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Named Reactions

The document lists over 100 named organic reactions categorized by their common name. Some of the reactions included are the Diels-Alder reaction, Grignard reaction, Claisen condensation, Wittig reaction, Michael addition, and Aldol reaction. The reactions involve processes such as addition, elimination, rearrangement, substitution, oxidation, and reduction to transform functional groups and form new carbon-carbon bonds in organic compounds.

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0% found this document useful (0 votes)
363 views19 pages

Named Reactions

The document lists over 100 named organic reactions categorized by their common name. Some of the reactions included are the Diels-Alder reaction, Grignard reaction, Claisen condensation, Wittig reaction, Michael addition, and Aldol reaction. The reactions involve processes such as addition, elimination, rearrangement, substitution, oxidation, and reduction to transform functional groups and form new carbon-carbon bonds in organic compounds.

Uploaded by

scicws1133
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© Attribution Non-Commercial (BY-NC)
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Acyloin Ester Condensation: -Hydroxyketones from carboxylic esters

Aldol Reaction: Reaction of aldehydes or ketones to give -hydroxy carbonyl compounds

Alkene Metathesis: Exchange of alkylidene groups of alkenesmetathesis of olefins

Arbuzov Reaction: Alkyl phosphonates from phosphites

ArndtEistert Synthesis: Chain elongation of carboxylic acids by one methylene group

BaeyerVilliger Oxidation: Oxidation of ketones to carboxylic esters

BamfordStevens Reaction: Alkenes from tosylhydrazones

Barton Reaction: Photolysis of nitrite esters

BaylisHillman Reaction: Hydroxyalkylation of activated alkenes

Beckmann Rearrangement: Rearrangement of oximes to give Nsubstituted carboxylic amides

Benzidine Rearrangement: Rearrangement of hydrazobenzene to yield benzidine

Benzilic Acid Rearrangement: Rearrangement of 1,2-diketones to give hydroxy carboxylic acids

Benzoin Condensation: Benzoins from aromatic aldehydes

Bergman Cyclization: Cyclization of enediynes

Birch Reduction: Partial reduction of aromatic compounds

Blanc Reaction: Chloromethylation of aromatic compounds

Bucherer Reaction: Interconversion of naphtholes and naphthylamines

Cannizzaro Reaction: Disproportionation of aldehydes

Chugaev Reaction: Formation of olefins from xanthates

Claisen Ester Condensation: Formation of -keto esters from carboxylic esters

Claisen Rearrangement: Rearrangement of allyl vinyl ethers or allyl aryl ethers

Clemmensen Reduction: Reduction of aldehydes and ketones to methylene


compounds

Cope Elimination Reaction: Olefins from amine oxides

Cope Rearrangement: Isomerization of 1,5-dienes

CoreyWinter Fragmentation: Olefins from vicinal diols

Curtius Reaction: Isocyanates from acyl azides

1,3-Dipolar Cycloaddition: Five-membered heterocycles through a cycloaddition reaction

[2+2 ] Cycloaddition: Photochemical dimerization of alkenes

Darzens Glycidic Ester Condensation: ,-Epoxycarboxylic esters from aldehydes or ketones and -halo esters.

Delepine Reaction: Primary amines through reaction of alkyl halides with hexamethylenetetramine

Diazo Coupling: Coupling reaction of diazonium ions with electron-rich aromatic compounds

Diazotization: Diazonium salts from primary aromatic amines

DielsAlder Reaction: [4 + 2] Cycloaddition of diene and dienophile

Di-p-Methane Rearrangement: Photochemical rearrangement of 1,4-dienes to vinylcyclopropanes

Dotz Reaction: Benzo-anellation via chromium carbene complexes

Elbs Reaction: Oxidation of phenols by peroxodisulfate

Ene Reaction: Addition of a double bond to an alkene with allylic hydrogen

Ester Pyrolysis: Alkenes by pyrolysis of carboxylic esters

Favorskii Rearrangement: Carboxylic esters from -haloketones

Finkelstein Reaction: Exchange of the halogen in alkyl halides

Fischer Indole Synthesis: Indoles from aryl hydrazones

FriedelCrafts Acylation: Acylation of aromatic compounds

FriedelCrafts Alkylation: Alkylation of aromatic compounds

Friedlander Quinoline Synthesis: Condensation of o-aminobenzaldehydes with -methylene carbonyl compounds

Fries Rearrangement: Acylphenols from phenyl esters

Gabriel Synthesis: Primary amines from N-substituted phthalimides

Gattermann Synthesis: Formylation of aromatic compounds

Glaser Coupling Reaction: Coupling of terminal alkynes

Glycol Cleavage: Oxidative cleavage of vicinal diols

GombergBachmann Reaction: Synthesis of biaryls

Grignard ReactionL: Addition of organomagnesium compounds to polarized multiple bonds

Haloform Reaction: Oxidative cleavage of methyl ketones

Hantzsch Pyridine Synthesis: 1,4-Dihydropyridines from condensation of ketoesters with aldehydes and ammonia

Heck Reaction: Arylation or vinylation of alkenes

HellVolhardZelinskii Reaction: -Halogenation of carboxylic acids

Hofmann Elimination Reaction: Alkenes from amines

Hofmann Rearrangement: Primary amines from carboxylic amides

Hunsdiecker Reaction: Alkyl bromides from carboxylates

Hydroboration: Addition of boranes to alkenes

Japp-Klingemann Reaction: Arylhydrazones from reaction of -dicarbonyl compounds with arenediazonium salts

Knoevenagel Reaction: Condensation of an aldehyde or ketone with an active methylene compound

Knorr Pyrrole Synthesis: Formation of pyrroles by condensation of ketones with -aminoketones

Kolbe Electrolytic Synthesis: Electrolysis of carboxylate salts

Kolbe Synthesis of Nitriles: Nitriles from alkyl halides

KolbeSchmitt Reaction: Carboxylation of phenolates/synthesis of salicylic acid

LeuckartWallach Reaction: Reductive alkylation of amines

Lossen Reaction: Isocyanates from hydroxamic acids

Malonic Ester Synthesis: Alkylation of malonic esters

Mannich Reaction: Aminomethylation of CH-acidic compounds

McMurry Reaction: Reductive coupling of aldehydes or ketones

MeerweinPonndorfVerley Reduction: Reduction of aldehydes and ketones with aluminum isopropoxide

Michael Reaction: 1,4-Addition to ,-unsaturated carbonyl compounds

Mitsunobu Reaction: Esterification of an alcohol with carboxylic acid in the presence of dialkyl azodicarboxylate and triphenylphosphine

Nazarov Cyclization: Cyclization of divinyl ketones to yield cyclopentenones

Neber Rearrangement: -Amino ketones from ketoxime tosylates

Nef Reaction: Carbonyl compounds from nitro alkanes

Norrish Type I Reaction: Photochemical cleavage of aldehydes and ketones

Norrish Type II Reaction: Photochemical reaction of aldehydes or ketones bearing -hydrogens

Ozonolysis: Cleavage of a carboncarbon double bond by reaction with ozone

PaternoBuchi Reaction: Cycloaddition of a carbonyl compound to an alkene

PausonKhand Reaction: Synthesis of cyclopentenones by a formal [2 C 2 C 1]cycloaddition

Perkin Reaction: Condensation of aromatic aldehydes with carboxylic anhydrides

Peterson Olefination: Synthesis of alkenes from ketones or aldehydes

Pinacol Rearrangement: Rearrangement of vicinal diols

Prilezhaev Reaction: Epoxidation of alkenes

Prins Reaction: Addition of formaldehyde to alkenes

RambergBacklund Reaction: Conversion of -halosulfones to alkenes

Reformatsky Reaction: Synthesis of -hydroxy esters

ReimerTiemann Reaction: Formylation of aromatic substrates with chloroform

Robinson Annulation: Annulation of a cyclohexenone ring

Rosenmund Reduction: Aldehydes by reduction of acyl chlorides

Sakurai Reaction: Conjugate addition of an allylsilane to an ,-unsaturated ketone

Sandmeyer Reaction: Conversion of arenediazonium salts into aryl halides

Schiemann Reaction: Aryl fluorides from arenediazonium fluoroborates

Schmidt Reaction: Reaction of carboxylic acids, aldehydes or ketones with hydrazoic acid

Sharpless Epoxidation: Asymmetric epoxidation of allylic alcohols

SimmonsSmith Reaction: Cyclopropanes from alkenes

Skraup Quinoline Synthesis: Quinolines by reaction of anilines with glycerol

Stevens Rearrangement: Tertiary amines from quaternary ammonium salts by migration of an alkyl group

Stille Coupling Reaction: Coupling reaction of organotin compounds with carbon electrophiles

Stork Enamine Reaction: Alkylation and acylation of enamines

Strecker Synthesis: -Amino acids from aldehydes or ketones

Suzuki Reaction: Palladium-catalyzed cross-coupling with organoboron compounds

Swern Oxidation: Oxidation of alcohols by activated dimethyl sulfoxide

TiffeneauDemjanov Reaction: Ring enlargement of cyclic -amino alcohols

Vilsmeier Reaction: Formylation of aromatic compounds and of alkenes

Vinylcyclopropane Rearrangement: Cyclopentenes by rearrangement of vinylcyclopropanes

WagnerMeerwein Rearrangement: Rearrangement of the carbon skeleton via carbenium ions

Weiss Reaction: A synthesis of the bicyclo[3.3.0]octane skeleton

Willgerodt Reaction: -Arylalkane carboxylic amides from aryl alkyl ketones

Williamson Ether Synthesis: Ethers by reaction of alkyl halides with alkoxides

Wittig Reaction: Alkenes (olefins) from reaction of phosphonium ylides with aldehydes or ketones

Wittig Rearrangement: Rearrangement of ethers to yield alcohols

WohlZiegler Bromination: Allylic bromination with N-bromosuccinimide

Wolff Rearrangement: Ketenes from -diazo ketones

WolffKishner Reduction: Hydrocarbons by reduction of aldehydes or ketones

Wurtz Reaction: Hydrocarbons by coupling of alkyl halides

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