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The UK is ranked third overall with 492 highly cited researchers behind the US (2,622) and China
(935). He performed his doctoral (2001-2005) and post-doctoral research (2005-2007) in the
laboratories of Profs. The recipient is invited to address the Society at the Plant Biology annual
meeting the following year. We recommend updating your browser to its latest version. We aim at
deciphering the signaling events linking perception of pathogen-associated molecular patterns
(PAMPs) to the establishment of immunity. He found that the brassinosteroid co-receptor, BAK1,
also cooperates with 2 FLS2 and EFR, and he identified residues of BAK1 that are key to specifying
co-receptor output toward brassinosteroid signaling, cell death control, or innate immunity. Our
research is generated and supported by the broad TSL family of postdocs, students, and staff across
the institute. TSL group leaders have been part of this list since its creation, which demonstrates the
enduring influence and impact of the research that we carry out. Before that, he was Senior Group
Leader and Head of The Sainsbury Laboratory (TSL) in Norwich (UK) where he had his group since
2007. FLS2 and EFR) also form a complex with the membrane-associated cytoplasmic kinase BIK1
that get phosphorylated in a BAK1-dependent manner upon PAMP binding. Thomas Boller
(Friedrich-Miescher Institute, Basel, Switzerland) and Jonathan Jones (TSL Norwich, UK)
(supported by an EMBO Long-Term Post-Doctoral Fellowship), respectively. I am grateful to all of
them for their part in achieving such recognition.”. He is a pioneer and leader in the field of plant
innate immunity and receptor kinases. This is the case when a seed germinates in the soil, for
example. Now in its eighth year, the list recognises the most influential researchers on a global scale,
representing those ranking in the top 1% by citations for their field. He was elected to the European
Molecular Biology Organisation in 2018. The current study shows that reducing their levels or their
activity could have the added benefit of making crops better able to resist disease. It identifies some
6,600 researchers from across the globe who demonstrated significant influence in their chosen field
or fields through the publication of multiple highly cited papers during the last decade. Hardtke The
Arabidopsis pattern recognition receptor EFR enhances fire blight resistance in apple Piazza,
Stefano; Campa, Manuela; Pompili, Valerio; Dalla Costa, Lorenza; Salvagnin, Umberta; et al. It is
involved in growth mediated by steroid hormones called brassinosteroids, which are common to all
plants. Honors will be presented at the Plant Biology 2015 meeting in Minneapolis. It makes
fundamental scientific discoveries in molecular plant-microbe interactions and applies these to reduce
crop losses caused by plant diseases, particularly in low-income countries. We use the leucine-rich
repeats receptor kinases EFR and FLS2, which perceive bacterial EF-Tu and flagellin, respectively,
as model pattern recognition receptors (PRRs). We aim at deciphering the signaling events linking
perception of pathogen-associated molecular patterns (PAMPs) to the establishment of immunity.
Brassinosteroids are already the focus of studies to breed semi-dwarfed cereal crops. BIK1 is a
positive regulator of several FLS2- and EFR-mediated responses. His work is focused on
understanding the molecular basis of plant innate immunity mediated by surface-localized immune
receptors, as well as the application of this research to engineer disease resistance in crops. The
mechanisms controlling PRR activation at the plasma membrane and regulating intracellular signaling
remain however largely unknown. The Laboratory is generously supported by the Gatsby Charitable
Foundation and by the University of East Anglia, wins competitive grants from the BBSRC, ERC
and other research grant funding bodies and, for some research programmes, is funded by commercial
companies. Around one hundred and twenty staff and students work and study at the Laboratory
which is located on the Norwich Research Park, United Kingdom.
Cyril played a leading role in the discovery of pattern-triggered immunity in plants, including the
characterization of the bacterial peptides flagellin (flg22) and EF-Tu (elf18) as pattern-associated
molecular markers that activate signaling by the receptor-like kinases FLS2 and EFR, respectively,
leading to plant immunity. The current study shows that reducing their levels or their activity could
have the added benefit of making crops better able to resist disease. We aim at deciphering the
signaling events linking perception of pathogen-associated molecular patterns (PAMPs) to the
establishment of immunity. Now in its eighth year, the list recognises the most influential researchers
on a global scale, representing those ranking in the top 1% by citations for their field. It makes
fundamental scientific discoveries in molecular plant-microbe interactions and applies these to reduce
crop losses caused by plant diseases, particularly in low-income countries. We recommend updating
your browser to its latest version. You can read the full list of 2015 ASPB awardees on the ASPB
website. It is involved in growth mediated by steroid hormones called brassinosteroids, which are
common to all plants. The Arabidopsis leucine-rich repeat receptor kinases FLS2 and EFR are the
PRRs for bacterial flagellin (or the peptide flg22) and elongation factor Tu (or the peptide elf18),
respectively. It is a monetary award made annually and is given for outstanding investigations in the
field of plant biology by a scientist who is under 45 years of age on January 1 of the year of
presentation, or who is fewer than 10 years from the granting of the doctoral degree. TSL group
leaders have been part of this list since its creation, which demonstrates the enduring influence and
impact of the research that we carry out. He found that the brassinosteroid co-receptor, BAK1, also
cooperates with 2 FLS2 and EFR, and he identified residues of BAK1 that are key to specifying co-
receptor output toward brassinosteroid signaling, cell death control, or innate immunity. We aim at
deciphering the signaling events linking perception of pathogen-associated molecular patterns
(PAMPs) to the establishment of immunity. In addition to our own research, we also collaborate with
researchers across TSL and contribute to joint research programmes. I am grateful to all of them for
their part in achieving such recognition.”. Around one hundred and twenty staff and students work
and study at the Laboratory which is located on the Norwich Research Park, United Kingdom.
Brassinosteroids are already the focus of studies to breed semi-dwarfed cereal crops. This is the case
when a seed germinates in the soil, for example. The UK is ranked third overall with 492 highly cited
researchers behind the US (2,622) and China (935). Established in 1987, highlights of The Sainsbury
Laboratory include: discovery of RNA interference in plants by Prof. I will present recent work
illustrating how activated PRR complexes at the plasma membrane directly engage with downstream
signaling, and how these events are tightly regulated by phosphorylation. Hardtke The Arabidopsis
pattern recognition receptor EFR enhances fire blight resistance in apple Piazza, Stefano; Campa,
Manuela; Pompili, Valerio; Dalla Costa, Lorenza; Salvagnin, Umberta; et al. We use the leucine-rich
repeats receptor kinases EFR and FLS2, which perceive bacterial EF-Tu and flagellin, respectively,
as model pattern recognition receptors (PRRs). He is a pioneer and leader in the field of plant innate
immunity and receptor kinases. Cyril also made the major practical discovery that transgenic
expression of Arabidopsis EFR in Solanaceous species, which normally do not recognize the
bacterial ligand EF-Tu, confers immunity to a broad range of bacteria, and he has extended this
approach to cereals. In particular, we are focusing on cell surface-localised immune receptors, called
pattern recognition receptors, that perceive microbe-derived or endogenous patterns to activate
innate immune responses. Sir David Baulcombe FRS as recognised by the Lasker Award and the
Wolf Prize in Agriculture, discovery of the first immune receptor in plants by Prof. He performed his
doctoral (2001-2005) and post-doctoral research (2005-2007) in the laboratories of Profs. It identifies
some 6,600 researchers from across the globe who demonstrated significant influence in their chosen
field or fields through the publication of multiple highly cited papers during the last decade. His
work is focused on understanding the molecular basis of plant innate immunity mediated by surface-
localized immune receptors, as well as the application of this research to engineer disease resistance in
crops.
Before that, he was Senior Group Leader and Head of The Sainsbury Laboratory (TSL) in Norwich
(UK) where he had his group since 2007. The Laboratory is generously supported by the Gatsby
Charitable Foundation and by the University of East Anglia, wins competitive grants from the
BBSRC, ERC and other research grant funding bodies and, for some research programmes, is funded
by commercial companies. Honors will be presented at the Plant Biology 2015 meeting in
Minneapolis. The Arabidopsis leucine-rich repeat receptor kinases FLS2 and EFR are the PRRs for
bacterial flagellin (or the peptide flg22) and elongation factor Tu (or the peptide elf18), respectively.
Cyril also made the major practical discovery that transgenic expression of Arabidopsis EFR in
Solanaceous species, which normally do not recognize the bacterial ligand EF-Tu, confers immunity
to a broad range of bacteria, and he has extended this approach to cereals. The current study shows
that reducing their levels or their activity could have the added benefit of making crops better able to
resist disease. The recipient is invited to address the Society at the Plant Biology annual meeting the
following year. Hardtke The Arabidopsis pattern recognition receptor EFR enhances fire blight
resistance in apple Piazza, Stefano; Campa, Manuela; Pompili, Valerio; Dalla Costa, Lorenza;
Salvagnin, Umberta; et al. This is the case when a seed germinates in the soil, for example. Cyril
played a leading role in the discovery of pattern-triggered immunity in plants, including the
characterization of the bacterial peptides flagellin (flg22) and EF-Tu (elf18) as pattern-associated
molecular markers that activate signaling by the receptor-like kinases FLS2 and EFR, respectively,
leading to plant immunity. It makes fundamental scientific discoveries in molecular plant-microbe
interactions and applies these to reduce crop losses caused by plant diseases, particularly in low-
income countries. In particular, we are focusing on cell surface-localised immune receptors, called
pattern recognition receptors, that perceive microbe-derived or endogenous patterns to activate
innate immune responses. BIK1 is a positive regulator of several FLS2- and EFR-mediated
responses. It is involved in growth mediated by steroid hormones called brassinosteroids, which are
common to all plants. In addition, we are interested in identifying and engineering immune receptors
to improve disease resistance in crops. FLS2 and EFR) also form a complex with the membrane-
associated cytoplasmic kinase BIK1 that get phosphorylated in a BAK1-dependent manner upon
PAMP binding. We aim at deciphering the signaling events linking perception of pathogen-associated
molecular patterns (PAMPs) to the establishment of immunity. He found that the brassinosteroid co-
receptor, BAK1, also cooperates with 2 FLS2 and EFR, and he identified residues of BAK1 that are
key to specifying co-receptor output toward brassinosteroid signaling, cell death control, or innate
immunity. Brassinosteroids are already the focus of studies to breed semi-dwarfed cereal crops. We
use the leucine-rich repeats receptor kinases EFR and FLS2, which perceive bacterial EF-Tu and
flagellin, respectively, as model pattern recognition receptors (PRRs). It is a monetary award made
annually and is given for outstanding investigations in the field of plant biology by a scientist who is
under 45 years of age on January 1 of the year of presentation, or who is fewer than 10 years from
the granting of the doctoral degree. He was elected to the European Molecular Biology Organisation
in 2018. Now in its eighth year, the list recognises the most influential researchers on a global scale,
representing those ranking in the top 1% by citations for their field. We aim at deciphering the
signaling events linking perception of pathogen-associated molecular patterns (PAMPs) to the
establishment of immunity. It identifies some 6,600 researchers from across the globe who
demonstrated significant influence in their chosen field or fields through the publication of multiple
highly cited papers during the last decade. He is a pioneer and leader in the field of plant innate
immunity and receptor kinases. Plant pattern recognition receptors are receptor kinases or are part of
receptor kinase complexes, and thus offer exquisite model systems to study the molecular basis of
plant immunity, but also the mechanisms underlying the function, activation and regulation receptor
kinase-mediated pathways in growth, development and responses to environmental stresses. I am
grateful to all of them for their part in achieving such recognition.”. Around one hundred and twenty
staff and students work and study at the Laboratory which is located on the Norwich Research Park,
United Kingdom.
TSL group leaders have been part of this list since its creation, which demonstrates the enduring
influence and impact of the research that we carry out. In particular, we are focusing on cell surface-
localised immune receptors, called pattern recognition receptors, that perceive microbe-derived or
endogenous patterns to activate innate immune responses. He is a pioneer and leader in the field of
plant innate immunity and receptor kinases. Around one hundred and twenty staff and students work
and study at the Laboratory which is located on the Norwich Research Park, United Kingdom. The
UK is ranked third overall with 492 highly cited researchers behind the US (2,622) and China (935).
Brassinosteroids are already the focus of studies to breed semi-dwarfed cereal crops. In addition to
our own research, we also collaborate with researchers across TSL and contribute to joint research
programmes. We recommend updating your browser to its latest version. I will present recent work
illustrating how activated PRR complexes at the plasma membrane directly engage with downstream
signaling, and how these events are tightly regulated by phosphorylation. Our research is generated
and supported by the broad TSL family of postdocs, students, and staff across the institute. He
found that the brassinosteroid co-receptor, BAK1, also cooperates with 2 FLS2 and EFR, and he
identified residues of BAK1 that are key to specifying co-receptor output toward brassinosteroid
signaling, cell death control, or innate immunity. He performed his doctoral (2001-2005) and post-
doctoral research (2005-2007) in the laboratories of Profs. Jonathan Jones FRS, three current Group
Leaders are Fellows of the Royal Society, and five researchers who have been on the Highly Cited
Researchers list of top 1% scientists in the world since 2018. Hardtke The Arabidopsis pattern
recognition receptor EFR enhances fire blight resistance in apple Piazza, Stefano; Campa, Manuela;
Pompili, Valerio; Dalla Costa, Lorenza; Salvagnin, Umberta; et al. I am grateful to all of them for
their part in achieving such recognition.”. You can read the full list of 2015 ASPB awardees on the
ASPB website. It makes fundamental scientific discoveries in molecular plant-microbe interactions
and applies these to reduce crop losses caused by plant diseases, particularly in low-income countries.
Sir David Baulcombe FRS as recognised by the Lasker Award and the Wolf Prize in Agriculture,
discovery of the first immune receptor in plants by Prof. This is the case when a seed germinates in
the soil, for example. Cyril also made the major practical discovery that transgenic expression of
Arabidopsis EFR in Solanaceous species, which normally do not recognize the bacterial ligand EF-
Tu, confers immunity to a broad range of bacteria, and he has extended this approach to cereals. He
was elected to the European Molecular Biology Organisation in 2018. Established in 1987, highlights
of The Sainsbury Laboratory include: discovery of RNA interference in plants by Prof. The
Arabidopsis leucine-rich repeat receptor kinases FLS2 and EFR are the PRRs for bacterial flagellin
(or the peptide flg22) and elongation factor Tu (or the peptide elf18), respectively. Plant pattern
recognition receptors are receptor kinases or are part of receptor kinase complexes, and thus offer
exquisite model systems to study the molecular basis of plant immunity, but also the mechanisms
underlying the function, activation and regulation receptor kinase-mediated pathways in growth,
development and responses to environmental stresses. Cyril played a leading role in the discovery of
pattern-triggered immunity in plants, including the characterization of the bacterial peptides flagellin
(flg22) and EF-Tu (elf18) as pattern-associated molecular markers that activate signaling by the
receptor-like kinases FLS2 and EFR, respectively, leading to plant immunity. We use the leucine-rich
repeats receptor kinases EFR and FLS2, which perceive bacterial EF-Tu and flagellin, respectively,
as model pattern recognition receptors (PRRs). The Laboratory is generously supported by the
Gatsby Charitable Foundation and by the University of East Anglia, wins competitive grants from
the BBSRC, ERC and other research grant funding bodies and, for some research programmes, is
funded by commercial companies. It identifies some 6,600 researchers from across the globe who
demonstrated significant influence in their chosen field or fields through the publication of multiple
highly cited papers during the last decade. Before that, he was Senior Group Leader and Head of
The Sainsbury Laboratory (TSL) in Norwich (UK) where he had his group since 2007.