Specialised Print Applications Part 3
Specialised Print Applications Part 3
MODULE 3
3D PRINTING
NANOGRAPHY
6103- Specialized Printing Applications
3D PRINTING
INTRODUCTION:
There are typically four types of manufacturing processes
1 Joining processes are characterized by their ability to
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grinding.
These processes are either performed manually or more
commonly, driven by computer numerical control (CNC).
4 Additive manufacturing processes, in contrast to the
subtractive process, build objects by adding material
one layer at a time, with each successive layer bonding
to the preceding layer until the part is complete.
This method is also called as 3D printing or Rapid
Prototyping.
3D PRINTING- PRINCIPLE AND CHARACTERISTICS
3D printing is a process that creates a physical object from a
digital design. There are different 3D printing technologies and
materials you can print with, but all are based on the same
principle: a digital model is turned into a solid three-
dimensional physical object by adding material layer by layer.
3D printing does not constitute a single technology but a set of
manufacturing processes, very different from each other, that
share three common characteristics:
1. They are manufacturing processes by addition of material to
construct a solid three-dimensional object.
2. The object is constructed by superimposing successive layers
of material.
3. The object is made from a digital 3D model.
3D PRINTING WORKFLOW
The starting point for any 3D printing process is obtaining a virtual design of the object,
which can either be created using a variety of 3D software programs, like 3D CAD, or
6103- Specialized Printing Applications
scanned with a 3D scanner. The files are saved in STL or OBJ file form.
The model is then into layers, thereby converting the design into a file readable by
the 3D printer.
Toolpath is calculated for each layer and the machine code or G-Code is generated.
Which contains the information about the Thickness, Holes or gaps, Angles and overhang in
the design. This code is the translation of the piece into instructions that the machine can
understand.
Once the G-Code has being obtained the process of 3D printing can be implemented. The
G-Code is sent to the machine, and the machine starts to work.
Extracting pieces: When the printer has finished printing, it is the moment to implement the
process of extracting the piece/s.
6103- Specialized Printing Applications
For a lot of printed pieces, a finishing process is needed, that varies along the kind of
technology and kind of machine. For some technologies and machines this process is
necessary which includes removing support structures, Curing, Polishing, Sanding and
Coating.
3D PRINTING TECHNOLOGIES
Several printing technologies are available for producing 3D prints using various materials:
6103- Specialized Printing Applications
a time.
For each layer, the laser beam traces a cross-section of
the part pattern on the surface of the liquid resin.
Exposure to the ultraviolet laser light cures and solidifies
the pattern traced on the resin and joins it to the layer
below.
After the pattern has been traced, the elevator platform
descends by a distance equal to the thickness of a single
layer. Then, a resin-filled blade sweeps across the cross
section of the part, re-coating it with fresh material. On
this new liquid surface, the subsequent layer pattern is
traced, joining the previous layer. And the process is
repeated until the model is finished.
After print, the object is immersed in a chemical bath in order to be cleaned of excess resin
and are subsequently cured in an ultraviolet oven
The design for this method requires supporting structures which serve to attach the part to
the elevator platform, prevent deflection due to gravity and hold the cross sections in place
so that they resist lateral pressure from the re-coater blade.
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The primary difference is that the heat and precision of the laser fully melt the particles of
material, and the cooling will fuse back together to create the final solid structure.
Materials used:
Aluminum, Titanium, Stainless Steel, Cobalt Chrome
2. DMLS (Direct Metal Laser Sintering)
In principle, this is an SLM technology specifically for metals. The core difference is that
DMLS sinters particles of metal powder, which produces parts that have a higher porosity
than those produced by standard SLM.
Materials:
Stainless Steel, Maraging Steel, Cobalt Chromium, Aluminium, Titanium
Pros:
One of the key advantages of this process is that the powder
bed serves as an in-process support structure for overhangs
and undercuts.
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Pros:
Produce larger-scaled models.
Usually inexpensive.
Fast and accurate.
Cons:
Need for decubing, which requires a lot of labor.
Source: 1. 3D Printing and Additive Manufacturing Technologies Springer, L. Jyothish Kumar, Pulak M. Pandey, David Ian Wimpenny.
2. The 3D printing handbook: Technologies, design and applications- Ben redwood, Filemon Schoffer, Brian Garret
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3D BIOPRINTING &
NANO SCALE 3D PRINTING
3D BIOPRINTING
3D bioprinting is an additive manufacturing process that uses bioinks to print living cells
developing structures layer-by-layer which imitate the behavior and structures of natural
tissues. Bioinks, that are used as a material in bioprinting, are made of natural or synthetic
6103- Specialized Printing Applications
biomaterials that can be mixed with living cells. The technology and bio printed structures
enable researchers to study functions of the human body in vitro.
The first steps in 3D printing were taken in 1980s, when in 1984 Charles Hull filed a patent
for the first commercial 3D printing technology. This has been a symbol of the birth of 3D
printing, and it created the base for 3D bioprinting as well. Bioprinting came into picture in
1988, when Robert J. Klebe used inkjet printer for printing cells. After these first steps, the
field has constantly evolved, and new methods and techniques have been discovered.
This process is a multidisciplinary area of interconnection between life sciences and
engineering. Through the combination of cells, growth factors, and biomaterials, and the
principles of additive manufacturing-the creation of 3D structure layer by layer- using Bio-
Inks.
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1. Pre-bioprinting. This involves creating a digital file for the printer to read. Today, these
files are often based on CT and MRI scans. Researchers prepare cells and mix them with
their bioink, using a live-cell imaging system to ensure there are enough cells to bioprint a
tissue model successfully.
2. Bioprinting. Researchers load the cell-laden bioink into a cartridge and choose one or
multiple printheads, depending on the structure trying to build. Developing different
types of tissue requires researchers to use different types of cells, bioinks and equipment.
3. Post-bioprinting. Most structures are crosslinked to become fully stable. Crosslinking is
usually done by treating the construct with either ionic solution or UV light the
composition helps researchers determine what kind of crosslinking to use. Then the cell-filled
constructs are placed inside an incubator for cultivation.
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Source:- Journal of Functional Biomaterials: 3D Bioprinting Technology and Hydrogels Used in the Process
Preparation
3D imaging: Similarly to what 3D scanning is to
conventional 3D printing, normal computed
tomography (CT) and magnetic resonance imaging
(MRI) scans are utilized to get as much information as
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Post-Bioprinting
Crosslinking: Once printed, the materials are still in a relatively sluggish state, so an extra
step is necessary to properly solidify and blend them together. This is known as crosslinking,
and an essential step to ensure the mechanical and chemical properties of the printed
structure. Crosslinking can use different environmental controls like UV light, temperature, and
chemicals, among others.
Maturation: Finally, the bioprinted and crosslinked structures need to grow biologically. This
means that the printed living cells will reproduce, and tissue will grow following the
underlying printed structures. This step is also called incubation and is done inside bioreactors
that create a favorable environment for reproduction and tissue growth.
BIOINKS
The term bioink refers to the printable substance in bioprinting, which contains cells or other
biological parts. Bioinks are used as the base material when bioprinting tissue, organ, or
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and accuracy. They can work with single or multi ink system,
and materials with accuracy and complex geometry. This
type of bioprinting can be performed using thermal or
piezoelectric actuator methods to deposit liquid droplets of
defined size layer by layer
In thermal actuator, rapid electrical heating is provided to
the bioprinter head, which generates pressure pulses which
forces the droplets out through the nozzle. This heating can
vary from 200 °C -300 °C with out damaging the cells. The
piezo electric forces generate an acoustic wave causing the
pressure necessary to eject the droplet from the nozzle. For
this class of bio printers we can use inks with low viscosity and
cell density.
2. Pressure-assisted bioprinting:
This technique relies on the extrusion of selected biomaterials
usually formulated as pastes, solutions or dispersions. These
biomaterials are extruded by coordinating the motion of
pneumatic pressure or plunger or screw-based pressure in the
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Using bio-printed tissue can help researchers determine a drug efficacy sooner,
enabling them to save money and time.
Artificial organs: Being able to bio print organs could help clinicians keep up with patients or
eliminate the organ donation list entirely. While this solution is far down the line, it is one of
the most impactful possibilities in the field.
Wound healing: A lot of tissue-specific bioinks are available today, enabling researchers to
work with artificial skin cells, neurons, hepatocytes and more. One day, clinicians could use
these models for therapeutic procedures like skin grafts, bone bandages for combat wounds
or even plastic surgery.
RECENT DEVELOPMENTS
We are still quite far from mass-producing artificial organs and human tissues.
6103- Specialized Printing Applications
In April 2019, news media outlets worldwide reported the first vascularized 3D printed
miniature heart developed by Tel Aviv School of Molecular Cell Biology and
Biotechnology. The mini-organ was created using patient-specific materials but showed no
functionality whatsoever.
Few months later an American biotech company BioLife4D announced its own bio-printed
heart that was bigger and replicated some functionality found in human hearts.
In 2019, the researchers at the Rensselaer Polytechnic Institute in New York were able to
create fully-vascularized skin patches.
ADVANTAGES OF 3D BIOPRINTING
Allows mimicking the real structure of desired tissue/organ etc.
Possible creation of patient-specific and organ-specific treatments.
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Source: 3D Bioprinting Methods and Techniques: Applications on Artificial Blood Vessel Fabrication,
Theodore G. Papaioannou, Danae Manolesou, Evangelos Dimakakos, Gregory Tsoucalas, Manolis Vavuranakis and Dimitrios Tousoulis , doi: 10.6515/ACS.201905_35(3).20181115A
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NANOSCALE 3D PRINTING
NANOSCALE 3D PRINTING
Nanotechnology refers to technology that deals with measurements and tolerances of less
than 100 nanometers. For some sense of just how small this technology is, 0.05 millimeters (the
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NANOGRAPHY
NANOGRAPHY®
Nanography® is a digital printing process developed by Landa Digital Printing (In May 2012,
by Benny Landa) that employs a combination of offset, inkjet and nanotechnologies to print on
6103- Specialized Printing Applications
virtually any paper or film. The name is derived from Landa's colorants (inks), which have
pigment particles measured in the tens of nanometers.
The Nanographic Printing process, also called Nanography, differs from other printing
technologies because it uses an innovative system and printing process that employs Landa
NanoInk colorants, a water-based ink with nano-pigment particles.
Nanographic Printing technology harnesses the advantages of digital printing, and at the same
time, it also offers offset qualities
WORKING
In nanography, Printing process begins with the jetting of
billions of droplets (spread, sprayed or dropped) the
droplets are not ejected directly onto the substrate. Instead,
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The ink carrier Landa NanoInk solutions are based on water which is a less costly ink
carrier than any solvent or UV based inks.
The amount of ink used The Landa Nanographic Printing process creates a film of about
500 nm that is approximately half the thickness of an offset printed image and uses less ink
for the same image.
Substrate cost Printing on any substrate enables you to print on low cost, off-the-shelf
uncoated paper rather than expensive coated paper or specially designed paper.
6103- Specialized Printing Applications