Neurology Notes DR Arshan 2
Neurology Notes DR Arshan 2
CLINICAL
NEUROLOGY
HEADACHE CLUSTER
HEADACHE D/D
❑Tension headache
❑Trauma
❑Tumor
❑Temporal arteritis
❑Migraine
❑Meningitis
❑Cluster headache
History:
❑Hemodynamic stability
❑Painkiller( I got to know from the notes that you are having headache. I am really sorry to hear
that. Would you please tell me how severe is your pain in a scale of 1-10? Do you have any allergy
to painkiller? Okay, I am going to arrange a strong painkiller for you right now, hopefully you will
feel comfortable.)
❑How are you feeling now? Are you okay to answer few of my questions please?
❑History of presenting complaints: PAIN QUES
Since when? Where exactly you are having the pain? Is it for the 1st time? If prev
episodes then ask – how many episodes so far? Any change in severity/ character of the
pain? Does it come suddenly or gradually? How long does it last? Can you describe the
pain for me? Does the pain go to anywhere? Anything makes it better?(like taking rest or
avoiding light or noise)Anything makes it worse like bright light/noise/strong odor/ any
foods like coffee , chocolate , cheese, red wine?
❑Associated : nausea/ vomiting?
❑D/D:
❑Migraine: any strange sensation before the headache starts like flashing lights/ zigzag lines?
Does the light hurt your eyes? Any FHx of migraine?
❑Meningitis: any fever/ rash/ neck pain or stiffness?
❑Trauma: any injury to the head?
❑Tumor: is the headache worse in the morning? any early morning nausea/ vomiting?
❑Temporal arteritis: any pain while chewing? Any pain/ stiffness in the shoulder or hip? Any
blurring of vision?
❑Cluster headache: any runny nose /red eyes ?
❑Sinusitis: any pain in the face? Does the headache become worse when you lean forward?
❑Stroke: any weakness in any part? Any problem with vision or speech? Any problem with
walking?
❑Refractive error : do you wear glasses?
❑Dental infection : any toothache/ ear pain or discharge? Any flu like illness/
❑Tension headache: Any stress at your home or work? How is your mood these days/
any financial issues? Do you always like to keep things in order/ are
you perfectionist in nature?
❑Somatoform / hypochondriasis : Do you have any specific concern about this
headache?
❑PMHx : How is your general health? Any past medical hx like DM/ HTN/stroke?
❑SADMA (smoking/alcohol/medication)
❑FHx : Cancer? Migraine?
❑For Migraine ask ➔ OCP ( are you taking any pill esp. OCP) / any relation with period?
PEFE :
❑GA
❑VITALS & BMI
❑Neck stiffness
❑Paravertebral muscle stiffness
❑Head : temporal artery tenderness
❑ENT: Nasal discharge /sinus tenderness
❑CNS : complete neurological examination including cranial nerves esp.
EYE : visual acuity, visual filed, pupillary response, eye movement, nystagmus ,
Diplopia, FUNDOSCOPY****
CNS : ITPRCS ( inspection , Tone , power, reflex , co-ordination, sensation)
❑CVS and other system
❑Office test: UDT/BSL
MIGRAINE
QUES: a 35 years old woman comes to your ED with on and off
headache for the last 6 months.
TASK:
❑Take history
❑PEFE
❑DX and DDX
QUES: A lady of 35 years came to your GP with recurrent headache for last 6
years. Sometimes very severe and subsides by taking panadol and rest. She
is very concern regarding this and have visited many doctors but not
relieved. All investigation including CT scan done and were normal
Company secretary/Busy with work and kids at home and have less time for
rest/No Family history of DM, HTN, Epilepsy, cancer etc./Family history of
Migraine present/Social drinker but do not smoke/No financial stress but
have stress in work and she is a perfectionist.
Task:
1.Take focus history
2.Give diagnosis
3.Further Management
POSITIVE POINTS IN HISTORY:
❑Unilateral throbbing type of headache
❑On and off for last 6 months
❑Worsened by bright lights, loud noise, certain foods like cheese, red wine, chocolate ,
coffee , hunger , stress
❑Relieved by taking rest in a quiet dark room
❑Associated nausea /vomiting
❑No aura like features, no photophobia
❑FHx of migraine +ve
❑Was on OCP
❑PEFE normal
EXPLANATION:
❑Most likely you are having a condition called Migraine headache. Do you know what it
is?
❑It’s a very common cause of headache specially in females.
❑The exact cause why this occurs is not known but it has certain triggers like fatigue,
hunger, strong odors, loud noise, hormonal changes and certain kind of foods like
cheese, coffee, chocolates etc.
❑The headache is usually one-sided throbbing in nature and sometimes you can have
nausea or vomiting along with it. Also, you can have some strange sensation like seeing
flashing lights or zigzag lines before the onset of the headache.
❑Don’t worry, its not a serious condition and its quite manageable .
❑When you have this attack try to rest in a quiet, dark room and try to avoid reading,
watching TV etc.
❑You can also take aspirin or paracetamol tablets along with a medication for vomiting
as soon as you suspect you are going to have an attack.
❑If these drugs are not effective, then we will start you with ergotamine /triptan .these
are the drugs which is used for more severe cases of migraine.
❑To prevent further episodes:
❑Try to avoid trigger factors
❑Adopt a healthy life-style
❑Try some relaxation techniques like meditation, yoga etc
❑If you get 3 or more attacks in one month, we will also start you with preventive
medication propranolol to reduce the attack
❑If pt on OCP : Stop it
❑4R
PASSED FEEDBACK:
❑40-year-old male patient comes to your GP. Has had headaches since adolescence.
❑Relevant history
❑Explain most probable diagnosis and other diagnosis to the patient with reasons.
❑Patient gave a TYPICAL textbook history of migraine since adolescence self-medicated
with ibuprofen up to now (it works most of the time), never sought medical help
before. No red flag symptoms present. (Not increased with coughing, sneezing/ not
associated with eye movement, blurred vision, stiff neck, rash, malaise/ no
neurological signs/ no sudden severe) Excluded other DDs but diagnosis of migraine
was quite clear. (When asked if anything about headache changed, to see why he
came this time, said it’s getting worse now. Any other worries? His cousin was
diagnosed with brain cancer recently. (Now started to show anxiety. Do I have cancer
too doctor??? Had to address this showing empathy and explaining his symptoms are
quite different from that of brain tumor.)
❑General health good. No significant past illness/medications. SAD -nothing significant.
He is an accountant had some worries at workplace. Can faintly remember that he had
a family history of migraine too (brother).
❑Explain most probable diagnosis and other diagnosis to the patient with reasons
❑Explained typical pattern of migraine pain. Tried to explain a bit of pathophysiology
about vessel dilatation etc. Explained other diagnosis like cluster headache/ tension
headache/ brain tumor for long standing headache, but said infectious causes
(sinusitis/meningitis) also considered but unlikely. Ran out of time to finish.
❑3/5 key steps covered. PASSED
Physical examination:
❑GA: any facial asymmetry?
❑Vitals: BP, Pulse( regular/irregular)
❑BMI
❑Neck: carotid bruit
❑EYE: PEARL( is the pupil equal and reactive to light?) , visual acuity, visual filed, eye
movement, light reflex and accommodation reflex, FUNDOSCOPY
❑CNS: ITPRCS
❑CVS
❑Office test: BSL, ECG
EXPLANATION:
❑The blurring of vision that you had is most likely due to a condition called amaurosis fugax
which is due to temporary lack of blood flow to the back of your eye called retina.
We also call it TIA or mini stroke.
❑Let me draw a picture for you. In your case one of the blood pipes supplying the back of
your eye got blocked by some clot , but as the clot was small it has dislodged by itself, and
your symptoms resolved spontaneously. This clot can be formed in your neck blood pipes
and then travel to the retinal blood pipes, or it can come from your heart as well.
❑But It can be risky as you might develop a major stroke later on. That’s why It is a medical
emergency.
❑I would like to send you to the hospital where you will be admitted and seen by the
neurologist and a cardiologist and further investigations will be done like FBE, ESR/CRP, UEC,
LFT, BSL, coagulation profile, lipid profile, ECG, carotid Doppler, and brain imaging
❑If the investigations confirm TIA, they will monitor you and start you on a blood thinning
medication called Aspirin. Also, they may start you with cholesterol lowering drugs called
statin.
❑Depending on the carotid doppler further definitive treatment will be done. If the level of
blockage of your neck blood pipes is severe the specialist might consider surgery to remove
the fatty deposition and restore normal blood flow.
❑There are certain risk factors for this condition like smoking, alcohol, Diabetes,
Hypertension, but sometimes it can happen spontaneously
❑That’s why It is very important to adopt healthy lifestyle.
❑Once you are discharged from the hospital, I will follow you up regularly, and we can further
discuss in detail about the risk factors.
QUES: A 60 years old female came to the GP clinic with weakness of her right
leg that get resolved after 30 minutes. She is a diabetic patient and in on
metformin for last 10 years.
TASK:
1.Take hx
2.PEFE
3.Dx and DDX
D/Dx OF ONE-SIDED WEAKNESS:
❑Stroke
❑TIA
❑Space occupying lesion/Tumor
❑Subdural hematoma
❑Epidural hematoma
❑Subarachnoid hemorrhage (aneurysmal bleed)
❑Complex migraine
❑Epilepsy
❑Meningitis
❑Encephalitis
❑Trauma: Head injury
❑Psychogenic
History:
❑Presenting complaints
❑D/Dx
❑CVS risk QUES: ABCDEFS
❑PMHX
❑FHX
❑SADMA
Ques: 72 years old lady presents with left sided weakness of her arms
and legs. PEFE shows left sided spastic paralysis, hypertonia and
Hyperreflexia.
Task:
History
Dx and DDx with reasons
History suggests patient had a recent head trauma and she is on
warfarin for multiple DVT.
DELIRIUM
D/Dx of DELIRIUM:
❑D - drugs, depression, alcohol, ❑ T - trauma or tumor
dementia
❑ I - infections (meningitis,
❑E - electrolyte imbalance
pneumonia, gastroenteritis,
UTI)
❑M - metabolic (hypo or hyperglycemia,
hypo or hyperthyroidism), liver failure
❑ A - arteriovascular (ACS,
❑E - eyes and ears (difficulty hearing) arrythmia)
TASKS
1. Determine the cause of sleeping problem
2. Explain to the patient the nature of the problem
❑History:
❑May I know a bit more about what happened? When did it happen? How were you
brought to the hospital? Do you know which hospital you are admitted and for how long?
❑I understand you’re unable to sleep. May I know the reason for it? For how long is this
happening to you? Do you hear or see things when nobody else is around? Do you think
somebody is trying to hurt you? By any chance, do you think of harming yourself or others?
❑Do you feel pain at the moment?
❑How is your general health? Do you feel feverish? Any headaches, SOB, racing of heart, or
tummy pain?
❑How’s your appetite? Do you have N/V? What about your waterworks or bowel motions?
Any pain or burning sensation?
❑Are you comfortable in this hospital environment?
• PMHx: Any condition like diabetes, thyroid, liver, kidney, or heart disease, anemia? CVA?
Mental/psychiatric illness ?Previous hospitalization? Previous similar episodes?
• SADMA?
• FHx of psychiatric illnesses?
• How’s your home situation?
EXPLAIN:
❑Most likely you have a condition called delirium or acute brain syndrome. This is a
common complication of major injuries and their treatment such as your burns. It will get
better along with your recovery. Your visual problems and fears are part of it and do not
mean that you have a mental illness.
❑We need to find out the cause. In your case, pain relief medication (ketamine/morphine)
may be the cause, But there are many other reasons of such condition----give all ddx
❑That’s why we need to arrange a complete delirium work up:
BLOOD==FBC, ESR/CRP, LFT, RFT, TFT
URINE== Urine MCU , Urine Na and osmolarity
IMAGING= CXR, ECG, CT SCAN of brain
❑I will let the nursing staff know about your concern so that they will take extra care for you
and explain what they are doing (assign same staff each shift to care for the patient).
❑ Environmental disturbances like lighting and noise will be addressed for your benefit. If you
want your family/friends to be here, I can help with that.
❑You will also be seen by a physician registrar to give some medication to help with your
sleep and arrange other painkillers if required.
Facial pain
• Case:
Question: middle aged lady presented with right sided facial pain for
some weeks.
Task:
• history
• pefe
• diagnosis and dd to patient
D/D of Facial Pain:
• Dental pathology
▪ Parotid gland: Infection
• Eye disorders
▪ Temporal Arteritis
• EAR infection
▪ Chronic paroxysmal hemicrania
• Nose: Rhinitis, sinusitis
▪ Cervical spinal dysfunction
• Mouth: Ulcer/ Cancer/ Tonsillitis
• TMJ dysfuction
• Erysipelas
• Herpes zoster
• Trigeminal neuralgia (tic douloureux
• Glossopharyngeal neuralgia
• Migrainous neuralgia (cluster
headache
History:
▪ Greet and introduce.
▪ Offer analgesia.
▪ Pain Questions:
▪ D/D Ques
▪ PMHX
▪ SADMA
▪ FHX
Trigeminal Neuralgia:
▪ Patient over the age of 50.
▪ Quality: excruciating, searing jabs of pain like a burning knife or electric shock
▪ Frequency: variable and no regular pattern
▪ Duration: seconds to 1–2 minutes (up to 15 minutes)
▪ Onset: spontaneous or trigger point stimulus
▪ Offset: spontaneous
▪ Precipitating factors: talking, chewing, touching trigger areas on face (e.g. washing,
shaving, eating), cold weather or wind, turning onto pillow)
▪ Relieving factors: nil
▪ Associated features: rarely occurs at night; spontaneous remissions for months or
years
Explain:
▪ Most likely you have got a condition called TN which is the pain arising from the
nerves that supply your face known as Trigeminal nerve.
▪ The exact cause why it occurs is not known but it is thought to be caused by
compression of the nerve by a loop of artery or vein.
▪ In this case, the pain usually comes very suddenly which feels like an electric
shock or sharp stabbing pain lasting for a few sec to minutes. It usually gets
aggravated with talking, chewing, touching trigger areas on face (e.g. washing,
shaving, eating), cold weather or wind, turning onto pillow etc. There is no
investigations to confirm it, usually can be diagnosed by clinical signs and
symptoms.
▪ Please don’t worry, its not a serious condition and the pain can be managed with
effective painkillers.
▪ Give DDx