International Journal of Unani and Integrative Medicine 2023; 7(3): 04-12

E-ISSN: 2616-4558
P-ISSN: 2616-454X
https://www.unanijournal.com Clinical validation of unani pharmacopoeial
IJUIM 2023; 7(3): 04-12
Impact Factor (RJIF): 6.3 formulation Majoon-e-Piyaz in Surat-e-Inzal
Peer Reviewed Journal
Received: 07-08-2023
(Premature ejaculation)
Accepted: 12-09-2023

Dr. Shamsul Arfeen Dr. Shamsul Arfeen, Dr. Barkat Bari, Dr. Faiyaz Ahmad and Dr. M
Research Officer (U) SL-IV, PI
Central Research Institute of
Nafees Khan
Unani Medicine, Lucknow,
Uttar Pradesh, India DOI: https://doi.org/10.33545/2616454X.2023.v7.i3a.242

Dr. Barkat Bari Abstract

Technical Officer, (U) Co PI, Each participant was well informed about the trial and written consent was obtained before initiation of
Central Research Institute of the study. Demographic data and information on the present disease condition, concomitant disease and
Unani Medicine, Lucknow,
therapy was recorded. Thorough general physical and systemic clinical examination was carried out.
Uttar Pradesh, India
Signs and Symptoms pertaining to premature ejaculation were recorded in CRF. The vital parameters
Dr. Faiyaz Ahmad
like blood pressure, heart rate, temperature and respiratory rate were also recorded. Blood sample were
Research Associate, (U) Co PI, collected for the evaluation of laboratory parameters like Haemogram, complete blood picture, kidney
Central Research Institute of function test, liver function test and routine and microscopic examination of urine were done. All
Unani Medicine, Lucknow, clinical and laboratory follow up were done at every 4 weeks.
Uttar Pradesh, India The study was carried out in a total number of 105 patients of premature ejaculation satisfying the
criteria, 80 patients completed the trial. All the patients received treatment with Majoon-e-Piyaz, out of
Dr. M Nafees Khan 80 subjects 06 patients got complete remission, 47 patients got partially remission, 27 patients showed
Deputy Director, Co PI, poor remission and 25 patients dropped out. No hepatotoxic and nephrotoxic side effects noticed during
Central Research Institute of the course of study. The clinical and laboratory findings after treatment have shown that Majoon-e-
Unani Medicine, Lucknow, Piyaz possessed efficacy in the treatment of premature ejaculation.
Uttar Pradesh, India
Keywords: Premature ejaculation, Surat-e-inzal, Unani medicine, Majoon-e-Piyaz, remission

Introduction
According to Tibb-e-Unani literature all sexual functions (including generation of semen,
sperm and ovum and formation of foetus in the mother’s womb) depend on Al quwa-e-
tanasuliyah (reproductive faculties). This Quwa (Faculty) controls many other functions
related to reproduction including male and female functions. Quwat-e-Bah (Faculty of sexual
potency and libido) governs sexual functions and is essential for maintenance of sexual
functions, Bah caries the meaning of virility, lust venereal passion and generative poser.
The faculty of sexual potency and libido (Quwat-e-Bah) depends on health and proper
functioning of vital organs viz. brain, heart, liver, whereas the sexual function depends on
health and proper functioning of vital and genital organs. Any condition affecting adversely
on these organs results in Surat-e-Inzal (Premature Ejaculation). (Ishtiyaque 1980) [18]
Surat-e-Inzal (Premature ejaculation) is a condition in which ejaculation of semen takes
place earlier than normal. It occurs immediately after insertion of penis or rarely even on
friction with clothes.
It is caused by predominance of Burūdat (Cold) and Rutūbat (Wetness) leading to the
weakening of Quwwat Māsika (Retentive power), Kasrat-i Manī (Excess of semen),
predominace of Dam (Sanguine), Hurqat o Hiddat-i Manī (Increased motility and acuteness
of semen), Zu‘f-i A‘zā Ra’īsa (Weakness of vital organs) and Ittisā‘-i Majārī-i Qazeīb
(Dialatation of passages for semen).2 Sometimes it is caused by Sū’-i Mizāj Hār (Hot morbid
temperament) of kidneys and testicles and it may be congenital also. It is characterized by
ejaculation of semen during foreplay or shortly after the insertion of penis.
Corresponding Author: The Second International Consultation on Sexual and Erectile Dysfunction defined PE as
Dr. Shamsul Arfeen ‘ejaculation with minimal stimulation and earlier than desired, before or soon after
Research Officer (U) SL-IV, PI penetration, which causes bother or distress, and over which the sufferer has little or no
Central Research Institute of
Unani Medicine, Lucknow, voluntary control’ (McMahon CG 2004) [26].
Uttar Pradesh, India

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The International Society for Sexual Medicine (ISSM) has survey of men aged 40 to 80 years estimated the prevalence
adopted a completely new definition of PE which is the first of premature ejaculation at 16% (Buvat J, 2009) [8]. A
evidence-based definition, ‘Premature ejaculation is a male Swedish interview reported an overall prevalence rate of 9%
sexual dysfunction characterized by ejaculation which in men aged 18 to 74 years (Fugl-Meyer AR, 1999) [12], with
always or nearly always occurs prior to or within about one prevalence by age being 4% (18-24 years), 7% (25-34
minute of vaginal penetration; and inability to delay years), 8% (35-49 years), 8% (50-65 years) and 14% (66-74
ejaculation on all or nearly all vaginal penetrations; and years). A Danish study about sexual problems using a
negative personal consequences, such as distress, bother, questionnaire (12 questions) and an interview (23 questions)
frustration and/or the avoidance of sexual intimacy’. It must reported the prevalence rate for PE to be 14% in men aged
be noted that this definition is limited to men with lifelong 51 years (Solstad K, 1993) [41] while in another Danish
PE who engage in vaginal intercourse since there are random population survey using a structured personal
insufficient objective data to propose an evidence-based interview the prevalence rates of PE were 7% in men aged
definition for acquired PE (McMahon CG, 2008) [27]. 16-95 years (Christensen BS, 2011, 22) [9]. An Italian
All the definitions have taken into account the time to questionnaire-based survey in andrological centres recorded
ejaculation, the inability to control or delay ejaculation, and a prevalence rate of 21% (Basile Fasolo C, 2005) [6]. In a
negative consequences (bother/distress) from PE. However, self-administered questionnaire-based survey in the
the major point of debate is quantifying the time to Netherlands, the prevalence rate was 13% in men aged 50-
ejaculation, which is usually described by intravaginal 78 years (Blanker MH, 2001) [7].
ejaculatory latency time (IELT). Several proposals for The prevalence of PE in the Premature Ejaculation
updating the definition of PE in the forthcoming DSM-V Prevalence and Attitudes (PEPA) survey (a multinational,
and ICD-11 have been presented (Balon R, 2007, Waldinger internet-based survey) was 22.7% (24.0% in the USA,
MD, 2007 Waldinger MD, 2006) [4, 48, 46]. 20.3% in Germany, and 20.0% in Italy). The Global Study
Premature ejaculation is classified as ‘lifelong’ (primary) or of Sexual Attitudes and Behaviours (GSSAB) survey was
‘acquired’ (secondary) (God pod in off ML. 1989). conducted in men between 40 and 80 years old in 29
Lifelong PE is characterized by onset from the first sexual different countries using personal and telephone interviews
experience, remains so during life and ejaculation occurs too and self-completed mailed questionnaires; it confirmed that
fast (before vaginal penetration or < 1-2 min after). the worldwide prevalence of PE was almost 30%. Except
Acquired PE is characterized by a gradual or sudden onset for a low reported rate of PE in Middle Eastern countries
following normal ejaculation experiences before onset and (10-15%), prevalence was relatively similar throughout the
time to ejaculation is short (usually not as short as in rest of the world. The prevalence rate of PE was 18% in a
lifelong PE).Recently, two more PE syndromes have been five-country European Observational study using the IELT
proposed (Waldinger MD, 2006) [46]: and the Premature Ejaculation Profile (PEP), comparable to
Natural variable PE’ is characterized by inconsistent and those obtained in a similarly designed US observational
irregular early ejaculations, representing a normal variation study. Two studies reported on PE prevalence rates based on
in sexual performance. the Premature Ejaculation Diagnostic Tool (PEDT). A
Premature-like ejaculatory dysfunction’ is characterized by computer-assisted interviewing, online, or in-person survey
subjective perception of consistent or inconsistent rapid in nine countries in the Asia-Pacific region reported
ejaculation during intercourse, while ejaculation latency prevalence rates of 16% (premature ejaculation), 15%
time is in the normal range or can even last longer. It should (Probable PE) and 13% (self-reported PE). Another study at
not be regarded as a symptom or manifestation of true a primary care clinic in Malaysia reported prevalence rates
medical pathology. of 20.3% for PE and 20.3% for probable PE (28). Finally,
The addition of these new types may aid patient the only study reporting prevalence of all four proposed
stratification, diagnosis and treatment, but their exact role classifications of PE was a non-interventional,
remains to be defined (Waldinger MD. 2007) [48]. observational, cross-sectional field survey conducted in
The major problem in assessing the prevalence of PE is the Turkey (29). Overall, the prevalence rate of PE was 20%.
lack of an accurate (validated) definition at the time the The prevalence rates were 2.3% (lifelong), 3.9% (acquired
surveys were conducted (Waldinger MD. 2002) [51]. PE), 8.5% (natural variable PE) and 5.1% (premature-like
However, epidemiological research has consistently shown ejaculatory dysfunction) (Patrick DL, 2005, Tang WS, 2011
that PE, at least according to the DSM-IV definition, is the Serefoglu EC, 2011) [33, 43, 39].
most common male sexual dysfunction, with prevalence Further research is needed on the prevalence of lifelong and
rates of 20-30% (Laumann EO 2005, Laumann EO, 1999, acquired PE. Limited data suggests that the prevalence of
Porst H, 2007) [24, 25]. lifelong PE, defined as IELT < 1-2 min, is about 2-5%.
The highest prevalence rate of 31% (men aged 18-59 years) These results are supported by the moderate genetic
was found by the National Health and Social Life Survey influence on PE and low prevalence rates of IELT < 1
(NHSLS) study in USA (Laumann EO, 1999) [25]. minute (Jern P, 2007 Waldinger MD, 2005) [19, 45].
Prevalence rates were 30% (18-29 years), 32% (30-39 Pathophysiology and risk factors the aetiology of PE is
years), 28% (40-49 years) and 55% (50-59 years). These unknown, with little data to support suggested biological
high prevalence rates may be a result of the dichotomous and psychological hypotheses, including anxiety, penile
scale (yes/ no) in a single question asking if ejaculation hypersensitivity, and 5-HT receptor dysfunction (McMahon
occurred too early, as the prevalence rates in European CG, 2004) [26].
studies have been significantly lower. A British self-
completed mailed questionnaire survey estimated that the Factors responsible for Surat-e-Inzal (Premature
prevalence rate of PE was between 14% (3 months) and ejaculation)
31% (life-time) (Dunn KM, 1998) [11]. A French telephone 1. Inexperience and ignorance of sexual techniques.

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2. Zakawat-e-Hiss (Hypersensitivity) of genital organs. significantly lower intravaginal ejaculatory latency time
3. Zofe-e-Quwat-e-Maska (Decrease retentive power) (IELT), the IELT in those who fit the DSM-IV-TR criteria
4. Increase Quwat-e-Dafeayah (Increased power of for premature ejaculation overlaps with the IELT in patients
propulsion) who do not fit the criteria. However, while a shorter IELT
5. Kasrat-e-Mani (Seminal abundance) due to excessive has been the measure of premature ejaculation in many
use of Movallide mani (Seminopoietic substance and studies, the perception of ejaculation control has been
long abstinence from intercourse). shown to mediate patient and/or partner satisfaction with
6. Hiddat-e-Mani (Seminal pungency). sexual intercourse and ejaculation-related distress. While
7. Riqqat-e-Mani (Decreased viscosity of semen) premature ejaculation is most likely not a purely
8. Zofe-e-Aza-e-Raeesa and Zof-e-Bah (Debility of vital psychological disorder, such associations demonstrate a
organs and sexual debility). significant psychological role in the disorder.
9. Iltehab Aza-e-Tanasuliyah (Inflammation of genital If the patient has always experienced premature ejaculation
organs) e.g. Urethritis and inflammation of seminal from the time he began coitus, then he has primary
vesicle. 3 premature ejaculation. If he had successful coital
10. Miscellaneous Causes: Excessive sexual thoughts over relationships in the past, yet began experiencing premature
indulgence in sexual intercourse, anxiety, guilt ejaculation with the current relationship, then he has
associated with masturbation, sodomy, abnormalities in secondary premature ejaculation. In most cases, secondary
prepuce, dilation of urethra, spermatorrhea, too narrow premature ejaculation is easier to treat and has a better
vagina, Bladder stone, intestinal worms, haemorrhoides prognosis. (Cihan A. et al 2009, Vignozzi L et al 2005) [10,
44]
etc. (Khan 1769, Kabiruddin 1926, Mobeen 1934 and .
Basheer 1886) [23, 20, 34, 5].
Material and Methods
The aetiology of premature ejaculation is not known. To Type of trial: An open level clinical trial.
date, no biological factor has been shown to be causative in Research Methodology
the majority of men with PE. Each participant was well informed about the trial and
Premature ejaculation is believed to be a psychological written consent was obtained before initiation of the study.
problem and does not represent any known organic disease Demographic data and information on the present disease
involving the male reproductive tract or any known lesions condition, concomitant disease and therapy was recorded.
in the brain or nervous system. The organ systems directly Thorough general physical and systemic clinical
affected by premature ejaculation include the male examination was carried out. Signs and Symptoms
reproductive tract (i.e. penis, prostate, seminal vesicles, pertaining to Surat-e-Inzal (Premature Ejaculation) were
testicles, and their appendages), the portions of the central recorded in CRF. The vital parameters like blood pressure,
and peripheral nervous system controlling the male heart rate, temperature and respiratory rate were also
reproductive tract, and the reproductive organ systems of the recorded and blood samples were collected for the
sexual partner. evaluation of laboratory parameters like Haemogram, and
Labor questions have been raised regarding possible confirm inclusion criteria and other laboratory test like
biochemical factors in premature ejaculation. Testosterone complete blood picture, kidney function test, liver function
is thought to play a role in the ejaculatory reflex. Higher test and routine and microscopic examination of urine were
testosterone (free and total) levels have been demonstrated done. All clinical and laboratory follow-up were done at
in men with premature ejaculation than in men without every 4 weeks.
premature ejaculation. (Waldinger MD. 2007) [48]
Research published in a Chinese andrology journal showed Selection criteria
that semen from men with premature ejaculation contained The patients of Surat-e-Inzal (Premature Ejaculation)
significantly less acid phosphatase and alpha-glucosidase attending the OPD of respective centres will be selected for
than did the semen of controls. These researchers concluded the study. A detailed clinical history will be taken and
that these biochemical parameters may reflect dysfunction complete physical examination will be carried out to make
of the prostate and epididymis, possibly contributing to the clinical diagnosis of Surat-e-Inzal (Premature
premature ejaculation; however, these have yet to be Ejaculation). Patients will be considered eligible for
supported by subsequent studies. enrolment into this study if they fulfill all of the inclusion
In other biochemical parameters, many men with premature criteria and none of the exclusion criteria, as defined below:
ejaculation have been shown to have low serum levels of
prolactin. However, in this same study of prolactin in men Inclusion Criteria
with sexual dysfunction, men in the lowest quartile of serum The following criteria will be strictly followed for inclusion
prolactin levels who had premature ejaculation also of cases in the study.
demonstrated associated metabolic syndrome, erectile 1. Male patients in the age group of 21 to 65 years.
dysfunction, and anxiety. In other words, while biochemical 2. Men with an IELT (Intra-vaginal ejaculatory latency
markers such as prolactin may contribute to premature time) of less than 1 minute will be included in the study
ejaculation, organic and psychological associations (i.e. 3. Men with a PEDT Score >11
anxiety) suggest that biochemical parameters play only a
partial role in premature ejaculation. Exclusion Criteria
While other factors may play roles of unknown significance, The patients of Surat-e-Inzal (Premature ejaculation) with
psychological factors have been found to contribute greatly following conditions will be excluded from the study:
to premature ejaculation beyond merely the time to 1. Patients with Erectile Dysfunction
ejaculation. While patients with premature ejaculation show 2. Patients with diseases requiring long term treatment

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3. Patients with cognitive impairments grades starting from “+” to “+++” at the time of Base line
4. History of addiction (smoking, alcohol, drugs) and at different follow up. Percentage in grading was
calculated and results were assessed in terms of complete
Subject recruitment remission (more than 70%), partially remission (50% to
Patients with Surat-e-Inzal (Premature Ejaculation) 70%), Poor remission (less than 50%).
attending the OPD of respective Centers will be assessed for Each participant will be well informed about the study and
clinical, biochemical, and pathological parameters. If they provided a participant information sheet (PIS); a written
do not meet the exclusion criteria and fulfill the inclusion informed consent will be obtained before initiation of any
criteria, they will be enrolled in the present study. They will study related procedure. Demographic data and information
be informed about the nature and objectives of the study and on the present disease condition, concomitant disease and
details of other study related procedures. Informed consent therapy will be recorded. Thorough general physical and
will be obtained before enrolling into the study. The detailed systemic clinical examination will be carried out. Signs and
history will be recorded and the patients will be examined in symptoms pertaining to Surat-e-Inzal (Premature
detail clinically to record the various signs and symptoms of Ejaculation) will be recorded in the CRF. Vital signs
Surat-e-Inzal (Premature Ejaculation). The study drug will including blood pressure, heart rate, temperature and
be dispensed as per the schedule and patients will be respiratory rate will be noted. Blood samples will be
instructed to take the medicine as per the protocol. collected for the evaluation of laboratory parameters
including, Haemogram, LFTs, KFTs, and Fasting Blood
Sample Size: 80 Completed subjects in all respects. Glucose to establish and confirm Inclusion and Exclusion
criteria. The follow-up for clinical parameters will be done
Duration of protocol therapy once in a week during treatment.
The total duration of treatment will be 2 weeks.
Subject recruitment
Duration of study Patients with Surat-e-Inzal (Premature Ejaculation)
The required number of study subjects will be attainable in attending the OPD of respective Centers will be assessed for
the institute’s OPD in two years. Hence, the duration of clinical, biochemical, and pathological parameters. If they
research project will be two years. do not meet the exclusion criteria and fulfill the inclusion
criteria, they will be enrolled in the present study. They will
Follow up of subject be informed about the nature and objectives of the study and
Patients were followed up at every 15 days to record change details of other study related procedures. Informed consent
in symptoms and signs. Clinical follow up and will be obtained before enrolling into the study. The detailed
investigations were performed at the base line, after Munzij- history will be recorded and the patients will be examined in
Mushil therapy and every 30 days gap and at the end of detail clinically to record the various signs and symptoms of
study. Follow up of relieved cases were performed after Surat-e-Inzal (Premature Ejaculation). The study drug will
every three months for one year. be dispensed as per the schedule and patients will be
instructed to take the medicine as per the protocol.
Safety assessment: The safety was assessed by monitoring
adverse events reported by the patients or elicited by the Duration of protocol therapy
investigator on clinical as well as laboratory investigations The total duration of treatment will be 2 weeks.
before and after treatment. The laboratory tests included
Haematological tests (Hb, TLC, DLC, ESR), Liver function Duration of study
test (Serum bilirubin, SGOT, SGPT and alkaline The required number of study subjects will be attainable in
phosphatise) and Kidney function tests (Blood urea and the institute’s OPD in two years. Hence, the duration of
serum creatinine). research project will be two years.

Statistical data recording: Data recording was done on Study drug management
separate case record form for each subject at base line, after The following Unani pharmacopeial formulation will be
M. M. Therapy and at every 15 days up to three months. used in this study:
Active and passive complaints of patients were recorded in

S. No. Study Drug Dosage Form Dose Frequency Route of Administration Method of administration
1. Majoon-e-Piyaz Semi solid 7g Twice daily Oral To be taken with water after meals

Composition of Majoon -e- Piyaz

S. No. Ingredients Botanical / Chemical Name Quantity

1. Tudri Surkh Matthiola incana 35 g
2. Tudri Safaid 35 g
3. Salab Misri Orchis latifolia 35g
4. Behman Surkh Salvia haematodes 35 g
5. Behman Safaid Centaurea behman 35 g
6. Zanjabeel Zingiber officinale 35 g
7. Tukhm-e-Piyaz Allium cepa 35 g
8. Tukhm-e-Turb Raphanus sativus 35 g
9. Tukhm-e-Gandana Allium ascalonicum 35 g

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10. Tukhm-e-Shalgham Brassica rapa 35g

11. Talmakhana Asteracantha longifolia 35g
12. Musli Safaid Chlorophytum arundinaceum 35g
13. Musli Siyiah Curculigo orchioides 35g
15. Aab-e-Piyaz Allium cepa (aqueous Extract) 1.5 litter
16. Asal/Quand Safaid 1.5kg
(NFUM, Part-I, p. 139)

Laboratory Investigations Assessment of safety

Each case of Surat-e-Inzal (Premature ejaculation) selected Safety will be assessed clinically and by laboratory
for the study will be subjected to the following pathological parameters at baseline and end of the study:
and biochemical investigations at baseline and at the end of
treatment and the reports received from the laboratory will Laboratory Parameters
be attached to the CRF.  Haemogram 7
 LFTs: S. Bilirubin, SGOT, SGPT, S. Alkaline
Pathological Investigations Phosphatase
 Haemogram: Hb, Ht (PCV), Reticulocyte count, MCV,  KFTs: S. Urea, S. Creatinine, S. Uric Acid
MCH, MCHC, TLC, DLC, platelet count, ESR  Urine Examination: Routine & Microscopic
 Urine (Routine and Microscopic Examination)
Assessment of efficacy
Biochemical Investigations Patients fulfilling the enrolment criteria will be assessed on
 Liver Function Tests (LFTs): (Serum Bilirubin, the basis of PEDT (Premature Ejaculation Diagnostic Tool)
SGOT, SGPT and S Alkaline Phosphatase) at every follow up and score will be recorded in the Case
 Kidney Function Tests (KFTs): (Serum Creatinine, Record Form. PEDT (Premature Ejaculation Diagnostic
Serum Urea) Tool) is a questionnaire to help identify men who may have
 Fasting Blood Glucose (at baseline only) a problem with ejaculating too soon during sexual activity

S. Not difficult Somewhat Moderately Very Extremely

PEDT Questionnaire
No at all difficult difficult difficult difficult
How difficult is it for you to delay ejaculation? 0 1 2 3 4
Less than Almost always
Almost never About half More than half
half the or always
or never 0% the time 50% the time 75%
time 25% 100%
Do you ejaculate before you wish? 0 1 2 3 4
Do you ejaculate with very little stimulation? 0 1 2 3 4
Not at all Slightly Moderately Very Extremely
Do you feel frustrated because of ejaculating before you want to? 0 1 2 3 4
How concerned are you that your time to ejaculation leaves your
0 1 2 3 4
partner sexually unfulfilled?
The details on how to calculate the score and the grades are given in Annexure -IV

Assessment of results The data shows that out of 80 cases studied maximum 38
On the basis of percentage efficacy obtained by the above cases having Safravi temperament followed by 27
mentioned scoring system, there will be the following four Balghami, 14 cases Saudavi, and 01 Damvi case. As per
grades of results of the study: temperament and response of the formulae concerned, it is
more effective in Balghami temperament as out of 27 cases
S. No. Percentage efficacy Result 04 cases got complete remission, 15 cases got partially
1. 95 – 100% Cured remission and 08 got poor response. In Saudavi 14 cases, 00
2. 50 – 94% Relieved cases got complete remission and 07 cases got partially
3. 25 – 49% Partially Relieved remission. In Safravi 38 case 01 got complete remission, 25
4. 0 – 24% Not Relieved got poor remission and Damvi temperament only case got
complete remission as presented in table-1.
Temperament and response

Table 1: Response according to Mizaj (Temperament):

Response
Mizaj (Temperament) Total (%)
Complete Remission Partially Remission Poor Remission
Balghami 4 15 8 27 (33.75%)
Saudavi - 7 7 14 (17.5%)
Safravi 1 25 12 38 (47.5%)
Damvi 1 - - 01 (1.25%)
Total (%) 06 (7.5%) 47 (58.75%) 27 (33.75%) 80 (100%)

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Chronicity and response formulae concerned, it is effective in the cases having

Study data shows that maximum 55 cases were having chronicity up to 02 years and 55 cases having chronicity up
chronicity up to 02 years followed by 08 cases 2-4 years, 07 to 2 years 5 case got complete remission, 33 cases got
cases 6-8 years, 05 cases 4-6years, 3 cases 8-10 years and partially remission and 17 case got poor remission. Table-2
above 10 years 02 cases. As chronicity and response of the

Table 2: Response according to chronicity of the disease:

Response
Chronicity Total (%)
Complete Remission Partially Remission Poor Remission
Up to 02 year 5 33 17 55 (68.75%)
02-04 year - 5 3 8 (10%)
04-06 year 1 2 2 5 (6.25%)
06-08 year - 5 2 7 (8.75%)
08-10 year - 1 2 3 (3.75%)
Above10 year - 1 1 2 (2.5%)
Total (%) 6 (7.5%) 47 (58.75%) 27 (33.75%) 80 (100%)

Sex and Response Dietary habits and response

In the table-3, the study shows that this disease is only in Data projected from study shows that it is more common in
males as out of 80 cases studied, As per response concerned, non-vegetarian and vegetarian approximately; out of 80
06 got complete remission, 47 cases got partially remission cases studied 17 cases were vegetarian and 63 non-
and 27 cases got poor remission. Table 3 vegetarian. As per response concerned, good response
recorded in both the types of habits, out of 17 vegetarian
Table 3: Response according to sex of patients: cases 01 got complete remission, 09 cases got partial
Response remission and 07 cases got poor remission. Likewise 63
Total non-vegetarian cases, 05 cases got complete remission, 38
Complete Partially Poor
Sex (%) cases got partial remission and 20 cases got poor
Remission Remission Remission
Male 06 47 27 80 remissions.Table-4.
Total (%) 06 47 27 80(100%)

Table 4: Response according to dietary habits:

Response
Dietary Habits Total (%)
Complete Remission Partially Remission Poor Remission
Vegetarian 1 9 7 17 (21.25%)
Non-vegetarian 5 38 20 63 (78.75%)
Total (%) 6 (7.5%) 47 (58.75%) 27 (33.75%) 80 (100%)

Social status and response response recorded in MIG as out of 60 cases, 06 cases got
Study also shows that out of 80 cases, 04 cases were from complete remission, 35 cases got partial remission and 19
lower income group, followed by 60 cases from middle cases got poor remission. In HIG as out of 16 cases studied
income group and 16 cases from high income group. As per no case got complete remission, 09 cases got partial
income group and response of the drug concerned, good remission and 07 cases got poor remission.Table-5.

Table 5: Response according to social status of patients:

Response
Social Status Total (%)
Complete Remission Partially Remission Poor Remission
Lower Income Group 00 3 1 04 (5%)
Middle Income Group 6 35 19 60 (75%)
Higher Income Group - 9 7 16 (20%)
Total (%) 6 (7.5%) 47 (58.75%) 27 (33.75%) 80 (100%)

Age and Response observed in the age group of 21-30 years as out of 29 cases
In the table-6, the study shows that this is very common in belonging to this group 03 cases got complete remission, 18
the age group of 21 to 40 years as out of 80 cases studied cases got partial remission and 08 cases got poor remission.
maximum 32 cases were belonging to 31-40 age group, In the age group of 31-40 years 03 cases got complete
followed by 29 cases in the age group of 21-30 years. 02 remission, 15 cases got partial remission and 14 cases got
cases were 51-60 years age group and only 01 case above 60 poor remission. Table-6
years age. As per response is concerned, good response

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Table 6: Response according to age group of patients:

Age Group Response
Total (%)
(In years) Complete Remission Partially Remission Poor Remission
UP TO - 20 0 0 0 00
21-30 3 18 8 29 (36.25%)
31-40 3 15 14 32 (40%)
41-50 0 11 5 16 (20%)
51-60 0 2 0 02 (2.5%)
Above 60 0 1 0 1 (1.25%)
Total (%) 6 (7.5%) 47 (58.75%) 27 (33.75%) 80 (100%)

Conclusion 200.
The study reveals that result of the Unani coded formulae 5. Basheer A. Risala-e-Quwar-e-Bah, Munshi Nawal
effective, as out of 55 cases studied 21 cases got complete Kishore, Kanpur; c1886.
remission, 25 cases got partial remission and 09 cases got 6. Basile Fasolo C, Mirone V, Gentile V. Andrology
poor remission. The formulae reduced signs and symptoms Prevention Week centers; Italian Society of Andrology
like pain, tenderness, swelling, loss of functions and (SIA).Premature ejaculation: prevalence and associated
morning stiffness in uniform way. During the study blood conditions in a sample of 12,558 men attending the
investigations of each patient for haemogram, liver function andrology prevention week 2001-a study of the Italian
test, kidney function test, Rheumatoid factor, C- reactive Society of Andrology (SIA). J Sex Med. 2005
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found that there was no significant effect of formulae on RA ejaculatory dysfunction in a community based sample
factor after completion of study, however there was slight of men 50 to 78 years old: prevalence, concern, and
increased in Hb% and marked decline ESR in well relation to sexual activity. Urology. 2001
responded cases. No Toxicity and adverse effect of the Apr;57(4):763-8.
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Acknowledgment dysfunctions and difficulties in Denmark: prevalence
We are highly thankful to Director General and Deputy and associated sociodemographic factors. Arch Sex
Director General, CCRUM, New Delhi for their kind Behav. 2011 Feb;40(1):121-32.
guidance, encouragement and patronage all through the 10. Cihan A, Demir O, Demir T, Aslan G, Comlekci A,
research work. Esen A. The relationship between premature ejaculation
and hyperthyroidism. J Urol. 2009;181:1273-80.
Conflict of Interest 11. Dunn KM, Croft PR, Hackett GI. Sexual problems: a
Not available study of the prevalence and need for health care in the
general population. Fam Pract. 1998 Dec;15(6):519-24.
Financial Support 12. Fugl-Meyer AR, Sjogren Fugl-Meyer K. Sexual
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Swedes. Scan J Sexol. 1999;2:79-105.
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How to Cite This Article

Arfeen S, Bari B, Ahmad F, Khan MN. Clinical validation of unani
pharmacopoeial formulation Majoon-e-Piyaz in Surat-e-Inzal
(Premature ejaculation). International Journal of Unani and
Integrative Medicine. 2023;7(3):04-12.

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