 (Semen Benincasae) 30g
15g • Jin Yin Hua 金银花 (Flos Lonicerae
• Tao Ren 桃仁 (Semen Persicae) 12g Japonicae) 15g
• Ban Xia 法半夏 (Rhizoma Pinelliae) 10g • Lian Qiao 连翘 (Fructus Forsythiae) 15g
• Gua Lou Pi 瓜蒌皮(Pericarpium
Trichosanthis) 15g • Shi Gao 石膏 (Gypsum Fibrosum) 20g

Closed Interior and Abandoned Exterior Insufficiency of qi and yin, Deficiency of

内闭外脱 Lung and Spleen. 气阴不足，肺脾两虚

‧ 四逆加人参汤、安宫牛黄丸 (Si Ni Jia Ren Shen Tang • S/sx: dry cough, feeling of chest
(Frigid Extremities Decoction plus Ginseng), An Gong Niu
Huang Wan (Calm the Palace Pill with Cattle Gallstone) oppression, shortness of breath, dyspnea
• An Gong Niu Huang Wan (Calm the Palace Pill with upon movement
Cattle Gallstone) plus Ren Shen (Radix et Rhizoma
Ginseng) 15g, Fu Zi (Radix Aconiti Lateralis Praeparata)
15g, Gan Cao (Radix et Rhizoma Glycyrrhizae) 10g, Shi
Chang Pu (Rhizoma Acori Tatarinowii) 10g
• If needed, intravenous infusion of Shenfu 参附 Injection,
Shengmai 生脉 Injection

Lotus Institute of Integrative Medicine, PO Box 92493, City of Industry, CA 91715

Tel: 626-780-7182 • Fax: 626-363-9751 • Website: www.eLotus.org • Email: info@eLotus.org
Shall not be copied, duplicated, or distributed in any format or be used for teaching without prior written consent from Lotus Institute of Integrative Medicine. 12
 Insufficiency of qi and yin, Deficiency of
Lung and Spleen. 气阴不足，肺脾两虚
• Sha Shen 沙参 (Radix Glehniae seu Adenophorae) 15g
• Mai Dong 麦冬 (Radix Ophiopogonis) 15g
• Yu Zhu 玉竹 (Rhizoma Polygonati Odorati) 10g
• Tian Hua Fen 天花粉 (Radix Trichosanthis) 15g
• Xi Yang Shen 西洋参 (Radix Panacis Quinquefolii) 10g
• Wu Wei Zi 五味子 (Fructus Schisandrae Chinensis) 10g
• Si Gua Luo 丝瓜络 (Retinervus Luffae Fructus) 15g
• Bai Bian Dou扁豆 (Semen Lablab Album) 10g
• Sang Ye 桑叶 (Folium Mori) 10g
• Ju Luo 橘络 (Vascular Citri Reticulatae) 5g
• Zi Su Zi 苏子 (Fructus Perillae) 10g
• Zhe Bei Mu 浙贝 (Bulbus Fritillariae Thunbergii) 10g
• Ku Xing Ren 杏仁 (Semen Armeniacae Amarum) 10g
• Gan Cao 甘草 (Radix et Rhizoma Glycyrrhizae) 6g
• Di Long 地龙 (Pheretima) 10g

英文版全文 _ 新型冠状病毒肺炎防控和诊疗指南
https://mp.weixin.qq.com/s/nOAmosQ4YqkXHKdJbBE9GA

Guidance for Corona Virus Disease 2019 Guidance for Corona Virus Disease 2019
• Medical Observation Period 医学观察
• Medical Observation Period 医学观察
• Clinical Treatment Period 临床治疗
• Clinical Treatment Period 临床治疗 – Cold Dampness Stagnating Lungs 寒湿郁肺证
– Damp-Heat Accumulated Lung 湿热蘊肺证
• Recovery Period 恢复期 – Damp-Poison Stagnating Lung 湿毒郁肺证
– Cold Dampness Obstructing Lung 寒湿阻肺证
– Lung Blocked by Epidemic Toxin 疫毒闭肺证
– Flaring Heat in Qi and Ying 气营两燔
– Internal Block and Outward Desertion 内闭外脱
• Recovery Period 恢复期
– Lung and Spleen Qi Deficiency 肺脾气虚证
– Deficiency of Qi and Yin 气阴两虚证

英文版全文 _ 新型冠状病毒肺炎防控和诊疗指南
https://mp.weixin.qq.com/s/nOAmosQ4YqkXHKdJbBE9GA

Lotus Institute of Integrative Medicine, PO Box 92493, City of Industry, CA 91715

Tel: 626-780-7182 • Fax: 626-363-9751 • Website: www.eLotus.org • Email: info@eLotus.org
Shall not be copied, duplicated, or distributed in any format or be used for teaching without prior written consent from Lotus Institute of Integrative Medicine. 13
 Qing Fei Pai Du Tang 清肺排毒汤 Qing Fei Pai Du Tang 清肺排毒汤
(Clear the Lung and Eliminate Toxins Decoction) (Clear the Lung and Eliminate Toxins Decoction)
• Ma Huang (Herba Ephedrae), 9g • Jiang Ban Xia (Rhizoma Pinelliae Praeparatum • Ma Huang Xing Ren Gan Cao Shi Gao Tang 麻杏甘石湯
• Zhi Gan Cao (Radix et Rhizoma Glycyrrhizae cum Zingibere et Alumine), 9g
Praeparata cum Melle), 6g • Sheng Jiang (Rhizoma Zingiberis Recens), 9g (Ephedra, Apricot Kernel, Licorice, Gypsum Decoction)
• Ku Xing Ren (Semen Armeniacae Amarum), 9g • Zi Wan (Radix et Rhizoma Asteris), 9g • Xiao Chai Hu Tang 小柴胡湯
• Shi Gao (Gypsum Fibrosum), 15-30g (pre-decoct) • Kuan Dong Hua (Flos Farfarae), 9g
• Gui Zhi (Ramulus Cinnamomi), 9g • She Gan (Rhizoma Belamcandae), 9g (Minor Bupleurum Decoction)
• Ze Xie (Rhizoma Alismatis), 9g • Xi Xin (Radix et Rhizoma Asari), 6g • She Gan Ma Huang Tang 射干麻黃湯
• Zhu Ling (Polyporus), 9g • Shan Yao (Rhizoma Dioscoreae), 12g
(Belamcanda and Ephedra Decoction)
• Bai Zhu (Rhizoma Atractylodis Macrocephalae), 9g • Zhi Shi (Fructus Aurantii Immaturus), 6g
• Fu Ling (Poria), 15g • Chen Pi (Pericarpium Citri Reticulatae), 6g • Wu Ling San 五苓散
• Chai Hu (Radix Bupleuri), 16g • Guang Huo Xiang (Herba Pogostemonis), 9g (Five-Ingredient Powder with Poria)
• Huang Qin (Radix Scutellariae), 6g

国家中医药管理局; https://mp.weixin.qq.com/s/0U9tAMdfQfrWZz_43Bc0bg 国家中医药管理局; https://mp.weixin.qq.com/s/0U9tAMdfQfrWZz_43Bc0bg

Qing Fei Pai Du Tang 清肺排毒汤 Qing Fei Pai Du Tang 清肺排毒汤
(Clear the Lung and Eliminate Toxins Decoction) (Clear the Lung and Eliminate Toxins Decoction)

• Drink the warm decoction twice daily 40 • 701 patients in 10 provinces:

minutes after meals. Folllow with half to – 130 recovered and discharged
one bowl of rice porridge. – 51 resolution of s/sx
• Dosage
D off Shi Gao
G (Gypsum
(G Fibrosum)
Fib ) – 268 iimprovementt off s/sx
/
should be adjusted based on severity of – 212 stabilization of s/sx
fever. – 94.3% rate of effectiveness

• •
国家中医药管理局; https://mp.weixin.qq.com/s/0U9tAMdfQfrWZz_43Bc0bg 国家中医药管理局; https://mp.weixin.qq.com/s/0U9tAMdfQfrWZz_43Bc0bg

Ma Huang (Herba Ephedrae) Ma Huang (Herba Ephedrae)

• Ephedra sinica, • Ephedra nevadensis • Relieves wheezing

Ephedra intermedia, aka: momon tea and dyspnea, stops
Ephedra equisetina . cough
– Ephedrine alkaloids – No ephedrine alkaloids – Di Longg ((Pheretima))
0.481-2.47% (l- – Ku Xing Ren (Semen
ephedrine, d-
Armeniacae Amarum)
pseudoephedrine, l-
norephedrine, d- – Zi Su Zi (Fructus
norpseudoephedrine, l- Perillae)
methylephedrine, d-
methylpseudoephedrine)

Chen J and Chen T. Chinese Medical Herbology and Pharmacology. Art of Medicine Press. 2004. Chen J and Chen T. Chinese Medical Herbology and Pharmacology. Art of Medicine Press. 2004.

Lotus Institute of Integrative Medicine, PO Box 92493, City of Industry, CA 91715

Tel: 626-780-7182 • Fax: 626-363-9751 • Website: www.eLotus.org • Email: info@eLotus.org
Shall not be copied, duplicated, or distributed in any format or be used for teaching without prior written consent from Lotus Institute of Integrative Medicine. 14
 Xi Xin (Radix et Rhizoma Asari) Kuan Dong Hua (Flos Farfarae)

• Dispels exterior wind-cold • Moistens the Lung,

– Qiang Huo (Rhizoma et descends qi, dissolves
Radix Notopterygii)
phlegm, stops cough
– Fang Feng (Radix
Saposhnikoviae) – Ku Xingg Ren ((Semen
Armeniacae Amarum)
• Warms the lung and
resolves phlegm – Zi Wan (Radix et
Rhizoma Asteris)
– Gan Jiang (Rhizoma
Zingiberis) – Zi Su Zi (Fructus
– Jie Zi (Semen Sinapis) Perillae)

Chen J and Chen T. Chinese Medical Herbology and Pharmacology. Art of Medicine Press. 2004. Chen J and Chen T. Chinese Medical Herbology and Pharmacology. Art of Medicine Press. 2004.

Hubei Provincial Hospital Wuhan Union Hospital Guidance for Covid-19

Prevention Phase Prevention

Early Phase Wind-Heat Invading the Medical Observation

Exterior Syndrome Period

Pneumonia Phase Damp Warmth in Early Clinical Treatment Period

Phase
Damp Heat Obstructing
the Lung Syndrome
Epidemic Toxins Blocking
the Lung
Closed Interior and
Abandoned Exterior • https://www.journalofchinesemedicine.com/acupuncture-in-the-treatment-of-covid-19-an-exploratory-study.html?fbclid=IwAR2dUlmkqaEHnjjP5-
jcJepRq6G2R8BkSWnTE510-axx57HJdRaszd1pgJQ

Recovery Phase Insufficiency of qi and yin, Recovery Period

Deficiency of Lung and
Spleen.

Research Research

• Pharmacological research of single herbs • Pharmacological research of single herbs

• Clinical research of herbal formulas – Huang Qi (Radix Astragali)
– Jin Yin Hua (Flos Lonicerae Japonicae)
– Ban
B Lan G (Radix
L Gen (R di Isatidis)
I tidi )
– Yu Xing Cao (Herba Houttuyniae)
– Xiang Chun Ye (Folium Toonae Sinensis)
– Wu Bei Zi (Galla Chinensis)

Lotus Institute of Integrative Medicine, PO Box 92493, City of Industry, CA 91715

Tel: 626-780-7182 • Fax: 626-363-9751 • Website: www.eLotus.org • Email: info@eLotus.org
Shall not be copied, duplicated, or distributed in any format or be used for teaching without prior written consent from Lotus Institute of Integrative Medicine. 15
 Huang Qi (Radix Astragali) Huang Qi (Radix Astragali)

• Tonifies qi and raises yang • Immunostimulant:

• Tonifies wei (defensive) qi, – Administration of Huang Qi (Radix Astragali) is
consolidates the exterior associated with promotion of T cells.
• Promotes the discharge of – The polysaccharides from Huang Qi (Radix Astragali)
pus andd generates
t fl
flesh
h have been shown to activate B cells.
• Regulates water circulation,
reduces edema
• Relieves numbness and pain
• Qu LL, et al. Astragalus membranaceus injection delayed allograft survival related with CD4+ CD25+ regulatory T cells. Transplant Proc.
2010 Nov;42(9):3793-7.
• Shao BM, et al. A study on the immune receptors for polysaccharides from the roots of Astragalus membranaceus, a Chinese medicinal
herb. Biochem Biophys Res Commun. 2004 Aug 6;320(4):1103-11.

Chen J and Chen T. Chinese Medical Herbology and Pharmacology. Art of Medicine Press. 2004.

Jin Yin Hua (Flos Lonicerae Japonicae) Jin Yin Hua (Flos Lonicerae Japonicae)

• Clears heat • Antibacterial

• Clears heat and • Antiviral
eliminates toxins

•
Chen J and Chen T. Chinese Medical Herbology and Pharmacology. Art of Medicine Press. 2004. Chen J and Chen T. Chinese Medical Herbology and Pharmacology. Art of Medicine Press. 2004.

Jin Yin Hua (Flos Lonicerae Japonicae) Jin Yin Hua (Flos Lonicerae Japonicae)

• Antibacterial: Jin Yin Hua has a broad spectrum • Antiviral: Shuangkangsu, a cyclic peroxide from Jin Yin
of inhibitory actions against Staphylococcus Hua, has significant antiviral activities against influenza
virus and respiratory syncytial. The homosecoiridoid
aureus, beta-hemolytic streptococcus, E. coli,
alkaloids of Jin Yin Hua have antiviral activity against the
Bacillus dysenteriae, Vibrio cholerae, Salmonella influenza virus H3N2 (A/Hanfang/359/95) and coxsackie
typhi, Diplococcus pneumoniae, Diplococcus virus B3. The glucosylated caffeoylquinic acid isomers
meningitidis, Pseudomonas aeruginosa, and from Jin Yin Hua shows inhibitory activity against
Mycobacterium tuberculosis. Chlorogenic acid coxsackie virus B3.
• Yu DQ, et al. The structure and absolute configuration of Shuangkangsu: a novel natural cyclic peroxide from
and isochlorogenic acid have the strongest Lonicera japonica (Thunb.). J Asian Nat Prod Res. 2008 Sep-Oct;10(9-10):851-6.
• Yu Y, et al. Homosecoiridoid alkaloids with amino acid units from the flower buds of Lonicera japonica. J Nat Prod.
antibiotic effects. •
2013 Dec 27;76(12):2226-33.
Yu Y, et al. Glucosylated caffeoylquinic acid derivatives from the flower buds of Lonicera japonica. Acta Pharm Sin
B. 2015 May;5(3):210-4.

•• Xin Yi Xue (New Medicine), 1975; 6(3):155. •

• Jiang Xi Xin Yi Yao (Jiangxi New Medicine and Herbology); 1960;(1):34.

Lotus Institute of Integrative Medicine, PO Box 92493, City of Industry, CA 91715

Tel: 626-780-7182 • Fax: 626-363-9751 • Website: www.eLotus.org • Email: info@eLotus.org
Shall not be copied, duplicated, or distributed in any format or be used for teaching without prior written consent from Lotus Institute of Integrative Medicine. 16
 Jin Yin Hua (Flos Lonicerae Japonicae) Ban Lan Gen (Radix Isatidis)

• Jin Yin Hua inhibits SARS-CoV • Clears heat,

replication at non-toxic concentration. eliminates toxins,
cools blood and
benefits the throat

• Li Y, Ooi LS, Wang H, But PP, Ooi VE. Antiviral activities of medicinal herbs traditionally used in southern mainland China. Phytother
Res 2004; 18: 718-722.

•
Chen J and Chen T. Chinese Medical Herbology and Pharmacology. Art of Medicine Press. 2004.

Ban Lan Gen (Radix Isatidis) Ban Lan Gen (Radix Isatidis)

• Antibacterial • Antiviral: Ban Lan Gen exerts antiviral effect

against influenza A virus, seasonal influenza
• Antitoxin virus, human or avian influenza virus, novel
• Antiviral swine-originating influenza virus, Japanese
encephalitis virus
virus, adenovirus
adenovirus, herpes simplex
• Anti-inflammatory virus, hepatitis B virus, human cytomegalovirus,
swine pseudorabies virus, coxsackie virus B3.
• Hsuan SL, et al. The cytotoxicity to leukemia cells and antiviral effects of Isatis indigotica extracts on pseudorabies
virus. J Ethnopharmacol. 2009 May 4;123(1):61-7. Epub 2009 Mar 4.
• Chen C, et al. Zhongyao Yaolixue, 2nd Edition. Shanghai Science and Technology Publishing, 2015; 88-90.
• Yang Z, et al. Antiviral activity of Isatis indigotica root-derived clemastanin B against human and avian influenza A
and B viruses in vitro. Int J Mol Med. 2013 Apr;31(4):867-73.
• Wang XL, et al. Chemical consitituents from root of Isatis indigotica. Zhongguo Zhong Yao Za Zhi. 2013
Apr;38(8):1172-82.

• •
Chen J and Chen T. Chinese Medical Herbology and Pharmacology. Art of Medicine Press. 2004.

Ban Lan Gen (Radix Isatidis) Yu Xing Cao (Herba Houttuyniae)

• Ban Lan Gen shows direct effect to inhibit • Clears heat,

the enzyme activity of SARS coronavirus. eliminates toxins
and drains pus
• Promotes
P t normall
urination

• Lin CW, Tsai FJ, Tsai CH, Lai CC, Wan L, Ho TY, et al. AntiSARS coronavirus 3C-like protease effects of Isatis indigotica root and plant-
derived phenolic compounds. Antiviral Res 2005; 68: 36-42.

•
Chen J and Chen T. Chinese Medical Herbology and Pharmacology. Art of Medicine Press. 2004.

Lotus Institute of Integrative Medicine, PO Box 92493, City of Industry, CA 91715

Tel: 626-780-7182 • Fax: 626-363-9751 • Website: www.eLotus.org • Email: info@eLotus.org
Shall not be copied, duplicated, or distributed in any format or be used for teaching without prior written consent from Lotus Institute of Integrative Medicine. 17
 Yu Xing Cao (Herba Houttuyniae) Yu Xing Cao (Herba Houttuyniae)

• Antibacterial • Antiviral and virucidal: Yu Xing Cao has

antiviral effect against numerous types of
• Antiviral
viruses: herpes simplex virus (HSV), acyclovir-
• Anti-inflammatory resistant HSV, H1N1 influenza virus,
pseudorabies herpes, influenza virus, and
human immunodeficiency virus.
• Chiang LC, et al. Anti-Herpes simplex virus activity of Bidens pilosa and Houttuynia cordata. Am J Chin Med.
2003;31(3):355-62.
• Chou SC, et al. The constituents and their bioactivities of Houttuynia cordata. Chem Pharm Bull (Tokyo). 2009
Nov;57(11):1227-30.
• Ren X, et al. The effect of Houttuynia cordata injection on pseudorabies herpesvirus (PrV) infection in vitro. Pharm
Biol. 2011 Feb;49(2):161-6.
• Hayashi K, et al. Virucidal effects of the steam distillate from Houttuynia cordata and its components on HSV-1,
influenza virus, and HIV. Planta Med. 1995 Jun;61(3):237-41.
• •
Chen J and Chen T. Chinese Medical Herbology and Pharmacology. Art of Medicine Press. 2004.

Yu Xing Cao (Herba Houttuyniae)

• The water extract of Yu Xing Cao also

demonstrates antiviral effect to treat
coronavirus in severe acute respiratory
syndrome (SARS).
(SARS) Yu Xing Cao exhibits
significant inhibitory effects on the virus,
and increases the proliferation of
lymphocytes in a dose-dependent manner.
• Lau KM, et al. Immunomodulatory and anti-SARS activities of Houttuynia cordata. Institute of Chinese Medicine, The Chinese University of
Hong Kong, Shatin, Hong Kong SAR, China. J Ethnopharmacol. 2008 Jun 19;118(1):79-85.
Xiang Chun Ye 香椿葉 (Folium Toonae Sinensis)
https://www.sciencedirect.com/science/article/pii/S0378874108004200?via%3Dihub

Xiang Chun Ye (Folium Toonae Sinensis) Xiang Chun Ye (Folium Toonae Sinensis)

• Xiang Chun Ye clears • Xiang Chun Ye (Folium Toonae Sinensis)

heat and eliminates contains a compound (TSL-1) that
toxins to treat Lung selectively bind to SARS-CoV virus to
heat with cough.
inhibit the cellular entry of the virus into the
• It also clears heat and
host cells.
eliminates toxins from
the skin to treat sores
and abscesses. 香椿葉
• Chen CJ, Michaelis M, Hsu HK, Tsai CC, Yang KD, Wu YC, et al. Toona sinensis Roem tender leaf extract inhibits SARS coronavirus
replication. J Ethnopharmacol 2008; 120: 108-111.

•
Chen J and Chen T. Chinese Medical Herbology and Pharmacology. Art of Medicine Press. 2004.

Lotus Institute of Integrative Medicine, PO Box 92493, City of Industry, CA 91715

Tel: 626-780-7182 • Fax: 626-363-9751 • Website: www.eLotus.org • Email: info@eLotus.org
Shall not be copied, duplicated, or distributed in any format or be used for teaching without prior written consent from Lotus Institute of Integrative Medicine. 18
 Xiang Chun Ye (Folium Toonae Sinensis) Xiang Chun Ye (Folium Toonae Sinensis)

• Xiang Chun Ye inhibits the replication of • Xiang Chun Ye is the most effective herb
coronavirus to treat severe acute of all tested from Shang Han Lun
respiratory syndrome (SARS). (Discussion of Cold-Induced Disorders)
and Wen Bing Tiao Bian (Systematic
Differentiation of Warm Disease).

• Chen CJ, et al. Toona sinensis Roem tender leaf extract inhibits SARS coronavirus replication. J Ethnopharmacol. 2008 Oct 30;120(1):108-
11.

• Chen CJ, et al. Toona sinensis Roem tender leaf extract inhibits SARS coronavirus replication. J Ethnopharmacol. 2008 Oct 30;120(1):108-
11.

• •

Wu Bei Zi (Galla Chinensis) Wu Bei Zi (Galla Chinensis)

• Contains leakage of lung • Antiviral: Administration of moronic acid from Wu

qi, clears deficiency fire Bei Zi is associated with antiviral effect against
• Binds the intestines Epstein-Barr virus via the inhibition of the lytic
• Consolidates kidney jing cycle. Wu Bei Zi also shows antiviral activities
(
(essence) ) against HIV
HIV-11 virus by inhibiting HIV
HIV-1
1 viral
• Restrains sweating replication. The main active compounds include
• Stops bleeding
rhuscholide A, betulonic acid, moronic acid, and
others.
• Eliminates toxins and • Chang FR, et al. Inhibition of the Epstein-Barr virus lytic cycle by moronic acid. Graduate Institute of Natural Products, Antiviral Res. 2010
Mar;85(3):490-5.
reduces swelling • Wang RR, et al. Anti-HIV-1 activities of compounds isolated from the medicinal plant Rhus chinensis. J Ethnopharmacol. 2008 May
8;117(2):249-56.
• Gu Q, et al. A new benzofuranone and anti-HIV constituents from the stems of Rhus chinensis. Planta Med. 2007 Mar;73(3):279-82.

Chen J and Chen T. Chinese Medical Herbology and Pharmacology. Art of Medicine Press. 2004.

Wu Bei Zi (Galla Chinensis) Research

• Wu Bei Zi (Galla Chinensis) contains tetra-O- • Clinical research of herbal formulas

galloyl-β-D-glucose (TGG) and luteolin, were – Yu Ping Feng San (Jade Windscreen Powder)
identified to exhibit prominent anti-SARS virus
activity.
• These natural molecules bound avidly with the
surface spike protein of SARS virus and thus
interfered with the entry of the virus to its host
cells.
• Yi L, Li Z, Yuan K, Qu X, Chen J, Wang G, et al. Small molecules blocking the entry of severe acute respiratory syndrome coronavirus into
host cells. J Virol 2004; 78: 1133411339.

Lotus Institute of Integrative Medicine, PO Box 92493, City of Industry, CA 91715

Tel: 626-780-7182 • Fax: 626-363-9751 • Website: www.eLotus.org • Email: info@eLotus.org
Shall not be copied, duplicated, or distributed in any format or be used for teaching without prior written consent from Lotus Institute of Integrative Medicine. 19
 Prevention of SARS Prevention of SARS

• The Use of an Herbal Formula by Hospital • Study: 16,437 hospital care workers, including
Care Workers During the Severe Acute doctors, nurses and others in Hong Kong
Respiratory Syndrome Epidemic in Hong – 1,063 herb group
Kong to Prevent Severe Acute Respiratory – 15,374
15 374 in non-herb group
Syndrome Transmission, Relieve Influenza-
Related Symptoms, and Improve Quality of
Life: A Prospective Cohort Study

• Lau J, Leung P, Wong E, Fong C, Cheng K, Zhang S, et al. The use of an herbal formula by hospital • Lau J, Leung P, Wong E, Fong C, Cheng K, Zhang S, et al. The use of an herbal formula by hospital
care workers during the severe acute respiratory syndrome epidemic in Hong Kong to prevent severe care workers during the severe acute respiratory syndrome epidemic in Hong Kong to prevent severe
acute respiratory. J Alternat Complement Med 2005;11:49-55. acute respiratory. J Alternat Complement Med 2005;11:49-55.

Prevention of SARS Prevention of SARS

• Huang Qi 黃耆(Radix Astragali)
• Bai Zhu 白朮(Rhizoma Atractylodis Macrocephalae)
• Yu Ping Feng San (Jade Windscreen Powder)
• Fang Feng 防風 (Radix Saposhnikoviae) • Sang Ju Yin (Mulberry Leaf and Chrysanthemum
• Sang Ye 桑葉 (Folium Mori)
• Ju Hua 菊花 (Flos Chrysanthemi)
Decoction)
• Bo He 薄荷 (Herba Menthae) • Da Qing Ye (Folium Isatidis)
• Lian Qiao 連翹 (Fructus Forsythiae)
• Jie Geng 桔梗 (Radix Platycodonis) • Huang Qin (Radix Scutellariae)
• Ku Xing Ren 苦杏仁 (Semen Armeniacae Amarum)
• Lu Gen 蘆根 (Rhizoma Phragmitis)
• Gan Cao 甘草 (Radix et Rhizoma Glycyrrhizae) • Take the herbal supplement daily for 2 weeks.
• Da Qing Ye 大青葉 (Folium Isatidis)
• Huang Qin 黃芩 (Radix Scutellariae)
• Lau J, Leung P, Wong E, Fong C, Cheng K, Zhang S, et al. The use of an herbal formula by hospital
• Lau J, Leung P, Wong E, Fong C, Cheng K, Zhang S, et al. The use of an herbal formula by hospital care workers during the severe acute respiratory syndrome epidemic in Hong Kong to prevent severe
care workers during the severe acute respiratory syndrome epidemic in Hong Kong to prevent severe acute respiratory. J Alternat Complement Med 2005;11:49-55.
acute respiratory. J Alternat Complement Med 2005;11:49-55.

Prevention of SARS Prevention of SARS

• Results: • Study: 3,561 medical staff in hospital 1, and 163

– 1,063 herb group; 0 infected (0%) hospitals in hospitals 2, in Beijing China.
– 15,374 in non-herb group; 64 infected (0.4%) • Rx: Yu Ping Feng San (Jade Windscreen
– P = 0.035
0 035 Powder) + heat
heat-clearing
clearing and detoxifying herbs for
6 days and 12-25 days.
• Note: Among 1,063 who took herbs, 19 (1.8%) with minor • Results: 0 infection among participants
side effects such as diarrhea, sore throat, dizziness and
nausea
• Xu J, Jiang X, Liu F, Zhang W. Clinical observation of Yinhua Yupingfeng Decoction in preventing SARS: analysis of 163 fi rst-line medical
staff. Conference on the prevention and treatment of SARS in integrated traditional Chinese and Western medicine in five provinces of North
China. Beijing, 2006:158-159.
• Zhang L, Chen B, Zeng H. Analysis of fangdu decoction on SARS and zero infection in hospital. Chin J Hosp Pharm (Chin) 2005;25:59-60.

• Lau J, Leung P, Wong E, Fong C, Cheng K, Zhang S, et al. The use of an herbal formula by hospital
care workers during the severe acute respiratory syndrome epidemic in Hong Kong to prevent severe
acute respiratory. J Alternat Complement Med 2005;11:49-55.

Lotus Institute of Integrative Medicine, PO Box 92493, City of Industry, CA 91715

Tel: 626-780-7182 • Fax: 626-363-9751 • Website: www.eLotus.org • Email: info@eLotus.org
Shall not be copied, duplicated, or distributed in any format or be used for teaching without prior written consent from Lotus Institute of Integrative Medicine. 20
 吴有性 Wū Yŏu-Xìng, 1580’s-1660’s

Where Do We Go From Here?

Rè Bìng 熱病(Hot Diseases)

Huang Di Nei Jing
(Yellow Emperor’s Inner Classic),
1st or 2nd Century A.D.

References (WHO, NIH, CDC, FDA) References (WM)

Organization Link Organization Link
Elsevier https://www.elsevier.com/connect/coronavirus-information-
WHO https://www.who.int/emergencies/diseases/novel- center
coronavirus-2019 Johns Hopkins https://coronavirus.jhu.edu/
University
NIH https://www nih gov/health-information/coronavirus
https://www.nih.gov/health-information/coronavirus New England https://www nejm org/doi/full/10 1056/NEJMoa2001017
https://www.nejm.org/doi/full/10.1056/NEJMoa2001017
Journal of Medicine
CDC https://www.cdc.gov/coronavirus/2019-ncov/about/index.html
JAMA https://jamanetwork.com/journals/jama/pages/coronavirus-alert
The Lancet https://www.thelancet.com/journals/lancet/article/PIIS0140-
FDA https://www.fda.gov/emergency-preparedness-and- 6736(20)30305-6/fulltext
response/mcm-issues/novel-coronavirus-2019-ncov
Internet Book of https://emcrit.org/ibcc/covid19/?fbclid=IwAR31Xy-
Critical Care vkhL39xSWNAqkx3fECRR2yQLVbyWD2EOOoDG7FYv2WXqd
Qm7Lu_U#biology

Lotus Institute of Integrative Medicine, PO Box 92493, City of Industry, CA 91715

Tel: 626-780-7182 • Fax: 626-363-9751 • Website: www.eLotus.org • Email: info@eLotus.org
Shall not be copied, duplicated, or distributed in any format or be used for teaching without prior written consent from Lotus Institute of Integrative Medicine. 21
 References (TCM) Reference
Organization Link
• John K. Chen, Ph.D., Pharm.D., O.M.D., L.Ac.
Lotus Institute https://www.elotus.org/articles
• drjohnchen@gmail.com
Guidance of Covid-19 https://mp.weixin.qq.com/s/Wikq6hrnKIZl7Iumg2bq5
7th Edition A
Guidance off Covid-19
G C https://mp.weixin.qq.com/s/nOAmosQ4YqkXHKdJb
// / / O Q
English Edition BE9GA

Acupuncture in the https://www.journalofchinesemedicine.com/acupunct

Treatment of COVID-19 ure-in-the-treatment-of-covid-19-an-exploratory-
study.html?fbclid=IwAR2dUlmkqaEHnjjP5-
jcJepRq6G2R8BkSWnTE510-
axx57HJdRaszd1pgJQ

Single/Individual Herbs Herbal Formulas

 To read articles by today’s speaker, watch online  More information on the classic single herbs mentioned in
this seminar/webinar can be found in the
videos, or to see his/her complete Chinese Medical Herbology and Pharmacology
seminar/webinar schedule for this year, please
visit www.elotus.org  More information on the classic formulas can be found in
the Chinese Herbal Formulas and Applications

 Collection formulas can be found in the eLotus

Clinical Manual of Oriental Medicine

 All the above texts are available through www.elotus.org

Lotus Institute of Integrative Medicine, PO Box 92493, City of Industry, CA 91715

Tel: 626-780-7182 • Fax: 626-363-9751 • Website: www.eLotus.org • Email: info@eLotus.org
Shall not be copied, duplicated, or distributed in any format or be used for teaching without prior written consent from Lotus Institute of Integrative Medicine. 22
  Herbs mentioned in this seminar/webinar, are
available through our sponsor Evergreen
Herbs & Medical Supplies. Please contact
them for a catalog and see how they can help
your practice. This webinar is sponsored by:

Evergreen Herbs & Medical Supplies

Toll-free Tel: 866-473-3697
Website: www.evherbs.com
Email: sales@evherbs.com

Lotus Institute of Integrative Medicine, PO Box 92493, City of Industry, CA 91715

Tel: 626-780-7182 • Fax: 626-363-9751 • Website: www.eLotus.org • Email: info@eLotus.org
Shall not be copied, duplicated, or distributed in any format or be used for teaching without prior written consent from Lotus Institute of Integrative Medicine. 23
Evergreen Herbs is not just an Herbal company, we are an
environmentally friendly, health conscious contributor to the health-
care community at large. Evergreen was founded by Dr. John Chen
and Tina Chen, siblings and coauthors of the Chinese Medical
Herbology and Pharmacology, and the Chinese Herbal Formulas
and Applications books.
Evergreen is a family business that is run by professionals like you
who care about Chinese medicine. And as a family business, we
have the well-being and satisfaction of our customers at the top
of our list. We care about the quality of our herbs, because we
care about our consumers, and have your best interest at heart.
Our goal is to support you in improving your clinical skills, and
enhancing the well-being of your patients.
To learn more about Evergreen Herbs and our products, please