Scribd
Upload
4K views2 pages

Clopidogrel

Clopidogrel is an antiplatelet drug that inhibits platelet aggregation by blocking ADP receptors on platelets. It is used to treat patients at risk of ischemic events like heart attack or stroke, and those with acute coronary syndrome. Clopidogrel should be used cautiously in patients with bleeding disorders, liver problems, or who are pregnant or breastfeeding. Common side effects include headache, dizziness, and gastrointestinal issues like nausea. Serious bleeding is a risk, especially when taken with NSAIDs or warfarin.

Uploaded by

api-3797941
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOC, PDF, TXT or read online on Scribd
4K views2 pages

Clopidogrel

Clopidogrel is an antiplatelet drug that inhibits platelet aggregation by blocking ADP receptors on platelets. It is used to treat patients at risk of ischemic events like heart attack or stroke, and those with acute coronary syndrome. Clopidogrel should be used cautiously in patients with bleeding disorders, liver problems, or who are pregnant or breastfeeding. Common side effects include headache, dizziness, and gastrointestinal issues like nausea. Serious bleeding is a risk, especially when taken with NSAIDs or warfarin.

Uploaded by

api-3797941
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOC, PDF, TXT or read online on Scribd
You are on page 1/ 2

clopidogrel

(cloe pid' oh grel)


Plavix

Pregnancy Category B

Drug classes
Adenosine diphosphate (ADP) receptor antagonist
Antiplatelet

Therapeutic actions
Inhibits platelet aggregation by blocking ADP receptors on platelets, preventing clumping
of platelets.

Indications
• Treatment of patients at risk for ischemic events—history of MI, ischemic stroke,
peripheral artery disease
• Treatment of patients with acute coronary syndrome

Contraindications and cautions


• Contraindicated with allergy to clopidogrel, active pathological bleeding such as
peptic ulcer or intracranial hemorrhage, lactation.
• Use cautiously with bleeding disorders, recent surgery, hepatic impairment,
pregnancy.

Available forms
Tablets—75 mg

Dosages
ADULTS
Recent MI or stroke: 75 mg PO daily.
Acute coronary syndrome: 300 mg PO loading dose, then 75 mg/day PO with aspirin,
given at a dose from 75–325 mg once daily.

Pharmacokinetics
Route Onset Peak Duration
Oral Varies 75 min 3–4 hr

Metabolism: Hepatic; T1/2: 8 hr


Distribution: Crosses placenta; enters breast milk
Excretion: Feces, bile, and urine

Adverse effects
• CNS: Headache, dizziness, weakness, syncope, flushing
• CV: Hypertension, edema
• Dermatologic: Rash, pruritus
• GI: Nausea, GI distress, constipation, diarrhea, GI bleed
• Other: Increased bleeding risk

Interactions
Drug-drug
• Potential increased risk of GI bleeding with NSAIDs, monitor patient carefully
• Potential increased bleeding with warfarin; monitor carefully

Nursing considerations
Assessment
• History: Allergy to clopidogrel, pregnancy, lactation, bleeding disorders, recent
surgery, hepatic impairment, peptic ulcer
• Physical: Skin color, temperature, lesions; orientation, reflexes, affect; P, BP,
orthostatic BP, baseline ECG, peripheral perfusion; R, adventitious sounds

Interventions
• Provide small, frequent meals if GI upset occurs (not as common as with aspirin).
• Provide comfort measures and arrange for analgesics if headache occurs.

Teaching points
• Take daily as prescribed. May be taken with meals.
• These side effects may occur: Dizziness, light-headedness (this may pass as you
adjust to the drug); headache (lie down in a cool environment and rest; over-the-
counter preparations may help); nausea, gastric distress (eat small, frequent
meals); prolonged bleeding (alert doctors, dentists of this drug use).
• Report skin rash, chest pain, fainting, severe headache, abnormal bleeding.

Adverse effects in Italic are most common; those in Bold are life-threatening.

You might also like

pFad - Phonifier reborn

Pfad - The Proxy pFad of © 2024 Garber Painting. All rights reserved.

Note: This service is not intended for secure transactions such as banking, social media, email, or purchasing. Use at your own risk. We assume no liability whatsoever for broken pages.


Alternative Proxies:

Alternative Proxy

pFad Proxy

pFad v3 Proxy

pFad v4 Proxy