Mega Neet BTR 1 Annotated
Mega Neet BTR 1 Annotated
B-blocker toxicity:
11. An autopsy is performed on a 9-month-old boy who died
due to refractory seizures. Examination shows microcephaly
and skin with diffuse hypopigmentation. Further work-up
reveals deficiency of a cofactor required for the formation of
neurotransmitters found predominantly in the substantia
nigra and locus caeruleus. The absence of this cofactor is
most likely to affect the function of which of the following
enzymes?
A. Branched-chain alpha-ketoacid dehydrogenase
B. Dopamine hydroxylase
C. Homogentisic acid oxidase
D. Dihydropteridine reductase
Glycine+ arginine + methionine:
Glycine + cysteine + glutamate:
Glycine + Glutamine + Aspartate:
Glutamine + aspartate:
Methionine + lysine:
Serine NO GABA
Purines Creatinine
Heme
Creatinine
Glutathione
Niacin
Bile salts
Melatonin
Basic: Collagen MC (every 3rd)
Keratin Serotonin
Universal methyl donor:
A. 1,2,3,4,5,6
B. 1,2,3
C. 2,3,4,5
D. 1,4,6
37. A 4-year-old child presents with easy fatiguability. The
mother also complains that the child has increased hunger
between meals, which is relieved after food. Liver
examination revealed no glycogen. What enzyme is most
likely deficient?
A. Glycogen phosphorylase
B. Glycogen synthase
C. Debranching enzyme
D. Glucose 6 phosphatase
Glucagon challenge test –ve: NADH CoQ reductase
Succinate CoQ Reductase
Cyt C reductase
Cyt C oxidase (Cu)
ATP synthase
ATP transporter
Co-translational modification
Selenocysteine : UGA
Pyrrolysine: UAG
Puberty:
Constituent Breast milk Cow’s milk
FEMALES: MALES:
(gm/L) (gm/L)
Proteins 11 33
• Casein 4 28
• Soluble 7 5
proteins
Lactose 70 50
• Ca 0.33 1
• P 0.15 1
Vitamins
• C 60mg 20mg
• D 501U 251U
12. A fetus with intrauterine growth restriction was born
prematurely with jaundice, hepatosplenomegaly,
microcephaly, and diffuse petechiae at birth. A brain CT was
done which revealed periventricular calcifications. What is
the best method for the diagnosis of the etiological agent?
A. Urine examination
B. Liver biopsy
C. Blood examination
D. CSF examination
16. Which of the following is not seen in a child with cystic
fibrosis?
CF: Chromosome:
-MC mutation:
-MC class of mutation:
-Trikafta: Elexacaftor + Tezacaftor + Ivacaftor
19. When do you consider administering epinephrine in a
neonate during resuscitation?
Q. CC
Q. Vascular access of -2 thumb
choice: -Lower 1/3 body sternum
-Midline
-1/3rd depth of AP
CC:PPV-
26. What can be the fluid of choice for a child in shock with
severe acute malnutrition?
A. Ringer lactate
B. Ringer lactate + 5% dextrose
C. Normal saline
D. Ringer lactate
27. Identify the correct statements
1. The greenish-black color of the first stool in the newborn is
due to bilirubin
2. According to current recommended dietary guidelines for
children, energy from saturated fats should be <10% be of total
energy intake
3. Most common cause of ventriculomegaly in newborns is
Arnold-Chiari malformation
4. Steroid-resistant nephrotic syndrome is defined as failure to
achieve remission after 4-6 weeks when on a daily
corticosteroid therapy regimen
A. 1,2,3,4
B. 2,3,4
C. 2,4
D. 1,3
30. A woman came to OPD with a newborn who has
complaints of chest retractions, dyspnea, and lethargy. The
paediatrician diagnosed the baby with respiratory distress
syndrome. This occurs due to the deficiency of:
A. Dipalmitoyl inositol
B. Lecithin
C. Sphingomyelin
D. Dipalmitoyl phosphatidylethanolamine
CAH MC Testosterone
21- hydroxylase deficiency
PM caloricity:
PELVIS SKULL Putrefaction Heat stroke
All large and wide in All large and wide in males except: delay:
females except: Pontine
-F/P eminence Strychnine, hemorrhage
O
S
-Nasal aperture metallic poison, Sepsis
A -Female forehead, orbit, chin round Carbolic acid NOT BURNS
A. 4 years
B. 18 years
C. 9 years
D. 13 years
2 mon:
3 mon:
3yr:
4yr:
5-6yr:
9-12yr:
15. A man running a 40-kilometre marathon on a hot summer
afternoon suddenly collapsed before completing his race.
On examination, his body temperature was 104 degrees, but
there were no physical signs of dehydration. Which of the
following symptoms is least likely to be seen in this patient?
A. Tachycardia
B. Hypotension
C. Sweating
D. Disorientation
18. In the civil negligence case against a doctor who bears
the onus of proof?
A. Patient
B. Police not under rank of sub inspector
C. Magistrate
D. Doctor
35. Identify the correct statements:
1. Bluish discoloration of the stomach mucosa is seen in
copper sulphate and sodium amytal poisoning.
2. Article 42 says that the state shall make provision for
securing just and humane conditions of work and maternity
relief
3. Fusion of Basiocciput with basisphenoid is seen
around 18-22 years.
4. Edmond Locard known for the study of fingerprints
A. 1,2,3,4
B. 1,2,3
C. 2,3
D. 1,4
Cadaveric spams not on traumatic
asphyxia
OBG
2. A female presents to OPD with 6 weeks of amenorrhea
complaints of bleeding per vagina and mild abdominal pain.
The urine pregnancy test is positive and hCG level is 2800
IU/L. On investigation, mass is seen on the left adnexa
measuring 3 x 2 cm. She is hemodynamically stable. How
will you manage this patient?
A. Oral methotrexate
B. Single-dose im methotrexate
C. Serial im methotrexate + leucovorin rescue
D. Salpingectomy
5. A pregnant woman with no other comorbid conditions
develops preeclampsia. She enquires about the cause of her
condition. The doctor explains that it is due to the failure of
the invasion of?
a) Spiral artery by villous trophoblasts
b) Radial artery by cytotrophoblasts
c) Spiral artery by extravillous trophoblasts
d) Arcuate artery by extravillous trophoblasts
10. A 30-year-old G4A3 woman had a history of miscarriage
at 8 weeks, the second miscarriage at 11 weeks with no
cardiac activity, and the third pregnancy loss at 24 weeks
with preterm delivery due to early-onset preeclampsia. What
is the most probable diagnosis?
A. Syphilis
B. Antiphospholipid antibody syndrome
C. TORCH infections
D. Gestational diabetes mellitus
14. A 49-year-old woman, gravida 5 para 5, comes to the
OPD due to involuntary, intermittent loss of urine over the
past 5 months. The patient loses a small amount of urine
when asked to cough. She has no dysuria, urgency, or
hematuria and usually awakens once a night to void.
Postvoid residual urine volume is 40 mL. Which of the
following is the most likely cause of this patient's
symptoms?
A. Bladder outlet obstruction
B. Detrusor overactivity
C. Urethral hypermobility
D. Vesicovaginal fistula
17. Patient is planned to undergo hysteroscopic
polypectomy using bipolar electrocautery. What is the ideal
agent for distention?
A. Distilled water
B. Normal saline
C. CO2
D. 70% dextrose
21. A 52-year-old woman diagnosed with carcinoma cervix
stage 2B was advised radiotherapy. Which of the following
statements regarding radiotherapy is false?
A. Point B is 3 cm lateral to point A
B. Point A is 2 cm above the external os and 5 cm lateral to the internal uterine canal
C. Point A receives a dose of 7000 cGy
D. Point B receives a dose of 6000 cGy
Abnormal FSH:
Abnormal AMH:
Modified BPP:
BPP:
Last to be affected:
• Normal stature
• Thelarche – absent
• FSH, LH – high
• Karyotype - 46 XX
A. Testicular feminizing syndrome
B. Gonadal dysgenesis
C. Kallmann syndrome
D. Turner syndrome
MALE PSEUDOHERMAPHRODITE
46 XY 46 XY 46 XY CAH
No uterus / FT Streak testes Testes present
Female external genitalia No ovary Male internal genitalia
IF not purely female: Uterus and FT + Female external
Breast present Female external genitalia genitalia
No axillary pubic hair No breast Virilisation at puberty:
Testosterone high No axillary pubic hair Acne, male axillary and
Testosterone low pubic hair, clitoromegaly
Female pseudohermaphrodite:
CAH
Aromatase deficiency
38. A pregnant woman presents with obstructed labor and is
grossly dehydrated. Investigations reveal fetal demise. What
will be the management?
A. Craniotomy
B. Decapitation
C. Cesarean section
D. Forceps extraction
40. A 22-year-old pregnant lady presents with fever and is
put on antibiotics. Fever is still not brought under control. On
further investigation, she is diagnosed to have septic pelvic
thrombophlebitis. Which among the following is the next
course of treatment for her?
A. Stop antibiotics and start heparin
B. Antibiotics + Heparin
C. Surgical embolectomy
D. Hysterectomy
Minipill: >3hrs
Cerazette: >12hrs
OCP
MIFEPRISTONE (RU-486)
Copper T
Eclampsia:
REGIMEN
CI: Asthma
While discharging a patient who underwent a vesicovaginal fistula
repair, which of the following would you recommend?
A. Sexual abstinence for 3 months and avoid pregnancy for a year
B. Sexual abstinence for 3 weeks and avoid pregnancy for 6 months
C. Sexual abstinence for 6 weeks and avoid pregnancy for a year