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Dka MX

Best notebook for Diabetic Ketoacidosis Management

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Arjudev Whrivo
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0% found this document useful (0 votes)
15 views14 pages

Dka MX

Best notebook for Diabetic Ketoacidosis Management

Uploaded by

Arjudev Whrivo
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF or read online on Scribd
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Fluid replacement + 0.9% Normal saline (NaCl) IV +1 Lover 1 hr (If systolic BP <90 mm Hg : 500 ml over 10-15 min, then reassess, if still low, repeat and hemodynamic monitoring/use of pressors) +1 Lover 2 kr +1 Lover 2 hrs +1 Lover 4 hr +1 Lover 4 hrs +1 Lover 6 hrs Fluid replacement... * When CBG <14 rimol/L, add 10% glucose 1 L 8 hrly (125 mi/hr) * If serum Na >155 mmol/L, .45% NS should be used. * Subsequent choice of fluid replacement depends on state of dehydration, serum electrolytes, urine output, blood glucose level. * Typical requirement is 6 L in first 24 hrs but be more cautious in older or young people, pregnant, heart or renal failure. Short acting/soluble insulin * Hourly fall of blood glucose should be 3 mmol/L * Target BG is in between 8.3-11.1 mmol/L until resolution of DKA. Insulin in limited facility + If IV insulin is not feasible : 10-20 units of soluble insulin IM followed by 5 units hourly. Transition from IV to SC insulin ition from IV to SC insulin therapy : if- * Patient is clinically stable * Patient is biochemically stable * Patient able to take oral food and drink normally Calculating dose of SC insulin + calculate total insulin required in last 6 hrs (eg . if patient getting 2 U/hr so in last 6 hr he got 2 * 6 = 12 units) * So 24 hrs insulin requirement 12 * 4= 48U . = 40U/day * eg. Inj. Gensulin R (Regular insulin) 100 6+ 6+ 6 and Inj. Gensulin N (NPH) 100 10+0+10 or Inj. Novorapid (Aspart) 6+ 6+ 6 and Inj. Lantus (Glargine) 0+ 0+ 20 Precaution to start SC insulin +The very short half life of IV insulin necessitates administering the first dose of SC insulin before discontinuation of IV inst * A combination of short/rapid and intermediate/long acting insulin is preferred. Potassium replacement * Depends on plasma level of K*. Add KCL except for first saline (1 L) bag. * Aim to maintain serum K* 4-5.5 mmol/L. + ECG monitoring or periodic tracing helpful to look cardiac toxicity. Plasma K* (mmol/L) KCL replacement (mmol/L of infusion) 3.5 40 until K* >3.5 with hold insulin 3.5-5.5 40 >5.5 0: patient is anuric not to give Potassium replacement in limited facility + Add KCL except for first saline (1 L) bag. * ECG monitoring or periodic tracing helpful to guide. Proper nursing care + NG tube if obtunded or persistent vomiting * Antibiotic if infection demonstrated or suspected Monitoring of DKA patient * Capillary BG and ketone testing (blood/urine) every hour until stable + ECG monitoring * Insertion of central venous line if CVS is compromised * Other tests as required Complications of Diabetic ketoacidosis * Acute circulatory failure * Hypokalemia and hyperkalemia + latrogenic hypoglycemia + Pulmonary oedema Cause of death of DKA * Cardiovascular collapse * Acidosis * Cerebral edema * Hypokalemis (insulin induced K* flux and unnecessary HCO3 infusion) Prognostic factors of DKA * Arterial PH <7 * Serum bicarbonate <10 mEq/L * Blood ketones >6 mmol/L + Anion gap >12 + Hypokalemia on admission (<3.5 mmol/L) * Oxygen saturation <92% on air + Systolic BP <90 mm Hg + Heart rate >100 or <60 beats/min * Glasgow coma scale score <12

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