ICMR – NATIONAL INSTITUTE OF TRADITIONAL MEDICINE,

BELAGAVI

I. Syllabus for the post of Technical Assistant (Pharmacy)

Sl. No. Subject Marks
01 General Knowledge
Test of Reasoning
General Aptitude 50 Marks
Basic English
Basic Mathematics / Basic Computer
02 ICMR Related 10 Marks
03 Subject Syllabus:
• Significance of quantitative analysis in quality control, Different techniques
of analysis, Types of errors, Statistical treatment of small data sets, Precision
and accuracy.
• Biometrics: Significant digits bend rounding of numbers, data collection,
random and non-random sampling methods, sample size, data
organization, diagrammatic representation of data, bar, pie, 2-D and 3-D
diagrams, measures of central tendency, measures of dispersion, Standard
Deviation and standard error of means, coefficient of variation, Student's
and paired t-test, F-test and elements of ANOVA
• Gravimetric Analysis: Precipitation techniques, Supersaturation co-
precipitation, Filter papers and crocibles,
• Standardization of analytical weights and calibration of volumetric
apparatus.
• Phytochemical Screening: a. Preparation of extracts. b. Screening of
alkaloids, saponins, cardenolides and bufadienolides, flavonoids and
leucoanthocyanidins, tannins and polyphenols, anthraquinones, cynogenetic
glycosides, amino acids in plant extracts.
40 Marks
• Chromatography: Introduction, classification and study of different
chromatographic methods and their applications in evaluation of herbal drugs.
• Spectroscopic analysis of organic compounds.
• The theoretical aspects, basic instrumentation, elements of interpretation of
spectra, and applications of the following analytical techniques: Ultraviolet
and visible spectrophotometry, Infrared spectrophotometry, Nuclear Magnetic
Resonance spectroscopy Mass Spectrometry.
• Sources of drugs: Biological, marine, mineral and plant tissue cultures as
sourcs of drugs
• Quality control of crude drugs: Adulteration of crude drugs and their
detection by organoleptic, microscopic, physical, chemical and biological
methods and properties.
• Preparation of herbarium sheets.
• Dehumidification and Humidity Control: Basic concepts and definition, wet
bulb and adiabatic saturation temperatures, Psychrometric chart and
measurement of humidity.
• Hazards and Safety Precautions: Mechanical, Chemical, Electrical, fire
hazards. Accident records etc.
• General considerations & concepts, half-life determination, Influence of
temperature, light, solvent, catalytic species and other factors, Accelerated
stability study, shelf-life determination and expiration dating of
pharmaceuticals.
• Buffers: Buffer equations and buffer capacity in general, buffers in
pharmaceutical systems, preparation, stability, buffered isotonic solutions,
measurements of tonicity, calculations and methods of adjusting isotonicity.
• Classification of microbes and their taxonomy. Actinomycetes, bacteria,
rickettsiae, spirochetes and viruses.
• Identification of Microbes: Stains and types of staining techniques, electron
microscopy, Nutrition, cultivation, isolation of bacteria, actinomycetes, fungi,
viruses, etc., Control of microbes by physical and chemical methods.
• Basic Principles of Cell Injury and Adaptation: Causes of Cellular injury,
pathogenesis, morphology of cell injury. Intercellular alterations in lipids,
proteins and carbohydrates, Cellular adaptation, atrophy, hypertrophy.
• Basic Mechanisms involved in the process of inflammation and repair:
• Biochemical organization of the cell and transport processes across cell
membrane.
• Bioenergetics, production of ATP.
• Carbohydrate Metabolism: Glycolysis, Gluconeogenesis and glycogenolysis.
• The Citric Acid Cycle
• Lipids Metabolism: Control of lipid metabolism.
• Biosynthesis of DNA and its replication.
• Regulation of gene expression.
• General Pharmacology: mechanism of action, Combined effect of drugs
Pharmacogenetics. Absorption, Distribution, Metabolism and Excretion of
drugs, Principles of Basic and Clinical pharmacokinetics, Adverse Drug
Reactions and treatment of poisoning, ADME drug interactions, Bioassay
of Drugs and Biological Standardization, Discovery and development of new
drugs. Drug receptor interaction including transduction mechanisms.
• Experimental Pharmacology: Preparation of different solutions for
experiments. Drug dilutions, use of molar and w/v solutions in
experimental pharmacology. Common laboratory animals and anesthetics
used in animal studies. Commonly used instruments in experimental
pharmacology.
• Bioavailability and bioequivalence: Measures of bioavailability, Cmax, t
max, and Area Under the Curve (AUC),
• Immunology and Immunological Preparations: Principles, antigens and
haptens, immune system, cellular humorai immunity, immunological
tolerance, antigen- antibody reactions and their applications.
• Quality assurance.
• Regulatory control, regulatory drug analysis, interpretation of analytical
data.
• Validation, quality audit: quality of equipment, validation of equipment,
validation of analytical procedures.
Total 100 Marks
II. Syllabus for the post of Lab. Attendant – 01
Sl. No. Subject Marks
01 General Knowledge
Test of Reasoning
General Aptitude 50 Marks
Basic English
Basic Mathematics / Basic Computer
02 ICMR Related 10 Marks
03 Subject Syllabus:
40 Marks
Basic Science and Laboratory related Science

Sd/-
Administrative Officer