Government of Jammu and Kashmir

TDIUTEo
OF MEDn INSTITUTE OF MEDICAL SCIENCES,
SHER--KASHMIR
[DEEMED UNIVERSITY] soURA-SRINAGAR

Professional MBBS, (Batch: 2020o)

First 2022
Feb-March
Examination-Session

Annual
Biochemistry (Paper -)
Subject:
Dated: 02.03.2022
Max. Marks: 100
Time allowed:
03 hours
Attempt all questions.

Marks Each)
LongAnswer Type (10
Section:A
of conditions
such as Diabetes mellitus

in the pathogenesis
Describe the role
of oxidative stress
1.
processes. [5+5]
and atherosclerosis. of various detoxification
an account
by detoxification? Give SEM
2. What is meant
its components?
extracellular matrix (ECM) with -

3. Describe the
Answer Type (5 Marks
Each)
Short
Section: B Enryne l e n a n

Short Notes useful. (3

the enzymes that are therapeutically
1. Name
delauey
2. What are Aquasomes.
therapeutic agents.
)

Antioxidants as used
3.
synthesis. cu e M
4. Rate limiting step ofHeme
What are(ntegrins? What
is theirfunction?-
Reasoning (4 Marks Each) to adults. "
5.

section:C higher level of ALP

in serum compared
Children have a alcoholpoisoning?
1.
for Ethyl alcohol given as
antidote for Methyl
2. Give reason
are endemic
for Malaria. 3) d
in areas that
is
of Hbs trait incrèese
common
Presence
or decrease
the activity of enzymes.
glucose estimation.
can
4. Phosphorylation
over Glucokinase for blood
5. Hexokinase in preferred
AETCOM (5 Marks Each)
Short Notes
health care _ystem?
therole of a physician in
Describe and discuss and prognosis?
1. diagnosis, therapy
be told about their
2. What should the patients ethics?
based practice and
understand by evidence- MCQ (One Mark Each)
3. What do you

Section D arsenate poisoning?

Which of the following step is inhibited during
1.
a. Glyceraldehyde-3-Phosphatedehydrogenase
b. 3-Phosphoglycerate mutase.

C. Enolase.

d.Pyruvate Kinase aminotransferase(AST) in the

blood is indication of:
2. The elevated activity of Aspartate
a. (Kidney disease.
b. Muscle dystrophy.
C. ACutepancreatitis
d. Myocardial infraction.
3 All the following metalloenzymescontain copper except
Glutathione peroxidase

(b. Superoxide dismutase.

Tyrosinase.
d. Cythochrome oxidase.

4. Which one of the following is a chain-breaking antioxidant?

 a. Selenium.
b. Glutathione Peroxidase.
C. Catalase.
d. Superoxide dismutase. has a
n a i iTe of 6 days.
antigen. It
S. to an
This immunoglobin is the second to respond d. IgE.
a. gA. c.IgM
. Cataract are formed due to the accumulation O d.
Rabitol.
Mannitol.
c.
a. Xylitol. . Galactitol.
7. Methotrexate acts by inhibiting: reductase. d. Cynocobalamine.
Folate
a. Cellular oxidation. b. RNA Synthesis.
Which mineral is essential for normal
maturation of collagenr d. Calcium.
c. Zinc.
a. Copper. b. Iron.
except.
syndrome,
. All manifestations are seen in Lesch-nyhan
a. Self-mutilation.
b. Immunodeficiency.
C. Hyperuricemia
d. X-linked inheritance."
substrate level phosphorylation.
10. Which of the enzymes listed catalyses a
a. Phosphofructokinase.
b. Hexokinase.
c. Pyruvate kinase.
d. Glucokinase.
telos a s
 81
and Kashmir
Government of Jammu
INSTITUTE OF MEDICAL SCIENCES,
SHER--KASHMIR
DEEMED UNIVERSITY] sOURA-SRINAGAR

First Professional MBBS, (Batch: 2020)

2022
Examination Session Feb-March
Annual
Subject: Physiology (Paper
1) -

Dated: 28.02.2022
Max. Marks: 100
hours
Time allowed: 03
Attempt all questions.
Each)
LongAnswerType (10 Marks
Section: A and factors affecting glomerularfiltration
(GFR). rate
1. Describe the mechanism, management of
Explain physiological actions parathyroid
Namethe hormones regulatingsecretion. metabolism.
Calcium
2.
hormone and regulation of its Endo
functions of Basal ganglia. Add a note on Parkinson's disease CNs
3Describe connections and

Section:B Short Answer Type (5 Marks Each)

(5 Marks each)
Short Notes
1. Obesity.
Role of hypothalamus in temperature regulation. urS
Myopia. CM
4 Diabetes Inspidus. ⑳

5 Indicators of ovulatiorn.
repre
Section:C Reasoning 4 MarksEach)
1. A1 year old boy is referred to a surgeon because of bilateral absence of testes within the
scrotum. The absence of testes was noted at birth and has persisted since then.
a. Whatis the function ofLeydig cells?
repre
bWhatwill happeniftestes donot.descend?
2. A 30yearoldfemale presents withsymptoms offMasculinisation with increased muscular
rOWthbdeepening ofvoiceandAmenorrhoea On examination she had male type of hair
growthandenlargement df clitoris.) Endo
a. What is the most likely diagnosis? dy
-
b.hat isthecause ofthiscondition?)
3. A8 year old boy presents witkPhysical growth retardation sluggish movements) constipation,
mental tetardation, pot belly (arge protruded tongue) Answer the following question:
a. What1s the likely diagnosis?
b. What will be the differential diagnosis
c. How
this child can be treated?
Ends
4. Young boy presents with complaints of weakness and weight.loss, yecurrent urinary infection
-

and sepsis of skin.

a. What is the most likely diagnosis? -cre
b.
C.
What investigation can be carried
What is the reason of weight loss?
Quttoestablish and diagnosis?
5. Road traffic accident patient presents with multiple injuries on right side of the back. On
examination he had upper motor neuron lesion of the right leg, loss of pain and temperature
sensation on the left side and postural sensation on the right side.)
CNS
a.What is the likely diagnosis? -
 b. What is anupper motorneurontype of paralysis?
J

Short Notes AETCOM (S Marks Each)

1. What are the duties of a doctor towards society?
2. What are the benefits of practice of vogaand meditationyn daily life?
3. What is the importance of lifelong learning of a physician?
Section D MCa (One Mark Each)
1. Sympathetic innervations of the liver regulate which function.
Formationofglucose from glycogen.
b. Bile synthesis and production.
ca
C. Iron storage.
d. Endocrine function.
2. A major stimulus for the release of ADH is
Rise in plasma osmolality.
b. Inhibition of osmoreceptors.
C. Increase in ECF water concentration.
d. Stimulation of barorerecptors.
3. The micturation reflex is centered in the
a. Medulla.
Sacral cord.
C. Hypothalamus.
Lumbar cord.
4. CD is a marker of
a. B cell.
b. Cytotoxic T cell.
C.Helper Tcell. c
d. T
An activated macrophage.
5. Turner's syndrome has the

wel
following sex chromosome
6.
a. XY.
xo.
Fovea is a part of the retina that
c.YO d. XXY
contains pohotoreceptors called
Rods. b. Gangilion cells.
C.Amacrine cells. os
7 Life span of corpus luteum in Cones.
non pregnant state

repre
a. 4 days. b. 6 days. 1 2 days. d. 14 days.
8 Steriod biosynthesis occurs in
a. Smooth endoplasmic reticulum.
c. Golgi body. .Rough endoplasmic reticulum
d. Liposome.
9. Maximum amount of adrenal
cortisolsecretion is of
Cortisol.
b. Corticosterone.
C. Dehydo Corticosterone.
d. Aldosterone.
10. Macula densa controls the
GFR through
a. Adenosine.

Nitric oxide.
C. Prostaglandin.
d. Thromboxane Az.
 Kashmir
of Jammu and
Government
MEDICALSCIENCES,
INSTITUTE OF
STITUTE F MEDIOA. S H E R - 1 - K A S H M

[DEEMED UNIVERSITY] SOURA-SRINAGAR

Professional MBBS, (Batch: 2020)

First 2022
-
Session Feb-March
Examination
Annual
Subject: Biochemistry (Paper-I)
Dated: 05.03.2022

Max. Marks: 100

allowed: 03 hours
Time
Attempt all questions.

LongAnswer Type
(10 Marks Each)
the
Section:A each and highlight
example of
Letgda

deamination
with one
transamination from
glutamate
Explainthe
role of
Differentiate
alpha-ketoglutatric.acid intransmination,
significance of
metabolism.{
2+2+3+3)
QxidizedLDLcan cause
blood pressure

tdehydrogenase in amino acid explain how

Enlist the constituents of "lipid profile"and
dysregulationlandarteriosclerosis (5+2.5+2.5) Operon
controls the gene
How the lac
not express
all ofits genes?
does
&Discuss why every cell
prokaryotes? (4+6)
expression in
Type(5 Marks Each)
ShortAnswerfunction
Section:B proteins and write one
each. of melitus.
Ho

1Enlist 10 plasma controlled diabetes

biochemical acidosis in poorly
basis of
how calcium
homeostasis is
2Write the humans and explain
various functions
of calcium in healthy
3 Enlist
maintained.
functions of collagen onedisease of collagen. name

structural features, properties and gel draw the

A- Write the On a hypotheticalplovacrylamide
is differentfrom ecrosis)
(5In what ways epoptosis anapoptoticcellpnd a úecrotic cell
pattern of DNAband(s) purified from
Reasoning (4 Marks Each)chromosomes in eukaryotes ênsure that
Section: C How do the linear
1 What is 'end replication problem'?
its ends are replicated completely?2 the basis of levels of T, T, and TSH and
on
hyperthyroidism.from.hypothyroidism
2 Differentiate
clinicalpresentations. Provide the following
someoroteins undergo modification aftertranslation? the
(3) Why do on post-translationally modified protein. (a) Non-protein part attached to
information any
ofattachment of non-protein part of the protein)
protein (b) mechanism that are tested in liver
function test and
analytes/compounds
Write the names and nature ofall
Ar performed in patients.
renal function test. Why LFT and RFT are
the name of the biomarker oflipid
How do free radicals causelipid peroxidation? Write
from peroxidation.
how antioxidants protect lipids
peroxidation and explain AETCOM ( Marks Each)
Short Notes
1. Patient's rights and responsibilities in hospitals.
providers (Doctor and Paramedical
2. Significance of good communication between healthcare
Staff) and patients.
and how to pacify the bereaved
3. How to break the death news of a patient to his family members
family? MCQ (One Mark Each)
Section D
1. A molecule of myoglobin devoid ofhemekan
bind up to following number of oxvgen molecule(s)
0
b. 1
 C. 2
d. 4
is responsible for anchoring
urdnSmembrane protein which
2. Which of the following proteins isa
matrix (ECM)
the extracellular
Integrins
b. Fibronectin

C. Collagen
d. Laminin
vesicles
formation of vesicles occurs. The membrane of these
3. For the process of autophagy the
are derived from
b. Cell membrane C. Mitochodria o l g i membrane
a. Nuclear membrane

How many DNA duplex is obtained from one DNA duplexd.after

4cycles of PCR
4.
32
a. 4 b. 16
with amino acids
5. Which of the following is notlikely to form whenceducing sugarsc.react
Alkapton bodies
b. Amadori products
aSchiffbase.
Advanced glycation end products.
6. Which of the following is not alipid storage disorder
d. Krabbe's disease
a. Fabry's disease b. Farber's disease C Forbe's disease

7. Theshells of some drugsand vitamins are madefrom the following

b. Albumin. C. Casein. d. Alpha-2 macroglobulin.
Gelatin.
8. Impairment in following function can leadto hyperammonemia
c. Throid function d. Pulmonary function
aRenal function b. Liverfunction.
with
9. Hydroxyapatite is formed whenphosphateforms acomplex
a. Manganese
b. Nickle
C. Magnesium
Calium
10. Which trace element is found in thioredoxin protein involvedin purine metabolism
Selenium
b. Chromium
C. Cobalt

(Manganese
=
 CHER--KASHMIR INSTITUTE OF MEDICAL SCIEN
Of MEDICA
SHER-4-KASH

NSTITUTE

IDEEMED UNIVERSITY) SOURA, SRINAGAR,

FIRS PROFESSIONAL MBBS ANNUAL Examination
BATCH-2020: SESSION: FEB-MARCH-2022
Subject: PHYSIOLOGY (Paper 1)
Dated :24-02-2022
Attempt all questions: Time allowed: 3 hrs. Max. Marks: 100
Note: Attempt all questions
LONG ANSWER TYPE (1o MARKS EACH)
Section:A
O
1. A75 Years old male was brought to Emergency
room by his son. Early in the day, the Patient
NS
has observed red blood in
his stool, which is attributed to
Haemorrhoids. He continued with
the daily chores. However bleeding continued
all day, and by evening, he could no longer
ignore it. There is no history of smoking or drinking alcohol. On
-headed, pale and anxious. His hematocrit examination, patient was light
wa[ 33% 6.P 90/60 mmHg in lying down and
75/45mmHg in standing position. His heart rate was 105
beats/min in supine and 135
beats/minin upright position.
Normal saline infusion was started and blood was cross-matched for
revealed that bleeding came from transfusion. Colonoscopy
2 units of
a
diverticulum and had stopped now. The patient received
whole blood.A bladder catheter was put in place to monitor urine output. By next
morning, patient better and was disch arged from the hospital
i. What is the definition of definition
of circulatory shock?
What are the major causes?
ii. After
gastrointestinal blood loss, what sequence of events led to
pressure inthe patient.? decreased arterial
ii. Why was patient's arterial pressure lower
in the upright position then in the lying
iv.Whywere changes in heart rate observed: position.
What is
v.
hematocrit: Why was it decreased inthis patient?
2. Describe Oxy- haemoglobin dissociation curve in detail. -|10]
Mention thefactors that lead
the cuNe.......ssosnss5tesereneesassseeassosesoseesoseesaenoses*ornseseesssosossessseooeesso**********seseseseymnn
to shift in
3. Describe the mechanism of
cellular and humoral * .[10]
immunity. Y. *******o****************e**************
Sectlon:B
Short Answer type (5x marks
1. each)
Write briefly about the effects of
2.
Describe briefly the properties of incompatible blood transfusion
Action potential
 tivate

agents on cardiac muscle

3. What is the effect of following as
-
K+ d. Cat+
a). Ach b). Epinephrine c).

Q.4 What are the dangers of inhalation of 100% pure oxygen?

note on þlatelet countand its

variations.
Q.5 Write a

Section: C Reasoning/. Short notes

cus
1.Give the physiological basis of Aspirin in prevention of myocarial infarction. [41
2. In case of extreme emergency'O' Rh-ive blood should be transfused-Give reason
I4
3What is the physiologicalsignificance of Cushing reflex?eavhiv
as
-
14
4. f HbF persists beyond age of 6 months after birth, what investigations are mandatory? [4]
Why is cyanosis absentin anaemia and histotoxic hypoxia?x 14]
What is the basis of breaking point during breath holding
7. What are the professional qualities of physician [51
8. Discuss the importance of dignity and diversity in management of patient
Ston
[5]-
 Section DMCQ's(10X 01) Marks
1. Cells responsible for innate inmmunity are activated most
most co
commonly by
a. glucocorticoids
b. pollen
in bacterial cell walls
C. carbohydrate sequences
d. eosinophils.
2. Which ofthe following is fhot)orrectly paired.
a. Synaptic transmiSSion antidromic Conduction
b. Molecular motorS: Dyneinand Kinesin
c. Nerve growth factor: retrograde transport
d. fast axonal transport: 400mm /day
3. Gap junctions
a. Are present in cardiac muscle.
b. Are present but of little functional importance in cardiac muscle.
C.Are present and provide the pathway for rapid spread of excitation from one
cardiac muscle fiber to another.
d. Are absent in,smooth muscle.
4. wliich of the following are incorrectly paired
a. Bcells:in_ulin
b. D cells: somatostatin
C. Acels Glucagon
dcells: Gastrin
5. wiich of the following has Highest PH
a. Gastric juice
b. colonic luminal contents
pahcreatic Juice
d. Saliva
6. Which part of ECG correspondence. ventricular repolarization

us
a. PWavve
b. QRS duration
T-Wave
U-Wave pre-potential
of the following normally has a slowly depolarizing
7. which
Anoatrial node

b. Atrial Muscle cell as

C. Purkinje fibers
Muscle cell
d. Ventricular ability of blood to
the following has the greate teffect onthe
8. Which of
transport oxygen?
dissolve oxygen
a. Capacity
of the blood to
in the blood
b. amount of hemoglobin
C. PH of the plasma
C o 2 content of RBc's for
The receptors responsible
Intravenousactic acia
increasesve itilation)
9.
in the:
thiseffect are located
Medulla oblongata
b. Carotid bodies
C. lung parenchyma
d. Aortic Baroreceptors
10.Erythropoietin issecreted by
a. cells in macula densa
tubule
b Cells in proximal
capillary bed
Cellsin peritubular
C.
IGA
d.Granular cellsin the