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Fluid replacement
+ 0.9% Normal saline (NaCl) IV
+1 Lover 1 hr (If systolic BP <90 mm Hg : 500 ml over 10-15 min,
then reassess, if still low, repeat and hemodynamic
monitoring/use of pressors)
+1 Lover 2 kr
+1 Lover 2 hrs
+1 Lover 4 hr
+1 Lover 4 hrs
+1 Lover 6 hrsFluid replacement...
* When CBG <14 rimol/L, add 10% glucose 1 L 8 hrly (125 mi/hr)
* If serum Na >155 mmol/L, .45% NS should be used.
* Subsequent choice of fluid replacement depends on state of
dehydration, serum electrolytes, urine output, blood glucose level.
* Typical requirement is 6 L in first 24 hrs but be more cautious in
older or young people, pregnant, heart or renal failure.Short acting/soluble insulin
* Hourly fall of blood glucose should be 3 mmol/L
* Target BG is in between 8.3-11.1 mmol/L until resolution of DKA.Insulin in limited facility
+ If IV insulin is not feasible : 10-20 units of soluble insulin IM
followed by 5 units hourly.Transition from IV to SC insulin
ition from IV to SC insulin therapy : if-
* Patient is clinically stable
* Patient is biochemically stable
* Patient able to take oral food and drink normallyCalculating dose of SC insulin
+ calculate total insulin required in last 6 hrs (eg . if patient getting 2
U/hr so in last 6 hr he got 2 * 6 = 12 units)
* So 24 hrs insulin requirement 12 * 4= 48U
. = 40U/day
* eg. Inj. Gensulin R (Regular insulin) 100 6+ 6+ 6 and
Inj. Gensulin N (NPH) 100 10+0+10
or
Inj. Novorapid (Aspart) 6+ 6+ 6 and
Inj. Lantus (Glargine) 0+ 0+ 20Precaution to start SC insulin
+The very short half life of IV insulin necessitates administering the
first dose of SC insulin before discontinuation of IV inst
* A combination of short/rapid and intermediate/long acting insulin
is preferred.Potassium replacement
* Depends on plasma level of K*. Add KCL except for first saline (1 L)
bag.
* Aim to maintain serum K* 4-5.5 mmol/L.
+ ECG monitoring or periodic tracing helpful to look cardiac toxicity.
Plasma K* (mmol/L) KCL replacement (mmol/L of infusion)
3.5 40 until K* >3.5 with hold insulin
3.5-5.5 40
>5.5 0: patient is anuric not to givePotassium replacement in limited facility
+ Add KCL except for first saline (1 L) bag.
* ECG monitoring or periodic tracing helpful to guide.Proper nursing care
+ NG tube if obtunded or persistent vomiting
* Antibiotic if infection demonstrated or suspectedMonitoring of DKA patient
* Capillary BG and ketone testing (blood/urine) every hour until
stable
+ ECG monitoring
* Insertion of central venous line if CVS is compromised
* Other tests as requiredComplications of Diabetic ketoacidosis
* Acute circulatory failure
* Hypokalemia and hyperkalemia
+ latrogenic hypoglycemia
+ Pulmonary oedemaCause of death of DKA
* Cardiovascular collapse
* Acidosis
* Cerebral edema
* Hypokalemis (insulin induced K* flux and unnecessary HCO3
infusion)Prognostic factors of DKA
* Arterial PH <7
* Serum bicarbonate <10 mEq/L
* Blood ketones >6 mmol/L
+ Anion gap >12
+ Hypokalemia on admission (<3.5 mmol/L)
* Oxygen saturation <92% on air
+ Systolic BP <90 mm Hg
+ Heart rate >100 or <60 beats/min
* Glasgow coma scale score <12