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2014 Internal COC Pharma

1. The document contains questions about pharmacokinetics, drug metabolism and mechanisms of action, drug interactions, and treatment of various medical conditions. 2. It addresses topics like volume of distribution, half-life, mechanisms of transmembrane signaling, types of drug receptors, appropriate treatment for deep vein thrombosis during pregnancy, and drug interactions with carbamazepine. 3. The questions assess understanding of concepts like how drugs are absorbed, distributed, metabolized and excreted from the body, different drug classes and their indications, and factors that influence drug therapy selection and dosing.

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0% found this document useful (0 votes)
763 views16 pages

2014 Internal COC Pharma

1. The document contains questions about pharmacokinetics, drug metabolism and mechanisms of action, drug interactions, and treatment of various medical conditions. 2. It addresses topics like volume of distribution, half-life, mechanisms of transmembrane signaling, types of drug receptors, appropriate treatment for deep vein thrombosis during pregnancy, and drug interactions with carbamazepine. 3. The questions assess understanding of concepts like how drugs are absorbed, distributed, metabolized and excreted from the body, different drug classes and their indications, and factors that influence drug therapy selection and dosing.

Uploaded by

tegenezewude
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
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1.

Pharmacokinetics is Associated with:


A. The study of biological and therapeutic effects of drugs
B. Distribution of drugs in the organism
C. The study of mechanisms of drug action
D. The study of methods of new drug development
2. What kind of substances can't permeate membranes by passive diffusion?
A) Lipid-soluble C) Hydrophobic substances
B) Non-ionized substances D) Hydrophilic substances
3. The volume of distribution (Vd) relates:
A. Single to a daily dose of an administrated drug
B. An administrated dose to a body weight
C. An uncharged drug reaching the systemic circulation
D. The amount of a drug in the body to the concentration of a drug in plasma
4. Regarding termination of drug action
(a) Drug must be exerted from the body to terminate their action
(b) Metabolism of drugs always increases their water solubility
(c) Metabolism of drugs always abolishes their pharmacologic activity
(d) Hepatic metabolism and renal excretion are the two most important mechanisms involved
5. Half life (t V2) is the time required to:
A. Change the amount of a drug in plasma by half during elimination
B. Metabolize a half of an introduced drug into the active metabolite
C. Absorb a half of an introduced drug
D. Bind a half of an introduced drug to plasma proteins
6. Mechanisms of transmembrane signaling are the following EXCEPT:
A. Transmembrane receptors that bind and stimulate a protein tyrosine kinase
B. Gene replacement by the introduction of a therapeutic gene to correct a genetic effect
C. Ligand-gated ion channels that can be induced to open or close by binding a ligand
D. Transmembrane receptor protein that stimulates a GTP-binding signal transducer protein
(G protein) which in turn generates an intracellular second messenger
7. Which of the following receptor types has 7 helical membrane, spanning amino acid
segments with 3 extracellular and 3 intracellular loops
(A) Tyrosine protein kinase receptor (c) Intrinsic ion channel containing receptor
(B) Gene expression regulating receptor (d) G protein coupled receptor

8. One of the following drug used in the treatment of Male Baldness


A. Propranolol B. Enalapril C. Minoxidil D. Hydralazine
9. . A patient who had history of Asthma is now on therapy of HTN ,after some days he
complain persistent dry cough W/c Anti HTN agent is may associated with the client
complain:
A. Lassix B. Enalapril C. Losartan D. None
10. . One of the following agent is not recommended for hypertensive Pregnant women
A. B-blocker B. ACEI C. Methyldopa D. Hydralazine
11. One of the following is not given in patient with Heart failure
A. Verapamil B. Labetalol C. Enalapril D. Digoxin
12. A 22-year-old woman who experienced pain and swelling in her right leg presented at the
emergency room. An ultrasound study showed thrombosis in the popliteal vein. The patient,
who was in her second trimester of pregnancy, was treated for 7 days with intravenous
unfractionated heparin. The pain resolved during the course of therapy, and the patient was
discharged on Day 8. Which one of the following drugs would be most appropriate out-
patient follow-up therapy for this patient, who lives 100 miles from the nearest hospital?
A. Warfarin. B. Alteplase. D. UFH. D. LMWH
13. In Which one of the following drug heparin-induced thrombocytopenia common
A. UFH B. Enoxaparin C. Dalteparin D, Tinzaparin
14. A 50-year-old man is diagnosed with deep-vein thrombosis. The patient was treated with a
bolus of heparin, and a heparin drip was started. One hour later, he was bleeding profusely
from the intravenous site. The heparin therapy was suspended, but the bleeding continued.
What therapy need to be administered to resolve the bleeding. What mechanism does the
reversal drug works to stop bleeding
A. Inactivates antithrombin. C. Activates tissue-plasminogen activator.
B. Activates the coagulation cascade. D. Ionically combines with heparin
15. A 30 years old hyperlipidemic girl was on lipid lowering agent for the last 3 month. Later on
she comes to emergency department of jugol hospital, complaining of GI distress. Up on
laboratory examination there is 4 fold increasing in liver enzymes from the normal as well as
there is sign of cholestatis. With which of the following drug does the patient was treated
A. Fenofibrate B. Atrovastatin C. Niacin D. Colestipol
16. A 54-year-old male with a prosthetic aortic valve replacement complained to his family
physician of black and tarry stools. Physical examination and vital signs were unremarkable
except for subconjunctival hemorrhages and bleeding gums. Stools tested positive for heme,
and hematuria was observed. The patient has been receiving oral warfarin since his valve
replacement 1 year earlier. Prothrombin time was found to be significantly elevated. Which
one of the following therapies would provide the most rapid recovery from the observed
bleeding secondary to warfarin treatment?
A. Intravenous vitamin K. C. Intravenous protamine
B. Transfusion of fresh-frozen plasma. D. Immediate withdrawal of warfarin
17. Which of the following Acts on both bound & free plasminogen
A. Sterptokinase B. Alteplase C. Aspirin D. Clopidogrel
18. Modest improvement in the memory of patients with Alzheimer's disease may occur with
drugs that increase transmission at which of the following receptors?
A. Adrenergic. C. Dopaminergic
B. Cholinergic. D. GABAergic. E. Serotonergic
19. Which of the following antiparkinson drugs may cause peripheral vasospasm?
A. Amantadine. C. Carbidopa
B. Bromocriptine. D. Entacapone. E. Ropinirole.
20. Peripheral adverse effects of levodopa, including nausea, hypotension, and cardiac
arrhythmias, can be diminished by including which of the following drugs in the therapy?
A. Amantadine. C. Carbidopa.
B. Bromocriptine. D. Entacapone. E. Ropinirole.
21. Which one of the following combinations of antiparkinson drugs is an appropriate therapy?
A. Amantadine, carbidopa, and entacapone.
B. Levodopa, carbidopa, and entacapone.
C. Pramipexole, carbidopa, and entacapone.
D. Ropinirole, selegiline, and entacapone.
E. Ropinirole, carbidopa, and selegiline.
22. A nine-year-old boy is sent for neurologic evaluation because of episodes of confusion. Over
the past year, the child has experienced episodes during which he develops a blank look on
his face and fails to respond to questions. However, it appears to take several minutes before
the boy recovers from the episodes. Which one the following best describes this patient's
seizures?
A. Simple partial. C. Tonic-clonic
B. Complex partial. D. Absence. E. Myoclonic.
23. The patient described in Question 5 was treated for six months with carbamazepine but,
recently, has been experiencing breakthrough seizures on a more frequent basis. You are
considering adding a second drug to this patient's antiseizure regimen. Which of the
following drugs is least likely to have a pharmacokinetic interaction with carbamazepine?
A. Topiramate. C. Levetiracetam.
B. Tiagabine. D. Lamotrigine. E. Zonisamide.
24. Which one of the following therapies would be appropriate for the patient described in the
above question Q5 ?
A. Ethosuximide. C. Diazepam
B. Carbamazepine. D. Carbamazepine plus primidone.
E. Watchful waiting
25. A 68-year-old patient with cardiac failure is diagnosed with ovarian cancer. She is started on
cisplatin but becomes nauseous and suffers from severe vomiting. Which of the following
medications would be most effective to counteract the emesis in this patient without
exacerbating her cardiac problem?
A. Droperidol. C. Prochlorperazine.
B. Dolasetron. D, Ondansetron
26. A 45-year-old woman is distressed by the dissolution of her marriage. She has been drinking
heavily and overeating. She complains of persistent heartburn and an unpleasant, acid-like
taste in her mouth. The clinician suspects gastrointestinal reflux disease and advises her to
raise the head of her bed 6 to 8 inches, not to eat for several hours before retiring, to avoid
alcohol, and to eat smaller meals. Two weeks later, she returns and says the symptoms have
subsided slightly but still are a concern. The clinician prescribes:
A. An antacid such as aluminum hydroxide. C. Dicyclomine.
B. An antianxiety agent such as alprazolam. D. Esomeprazole.
27. Which of the following agents interferes with most of the cytochrome P450 enzymes and,
thus, leads to many drug-drug interactions?
A. Famotidine. C. Sucralfate.
B. Omeprazole D. Cimetidine E. Ondansetron.
28. A couple celebrating their 30 year wedding anniversary is given a trip to ‘’Gondar
Fasileds’’. Due to past experiences while traveling, they ask their doctor to prescribe an
agent for diarrhea. Which of the following would be effective?
A. Omeprazole. C. Famotidine
B. Loperamide. D. Lorazepam.
29. A 70-year-old man has a history of ulcer disease. He has recently experienced swelling and
pain in the joints of his hands. His physician wants to begin therapy with an NSAID. Which
one of the following drugs might also be prescribed along with the NSAID to reduce the risk
of activating this patient's ulcer disease?
A. Allopurinol. B. Misoprostol. C. Colchicine. D. Probenecid.
30. A 24- year old pregnant women with morning sickness comes to a hospital complained with
morning sickness. Which anti emetics are recommended as 1st line theraphy?
A. Doxylamine & pyridoxine C. Metoclorpromide and Corticosteroid
B. Ondanesteron and Corticosteroid D. Prochlorperazine and mirtazapine
31. G.T. is a 58-year-old male patient who presented to the clinic with a complaint of convulsion
that occurred repeatedly for the past one and half year. A witness of the ictal event reported
that the patient lost consciousness and the contraction and relaxation of muscles were limited
to one part of the body. Moreover, the witness reported that the patient was showing
aberration of behaviors. Physical examination and diagnostic workups failed to show any
organic cause for the convulsion and the patient was diagnosed with epilepsy. Which
antiepileptic drug should be given for this patient?
B. Phenbarbitone C. Valproic acid
C. Carbamazepine D. Ethosuximide
32. Which one of the following statements is correct?
A. Phenobarbital shows analgesic properties.
B. Diazepam and phenobarbital induce the P450 enzyme system.
C. Phenobarbital induces respiratory depression,
in the treatment of acute intermittent porphyria.
E. Buspirone has actions similar to those of the benzodiazepines.
33. 45-year-old man who has been injured in a car accident is brought into the emergency room.
His blood alcohol level on admission is 275 mg/dL. Hospital records show a prior
hospitalization for alcohol-related seizures. His wife confirms that he has been drinking
heavily for 3 weeks. What treatment should be provided to the patient if he goes into
withdrawal?
A. None. C. Pentobarbital.
B. Lorazepam. D. Phenytoin.
34. Which one of the following anti-Parkinson's drug also had anti-viral activity
A) Procyclidine C) Amantadine
B) Pergolide D) levodopa
35. A 34 years old girl parkisnonian patients come to OPD of Hiwot fana specialized university
Hospital. She complains that abnormal lactation, breast pain as well as she complain of
infrequent or irregular period. Having taking her medical history inconsideration the
physician decides that she had problem of hyper-prolactinemia. So which one of the
following drug is appropriate for the treatment of her complain and Parkinsonism.
D. Amantadine C. Selegiline
E. Levodopa D. Bromocriptine
36. A 30 years old known Asthmatic women comes to emergency department of Dil-Chora
Hospital for her severe exacerbation of Asthma; which of the following is the best treatment
she must to get for her case
A. Oxygen with Epinephrine
B. Oxygen , frequent administration of corticosteroid with Salbutamol
C. Oxygen , frequent administration of corticosteroid with Ipartropium
D. Oxygen , frequent administration of corticosteroid with cromolyn
E. frequent administration of corticosteroid with Zileuton
37. Which one of the following is life saving drug that is given in severe Status Asthmaticus
patient that works through inhibiting Phospholipase A2
A. Epinephrine D. Methyl prednisolone
B. Aminophyilline E. Metaprotenerol
C. Salbutamol
38. Which one of the following Anti-Asthmatic drug works through inhibition of Lipoxygenase
enzyme
A. Albuterol B. Zafirlukast C. Zileuton D. Nedo-cromolyn
39. A 40 years old patient suffering from a persistent dry cough for the last 2 months due to
unknown reasons wants to get a drug without constipating effect
A. Codeine C. Hydro Codeine
B. Dextromethorphan D. Physiostgmine
40. A 24-year-old boy comes to emergency department of certain health institution complained
of cough, dyspnea, and wheezing after strenuous exercise . His symptoms became so severe
that his parents brought him to the emergency room. Physical examination revealed
diaphoresis, dyspnea, tachycardia, and tachypnea. The respiratory rate was 42 breaths per
minute, pulse rate 110 beats per minute, and blood pressure 132/65 mm Hg. Which of the
following is the most appropriate drug to rapidly reverse his bronchoconstriction?
A. Inhaled cromolyn. C. Inhaled albuterol.
B. Inhaled beclomethasone. D. Intravenous propranolol.

41. A 68-year-old male retired police officer who has smoked a 1/2 pack of cigarettes a day for
the past 40 years is diagnosed with chronic obstructive pulmonary disease (COPD). He has a
difficulty in expiration during breathing, but the symptoms are mild and intermittent. Which
one of the following agents would most appropriate initial therapy.

A. Systemic corticosteroids D. Tiotropium plus salmeterol


B. Salbutamol E. Theophylline
C. Salmeterol
42. A 58-year-old man is admitted to the Bilal hospital with moderately elevated BP. When
physician took history the patient had prior history of cough, dyspnea, and wheezing
indicative of Asthma. So which one of the following drug should not be given for this patient
to lower his Blood pressure?
A. Frusomide C. Propranolol
B. Lassix D. Losartan
43. A certain patient who had prior history of asthma came to Dil-chora Hospital complaining of
cough, dyspnea, and wheezing the patient is taking albuterol through inhalational route.
During examination there is an increased bronchial secretion. So which one of the following
should be given to enhances the bronchodilation and decrease secretion in bronchial tree.
A. Ipratropium C. Aminophylline
B. Hydrocortisone D. Montelukast
44. Which one of the following drug remove any thick Tenacious Mucus From The Respiratory
Passages
A. Dextromethorphan C. Diphenhydramine
B. Guanfenesin D. Codeine
45. Which of the following drug reduce congestion of nasal passages and in turn open clogged
nasal passages , enhance drainage of the sinuses
A. Dextromethorphan C. Diphenhydramine
B. Loratadine D. xylometazoline
46. A certain patient who had prior history of Rhinitis comes to local clinic with symptom of
Sneezing, nasal itching, watery rhinorrhea. The disease was exacerbated after an hours of
exposing dusts while cleaning his home. So which of the following drug is used to treat the
patient case
A. Chlorphenirarnine C. Codeine
B. Acetylcysteine D. xylometazoline
47. A patient with degenerative joint disease is to undergo insertion of a hip prosthesis. To avoid
complications due to postoperative infection, the surgeon will pretreat this patient with an
antibiotic. This hospital has a significant problem with MRSA. Which of the following
antibiotics should the surgeon select?
A. Ampicillin. C. Gentamicin/piperacillin.
B. Imipenem/cilastatin. D. Vancomycin.
48. A 30 years pregnant woman was hospitalized in Hiwot Fana Specialized Hospital and
catheterized with a Foley catheter. She developed a urinary tract infection caused by
Pseudomonas aeruginosa and was treated with gentamicin. Which of the following adverse
effects was a risk to the fetus when the woman was on gentamicin?
A. Hearing loss. C. Skeletal deformity.
B. Blindness D. Teratogenesis. E. Mental retardation.

49. Which one of the following Protein synthesis inhibiter used in triple therapy of patient with
PUD due to H. pylori
A. Azithromycin C. Clarithromycin
B. Amoxicillin D. Gentamcine
50. Sulfonamides increase the risk of neonatal kernicterus, because they:
A. Diminish the production of plasma albumin.
B. Increase the turnover of red blood cells.
C. Inhibit the metabolism of bilirubin.
D. Compete for bilirubin-binding sites on plasma albumin.
E. Depress the bone marrow.
51. A certain girl is comes to your health institution complaining of headache, fever, nuchal
rigidity, neck stiffness. The physician confirmed that serious systemic infection and
prescribed a particular drug “X”, However, the girl returns back to your health institution
after 7 days of complaining of gray skin color, cyanosis - blue lips & skin, hypotension, CV
collapse collectively known as Gray baby syndrome. So which one of the following is most
likely prescribed drug associated with patient manifestation
A. Gentamycine C. Chloramphenicol
B. Rifampin D. Cotrimoxazole

52. Identify false statement regarding Fluoroquinolone


A. Di- & tri-valent cations Greatly ↓ their absorption
B. When given with quinidine it result polymorphic ventricular tachycardia
C. Preferable drug for UTI associated with pregnancy
D. May result Pseudomembranous Colitis by overgrowth of C. difficile
53. Mrs Z is 25 years old non- pregnant women was admitted in the medical ward of HFSUH for
her CVs problem. Later she develops CNS infection due to meningococci species and the
physician prescribed combination of drug in which the one is from Sulfonamides analog. The
patient fluid intake habit was poor and later she develops Crystalluria, hematuria. So which
one of the following agent is preferable to reverse drug associated problem
A. Calciaum carbonate C. Cotrimoxazole
B. Sodium bicarbonate D. Cilastatin

54. Which of the following is odd as compared with the other


A. Isoniazid(INH) and rifampin(R) are the most active drugs
B. The addition of pyrazinamide(Z) to an INH, R combination for the first 2 months allows
the total duration of therapy to be reduced to 6 months without loss of efficacy
C. Continuation phase in TB treatment involving daily administration of 3 or more drugs
for 8 weeks
D. The continuation phase may be extended beyond 4 months when treating extra
pulmonary TB or AIDS – associated TB.
55. A 54 years old Man comes to emergency department of jugol Hospital complaining of a 2-
month history of fatigue, wt loss (10 kg), fevers, night sweats, & a productive cough. He
reports drinking 2–3 pints of hard alcohol per day for the last 15 years, & also reports a
history of Gouty Arthritis. In the emergency department, a chest x-ray shows a right apical
infiltrate with high suspicion for pulmonary TB, the patient is placed in respiratory isolation.
Then he starts DOT with HRZE containing regimen. However the patient comes to
emergency department with exacerbated Gouty Arthritis and Up on Lab investigation there is
excessive elevation of Plasma uric acid level. So which one of the following Anti TB drug is
most probably associated with the condition
A. Ethambutol(E) C. Rifampin(R)
B. Isoniazid (I) D. Pyrazinamide (Z)

56. A 30-year-old male is diagnosed in General Private Hospital and confirmed as HIV positive.
His CD4+ count is 200 cells/mm3 and his viral load is 10,000 copies/mL. In addition to
receiving antiviral therapy, which of the following is indicated to protect him against
pneumonia due to Pneumocystis jiroveci?
A. Trimethoprim. C. Ciprofloxacin.
B. Cotrimoxazole . D. Gentamycin.
57. A 9 month neonatal baby presents to emergency department of HFSUH. Up on examination
he develops neonatal encephalitis. And when Lab examination done it’s positive for herpes
simplex viruse (HSV). So which one of the following drug is best to be given for this baby
A. Acyclovir C. Ribavirin
B. Ganciclovir D. Amantadin
58. A 25-year-old man is diagnosed with HIV, and therapy is initiated. After the first week of
therapy, the patient complains of headaches, irritability, and nightmares. Which one of the
following antiretroviral drugs is most likely to be causing these symptoms?

A. Lamivudine. C. Efavirenz
B. Indinavir. D. Nevirapine. E. Stavudine.
59. An HIV-positive woman is diagnosed with CMV retinitis. She has been on a HAART
regimen containing zidovudine. Which of the following anti-CMV drugs is likely to cause
additive myelosuppression with zidovudine?
A. Acyclovir. C. Ganciclovir
B. Amantadine. D. Foscarnet. E. Ribavirin.

60. Which of the following ART drug associated with Renal dysfunction
A. Zidovudine C. Tenofovir
B. Neverapine D. Saquinavir

61. Which one of the following Protease inhibitor used as boosting drug for other it’s analog
A. Lopinavir C. Indinavir
B. Saquinavir D. Ritonavir
62. Tinnitus, dizziness, blurred vision, and headache are indicative of toxicity to which one of
the following antimalarial drugs?
A. Primaquine. C. Quinine.
B. Pyrimethamine. D. Chloroquine. E. Sulfadoxine.
63. Which of the following drugs is recommended for the treatment of severe, multidrug-
resistant Plasmodium falciparum malaria?
A. Artemisinin. C. Quinine
B. Chloroquine. D. Sodium stibogluconate.

64. A 22-year-old man, who frequently backpacks, complains of diarrhea and fatigue.
Examination of stool specimens shows binucleate organisms with four flagellae. Which one
of the following drugs would be effective in treating this patient's intestinal protozoal
infection infestation?
A. Metronidazole. B. Quinidine. C. Pentamidine. D. Sulfadoxine.
65. A 30 years old individual suffered from mild to moderated amebiasis, after getting a meal at
local restaurant , while later on he developed Amebic liver abscess which should be treated
by giving him for the encountered case
A. Diloxanide furoate plus Iodoquinol D. Emetine Plus Diloxanide furoate
B. Chloroquine E. Iodoquinolone alone
C. Metronidazole followed by Paramomycin
66. A 25 years old patient is suffering from an acute attack of malaria, his blood film has shown
P-Vivax parasites; he got chloroquine for his attack but to avoid future relapses of such
attacks he must be given
A. Quinine B. Mefloquine C. Primaquine D. Fansidar
67. Which one of the following NSAIDs produce an irreversible inhibition of cyclooxygenase
enzyme?

A. Ibuprofen. B. Indomethacin. C. Aspirin. D. Naproxen


68. Which one of the following drugs is superior to other NSAIDs for relief of dysmenorrhea?
A. Mefenamic acid. B. Ibuprofen. C. Aspirin. D. Diclofenac
69. Which of the following non-narcotic agents is salicylic acid derivative?
A) Phenylbutazone B) Ketamine C) Aspirin D) Tramadol
70. Which of the fo llowing non-narcotic agents inhibits mainly cyclooxygenase (COX) in CNS?
A) Ketorolac B) Paracetamol C) Acetylsalicylic acid D) Ibuprofen
71. Indicate the non-narcotic analgesic, which lacks an anti-inflammatory effect:
A) Naloxone B) Paracetamol C) Metamizole D) Aspirin
72. one of these is not one of the components of medical ethics:
A. pharmacist- patient relationship
B. the relationship of the pharmacist to the ministry of health
C. pharmacist-pharmacist relationship
D. the relationship of the pharmacist to society

72. all of these are true about non-malifecence principle except:

A. includes an obligation not to inflict harm intentionally


B. includes informed consent and truth
C. pharmacist must refrain from providing ineffective treatment or acting with malice toward
patients
D. offers little useful guidance to pharmacists because many beneficial therapies also have
serious risks

73. stopping a medication that is shown to be harmful is example of :

A. non-maleficence

B. autonomy

C. teleogical theories

D. beneficence

74. “patient-pharmacist privileged” best describes:

A. autonomy B. Justice

C. truth-teling D. Confidentiality

75. which of the following found on labeling but not on the prescription paper?
A. drug name

B. expiry date

C. patient name

D. drug dose and formulation

76. in FEFO stock rotation

A. a drug with earlier arrival is to be dispensed first

B. a drug with higher efficacy is to be dispensed first

C. a drug with near expiry to be dispensed

D. a drug with better economic value is to be dispensed first

77. most recent and in-depth information about health related topic is

A. primary

B. secondary

C. teritiary

D. quaternary

78. which is a good criterion of topic for drug information consult writing guide;

A. topic of DI consult should be prepared in the form of statement rather than questioner

B. topic of DI consult need to be minimum of two sentence long

C. topic of DI consult must include the disease state for which the drug is being processed

D. topic of DI consult should state only medication and appear at the bottom of consult paper

79. DI documents includes consult, news letter can be better prepared under

A. Microsoft office ppt

B. Microsoft office word

C. Microsoft excels

D. Microsoft publisher
80. one of the following is considered as best source of information for pharmacist to convince
physician during patient treatment

A. literature obtained from cross-section study design

B. literature obtained from RCT study design

C. literature obtained from simple Google search

D. source obtained from old text book

81. which of the following is true about goals of distribution management ?

A. encourages intermittent supply of drugs

B. keep drugs in good condition throughout distribution process

C. encourages inadequate geographical coverage

D. maximize drug losses

82. which of the following is true about collection and delivery methods of drug distribution?

A. collection method allows for better checking, handling and security of goods received

B. in delivery method, health facility may be closed when delivery truck arrives

C. in collection methods people meet from and discuss problems

D. A & B

83. which of the following term correctly describes the process of acquiring supplies from private or
public supplier or through purchasing from manufacturer or agencies or bilateral aids program?

A. quantification

B. logistic management

C. forecasting

D. procurement

84. which one of the following shows the advantage of limited list of essential medicine related to
prescribing objectives?

A. increase availability of irrational treatment


B. enables to provide focused drug information

C. reduction of antimicrobial resistance

D. all except A

85. which of the following is not area of focus in principles of medicine regulation in Ethiopia?

A. safety

B. effect

C. cost

D. quality

86. The scope of medicine regulatory sector in Ethiopia includes?

A. Practice

B. Products

C. Professional

D. All of the above

87. A pharmacist talks to his friend, an accountant, about patient’s medicine condition and the
medication that the patient is talking. Which of the ethical principle is breached by the pharmacist?

A. confidentiality

B. Fiedelity

C. Maleficence

D. Justice

88. Which one of the following unethical in pharmacy profession?

A. Respect patient

B. Collaborate with health professionals for malpractice

C. Cooperate with other health care professionals to improve patient care

D. None

89. All of the following should be taken in to consideration during extemporaneous compounding of
prescription except
A. Conditions required for extemporaneous production

B. Identify dosage forms

C. Make extemporaneous compounding in normal dispensary area

D. All of the above

90. All of the following are skills required to be integrated for the practice of clinical pharmacy except

A. Communication skills

B. Patient monitoring skills

C. Laboratory and diagnostic testing skills

D. None of the above

91. Which of the following department in pharmaceutical industry calls various health care
professionals to provide comprehensive information on a product to encourage the products aproprite
use by the health care provides?

A. Research and development

B. Production and quality control

C. Medicine information

D. Legal affairs

92. Which of the following is a main reason for regulating medicines?

A. The use of ineffective and poor-quality medicine can result in therapeutic failure

B. Money spent on substandard medicines is wasted

C. There is an information irregularity between stakeholders

D. All of the above

93. Patient medication records should include all except

A. Medication allergies

B. Diagnosis

C. Current medication therapy

D. pets kept at home


94. Ato Ahmed went to pharmacy with a prescription for nitroglycerin sublingual tablets. The pharmacy
workers repackaged the prescribed number of tablets in paper envelops and dispensed appropriate
instruction for use. Some other day, ato ahmed consulted the pharmacy professional about decreasing
efficacy of the drug dispensed. Which dispensing error occurred here?

A. Picking error

B. Packing error

C. Misreading the prescription error

D. Verbal communication error

95. “Your patient asked you for a recommended website that is dependable, to get answers for
questions related to her illness”. The stated case study belongs to which category of drug information
request?

A. Adverse drug reactions

B. Consumer drug informations

C. Disease state management

D. Drug compatability/stability

96. One is true about maintaining the bin card and stock card

A. One bin card should be maintained for each pack size, form or presentation of pharmacuticals

B. The bin card should be kept with the product in the storage area.

C. The bin card is used at all health facility

D. Stock record card is used at all health facility

97. ……………is the type of inspection undertaken to ensure the fulfillment of requirement by
pharmaceutical establishment before a license issued

A. Pre-licensing inspection

B. Post-licensing inspection

C. Routine inspection

D. Special inspection

98. …………..is the study of health profile of a single individual with unusual medical occurrence using a
careful and detailed report by one or more clincians
A. Case series

B. Case report

C. Cross sectional

D. Cohort

99. Pharmacist do have an obligation to:

A. Helping individuals with disabilities

B. Rescuing person who are in danger

C. Prevent and remove harm

D. All of the above

100. Which of the following enteral routes of drug administration avoid the first-pass metabolism in the
liver: a) rectal; b) sublingual; c) oral; d) transdermal.

Which of the following enteral routes of drug administration avoid the first-pass metabolism in the
liver:

A. Rectal
B. Sublingual
C. Oral
D. Transdermal.

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