Oxygen Delivery Systems
Oxygen Delivery Systems
Hypoxemia: when arterial oxygen tension (Pao2) is below normal (normal Pao2 =
80–100mmHg). Hypoxia: the failure of oxygenation at the tissue level. It is not
measured directly by a laboratory value (though an increased arterial lactate
level usually accompanies tissue hypoxia).
Hypoxia and hypoxemia may or may not occur together.
Generally, the presence of hypoxemia suggests hypoxia. However, hypoxia may
not be present in patients with hypoxemia if the patient compensates for a low
Pao2 by increasing oxygen delivery. This is typically achieved by increasing
cardiac output or decreasing tissue oxygen consumption.
Conversely, patients who are not hypoxemic may be hypoxic if oxygen delivery
to tissues is impaired or if tissues are unable to use oxygen effectively.
Nevertheless, hypoxemia is by far the most common cause of tissue hypoxia.
Most common aetiology of hypoxemia:
- Sepsis
- Cardiac abnormalities
- Pulmonary embolism
Clinical assessment:
- Patient susceptible to hypoxemia: cardiac or pulmonary disease, smoker,
history of respiratory illness
- Atelectasis and pneumonia risk factors: elderly, obese, neurological
disease, pt on sedatives or opiates
- SOB/ dyspnea, mental confusion
- Tachypnea (RR>24/min), can be absent in severe hypoxemia or limited
cardiac reserve
- Cynosis, hypothermia: tissue hypoxia
Management:
- Patient assessment: stable or life-threatening—check vital signs: HR, RR,
BP, mental status
- Unstable pt or SPO2 <90%:
o Start on O2/ immediate high-flow O2 therapy
o Send ABG & arterial lactate
o Chest x-ray,
o Determine O2 device and flow rate (venturi mask/CPAP/ intubation)
o Another workup to consider: C&S if infection suspected, cardiac
studies (ECG, echo, pulmonary artery catheterization)
- Stable patient:
o Order pulse oximetry
Normal saturation (>95%): hypoxemia unlikely, but ± tissue
hypoxia
VBG—check serum bicarbonate (abnormal: <18 or
>30) acid-base disorders
o Normal serum bicarbonate: observation
o Grossly abnormal: chest x-ray, ABG, arterial
lactate
Saturation 90-95%
Trial of low-flow O2 (by nasal cannula)
Chest x-ray
Observe for the response to O2
o If improving (SPO2 >98%): observe further with
indicated any diagnostic test
o If does not rise: ABG & arterial lactate. Consider
high-flow O2 or intubation
Intubation indication:
1) Need for positive pressure ventilation
2) Airway obstruction
3) Airway protection (eg: neurological impairment. GCS <8)
4) Provide tracheobronchial toilet when pt is unable to generate an effective
cough
Criteria for intubation:
1) Failure to maintain PaO2 of <70 on 100% O2
2) CO2 retention with a CO2 of >50
3) RR >35
4) Use of accessory muscle
5) Failure to protect airway—in neurological impairment (GCS <8)