MEDWAY IS YOUR DOOR TO DREAM

PHARMACOLOGY
MCQ Top 100 Questions

Pharmacology
Dr. Bharath Kumar V D

Medway Online
Follow us for more

www.medwayonline.com
 Q. Mr. Swamy aged 48years comes to the OPD with complains of drooping of
eyelids, difficulty while chewing food, weakness of upper and lower limbs,
which fluctuates in intensity overtime. The physician wanted to confirm
myasthenia gravis. Drug used to diagnose this condition is

Physostigmine

Edrophoinum

Tacrine

Pyridostigmine

www.medwayonline.com
 Q. A person was given a muscle relaxant that competitively blocks nicotinic
receptors. Which of the following drug is used for reversal of muscle relaxation
after surgery?
Neostigmine

Carbachol

Succinylcholine

Physostigmine

www.medwayonline.com
 Q. An ophthalmologist wanted to dilate pupil for short period to check the
fundus of the eye. Which among the following is the shortest acting
anticholinergic mydriatic used?
Phenylephrine

homatropine

tropicamide

tropine

www.medwayonline.com
 Q. A 38 year old male had a drug addiction and was given Varenicline. In which
drug addiction Varenicline is used?

alcohol dependence

opioid dependence

smoking cigarettes

sialorrhea

www.medwayonline.com
 Q. A patient with diabetes and COPD developed post-operative urinary
retention. Which of the following drugs can be used for short term treatment to
relieve the symptoms of this person?
Bethanechol

Methacholine

Terazosin

Tamsulosin

www.medwayonline.com
 Q. Penicillin was injected to a patient and suddenly went into anaphylactic
shock. In Anaphylactic shock, the drug given is

adrenaline 0.5 mg 1:1000 IM vastus lateralis

adrenaline 1mg 1:1000 IV

Atropine 3 mg IV

Norepinephrine 12mg

www.medwayonline.com
 Q. A 55 year old patient had cardiogenic shock. His GFR was 30ml/min/m2.
Which of the following drug is best in this patient?

dobutamine

dopamine

Fenoldopam

Midodrine

www.medwayonline.com
 Q. Midodrine is used in the below condition

Orthostatic hypotension

Acute heart failure

Hypertension

Asthma

www.medwayonline.com
 Q. A 55 year old male patient had diabetes and Bronchial asthma . Which of the
following beta blocker is contraindicated in this patient
Metoprolol

Betaxolol

Atenolol

Sotalol

www.medwayonline.com
 Q. Which of the following is not a contraindication of beta blocker?

Chronic CHF

Bronchial asthma

ariant angina

AV block

www.medwayonline.com
 Q. Antihypertensive drug preferred in patients with BPH and hypertension is

Phenoxybenzamine

Phentolamine

Prazosin

Tamsulosin

www.medwayonline.com
 Q. The adverse effect shown in image is caused by

dipivefrine

bimatoprost

Echothiophate

Apraclonidine

www.medwayonline.com
 Q. A boy is planning to travel by bus. Which of the following drug can be used
to prevent motion sickness in this person?
Hyoscine

Doxylamine + pyridoxine

Cetrizine

Fexofenadine

www.medwayonline.com
 Q. Prostaglandins are used in abortion, MTP and PPH because they cause
contraction of uterus. Which among the following is methyl PG F2 alpha
preparation of prostaglandin?
Misoprostol

Alprostadil

Dinoprostone

carboprost

www.medwayonline.com
 Q. A 33 year old female has recurrent episodes of migraine headaches. She
needs a drug to prevent these recurrences. Which of the following drug is used
in prophylaxis of migraine?
Sumatriptan

Indomethacin

Flumazenil

Propranolol

www.medwayonline.com
 Q. A patient came with pain in first metatarsophalangeal joint and high uric
acid levels. He was diagnosed with acute gouty arthritis. Which of the following
is not used in treatment of acute gout?
Indomethacin

Allopurinol

Prednisolone

colchicine

www.medwayonline.com
 Q.A 53year old female complains of early morning stiffness of hands since 3
months and her rheumatoid factor & ESR are elevated. She was diagnosed with
rheumatoid arthritis .Which of the following drugs used in rheumatoid arthritis
doesn’tmethotrexate
stop disease progression?

Indomethacin

Infliximab

Leflunomide

www.medwayonline.com
 Q.Which of the following diuretic acts by inhibiting Na+K+ 2Cl¯ symport
chlorthalidone

acetazolamide

Spironolactone

furosemide

www.medwayonline.com
 Q.Which of the following diuretic is preferred in a patient with road traffic
accident with head injury and raised ICP
Furosemide

Mannitol

Spironolactone

Acetazolamide

www.medwayonline.com
 Q.A 55 year old male patient with resistant hypertension was started on
Spironolactone. Which of the following drugs is used carefully with
Spironolactone?
Enalapril

Atenololl

Verapamil

Chlorothiazide

www.medwayonline.com
 Q. Which of the following antihypertensive drug is avoided in patients with high
serum uric acid levels?

Hydrochlorothiazide

Enalapril

Prazosin

Atenolol

www.medwayonline.com
 Q. A 44 year old male patient has a history of chronic gout. His BP is now
156/90mmHg and the physician decided to start him on an ARB for managing
his HTN. Which one of them is best to this patient?
Telmisartan

Olmesartan

Losartan

Irbesartan

www.medwayonline.com
 Q. ACE inhibitors are contraindicated in all conditions except
pregnancy

history of angioneurotic edema

bilateral renal artery stenosis

Sclerodermal crisis

www.medwayonline.com
 Q. A 60 year old female patient presented to cardiac center with dysnoea and
pedal edema. She was diagnosed with acute CHF. Which of the following is
useful in this condition?
Amrinone

Isoprenaline

Amiodarone

Dopamine

www.medwayonline.com
 Q. 58 year old male patient was started on digoxin for chronic CHF as he
started complaining dyspnea and weight gain. What is the Mechanism of action
of digoxin in this condition?
Inhibits Na+K+ATPase pump

AV blockade

PDE 3 Inhibitor

SGLT 2 inhibitors

www.medwayonline.com
 Q. DOC for treatment of ventricular tachycardia due to digoxin toxicity is?

Lignocaine

Quinidine

Verapamil

Amiodarone

www.medwayonline.com
 Q. Which of the following statement is false regarding management of CHF?

nesiritide is a BNP analogue used in decompensated CHF

Spironolactone is the only diuretic to decrease mortality in chronic CHF

Ivabradine is used in angina and CHF

furosemide is contraindicated in acute pulmonary edema

www.medwayonline.com
 Q. A 42 year old male patient is taking Sildenafil for erectile dysfunction. Which
of the following drug should not be used in this patient?
amlodipine

isosorbide dinitrate

Losartan

hydrochlorothiazide

www.medwayonline.com
 Q. Nitrates acts by stimulating Gunayl cyclase and increasing cGMP. This
causes smooth muscle relaxation. These nitrates are not useful in the following
condition
biliary spasm

renal colic

esophageal spasm

acute CHF

www.medwayonline.com
 Q. A hypertensive patient was on metoprolol treatment. Verapamil was added
to the therapy of this patient. This can result in
Atrial fibrillation

Bradycardia with AV block

Torsades de pointes

Tachycardia

www.medwayonline.com
 Q. A 52 year old patient has history of angina and heart rate of 94bpm and also
has tense personality. His BP now is 154/94mm of Hg. the preferred drug in the
treatment of hypertension in this patient is?

hydrochlorothiazide

metoprolol

Amlodipine

telmisartan

www.medwayonline.com
 Q. Which of the following K+ channel opener causes drug induced lupus?

Minoxidil

Hydralazine

Nicorandil

Diazoxide

www.medwayonline.com
 Q. A 32 year old pregnant lady has a BP of 152/96mm of Hg. Which of the
following is the first choice antihypertensive drug in pregnancy?

methyldopa

nifedipine

labetalol

Hydralazine

www.medwayonline.com
 Q. A 50 year old man is being treated for atrial arrhythmia. He develops
hypothyroidism and pulmonary fibrosis after 2 years. Which one of the
following antiarrythmic drug is the most likely cause?f the following is the first
choice antihypertensive drug in pregnancy?
Amiodarone

Procainamide

Propranolol

Quinidine

www.medwayonline.com
 Q. An asthmatic presents to the emergency department with PSVT, What will be
the drug used for its management
Verapamil

Adenosine

nifedipine

digoxin

www.medwayonline.com
 Q. Drug of choice in partial seizure is
Lamotrigine

Valproate

Carbamazepine

Ethosuximide

www.medwayonline.com
 Q. A 22 year old male patient is on long term anticonvulsant therapy. There is
progressive contractility of visual field. The likely anti-epileptic drug
responsible for this adverse effect is?
Vigabatri

Ethosuximide

Phenobarbital

Levetiracetam

www.medwayonline.com
 Q. A patient was recently started on Haloperidol. Few weeks later, he developed
tremors, rigidity and bradykinesia. First line of management for this patient is

Selegiline

Trihexyphenidyl

Dantrolene

Amantadine

www.medwayonline.com
 Q. A female patient was on lithium therapy for bipolar disorder for 6
months. She kept the fast for few days due to religious reasons and
presented with seizures, coarse tremors, confusion and weakness of
limbs. Which of the following should be done to diagnose her condition?
Serum Electrolytes

Serum lithium levels

ECG

MRI

www.medwayonline.com
 Q. which of the following adverse effect is seen with SSRI?
Visual disturbance

Constipation

Dry mouth

Sexual Dysfunction

www.medwayonline.com
 Q. Which of the following is a MAO B inhibitor used in Parkinson’s disease?
entacapone

selegeline

amantadine

pramipexole

www.medwayonline.com
 Q. Morphine is used in following conditions except
MI

Biliary colic

cancer pain

post-operative analgesic

www.medwayonline.com
 Q. Which of the following is used for relapse in opioid dependence?
methadone

clonidine

naltrexone

Buprenorphine

www.medwayonline.com
 Q. Which of the following is not used to decrease craving in alcohol
dependence?
Disulfiram

naltrexone

Topiramate

acamprosate

www.medwayonline.com
 Q. A patient comes with bleeding due to warfarin overdose, as a treating
physician what is the immediate treatment to treat warfarin induced
bleeding
Cryoprecipitate

Platelet concentrate

Fresh frozen plasma

vitamin k Injection

www.medwayonline.com
 Q. Antidote of fibrinolytic drug is

Heparin

Epsilon amino capreoic acid

Protamine

Alteplase

www.medwayonline.com
 Q. Rosuvastatin is a

PPAR gamma agonist

HMG CoA reductase inhibitor

inhibits intestinal cholesterol absorption

bile acid binder

www.medwayonline.com
 Q. DOC for late phase of Chemotherapy induced Nausea and vomiting

Aprepitant

Doxylamine

Palonosetron

nabilone

www.medwayonline.com
 Q. Which of the following is an anticholinergic drug used in acid peptic
disease
Aoeprazole

ranitidine

misoprostol

Pirenzepine

www.medwayonline.com
 Q. All of the following antibiotics have been used in treatment of H.pylori
infection, except:
Clarithromycin

Amoxicillin

Metronidazole

Ciprofloxacin

www.medwayonline.com
 Q. Which of the following is a Phosphodiesterase inhibitor used in asthma?

formoterol

Ciclesonide

Theophylline

Montelukast

www.medwayonline.com
 Q. The following drugs are used in Acute attack of asthma except

Salbutamol

Hydrocortisone

sodium cromoglycate

Terbutaline

www.medwayonline.com
 Q. Intermediate acting insulin among the following is

insulin aspart

regular insulin

insulin glargine

NPH insulin

www.medwayonline.com
 Q. A patient was diagnosed with diabetic ketoacidosis, but the treating
intern gave only insulin rapidly to lower blood glucose. What complication
is expected by this?
Hypokalemia

Hypernatremia

hypocalcaemia

hyperuricemia

www.medwayonline.com
 Q. 56-year-old man with a history of type 2 diabetes presents to his
physician for a follow up. He complains of recurrent hypoglycemic
reactions to his medications. Which of these medications is most likely
responsible for this patient's hypoglycemic reactions?
Glimepiride

Glucagon

Metformin

Acarbose

www.medwayonline.com
 Q. Which of the following decreases hepatic glucose output?

Pioglitazone

metformin

Glimepiride

Acarbose

www.medwayonline.com
 Q. Which of the Following is a GLP-1 receptor agonist?

Repaglinide

Empaglifozin

Pramlintide

liraglutide

www.medwayonline.com
 Q. All the following drugs used in diabetes mellitus cause weight loss
except:
Dapagliflozin

Sitagliptin

Liraglutide

Empaglifozin

www.medwayonline.com
 Q. Pegvisomant is used in the treatment of

Secretory diarrhea

acromegaly

down’s syndrome

hyperprolactinemia

www.medwayonline.com
 Q. Which of the following is not a therapeutic indication of Octreotide?

carcinoid syndrome

acromegaly

esophageal varices

bloody diarrhea

www.medwayonline.com
 Q. GnRH analogues are used with continuous administration to treat
following condition

Endometriosis

Uterine fibroids

Delayed puberty

prostate cancer

www.medwayonline.com
 Q. Which of the following is a tocolytic drug?

misoprostol

Atosiban

methylergometrine

carbetocin

www.medwayonline.com
 Q. Which of the following is the Mechanism of action of Methimazole?

Inhibits NaI symport

Inhibits thyroid peroxidase enzyme

Inhibits peripheral conversion T4 to T3

Inhibits release of thyroid hormones

www.medwayonline.com
 Q. Which of the following is not a contraindication for glucocorticoid
therapy?
Psychosis

Diabetes mellitus

Hypertension

Bronchial asthma

www.medwayonline.com
 Q. Monoclonal antibody against RANKL Ligand used in osteoporosis is

risedronate

Denosumab

Teriparatide

Raloxifene

www.medwayonline.com
 Q. Which of the following condition Bisphosphonates are not used

Malignancy

Pagets disease

post-menopausal osteoporosis

hypocalcaemia

www.medwayonline.com
 Q. Which of the following drug is used in breast carcinoma in
premenopausal women?
ethinyl estradiol

Raloxifene

tamoxifen

Clomiphene

www.medwayonline.com
 Q. Mifepristone is used in the below condition except

Cushing’s syndrome

Medical termination of pregnancy

post coital pill

Primary infertility

www.medwayonline.com
 Q. Combined oral contraceptive pills act by of the following mechanisms
except?
Inhibit implantation by bringing change in uterus

Inhibit ovulation

Makes cervical mucus thick and hostile

Increase gonadotropin secretion

www.medwayonline.com
 Q. Which One of the following is an aromatase inhibitor?

rituximab

mifepristone

raloxifene

letrozole

www.medwayonline.com
 Q. Identify the wrong match

Sildenafil: used in erectile dysfunction and pulmonary hypertension

Finasteride: approved in male pattern baldness

flutamide: used in Hirsutism in females

Dapoxetine : used in delayed ejaculation

www.medwayonline.com
 Q.Choose the incorrect statement regarding drug absorption

First pass metabolism reduces bioavailability

highly ionized molecule are absorbed from stomach

heparin not absorbed due to its large size

food interferes with drug absorption

www.medwayonline.com
 Q.A drug has very low volume of distribution (Vd). Which of the following
is the best explanation?
The drug is eliminated by the kidneys, and the patient has renal insufficiency

The drug is extensively bound to plasma proteins

The drug is present more in tissue

The drug is eliminated by zero-order kinetics

www.medwayonline.com
 Q.Which of the following antimicrobials should not be given to a chronic
asthmatic patient managed on theophylline therapy?
Erythromycin

Cefotaxime

Cotrimoxazole

Amoxicillin

www.medwayonline.com
 Q.A drug Z has affinity and intrinsic activity of 0, then it is a

Agonist

partial Agonist

.inverse Agonist

antagonist

www.medwayonline.com
 Q.which of the following receptor is a GPCR?

GABA A receptor

Nicotinic receptor

Muscarinic receptor

Insulin receptor

www.medwayonline.com
 Q.A 32yr old patient had anaphylactic shock and was give Inj. Adrenaline
1: 1000 by IM route. The actions of histamine are antagonized by
adrenaline. This type of antagonism is called
Chemical antagonism

competitive antagonism

noncompetitive antagonism

physiological antagonism

www.medwayonline.com
 Q.ED 50 is a measure of

Efficacy

potency

Safety

toxicity

www.medwayonline.com
 Q.In a clinical trial, a drug X was evaluated for Hypertension. It was used in
healthy human volunteers and drug caused severe gastritis in them. Which
phasePhase
of clinical
0
trial it was found out?

Phase 1

Phase 2

Phase 4

www.medwayonline.com
 Q.Which of the following drugs act by inhibiting cell wall synthesis?

Erythromycin

Cephalosporins

daptomycin

Sulfonamides

www.medwayonline.com
 Q.Which of the following drugs is anti-pseudomonal penicillin?

Cephalexin

Cloxacillin

Piperacillin

Dicloxacillin

www.medwayonline.com
 Q.Which of the following is Inhibitors of beta-lactamase?

Carbenicillin

Clavulanic acid

Cefamandole

Idoxuridine

www.medwayonline.com
 Q.DOC for typhoid fever is

Cefoperazone

Ceftazidime

Ceftriaxone

Cefepime

www.medwayonline.com
 Q.Drug of choice for methicillin resistant staphylococci aureus (MRSA) is

Stretomycin

Clindamycin

vancomycin

telithromycin

www.medwayonline.com
 Q.Which of the following drug is resistant to Pseudomonas?

Vancomycin

Aztreonam

Ciprofloxacin

Polymyxin B

www.medwayonline.com
 Q.Which of the following inhibits peptide bond formation in bacterial
protein synthesis?
Tetracyclines

chloramphenicol

amikacin

azithromycin

www.medwayonline.com
 Q.All of the following drugs need dose reduction in renal failure except

Amphotericin B

Vancomycin

Gentamicin

Doxycycline

www.medwayonline.com
 Q.DOC for tick typhus is

Doxycycline

Azithromycin

Ciprofloxacin

Chloramphenicol

www.medwayonline.com
 Q.Gray baby syndrome” is caused by

vancomycin

amiodarone

chloramphenicol

5 flurouracil

www.medwayonline.com
 Q.Which of the following drug doesn’t bind to 30S bacterial ribosomal?

Amikacin

doxycycline

tigecycline

Clindamycin

www.medwayonline.com
 Q.Ocular Side effects are seen with which anti-tubercular drug?

INH

Rifampicin

Ethambutol

Pyrazinamide

www.medwayonline.com
 Q.Drug that is effective for slow or intermittently dividing TB bacilli is

Isoniazid

streptomycin

Rifampicin

Pyrazinamide

www.medwayonline.com
 Q.Which of the following inhibits mycobacterial ATP SYNTHESIS?

Isoniazid

bedaquilline

Rifampicin

Ethambutol

www.medwayonline.com
 Q.Metronidazole is used in the below condition except

H.pylori

giardiasis

enteric fever

trichomoniasis

www.medwayonline.com
 Q.Mechanism of action of protease inhibitors is

Inhibits CCR5

Inhibits assembly of viral proteins

Inhibits Reverse transciptase

Inhibits gp 41

www.medwayonline.com
 Q.Mechanism of action of oseltamivir is

Neuraminidase inhibitor

RNA dependent RNA Polymerase inhibition

Viral M2 ion channel protein inhibition

Fusion inhibitor

www.medwayonline.com
 Q.Tendinitis, tendon rupture and cartilage damage is caused by which
antimicrobials
ciprofloxacin

doxycycline

amikacin

erythromycin

www.medwayonline.com
 Q.A patient visited an endemic area of falciparum malaria and was given
prophylaxis for malaria. How many weeks he needs to take the drug during
travel?
7 days during travel

14 days during travel

28 days during travel

entire duration of travel and later 4 weeks after travel

www.medwayonline.com
 Q.Drug of choice for Paragonismus westermani infections is

Piperazine

albendazole

Praziquantel

triclabendazole

www.medwayonline.com
 Q.DOC for visceral leishmaniasis (kala azar) is

liposomal amphotericin B

Sodium stibogluconate

miltefosine

pentamidine

www.medwayonline.com
 DOOR OF YOUR DREAM
www.medwayonline.com

Medway
Thank
Online You!
Medway Online
Follow us for more