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EXERCISE#1

The document discusses the LADMER system for designing rational dosage regimens. It provides exercises to illustrate the LADMER processes for a selected drug, discuss factors affecting drug liberation and give examples of dosage forms that alter liberation.

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Ana Garcia
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22 views3 pages

EXERCISE#1

The document discusses the LADMER system for designing rational dosage regimens. It provides exercises to illustrate the LADMER processes for a selected drug, discuss factors affecting drug liberation and give examples of dosage forms that alter liberation.

Uploaded by

Ana Garcia
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOC, PDF, TXT or read online on Scribd
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BIOPHARMACEUTICS AND PHARMACOKINETICS

Name: ________________________ Date: __________________


Section: _______________________ Score: _________________

Exercise No. 1
The LADMER System

In order to design a rational dosage regimen, a pharmacist must be familiar with the
concepts of the LADMER system (Liberation, Absorption, Distribution, Metabolism, Excretion
and Response). With the principles of this complex system on hand, one can make a suitable
treatment routine for a specific patient or group of patients with altered physiologic states.

1. Select one particular drug of interest. Illustrate a schematic diagram showing the LADMER
system that the selected drug undertakes inside the body. Specify the processes which the drug
goes through in each step of the complex LADMER system and the factors affecting these
processes. You may use product inserts and books as your reference.
BIOPHARMACEUTICS AND PHARMACOKINETICS

2. What are the pharmacotechnical factors affecting drug liberation? Discuss the significance of
liberation in drug’s bioavailability.

3. Give at least three (3) dosage forms in which liberation is altered?

4. Define the following terms:


a. Absorption ____________________________________________________
____________________________________________________
____________________________________________________

b. Bioavailability ____________________________________________________
____________________________________________________
____________________________________________________

c. Disposition ____________________________________________________
____________________________________________________
____________________________________________________

d. Volume of distribution____________________________________________________
____________________________________________________
____________________________________________________

e. Biliary recycling ____________________________________________________


____________________________________________________
____________________________________________________
BIOPHARMACEUTICS AND PHARMACOKINETICS

f. Excretion ____________________________________________________
____________________________________________________
____________________________________________________
g. Protein binding ____________________________________________________
____________________________________________________
____________________________________________________
h. Enzyme inhibitor ____________________________________________________
____________________________________________________
____________________________________________________

i. Enzyme inducer ____________________________________________________


________________________________________________
________________________________________________

j. Extravascular administration ______________________________________________


____________________________________________________
____________________________________________________

k. Intravascular administration_______________________________________________
________________________________________________
________________________________________________

l. Pharmacokinetics ____________________________________________________
____________________________________________________
____________________________________________________

m. Gastric emptying time____________________________________________________


________________________________________________
________________________________________________

n. Prodrug ____________________________________________________
____________________________________________________
____________________________________________________

o. Pharmacodynamics ____________________________________________________
________________________________________________
________________________________________________

p. Biopharmaceutics ____________________________________________________
____________________________________________________
____________________________________________________

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