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Core Learning Objectives

This document outlines the core learning objectives for a 10-week course on systematic reviews and meta-analysis. Over the course of the course, students will learn about developing focused research questions, performing literature searches, assessing biases, executing systematic review protocols, conducting meta-analyses, and assessing publication bias and heterogeneity. They will also learn about writing systematic reviews, interpreting forest plots and meta-regression results, and research ethics principles. The overall goal is for students to understand how to properly design, execute, analyze, and report the results of systematic reviews and meta-analyses.

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80 views4 pages

Core Learning Objectives

This document outlines the core learning objectives for a 10-week course on systematic reviews and meta-analysis. Over the course of the course, students will learn about developing focused research questions, performing literature searches, assessing biases, executing systematic review protocols, conducting meta-analyses, and assessing publication bias and heterogeneity. They will also learn about writing systematic reviews, interpreting forest plots and meta-regression results, and research ethics principles. The overall goal is for students to understand how to properly design, execute, analyze, and report the results of systematic reviews and meta-analyses.

Uploaded by

briella120899
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
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Briella Rodriguez
HPS432 Systematic Review and Meta-Analysis

Core Learning Objectives (CLOs)

Week 1: Reviewing Literature and Levels of Evidence

1. Discuss the concept of “Levels/Hierarchy of Evidence” and how internal and external

validity contributes to the ranking of evidence.

2. What are the key features of systematic reviews, randomised controlled trials, cohort

studies, case-control studies, case series & case reports and editorials, expert opinion

and textbooks, with respect to the levels of evidence hierarchy?

3. Explain why some sources of evidence are better than others.

Week 2: Starting a Systematic Review and Formulating a Research Question

1. Outline the key sections of a systematic review and how its structure differs from a

traditional review.

2. Understand how to use the P-I-C-O and P-E-C-O frameworks for developing a focused

question in a systematic review.

3. Understand the advantages and disadvantages of broad and narrow searches.

4. Have a preliminary understanding of selecting databases for a systematic review.

5. Understand how to write a search syntax that searches for studies that match one or

more elements of the PICO/PECO framework.

Week 3: Putting Together a Search Strategy and Writing a Systematic Review Protocol

1. Understand how to use truncation, wildcard and proximity operators when searching

databases.
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Briella Rodriguez
2. Understand how to set-up inclusion and exclusion criteria when deciding how to select

studies for a systematic review.

3. Understand the different types of bias.

4. Understand the purpose of the Cochrane Risk of Bias Tool and the domains of bias it

assesses.

5. Understand the main sections of a systematic review protocol.

6.

Week 4: Executing the Systematic Review Protocol (Finding and Sorting through Studies)

1. Learn how to run a search syntax in multiple databases.

2. Understand what a PRISMA Flowchart is and how to interpret them.

3. Understand why a reference manager is used in a systematic review.

4. Understand how to use a reference manager to create a PRISMA Flowchart.

Week 5: Writing up a Systematic Review

1. Understand the purpose of the PRISMA statement.

2. Understand the key content that is provided in each of the sections of a systematic

review (i.e., the information in the introduction, method, results and discussion).

3. Understand the different types of bias.

4. Understand the key bits of information we need to extract from each study to create a

summary table.

5. Understand the purpose of the Cochrane Collaboration's Risk of Bias Tool and how it

works.

6. Know how to interpret an assessment of bias figure.


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Briella Rodriguez

Week 6: Introduction to Meta-Analysis (and why we do Systematic Reviews)

1. Understand what meta-analysis is and what we do in a meta-analysis.

2. Know how to interpret a forest plot. Specifically, how to interpret study level and overall

effect sizes, confidence intervals and p-values.

Week 7: Combining Individual Studies and Understanding Heterogeneity

1. Understand how fixed and random effects models work to average effect sizes.

2. Understand the difference between random and systematic influences on effect sizes.

3. Understand how to interpret the I-squared statistic and Q-test.

Week 8: Assessing Publication Bias in Meta-Analysis

1. Obtain a conceptual understanding of how random and systematic bias influences the

average effect sizes in meta-analysis.

2. Understand how we use the Fail-Safe-N and Funnel Plots to assess publication bias.

3. Understand how the Trim and Fill Method works to measure the impact of systematic

bias on a meta-analysis.

Week 9: Wrapping up (meta-regression, PRISMA guidelines, and assessing meta-analyses)

1. Understand how to interpret the following parameters in meta-regression: R-squared

and the slope of the regression line.

2. Understand which type of unexplained heterogeneity meta-regression explains (hint, it

is systematic influence/error NOT random influence/error).

3. Understand the differences between fixed- and random-effects meta-regression.


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Briella Rodriguez
4. Understand the limitations of meta-regression.

5. Understand the purpose (i.e., why we have them) of the PRISMA guidelines.

6. Understand the purpose of the AMSTAR.

Week 10: Research Ethics

1. Understand the origins of the Declaration of Helsinki Ethical Principles of Research.

2. Understand how to apply the Declaration of Helsinki Principles to research.

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