2014 Internal COC Pharma
2014 Internal COC Pharma
41. A 68-year-old male retired police officer who has smoked a 1/2 pack of cigarettes a day for
the past 40 years is diagnosed with chronic obstructive pulmonary disease (COPD). He has a
difficulty in expiration during breathing, but the symptoms are mild and intermittent. Which
one of the following agents would most appropriate initial therapy.
49. Which one of the following Protein synthesis inhibiter used in triple therapy of patient with
PUD due to H. pylori
A. Azithromycin C. Clarithromycin
B. Amoxicillin D. Gentamcine
50. Sulfonamides increase the risk of neonatal kernicterus, because they:
A. Diminish the production of plasma albumin.
B. Increase the turnover of red blood cells.
C. Inhibit the metabolism of bilirubin.
D. Compete for bilirubin-binding sites on plasma albumin.
E. Depress the bone marrow.
51. A certain girl is comes to your health institution complaining of headache, fever, nuchal
rigidity, neck stiffness. The physician confirmed that serious systemic infection and
prescribed a particular drug “X”, However, the girl returns back to your health institution
after 7 days of complaining of gray skin color, cyanosis - blue lips & skin, hypotension, CV
collapse collectively known as Gray baby syndrome. So which one of the following is most
likely prescribed drug associated with patient manifestation
A. Gentamycine C. Chloramphenicol
B. Rifampin D. Cotrimoxazole
56. A 30-year-old male is diagnosed in General Private Hospital and confirmed as HIV positive.
His CD4+ count is 200 cells/mm3 and his viral load is 10,000 copies/mL. In addition to
receiving antiviral therapy, which of the following is indicated to protect him against
pneumonia due to Pneumocystis jiroveci?
A. Trimethoprim. C. Ciprofloxacin.
B. Cotrimoxazole . D. Gentamycin.
57. A 9 month neonatal baby presents to emergency department of HFSUH. Up on examination
he develops neonatal encephalitis. And when Lab examination done it’s positive for herpes
simplex viruse (HSV). So which one of the following drug is best to be given for this baby
A. Acyclovir C. Ribavirin
B. Ganciclovir D. Amantadin
58. A 25-year-old man is diagnosed with HIV, and therapy is initiated. After the first week of
therapy, the patient complains of headaches, irritability, and nightmares. Which one of the
following antiretroviral drugs is most likely to be causing these symptoms?
A. Lamivudine. C. Efavirenz
B. Indinavir. D. Nevirapine. E. Stavudine.
59. An HIV-positive woman is diagnosed with CMV retinitis. She has been on a HAART
regimen containing zidovudine. Which of the following anti-CMV drugs is likely to cause
additive myelosuppression with zidovudine?
A. Acyclovir. C. Ganciclovir
B. Amantadine. D. Foscarnet. E. Ribavirin.
60. Which of the following ART drug associated with Renal dysfunction
A. Zidovudine C. Tenofovir
B. Neverapine D. Saquinavir
61. Which one of the following Protease inhibitor used as boosting drug for other it’s analog
A. Lopinavir C. Indinavir
B. Saquinavir D. Ritonavir
62. Tinnitus, dizziness, blurred vision, and headache are indicative of toxicity to which one of
the following antimalarial drugs?
A. Primaquine. C. Quinine.
B. Pyrimethamine. D. Chloroquine. E. Sulfadoxine.
63. Which of the following drugs is recommended for the treatment of severe, multidrug-
resistant Plasmodium falciparum malaria?
A. Artemisinin. C. Quinine
B. Chloroquine. D. Sodium stibogluconate.
64. A 22-year-old man, who frequently backpacks, complains of diarrhea and fatigue.
Examination of stool specimens shows binucleate organisms with four flagellae. Which one
of the following drugs would be effective in treating this patient's intestinal protozoal
infection infestation?
A. Metronidazole. B. Quinidine. C. Pentamidine. D. Sulfadoxine.
65. A 30 years old individual suffered from mild to moderated amebiasis, after getting a meal at
local restaurant , while later on he developed Amebic liver abscess which should be treated
by giving him for the encountered case
A. Diloxanide furoate plus Iodoquinol D. Emetine Plus Diloxanide furoate
B. Chloroquine E. Iodoquinolone alone
C. Metronidazole followed by Paramomycin
66. A 25 years old patient is suffering from an acute attack of malaria, his blood film has shown
P-Vivax parasites; he got chloroquine for his attack but to avoid future relapses of such
attacks he must be given
A. Quinine B. Mefloquine C. Primaquine D. Fansidar
67. Which one of the following NSAIDs produce an irreversible inhibition of cyclooxygenase
enzyme?
A. non-maleficence
B. autonomy
C. teleogical theories
D. beneficence
A. autonomy B. Justice
C. truth-teling D. Confidentiality
75. which of the following found on labeling but not on the prescription paper?
A. drug name
B. expiry date
C. patient name
77. most recent and in-depth information about health related topic is
A. primary
B. secondary
C. teritiary
D. quaternary
78. which is a good criterion of topic for drug information consult writing guide;
A. topic of DI consult should be prepared in the form of statement rather than questioner
C. topic of DI consult must include the disease state for which the drug is being processed
D. topic of DI consult should state only medication and appear at the bottom of consult paper
79. DI documents includes consult, news letter can be better prepared under
C. Microsoft excels
D. Microsoft publisher
80. one of the following is considered as best source of information for pharmacist to convince
physician during patient treatment
82. which of the following is true about collection and delivery methods of drug distribution?
A. collection method allows for better checking, handling and security of goods received
B. in delivery method, health facility may be closed when delivery truck arrives
D. A & B
83. which of the following term correctly describes the process of acquiring supplies from private or
public supplier or through purchasing from manufacturer or agencies or bilateral aids program?
A. quantification
B. logistic management
C. forecasting
D. procurement
84. which one of the following shows the advantage of limited list of essential medicine related to
prescribing objectives?
D. all except A
85. which of the following is not area of focus in principles of medicine regulation in Ethiopia?
A. safety
B. effect
C. cost
D. quality
A. Practice
B. Products
C. Professional
87. A pharmacist talks to his friend, an accountant, about patient’s medicine condition and the
medication that the patient is talking. Which of the ethical principle is breached by the pharmacist?
A. confidentiality
B. Fiedelity
C. Maleficence
D. Justice
A. Respect patient
D. None
89. All of the following should be taken in to consideration during extemporaneous compounding of
prescription except
A. Conditions required for extemporaneous production
90. All of the following are skills required to be integrated for the practice of clinical pharmacy except
A. Communication skills
91. Which of the following department in pharmaceutical industry calls various health care
professionals to provide comprehensive information on a product to encourage the products aproprite
use by the health care provides?
C. Medicine information
D. Legal affairs
A. The use of ineffective and poor-quality medicine can result in therapeutic failure
A. Medication allergies
B. Diagnosis
A. Picking error
B. Packing error
95. “Your patient asked you for a recommended website that is dependable, to get answers for
questions related to her illness”. The stated case study belongs to which category of drug information
request?
D. Drug compatability/stability
96. One is true about maintaining the bin card and stock card
A. One bin card should be maintained for each pack size, form or presentation of pharmacuticals
B. The bin card should be kept with the product in the storage area.
97. ……………is the type of inspection undertaken to ensure the fulfillment of requirement by
pharmaceutical establishment before a license issued
A. Pre-licensing inspection
B. Post-licensing inspection
C. Routine inspection
D. Special inspection
98. …………..is the study of health profile of a single individual with unusual medical occurrence using a
careful and detailed report by one or more clincians
A. Case series
B. Case report
C. Cross sectional
D. Cohort
100. Which of the following enteral routes of drug administration avoid the first-pass metabolism in the
liver: a) rectal; b) sublingual; c) oral; d) transdermal.
Which of the following enteral routes of drug administration avoid the first-pass metabolism in the
liver:
A. Rectal
B. Sublingual
C. Oral
D. Transdermal.