SMC Training Manual A4
SMC Training Manual A4
Acknowledgements
The SMC toolkit was produced by
Medicines for Malaria Venture (MMV).
MMV gratefully acknowledges the following partners who
contributed to the technical content and development of
the materials (listed in alphabetical order):
Global Malaria Programme/ World Health Organization
Malaria Consortium
Médecins sans frontières
National Malaria Control Programmes (NMCP) of Bénin,
Burkina Faso, Cape Verde, Côte d’Ivoire, The Gambia,
Ghana, Guinea, Guinea Bissau, Liberia, Mali, Mauritania,
Niger, Nigeria, Senegal, Sierra Leone and Togo.
UNICEF
A special thank you to our partners at WARN (West
Africa Regional Network) and CARN (Central Africa
Regional Network) for their strong support throughout
the project.
2
Contents
Introduction5
1 Overview6
1.1 What is SMC? 6
2 Practical aspects 12
2.1 Who is SMC recommended for? 13
4 Materials22
4.1 What materials are available 22
References26
3
Professor Sir Brian Greenwood, London School of Hygiene and Tropical Medicine
4
Introduction
This is a comprehensive reference document for use by those running SMC (Seasonal Malaria
Chemoprevention) training. It assumes that SMC will be implemented using a Community Health
Worker strategy.
Each section has the same flow. At the start of each section there is a brief introduction to the
key elements in that section:
At the end of each section, there is a summary of key points. The summary looks like this:
Acronyms used:
AE - Adverse Event
AQ - Amodiaquine
CHW - Community Health Worker
ESA - East and Southern Africa
IPT - Intermittent Preventive Treatment
SAE - Serious Adverse Event
SP - Sulfadoxine-Pyrimethamine
WHO - World Health Organization
5
1 OVERVIEW & EVIDENCE
SMC benefits
This intervention has been shown to be effective, cost-effective, well tolerated, and feasible for preventing
malaria among children less than 5 years of age in areas with highly seasonal malaria transmission. 2
6
1.2 Where does seasonal malaria occur?
ESA:
Angola, Botswana, Malawi,
14 million Democratic Republic of the Congo
children (DRC), Namibia, Northern Mozambique,
under 5 1 Tanzania, Zambia, Zimbabwe
The period of SMC administration should be chosen to target the period when children are most at risk of
malaria attacks. 2 Exact start and end dates depend on the patterns of malaria transmission and rainfall,
so can vary within and between countries as well as from one season to the next.
+ =
7
1 OVERVIEW & EVIDENCE
20,000 80%
deaths from malaria could be of severe and uncomplicated malaria
prevented annually 1 cases could be prevented each year 1
Based on these impressive results, the World Health Organization has conducted an evidence-based review.
It has subsequently recommended SMC in those countries with seasonal transmission characteristics, and where
the two component drugs are both still effective against Plasmodium falciparum malaria.
For children aged between 3 and 59 months in the Sahel sub-region, WHO recommends a single dose of
SP, plus a three-day course of AQ, once a month, for 3 to 4 months during the malaria season.2
In December 2012, WHO published an SMC Field Guide (implementation manual) to provide malaria-endemic
countries with practical, adaptable and ready-to-use materials for use throughout the intervention, from planning
to monitoring phases. SMC is indicated as part of the malaria control strategies in areas of highly seasonal
malaria transmission. 2
Key interventions currently recommended by WHO for the control of malaria are: the use of long-lasting
insecticidal nets (LLINs) and/or indoor residual spraying (IRS) for vector control, prompt access to diagnostic
testing of suspected malaria and appropriate treatment of confirmed cases with effective artemisinin-based
combination therapy.
SMC: should be used as a malaria control strategy, and not as a malaria elimination strategy.
Additional interventions which are recommended for the prevention of Plasmodium falciparum malaria targeting
specific high risk groups in areas of high transmission include:
8
1.5 Medicines used in SMC
Meta-analysis (pooled data from clinical studies) of 7 SMC studies, where a course of antimalarials was given
periodically to children under 5 years during peak malaria season showed 80% reduction in clinical attacks of
malaria, and a similar reduction in the incidence of severe malaria.3
The SP+AQ combination used in most trials was well tolerated. 1, 2
In field trials testing SMC’s efficacy in protecting children from malaria, and a large-scale effectiveness study
in Senegal, SP+AQ was the preferred drug combination. This was for the following reasons: 2
• In clinical trials, SP+AQ gave greater protection than other drug combinations. The use of the two drugs in
combination limits the risk for selection for resistance to either SP or AQ use as monotherapy.
• Each drug retains its efficacy in areas of Sahel and sub-Sahel with seasonal transmission where
SMC is appropriate.
• The combination of SP+AQ does not include artemisinin derivatives. Therefore, artemisinin based
combinations can be reserved for clinical cases where they are most useful.
A review of available data reported no definite case of serious adverse events (SAEs) after more than
80,000 courses of SP+AQ had been administered to more than 30,000 children. However, no active case
detection was done.
80,000
treatments were administered with
no definite case of SAE
9
1 OVERVIEW & EVIDENCE
• The participation of community members in sensitisation and mobilisation built trust between implementers
and the community.
• Providing incentives played a major role in the commitment of CHWs and health personnel during SMC
implementation.
• Access to sufficient funding is important, to help plan and deliver activities and motivate staff.
• Combining SMC with vitamin A and albendazole (for de-worming) or alongside community case management
of malaria showed how SMC can be successfully delivered alongside other health programmes.
• The right period for SMC administration can differ between localities within one country, due to differences in
the pattern of transmission and other local factors.
• Training of all personnel involved is critical. Workshops explained how to recognize, manage and document
adverse drug reactions, and leaflets outlining how to spot adverse reactions to SP or AQ were distributed.
The ideal time to train CHWs is 2-4 weeks ahead of SMC beginning.
SMC has been administered to more than 175,000 children between 3 and 59 months in southern Mali and
in two areas of Chad. 4
• Preliminary results from the programme show that the number of cases of simple malaria dropped by 65% in
the intervention area in Mali, and by up to 86% in Chad. 4
• A significant decrease in cases of severe malaria has also been recorded. 4
10
Key points to remember:
11
2 Practical aspects
Children aged
3-59 months
WHO
HOW
3 - 4 months
during the rainy AQ AQ AQ
season
12
2.1 Who is SMC recommended for?
A complete treatment course of sulfadoxine-pyrimethamine (SP) plus amodiaquine (AQ) should be
given to children aged 3 - 59 months.
IMPORTANT:
Loose tablets should be given as replacement doses when a child vomits, spits out or regurgitates the drugs.
• Labelling SMC drug packages in different colours for younger and older children helps mothers administer the
right medication.
Missing one course of treatment does not prevent a child from receiving the next course of SMC drugs,
provided it is not contraindicated for the child to receive SMC.
13
3 Instructions & key messages for m
14
edical staff
A single dose of
250/12.5mg SP SP
on Day 1.
75mg AQ given once AQ AQ AQ
3-11 months on Day 1, 2 and 3.*
A single dose of SP
500/25mg SP
on Day 1.
AQ AQ AQ
150mg AQ given once
12-59 months on Day 1, 2 and 3.
The single dose of SP is given only on the first day together with the first dose of AQ.
Administration of at least the first dose (single dose of SP and the first dose of AQ) must be directly observed.
*Take half tablet of 150mg AQ / 500/25mg SP if strength/dose not available.
Intermittent Preventive Treatment with SP in infancy (IPTi) and SMC should not be administered together.
For that reason, IPTi should not be used in SMC target areas. Alternative antimalarial combinations,
containing neither SP nor AQ, must be provided to treat clinical malaria in the target age group.
15
3 Instructions & key messages for m
Tablets SP SP
PotableSP
water SP2 clean cups 1 clean spoon Sugar
SP SP
AQ AQ
AQ AQ
AQ AQ
Step-by-step process
Step 1 AQ AQ
3-11 months
1 3
12-59 months 4
AQ AQ
SP 250/12,5mg 2
SP 500/25mg
TakeAQ
one tablet of SP
and one tablet of AQ.AQ
AQ
AQ
AQ 75mg
SP AQ 150mg
AQ
AQ SP AQ SP AQ
5
AQcorrect dose for age ofAQ
1.Use child.
Step 2
1 3 4
6
2. Separately crush SP and AQ
drugs
1
2
3 AQ 4 2
1 3 4 6
AQ
5. Add sugar to mask the
bitterness of AQ
2
6. Stir
5
Step 3
16
edical staff
Step 4 5 minutes
Vomiting No Vomiting
If a child vomits, spits or regurgitates Proceed to
the medicines within 5 minutes, 5 minutes Step 8.
complete the following steps. (Young
children are more likely to vomit).
Step 5
Step 8
Step 7
17
3 Instructions & key messages for m
• Children who receive less than three courses or fewer doses per course of treatment are less protected against
clinical malaria, therefore it is important that a child receives full doses of each course of treatment.
• Up to a maximum of four courses may be given yearly, depending on the patterns of malaria transmission.
• If a child misses treatment after the CHW visit, their mother should take them to the health centre in the next
few days to receive SMC. If a child totally misses one treatment course because of illness or absence,
treatment should be given at the next round of SMC, provided the child is present and well.
Missing one course of treatment does not prevent a child from receiving the next course of SMC drugs if
there are no contraindications for the child to do so.
IMPORTANT:
Children who missed SMC doses in a given treatment course showed lower protection against
malaria attacks between the last and the next treatment round.
The length of protection varies, depending on the drug regimen used and the prevailing levels of
resistance to the drug. Therefore, it is important to keep a one month interval between treatment
courses. This creates a high level of protection and minimises the selection for malaria parasites
resistant to SP+AQ.
Treatment of breakthrough Plasmodium falciparum infections during the period of SMC should not
include either SP or AQ, or combination drugs containing either of these medicines, such as AS+AQ.
18
edical staff
• 2nd and 3rd doses must be given at home at Day 2 & Day 3
• Risk of adverse events: explain these to the mother and discuss actions she would take
if a serious event happens
19
3 Instructions & key messages for m
prepare material for the next day (clean cups, clean spoons, check availability of SMC treatment courses)
At the end of the community round distribution, CHWs should report to the health centre on the number of
treatment courses received, administered and remaining.
Supervision
Intensive supportive supervision should be put in place in the early stages of SMC implementation (first round/
first year) to identify and resolve problems. Supervision should be reduced to the minimum necessary once
SMC delivering staff have acquired some experience. If required, retraining can be offered on site to those
experiencing difficulties. Supervision should be carried out by the NMCP staff, the district medical staff and
nurses at peripheral health centres. Full checklists for this can be found in the WHO Field Guide.
20
edical staff
CHWs will be evaluated by supervisors. In addition, the supervisor should carry out a survey of a random
sample of mothers to assess knowledge about SMC and how well the strategy has been accepted.
This activity should be undertaken during the first round of SMC administration in the first year
and can be repeated every 2-3 years.
• The health centre needs to record the number of children with malaria or
fever. It also needs to record whether these children have received SMC
and how many doses of AQ they have taken.
• Coverage will be estimated using the number of children who should
potentially receive SMC as recorded by the CHW and the number of
children who actually receive the complete dose of SMC during each
treatment course for each transmission season. The number of children
who arrive at delivery points but cannot receive SMC should also be
recorded.
• Monitoring of adverse drug reactions is an important aspect of SMC
implementation.
• Health personnel, CHWs and mothers should be trained to identify and
report adverse events. It is important that mothers report all adverse
events, mild or trivial, and know what to do when they see them.
• The CHW must complete all necessary paperwork and reconcile the
number of tablets on a daily basis.
21
4
Materials
• Register
22
4.2 How to use the materials
For CHW
At:
Date:
Seasonal Malaria Chemoprevention (SMC) is a ■ A team of community health workers will come
A single dose of SP
DAY 1 DAY 2 DAY 3 • Feed the child before giving the
medication.
villages and health centre.
A summary of all
250/12.5mg SP on Day 1.
key information.
500/25mg SP on Day 1. • Report any illness following drug
150mg AQ given once AQ AQ AQ administration.
12-59 months on Day 1, 2 and 3.
(1-5 years)
Vomiting
Age :
No vomiting
If the child vomits again, If the child does
4th
If they become severe, you must seek
for medical advice. . Come back on:
Vomiting Mild skin reaction Tummy pain or Diarrhoea Drowsiness Fever Headache
23
24
JOUR JOUR
1 2 3
Each day:
4
For parents
DAY 1 DAY 2 DAY 3 DAY 1 DAY 2 DAY 3
• Write the date.
GIVEN BY GIVEN BY
• Tick the box corresponding to GIVEN BY GIVEN BY
HEALTH MOTHER Put your child state. HEALTH MOTHER Put
WORKER your stickers WORKER your stickers
here • Add the sticker on the card here
once the treatment completed
(Day 2+Day 3).
DATE DATE DATE DATE DATE DATE
MONTH
Well reported
tolerated side effects
1
MONTH 1
the child may experience.
DATE DATE DATE
MONTH
MONTH 2
MONTH
3
DATE DATE DATE
DATE DATE DATE
MONTH
information for parents. It has a clear visual
SMC Passport – This booklet contains key
MONTH 3
Logos partenaires
4
Materials
Age :
Age :
Head of the
Child’s name:
Head of the
household’s name:
child’s name:
household’s name:
Date :
/
/
Date :
S M C PA S S P O R T
/
/
s m c PA s s P o r T
S M C
For monitoring
Village / area
Zone
Health center
District
number of doses of
Treatment period (tick as appropriate) Month 1 Month 2
This form has to be filled in by the community health worker after each household visit and be given back to the
Month 3 Month 4
drug given and vs stock
health center.
Exemple:
Number of SMC tablets… 1 0 0 2 0 0 inventory. Helps with drug
returns.
All Children aged 3-59 months SP AQ
© 2013 Developped by Medicines for Malaria Venture (MMV).
Name
Number of SMC tablets received
CHILD COUNTING CARD Role
Number of SMC tablets used
Number of SMC tablets remaining Zone District Village / area Health center
Comments
Date Treatment period (tick as appropriate) Month 1 Month 2 Month 3 Month 4
This form has to be filled in by the community health worker after each household visit and be given back to the health center.
Role
– used by CHW to
3-11 months
Household 1 The child has taken as or aq over the last 2 weeks.
12-59 months
Date Zone District
and managing vs
Number of SMC tablets received
12-59 months
Number of SMC tablets used
3-11 months
target population in
Number of SMC tablets remaining
12-59 months
Comments
Total = Total = Total =
implementation plan.
Date
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Notes
references
1 Cairns, M. et al. Estimating the potential public health impact of seasonal malaria chemoprevention
in African children. Nat. Commun. doi:10.1038/ ncomms1879 (2012)
4 Doctors Without Borders/Médecins Sans Frontières (MSF). Press release, 24 September 2012.
Novel Program Shows Strong Promise in Malaria Prevention. [viewed 23 September 2013].
Available at
http://www.doctorswithoutborders.org/press/release.cfm?id=6319
26
Notes
27
Notes
28
29
Notes
30
31
© 2013 Materials developed by Medicines for Malaria Ventures (MMV).