2024 PHM202 Assignment #1 Care Plan Template FINAL
2024 PHM202 Assignment #1 Care Plan Template FINAL
Indication for Drug therapy (Medical condition or present illness/reason for visit): BPH
In terms of efficacy, both second- and third generation α1-adrenergic antagonists are widely
used for relaxing prostatic smooth muscle, typically improving the AUA Symptom Score by 40% and
reducing scores by three to six points within six weeks. While third-generation drugs exhibit greater
selectivity for the α1A receptor and lower systemic side effects, this pharmacological distinction does
not correlate with significant differences in efficacy.
The key distinction between the 1-adrenergic antagonists drug class lies in their adverse effects,
which must be carefully considered. MC initially started treatment with silodosin, which was effective
but caused undesirable side effects, specifically ejaculatory dysfunction. Since tamsulosin, another third-
generation option, also has a notable incidence of ejaculatory disorders, it is not suitable for MC,
especially given his concerns about sexual function and therefore will be ruled out. As suggested by the
guidelines, if the patient is sexually active and experiences ejaculatory dysfunction, switching the patient
from a third generation to a second-generation α1-adrenergic antagonist has been beneficial.
This narrows our options to second-generation agents Alfuzosin is considered functionally and
clinically uroselective for treating BPH, with fewer cardiovascular adverse effects and no need for dose
titration, unlike terazosin and doxazosin. Alfuzosin is particularly suitable for MC, as he has no history of
hypertension or medications that would interact negatively with antihypertensive agents. Since MC’s
primary concern is ejaculatory dysfunction, alfuzosin is an ideal choice, as it has not been reported to
cause this side effect The convenience of once-daily dosing with alfuzosin is ideal for MC's lifestyle, and
the cost among second-generation options is relatively similar. With MC’s private insurance, medication
coverage should facilitate access to this treatment. Overall, alfuzosin presents as the optimal choice for
managing MC's BPH symptoms effectively while addressing his concerns about side effects particularly
ejaculatory dysfunction.
Interventions: (5 marks)
- Discontinuation of Silodosin (Rapaflo) 8 mg: 1 tablet PO once daily
- Recommend Md to initiate: Alfuzosin 10 mg 1 tablet PO once daily after the same meal each,
For 6 weeks
Non pharmacological
- Reduce Caffeine and Alcohol intake. Caffeine can irritate the bladder and may exacerbate MC’s
urinary symptoms (urgency, frequency, incomplete emptying). Reduce or limit coffee intake to
1 small cup or switch to decaffeinated coffee. Advise MC to monitor if this change leads to
better bladder control
- Regular Physical Activity: MC is already active, which is beneficial for prostate and
cardiovascular health. Regular physical exercise is associated with improved urinary function
and overall health. Encourage him to continue his running/jogging routine 2–3 times per week
- Fluid Management: Reducing fluid intake, particularly in the evening, can minimize nocturia
- Double Voiding: Encouraging patients to attempt to urinate again a few minutes after the initial
void can help empty the bladder more completely.
- Continue to have well balanced healthy diet
Patient Education
- Advice MC to report any severe side effects and maintaining regular follow up appointments to
assess treatment effectiveness and prostate health
- Improvement in urinary symptoms may occur within 1-2 weeks and maximal effect within 4-6
weeks when taking α1-adrenergic antagonists
Schedule to Evaluate Drug Therapy (aka Monitoring Plan):
Effectiveness Parameters: (2 marks)
Parameter Desired Value Timeframe