Prelim 2
Prelim 2
Neurologic Disorders
Anatomy and Physiology
Nervous system divided into 2 regions:
1. Central nervous system (CNS):
brain and spinal cord
2. Peripheral nervous system
(PNS): cranial nerves, spinal
nerves and autonomic nervous
system
Function of the nervous system are
sensory input, integration, motor
output, homeostasis, mental activity.
BRAIN: Diencephalon
Thalamus – largest part,
influences mood and registers an
unlocalized, uncomfortable
perception of pain.
Epithalamus – small area superior
and posterior to the thalamus,
involved in the emotional and
visceral response to odors, pineal
body (onset of puberty)
Hypothalamus – most inferior
part, important in maintaining
homeostasis, plays a central role in
the control of body temperature,
hunger and thirst, plays a major
role in controlling the secretion of
hormones from the pituitary gland.
- Superior to the pons
- Smallest region of the brainstem
- CN 3 and 4
- Found superior and inferior
colliculus
- Superior colliculi – involved in
visual reflexes, turning the head, a
sudden loud noise, bright flash of
light
- Inferior colliculi – major relay
centers for the auditory nerve
pathways in the CNS
- General functions : coordination of
eye movements and in the control
BRAIN : Brainstem of pupil diameter and lens shape
- Connects the spinal cord to the - Contains a nuclear black mass
remainder of the brain called Substantia Nigra
- Consists of the medulla
oblongata, pons, and midbrain
NERVOUS SYSTEM
- Involved in vital body functions
such as the control of HR, BP, and
breathing
Brainstem : Pons
- Immediately superior to the
medulla oblongata
- Means “bridge”
- CN 5, 6, 7, 8
- Lower part of the pons: breathing,
swallowing and balance - Largest part of the brain
- Other nuclei in the pons control - Divided into left and right
functions such as chewing and hemisphere by a longitudinal
salivation fissures
- The surface of each hemisphere is
Brainstem : Midbrain wrinkled by presence of eminences
known as Gyri and furrows called
Sulci or Fissures
- Each cerebral hemispheres is
divided into lobes:
1. Frontal lobes
- Principal motor area (4)
- Important in the control of
voluntary motor functions,
motivation, aggression, mood, and
olfactory (smell) reception
- Brocas area (44,45) – Brocas
aphasia (executive, motor,
nonfluent, anterior)
2. Parietal lobe
- Principal center for the reception
and conscious perception of most
sensory information, such as touch, BRAIN : Cerebellum
pain, temperature, balance and - Composed of gray matters
taste - Posterior and inferior to the
- Principal sensory area (3,1,2) cerebrum
3. Occipital lobe - Involved in balance, maintenance
- Functions in the reception and of muscle tone and coordination of
perception of visual input fine motor movements
- Principal visual cortex (17) - Major function of the cerebellum is
4. Temporal lobe that of comparator
- Involved in olfactory (smell) and - Also involves learning motor skills
auditory (hearing) sensations and (riding a bicycle/playing a piano)
plays an important role in memory
- They associated in abstract
thought and judgement
- Primary auditory cortex (41,42)
- Wernicke’s area (22) – wernickes
aphasia (receptive, sensory, fluent,
posterior)
Cranial nerves
- sensory – I,II,VIII
- motor – III, IV, VI, XI, XII
- mixed – V, VII, IX, X
(thoracolumbar)
- Utilized by the body for FLIGHT and
FIGHT response
- Neurotransmitter agents are
Epinephrine and Norepinephrine
(coming from the adrenal gland)
- ADRENERGIC system
PNS: Spinal Nerves
-
Sympathetic Responses:
Categorized
Increased:
by the
- HR
region of
- RR
vertebral
- BP
column
- Visual Acuity (Pupillary Dilation)
- 31 pairs
- Smooth Muscle tone sphincters are
(c8, t12,
contracted
l5, s5, c1)
- Vasoconstriction – peripheral
- Metabolism ↑ glucose, ↑ fatty
acids
Decreased
- Peristalsis
- Salivary secretions
- Ejaculation
ANS: Parasympathetic Nervous - Flaccid muscle paralysis
System - Muscle atrophy
- CHOLINERGIC system - Absent or decreased reflexes
- The vegetative system
- Feed and Breed responses Structures supporting the brain
- Cranio-sacral location Skull
- Cranial nerves- 3, 7, 9, 10 and S2- - Frontal bone
S4 - Parietal bone
- Neurotransmitter is Acetylcholine - Temporal bone
- Occipital bone
Arachnoid
- Subdural space (space between
dura mater and arachnoid, contains
Comparison of UMN and LMN small amount of serous fluid)
Upper motor neuron lesions
- Loss of voluntary control
- Increased muscle tone
- Muscle spasticity
- No muscle atrophy
- Hyperactive and abnormal reflex
Cerebrospinal Fluid
- Bathes the brain and spinal cord
- Protective cushion aound the CNS
- Produced by the Choroid plexus of
the lateral, third, and fourth
ventricles
- Clear, colorless, SG of 1.007
- In normal adult, approximately 500
ml of CSF produced each day, all but
125 to 150 ml is absorbed by the
villi
BLOOD-BRAIN BARRIER
- CNS is inaccessible to many
substances
- Many substances cannot reach the
neurons of the CNS
- Formed by the endothelial cells of
the brains capillaries, which form
continuous tight junctions, creating
BBB to macromolecules
- Must filter through the capillary
endothelial cells and astrocytes
- Can be altered by trauma, cerebral - Serotonin (↓ depression, ↑ manic)
edema and hypoxia - Glutamine (excitatory
NEURONS ASSESSMENT OF THE
- Basic functional NEUROLOGIC SYSTEM PHYSICAL
unit of the brain EXAMINATION
- Composed of a cell 5 categories:
body, dendrite and 1. Cerebral function- LOC, mental
an axon status
2. Cranial nerves
3. Motor function
4. Sensory function
5. Reflexes
ASSESSMENT OF THE
NEUROLOGIC SYSTEM
Neuro Check
- Level of consciousness
- Pupillary size and response
- Verbal responsiveness
- Motor responsiveness
- Vital signs