TOLUENE SAFETY DATA SHEET

CAS NO 108-88-3
SECTION 1: Identification of the substance/mixture and of the company/undertaking
1.1 Product identifiers
Product name : TOLUENE
CAS-No. : 108-88-3
1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses : Laboratory chemicals, Industrial & for professional use only.
1.3 Details of the supplier of the safety data sheet
Company : Associated Chemical Enterprises
10 Amethyst Road
Gauteng, Johannesburg
South Africa
Telephone : +2711 496 3300
Email : assist@acechem.co.za
1.4 Emergency telephone number
Emergency Phone # : +2711 496 3300 (8:00 am - 5:00 pm) [Office hours]

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008
Flammable liquids (Category 2), H225
Skin irritation (Category 2), H315
Reproductive toxicity (Category 2), H361d
Specific target organ toxicity - single exposure (Category 3), Central nervous system, H336
Specific target organ toxicity - repeated exposure (Category 2), H373
Aspiration hazard (Category 1), H304
For the full text of the H-Statements mentioned in this Section, see Section 16.
2.2 Label elements
Labelling according Regulation (EC) No 1272/2008
Pictogram

Signal word Danger

Hazard statement(s)
H225 Highly flammable liquid and vapour.
H304 May be fatal if swallowed and enters airways.
H315 Causes skin irritation.
H336 May cause drowsiness or dizziness.
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 H361d Suspected of damaging the unborn child.
H373 May cause damage to organs through prolonged or repeated exposure.
Precautionary statement(s)
P210 Keep away from heat, hot surfaces, sparks, open flames and other
ignition sources. No smoking.
P260 Do not breathe dust/ fume/ gas/ mist/ vapours/ spray.
P280 Wear protective gloves/ protective clothing/ eye protection/ face
protection.
P301 + P310 IF SW ALLOWED: Immediately call a POISON CENTER/doctor.
P370 + P378 In case of fire: Use dry powder or dry sand to extinguish.
P403 + P235 Store in a well-ventilated place. Keep cool.
Supplemental Hazard none
Statements
2.3 Other hazards
This substance/mixture contains no components considered to be either persistent, bioaccumulative and
toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

SECTION 3: Composition/information on ingredients

3.1 Substances
Formula : C6H5CH3
Molecular weight : 92.14 g/mol
CAS-No. : 108-88-3
EC-No. : 203-625-9
Index-No. : 601-021-00-3
Hazardous ingredients according to Regulation (EC) No 1272/2008
Component Classification Concentration
Toluene
CAS-No. 108-88-3 Flam. Liq. 2; Skin Irrit. 2; Repr. <= 100 %
EC-No. 203-625-9 2; STOT SE 3; STOT RE 2;
Index-No. 601-021-00-3 Asp. Tox. 1; H225, H315,
H361d, H336, H373, H304
For the full text of the H-Statements mentioned in this Section, see Section 16.

SECTION 4: First aid measures

4.1 Description of first aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Consult a physician.
In case of eye contact
Flush eyes with water as a precaution.
If swallowed
Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with
water. Consult a physician.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in
section 11
4.3 Indication of any immediate medical attention and special treatment needed
No data available

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SECTION 5: Firefighting measures
5.1 Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
5.2 Special hazards arising from the substance or mixture
Carbon oxides
5.3 Advice for firefighters
Wear self-contained breathing apparatus for firefighting if necessary.
5.4 Further information
Use water spray to cool unopened containers.

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid breathing vapours, mist or gas. Ensure adequate ventilation.
Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to
form explosive concentrations. Vapours can accumulate in low areas.
For personal protection see section 8.
6.2 Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the
environment must be avoided.
6.3 Methods and materials for containment and cleaning up
Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and
place in container for disposal according to local regulations (see section 13).
6.4 Reference to other sections
For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling
Avoid contact with skin and eyes. Avoid inhalation of vapour or mist.
Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic
charge.
For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are
opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): Flammable liquids
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

8.1 Control parameters
Derived No Effect Level (DNEL)
Application Area Exposure Health effect Value
routes
Workers Inhalation Acute systemic effects 384 mg/m3
Workers Inhalation Acute local effects 384 mg/m3
Workers Skin contact Long-term systemic effects 384mg/kg BW /d
Workers Inhalation Long-term systemic effects 192 mg/m3

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 Workers Inhalation Long-term local effects 192 mg/m3
Consumers Inhalation Acute systemic effects 226 mg/m3
Consumers Inhalation Acute local effects 226 mg/m3
Consumers Skin contact Long-term systemic effects 226mg/kg BW /d
Consumers Inhalation Long-term systemic effects 56.5 mg/m3
Consumers Ingestion Long-term systemic effects 8.13mg/kg BW/d
Predicted No Effect Concentration (PNEC)
Compartment Value
Soil 2.89 mg/kg
Marine water 0.68 mg/l
Fresh water 0.68 mg/l
Marine sediment 16.39 mg/kg
Fresh water sediment 16.39 mg/kg
Sewage treatment plant 13.61 mg/l
Aquatic intermittent release 0.68 mg/l
8.2 Exposure controls
Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. W ash hands before breaks
and at the end of workday.
Personal protective equipment
Eye/face protection
Face shield and safety glasses Use equipment for eye protection tested and approved
under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
(without touching glove's outer surface) to avoid skin contact with this product. Dispose of
contaminated gloves after use in accordance with applicable laws and good laboratory
practices. Wash and dry hands.
Body Protection
Complete suit protecting against chemicals, Flame retardant antistatic protective clothing., The
type of protective equipment must be selected according to the concentration and amount of
the dangerous substance at the specific workplace.
Respiratory protection
Where risk assessment shows air-purifying respirators are appropriate use (US) or type ABEK (EN
14387) respirator cartridges as a backup to enginee protection, use a full-face supplied air
respirator. Use respirators and components tested and approved under appropriate government
standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into
the environment must be avoided.

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties
a) Appearance Form: liquid
Colour: colourless
b) Odour aromatic
c) Odour Threshold No data available
d) pH No data available
e) Melting point/freezing Melting point/range: -93 °C
point
f) Initial boiling point and 110 - 111 °C
boiling range

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 g) Flash point 4.0 °C - closed cup
h) Evaporation rate No data available
i) Flammability (solid, gas) No data available
j) Upper/lower Upper explosion limit: 7 %(V)
flammability or Lower explosion limit: 1.2 %(V)
explosive limits
k) Vapour pressure 21.8 mmHg at 20.0 °C
l) Vapour density No data available
m) Relative density 0.865 g/mL at 25 °C
n) Water solubility 0.5 g/l at 15 °C
o) Partition coefficient: n- No data available
octanol/water
p) Auto-ignition 535.0 °C
temperature
q) Decomposition No data available
temperature
r) Viscosity No data available
s) Explosive properties No data available
t) Oxidizing properties No data available
9.2 Other safety information
No data available

SECTION 10: Stability and reactivity

10.1 Reactivity
No data available
10.2 Chemical stability
Stable under recommended storage conditions.
10.3 Possibility of hazardous reactions
No data available
10.4 Conditions to avoid
Heat, flames and sparks.
10.5 Incompatible materials
Strong oxidizing agents
10.6 Hazardous decomposition products
Hazardous decomposition products formed under fire conditions. - Carbon oxides
Other decomposition products - No data available
In the event of fire: see section 5

SECTION 11: Toxicological information

11.1 Information on toxicological effects
Acute toxicity
LD50 Oral - Rat - > 5,580 mg/kg(Toluene)
LC50 Inhalation - Rat - 4 h - 12,500 - 28,800 mg/m3(Toluene)
LD50 Dermal - Rabbit - 12,196 mg/kg(Toluene)
Skin corrosion/irritation
Skin - Rabbit(Toluene)
Result: Skin irritation - 24 h

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 Serious eye damage/eye irritation
Eyes - Rabbit(Toluene)
Result: No eye irritation
(OECD Test Guideline 405)
Respiratory or skin sensitisation
No data available(Toluene)
Germ cell mutagenicity
Rat(Toluene)
Liver
DNA damage
Carcinogenicity
IARC: 3 - Group 3: Not classifiable as to its carcinogenicity to humans (Toluene)
Reproductive toxicity
Damage to fetus possible(Toluene)
Suspected human reproductive toxicant(Toluene)
Experiments have shown reproductive toxicity effects in male and female laboratory animals.(Toluene)
Specific target organ toxicity - single exposure
No data available(Toluene)
Specific target organ toxicity - repeated exposure
No data available
Aspiration hazard
No data available(Toluene)
Additional Information
RTECS: XS5250000
Lung irritation, chest pain, pulmonary edema, Inhalation studies on toluene have demonstrated the
development of inflamm scrotum in animals., Central nervous system(Toluene)

SECTION 12: Ecological information

12.1 Toxicity
Toxicity to fish LC50 - Oncorhynchus mykiss (rainbow trout) - 7.63 mg/l - 96 h(Toluene)
NOEC - Pimephales promelas (fathead minnow) - 5.44 mg/l - 7 d(Toluene)
Toxicity to daphnia and EC50 - Daphnia magna (Water flea) - 8.00 mg/l - 24 h(Toluene)
other aquatic
invertebrates
Immobilization EC50 - Daphnia magna (Water flea) - 6 mg/l - 48 h(Toluene)
Toxicity to algae EC50 - Chlorella vulgaris (Fresh water algae) - 245.00 mg/l - 24 h(Toluene)
EC50 - Pseudokirchneriella subcapitata (green algae) - 10.00 mg/l - 24
h(Toluene)
12.2 Persistence and degradability
Biodegradability Result: - Readily biodegradable.
12.3 Bioaccumulative potential
Bioaccumulation Leuciscus idus (Golden orfe) - 3 d
- 0.05 mg/l(Toluene)
Bioconcentration factor (BCF): 90
12.4 Mobility in soil
No data available(Toluene)

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12.5 Results of PBT and vPvB assessment
This substance/mixture contains no components considered to be either persistent, bioaccumulative and
toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
12.6 Other adverse effects
Toxic to aquatic life.

SECTION 13: Disposal considerations

13.1 Waste treatment methods
Product
Burn in a chemical incinerator equipped with an afterburner and scrubber b highly flammable. Offer
surplus and non-recyclable solutions to a licensed disposal company.
Contaminated packaging
Dispose of as unused product.

SECTION 14: Transport information

14.1 UN number
ADR/RID: 1294 IMDG: 1294 IATA: 1294
14.2 UN proper shipping name
ADR/RID: TOLUENE
IMDG: TOLUENE
IATA: Toluene
14.3 Transport hazard class(es)
ADR/RID: 3 IMDG: 3 IATA: 3
14.4 Packaging group
ADR/RID: II IMDG: II IATA: II
14.5 Environmental hazards
ADR/RID: no IMDG Marine pollutant: no IATA: no
14.6 Special precautions for user
No data available

SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
15.2 Chemical safety assessment
A Chemical Safety Assessment has been carried out for this substance.

SECTION 16: Other information

Full text of H-Statements referred to under sections 2 and 3.
H225 Highly flammable liquid and vapour.
H304 May be fatal if swallowed and enters airways.
H315 Causes skin irritation.
H336 May cause drowsiness or dizziness.
H361d Suspected of damaging the unborn child.
H373 May cause damage to organs through prolonged or repeated exposure.

Further information
The above information is believed to be correct but does not purport to be all inclusive and shall
be used only as a guide. The information in this document is based on the present state of our
knowledge and is applicable to the product with regard to appropriate safety precautions. It does
not represent any guarantee of the properties of the product. Associated Chemical Enterprises and its
Affiliates shall not be held liable for any damage resulting from handling or from contact with the
above product. See www.acechem.co.za for additional terms and conditions of sale.
END OF SDS
Form Ref: OHS13 Version 4.0 Date: 01 February 2021
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