PROKARYOTIC & EUKARYOTIC

CELLS
WEBQUEST

Thank you for downloading this product!

I hope you and your students find this resource
engaging, effective, and easy to use!
Thank you for your support!

Please leave feedback on TPT and check out

more great resources at Science Is Real!
HAPPY SCIENCING!
CELLS WEBQUEST TEACHER NOTES AND INFORMATION
Students complete this webquest by accomplishing six different
tasks and answer questions for each task. There are also 3
optional activities to complete at the end for early finishers or as
extension activities.

• Tasks each contain a full URL, a tiny URL, and a QR code.

• Each task has students answer questions, taking notes, filling in

graphic organizers, or labeling diagrams.

• This is a longer webquest, so consider chunking the tasks to fit

your needs. The MS Word doc is editable. I personally would
give 2-3 class periods for my students to complete all the
activities.

• All activities are non-flash based and will work on all devices.

Your download includes the following files and formats:

• Editable Microsoft Word Version
• PDF Version
• Google Slides Version Link (pg. 3)
• Answer Key (in PDF and MS Word)

Questions or Comments? CLICK ON THE

Please email me directly at LO G O A B O V E F O R
ajcatts@gmail.com M O R E G R E AT
HAPPY SCIENCING! WEBQUESTS!
 FOR DIGITAL USE
By purchasing this resource, you agree that the contents are the
property of Science Is Real and is licensed to you only for personal and
classroom use as a single user. All rights are reserved. Failure to follow
terms of use is a direct violation of the DCMA.

• You may post the activity to Google Classroom or other PASSWORD

PROTECTED LMS website for students to use only.
• You may NOT post any answer keys.
• You must DELETE digital activity from your digital classroom one
finished.
• Please, only post to your site if the access in limited only to your
students.
• Do not share on a website that can be accessed by anyone!

CLICK HERE
for Google Slides
Version

SPECIAL THANKS & CREDITS!

These clipart artists are incredible!
* Clip art is copyrighted and only available at
these amazing sellers.

THANK YOU!
Thank you for downloading my product and I hope you
and your students enjoy it! I truly appreciate your
support and your feedback!

You can connect with me on my website,

scienceisrealeducation.com or email me at
contact@scienceisrealeducation.com
Cells Webquest Name:

Task 1 – Introduction to Cells Video Tutorial

View the Introduction to Cells video by The Amoeba Sisters on YouTube and
answer the following questions.
Full URL: https://www.youtube.com/watch?v=8IlzKri08kk
Tiny URL: https://tinyurl.com/zurjaqp
1. List the 3 parts of the modern cell theory.

2. What type of cell are bacteria and Archaea made of?

3. What type of cell are fungi, animals, plants, and protists made of?

4. What 4 organelles do both eukaryote and prokaryote cells contain?

5. What do prokaryotes lack that eukaryotes contain?

6. What does it mean to be selectively permeable?

7. What role does the cytoplasm play in a cell?

8. What is the function of chloroplasts?

9. Which type of cell has a cell wall – animal cell or plant cell?

10. What are two functions of a cell wall?

11. What molecule makes instructions for proteins and is located inside a eukaryotic nucleus?

Task 2 – Assembling A Eukaryotic Cell Interactive

Complete the Assembling a Eukaryotic Cell interactive from the WISC online website. Follow
the directions and answer the questions below as you move through this activity.
Full URL: https://www.wisc-online.com/learn/natural-science/life-
science/mby3204/eukaryotic-cells-assembling-the-cell
Tiny URL: https://tinyurl.com/ycfdycvc

© SCIENCE IS REAL
Click the red arrow on bottom right of screen. Then click each organelle to get the information needed to
complete the table below.
Organelle Function
12. Nucleus

13. Rough Endoplasmic

Reticulum
14. Smooth Endoplasmic
Reticulum
15. Ribosomes

16. Golgi Complex

17. Mitochondria

18. Plasma Membrane

19. Click the red arrow again. Construct a eukaryotic cell and take the interactive quiz. Which
organelle is the site of synthesis of ribosomal RNA?

Task 3 – Plant Cell Parts and Functions Interactive

Complete the Plant Cell Parts and Functions tutorial on the Learn Biology website and
answer the following questions.
Full URL: https://learn-biology.com/plant-cell-parts-and-functions/
Tiny URL: https://tinyurl.com/z4wxtrxy

Organelle Function 1 Additional Fact

20. Cell wall

21. Central
Vacuole

22. Chloroplast

23. List 7 organelles shared by both plant and animal cells.

© SCIENCE IS REAL
24. Complete Part 2: Matching and Labeling Cell Parts and Functions Quiz. When prompted to sign in,
click “No Thanks”. Drag and drop the cell organelles to their correct place and then label the diagram
below

Task 4 – Prokaryotic vs. Eukaryotic Cells Video Tutorial

View the Prokaryote vs. Eukaryote video by The Amoeba Sisters on YouTube and answer
the following questions.
Full URL: https://www.youtube.com/watch?v=Pxujitlv8wc&t=116s
Tiny URL: https://tinyurl.com/yad9833z
25. What are four examples of eukaryotes?

26. How many cells does a prokaryote contain?

27. List the four main similarities between prokaryotic and eukaryotic cells.

28. Complete the Venn Diagram below to compare eukaryotic cells with prokaryotic cells.

Prokaryotic Eukaryotic
Cells Cells

© SCIENCE IS REAL
Task 5 – Prokaryotic Cells Article
Read the Prokaryotic Cells article from the Khan Academy website and answer the following
questions.
Full URL: https://www.khanacademy.org/science/biology/structure-of-a-cell/prokaryotic-and-
eukaryotic-cells/a/prokaryotic-cells
Tiny URL: https://tinyurl.com/j3ujxbt

29. Where is the majority of prokaryotic DNA found?

30. What are 3 functions of the cell wall?

31. Why is the capsule of a bacterium sticky?

32. What 2 organelles help bacteria to move?

33. Which are smaller – prokaryotic or eukaryotic cells?

34. Label the bacterial cell diagram.

Task 6 –Cell Explorer Game

Play the Cell Explorer Game from the BioMan Bio website. Make sure you read EVERY
screen that pops up in order to answer the questions below.
Full URL:
https://biomanbio.com/HTML5GamesandLabs/Cellgames/cellexplorerpagehtml5.html
Tiny URL: https://tinyurl.com/zasobft

Mission 1: RECON: Click on Mission 1 Recon. You will find and shoot organelles and answer questions
about each. You do not have to complete the questions in this mission in order. The organelle questions
below are listed in alphabetical order.

35. Cytoskeleton: What are three functions of the cytoskeleton?

36. Golgi Apparatus: What would happen if the Golgi bodies in the cell were destroyed?

37. Lysosomes: What are the functions of lysosomes?

© SCIENCE IS REAL
38. Mitochondria: What three substances does respiration produce?

39. Nucleolus: What would occur if the nucleolus in a cell were destroyed?

40. Nucleus: DNA is contained within the nucleus. What is the main function of DNA and RNA?

41. Plasma Membrane / Cell Membrane: Why is the membrane critical to the survival of the cell?

42. Ribosomes: What would occur if all the ribosomes in a cell were destroyed?

43. Rough Endoplasmic Reticulum: What would occur if all the rough ER in a cell were destroyed?

44. Smooth Endoplasmic Reticulum: What would occur if all the smooth ER in a cell were destroyed?

45. Vesicles: What is the primary function of vesicles?

Extension Activity
Choose from any of the extension activities below.
A. Draw and label the organelles in an animal cell.
B. Write a paragraph (4-6 sentences) about the differences and similarities between a prokaryotic cell
and a eukaryotic cell.
C. Choose any organelle. Write a creative paragraph (4-6 sentences) about a day in the life of this
organelle that summarizes that organelle’s structure and function.

© SCIENCE IS REAL
Prokaryotic and Eukaryotic Cells Webquest KEY

Task 1 – Introduction to Cells Video Tutorial

View the Introduction to Cells video by The Amoeba Sisters on YouTube and answer the
following questions.
Full URL: https://www.youtube.com/watch?v=8IlzKri08kk
Tiny URL: https://tinyurl.com/zurjaqp

1. List the 3 parts of the modern cell theory.

1. The cell is the smallest living unit in all organisms.
2. All living things are made of cells.
3. All cells come from other preexisting cells.

2. What type of cell are bacteria and Archaea made of?

• prokaryotic cell

3. What type of cell are fungi, animals, plants, and protists made of?
• eukaryotic cell

4. What 4 organelles do both eukaryote and prokaryote cells contain?

• genetic material, cytoplasm, ribosomes, and cell membrane

5. What do prokaryotes lack that eukaryotes contain?

• nucleus and other membrane bound organelles

6. What does it mean to be selectively permeable?

• Allows certain materials in and out to keep the cell in homeostasis

7. What role does the cytoplasm play in a cell?

• provides support for the cell and organelles, helps some cells to move

8. What is the function of chloroplasts?

• make glucose using light energy, photosynthesis

9. Which type of cell has a cell wall – animal cell or plant cell?
• plant cell

10. What are two functions of a cell wall?

• protection and shape maintenance

11. What molecule makes instructions for proteins and is located inside a eukaryotic nucleus?
• DNA

© SCIENCE IS REAL
Task 2 – Assembling A Eukaryotic Cell Interactive
Complete the Assembling a Eukaryotic Cell interactive from the WISC online website.
Follow the directions and answer the questions below as you move through this activity.
Full URL: https://www.wisc-online.com/learn/natural-science/life-
science/mby3204/eukaryotic-cells-assembling-the-cell
Tiny URL: https://tinyurl.com/ycfdycvc

Click the red arrow on bottom right of screen. Then click each organelle to get the information needed
to complete the table below.
Organelle Function
Contains the cell DNA
12. Nucleus
13. Rough Endoplasmic Contains ribosomes and synthesizes proteins
Reticulum
14. Smooth Endoplasmic Phospholipids, fats, and sterols are synthesized here.
Reticulum
Location of protein synthesis, mRNA is read on the ribosome
15. Ribosomes
Processes and sorts protein products
16. Golgi Complex
Main role in production of ATP
17. Mitochondria
Surrounds the cell and is responsible for transport in and out of the cell
18. Plasma Membrane

19. Click the red arrow again. Construct a eukaryotic cell and take the interactive quiz. Which
organelle is the site of synthesis of ribosomal RNA?
• nucleolus

Task 3 – Plant Cell Parts and Functions Interactive Tutorial

Complete the Plant Cell Parts and Functions tutorial on the Learn Biology website and
answer the following questions.
Full URL: https://learn-biology.com/plant-cell-parts-and-functions/
Tiny URL: https://tinyurl.com/z4wxtrxy

Organelle Function 1 Additional Fact

20. Cell wall Provides plants with strength and Can make wood, cotton, and paper
rigidity Composed of cellulose

21. Central Stores water, dissolved substances, Maintains water pressure inside the
Vacuole and waste. cell

22. Chloroplast Carry out photosynthesis Combines water and carbon dioxide to
create glucose and oxygen

© SCIENCE IS REAL
23. List 7 organelles shared by both plant and animal cells.
• cell membrane, cytoplasm, mitochondrion, Golgi apparatus, endoplasmic reticulum,
chromosomes, nucleus

24. Complete Part 2: Matching and Labeling Cell Parts and Functions Quiz. When prompted to sign
in, click “No Thanks”. Drag and drop the cell organelles to their correct place and then label the
diagram below

Central Vacuole Mitochondria

Golgi
Cytoplasm Apparatus

Endoplasmic
Cell Membrane Reticulum

Chromosome
Cell Wall s
Nucleus

Chloroplast

Task 4 – Prokaryotic vs. Eukaryotic Cells Video Tutorial

View the Prokaryote vs. Eukaryote video by The Amoeba Sisters on YouTube and
answer the following questions.
Full URL: https://www.youtube.com/watch?v=Pxujitlv8wc&t=116s
Tiny URL: https://tinyurl.com/yad9833z

25. What are four examples of eukaryotes?

• animals, plants, fungi, protists

26. How many cells does a prokaryote contain?

• 1

27. List the four main similarities between prokaryotic and eukaryotic cells.
• cell membrane, DNA, ribosomes, cytoplasm

© SCIENCE IS REAL
28. Complete the Venn Diagram below to compare eukaryotic cells with prokaryotic cells.

Eukaryotic
Prokaryotic Cells
Cells
• Have Nucleus
• No Nucleus
Genetic • Have Membrane
• No Membrane Bound
information Bound Organelles
Organelles Cytoplasm • Can be multicellular
• Single-Celled Ribosomes and unicellular
• Bacteria and Living Things • Plants, Animals,
Archaea
Protist, Fungi
• Many Have Cell
• Plants and Fungi
Walls
have cell walls

Task 5 – Prokaryotic Cells Article

Read the Prokaryotic Cells article from the Khan Academy website and answer the
following questions.
Full URL: https://www.khanacademy.org/science/biology/structure-of-a-cell/prokaryotic-
and-eukaryotic-cells/a/prokaryotic-cells
Tiny URL: https://tinyurl.com/j3ujxbt

29. Where is the majority of prokaryotic DNA found?

• nucleoid region

30. What are 3 functions of the cell wall?

• layer of protection, maintain cell shape, prevent dehydration

31. Why is the capsule of a bacterium sticky?

• to help it attach to surfaces in its environment

32. What 2 organelles help bacteria to move?

• flagella and pili

33. Which are smaller – prokaryotic or eukaryotic cells? Fimbriae

• prokaryotic Capsule
Cell Wall
34. Label the bacterial cell diagram.
Cell Membrane

Flagellum
Ribosome
Nucleoid
DNA Region
© SCIENCE IS REAL
Task 6 –Cell Explorer Game
Play the Cell Explorer Game from the BioMan Bio website. Make sure you read EVERY
screen that pops up in order to answer the questions below.
Full URL:
https://biomanbio.com/HTML5GamesandLabs/Cellgames/cellexplorerpagehtml5.html
Tiny URL: https://tinyurl.com/zasobft

Mission 1: RECON: Click on Mission 1 Recon. You will find and shoot organelles and answer
questions about each. You do not have to complete the questions in this mission in order. The
organelle questions below are listed in alphabetical order.

35. Cytoskeleton: What are three functions of the cytoskeleton?

• cell movement, maintaining cell shape, and maintaining cell structure

36. Golgi Apparatus: What would happen if the Golgi bodies in the cell were destroyed?
• The cell would have difficulty processing and transporting proteins

37. Lysosomes: What are the functions of lysosomes?

• digest and destroy viruses and invaders, digest food particles, recycle cell parts

38. Mitochondria: What three substances does respiration produce?

• ATP, carbon dioxide, and water

39. Nucleolus: What would occur if the nucleolus in a cell were destroyed?
• The cell would no longer be able to produces ribosomes which are needed to make proteins.

40. Nucleus: DNA is contained within the nucleus. What is the main function of DNA and RNA?
• DNA has the instructions to make RNA. RNA is used to make proteins.

41. Plasma Membrane / Cell Membrane: Why is the membrane critical to the survival of the cell?
• It regulates what enters and leaves the cell

42. Ribosomes: What would occur if all the ribosomes in a cell were destroyed?
• The cell would not be able to produce proteins

43. Rough Endoplasmic Reticulum: What would occur if all the rough ER in a cell were destroyed?
• The cell would no longer be able to send proteins to the Golgi bodies

44. Smooth Endoplasmic Reticulum: What would occur if all the smooth ER in a cell were destroyed?
• The cell would no longer be able to make lipids or break down poisons

45. Vesicles: What is the primary function of vesicles?

• to transport proteins and other substances

Extension Activity (OPTIONAL)

Choose from any of the extension activities below.
A. Draw and label the organelles in a prokaryotic cell, plant cell, or animal cell.
B. Write a paragraph (4-6 sentences) about the differences and similarities between a prokaryotic cell
and a eukaryotic cell.
C. Choose any organelle. Write a creative paragraph (4-6 sentences) about a day in the life of this
organelle that summarizes that organelle’s structure and function.
© SCIENCE IS REAL
 TERMS OF USE
Science Is Real! Terms of Use (TOU):
By purchasing this product, you own a license for one teacher only for personal use in their
own classroom. Licenses are non-transferable and therefore cannot be passed from one
teacher to another. If the teacher who purchased this license leaves the classroom or
changes schools, the license and materials leave with that teacher. No part of this resource
is to be shared with colleagues or used by an entire team, grade level, school or district
without purchasing the correct number of licenses. If you are a coach, principal or district
interested in transferable licenses that would accommodate yearly staff changes, please
contact me for a transferable license quote at ajcatts@gmail.com or
contact@scienceisrealeducation.com

Copyright by Science is Real. Please note - all material included in this resource belongs to
Ana Catts. By purchasing, you have a license to use the material, but you do not own the
material. You may not claim this work as your own, alter the files, or remove any copyright or
water marks. You may not upload any portion of this resource to the internet in any format,
including school/personal websites or network drives unless the site is password protected
and can only be accessed by students, not other teachers or anyone else on the internet.

By purchasing this resource, you agree that the contents are the property of Science Is Real
and is licensed to you only for personal and classroom use as a single user. All rights are
reserved.

• You may post the activity to Google Classroom or other PASSWORD PROTECTED LMS
website for students to use only.
• You may NOT post any answer keys.
• You must DELETE digital activity from your digital classroom one finished.
• Please, only post to your site if the access in limited only to your students.
• Do not share on a website that can be accessed by anyone!

THANK YOU!

HAPPY SCIENCING FROM SCIENCE IS REAL!

CHECK OUT MORE
GREAT THINGS!