PHARM. D.

POST BACCALAUREATE PROGRAM

(Inclusion of Pharmacotherapeutics I & II subject in the fourth year of the program)

SYLLABUS FOR PHARMACOTHERAPEUTICS I & II (THEORY)

Theory: 3Hrs/week

Etiopathogenesis and pharmacotherapy of diseases associated with

following systems/ diseases.

1. Cardiovascular system:
Hypertension, Congestive cardiac
failure, Angina Pectoris,
Total = 13 hrs
Myocardial infarction, ,
(3+2+2+2+2+2)
Hyperlipidaemias ,
Electrophysiology of heart and
Arrhythmias
2. Respiratory system : Introduction
to Pulmonary function test,
Total = 6
Asthma, Chronic obstructive
(1+2+2+1)
airways disease, Drug induced
pulmonary diseases
3. Endocrine system : Diabetes,
Thyroid diseases, Oral Total = 8
contraceptives, Hormone (3+2+1+1+1)
replacement therapy, Osteoporosis
4. General prescribing guidelines
for
Total = 4hrs
a. Paediatric patients
(1+1+2)
b. Geriatric patients
c. Pregnancy and breast feeding
5. Ophthalmology: Glaucoma,
(3 hrs)
Conjunctivitis- viral & bacterial
6. Introduction to rational drug use
Definition, Role of pharmacist Total = 2 hrs
Essential drug concept Rational (1+1)
drug formulations
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 7. Infectious disease: Guidelines for the
rational use of antibiotics and surgical
Prophylaxis, Tuberculosis, Meningitis,
Respiratory tract infections,
Total = 18 hrs.
Gastroenteritis, Endocarditis,
(2+1+1+2+1+1+1+2
Septicemia, Urinary tract infections,
+1+2+1+1+1+1)
Protozoal infection- Malaria, HIV &
Opportunistic infections, Fungal
infections, Viral infections,
Gonarrhoea and Syphillis
8. Musculoskeletal disorders
Rheumatoid arthritis, Osteoarthritis, Total = 6hrs.
Gout, Spondylitis, Systemic lupus (2+1+1+!+1)
erythematosus.
9. Renal system
Acute Renal Failure, Chronic Renal `Total = 05hrs.
Failure, Renal Dialysis, Drug induced (2+1+1+1)
renal disorders
10. Oncology: Basic principles of Cancer
therapy, General introduction to cancer
chemotherapeutic agents, Total = 06 hrs.
Chemotherapy of breast cancer, (2+1+2+1)
leukemia. Management of
chemotherapy nausea and emesis
11. Dermatology: Psoriasis, Scabies,
Total = 4hrs.
Eczema, Impetigo

PHARMACOTHERAPEUTICS – I & II (PRACTICAL)

Practicals: 3 Hrs./Week
Practicals:
Hospital postings in various departments designed to complement the
lectures by providing practical clinical discussion; attending ward rounds;
follow up the progress and changes made in drug therapy in allotted
patients; case presentation upon discharge. Students are required to
maintain a record of cases presented and the same should be submitted at

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the end of the course for evaluation. A minimum of 20 cases should be
presented and recorded covering most common diseases.

Assignments:
Students are required to submit written assignments on the topics given to
them. Topics allotted should cover recent developments in drug therapy of
various diseases. A minimum of THREE assignments [1500 – 2000
words] should be submitted for evaluation.

Format of the assignment:

1. Minimum & Maximum number of pages.
2. Reference(s) shall be included at the end.
3. Assignment can be a combined presentation at the end of the academic
year.
4. It shall be computer draft copy.
5. Name and signature of the student.
6. Time allocated for presentation may be 8+2 Min.
Scheme of Practical Examination:
Sessionals Annual

Synopsis 05 15

Major Experiment 10 25

Minor Experiment 03 15

Viva 02 15

Max Marks 20 70
Duration 03hrs 04hrs

Note: Total sessional marks is 30 (20 for practical sessional plus 10 marks
for regularity, promptness, viva-voce and record maintenance).

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 1.5 PHARMACEUTICAL INORGANIC CHEMISTRY (THEORY)

Theory : 2 Hrs. /Week

1. Scope and objectives: This course mainly deals with fundamentals of Analytical chemistry
and also the study of inorganic pharmaceuticals regarding their monographs and also the course
deals with basic knowledge of analysis of various pharmaceuticals.

2. Upon completion of the course student shall be able to:

a. understand the principles and procedures of analysis of drugs and also regarding t he
application of inorganic pharmaceuticals;
b. know the analysis of the inorganic pharmaceuticals their applications; and
c. Appreciate the importance of inorganic pharmaceuticals in preventing and curing the
disease.

3. Course materials:

Text books
a. A text book Inorganic medicinal chemistry by Surendra N. Pandeya

b. A. H. Beckett and J. B. Stenlake’s Practical Pharmaceutical chemistry Vol-I & Vol-II

c. Inorganic Pharmaceutical Chemistry III-Edition P.Gundu Rao

Reference books
a. Inorganic Pharmaceutical Chemistry by Anand & Chetwal

b. Pharmaceutical Inorganic chemistry by Dr.B.G.Nagavi

c. Analytical chemistry principles by John H. Kennedy

d. I.P.1985 and 1996, Govt. of India, Ministry of health

4. Lecture wise programme:

1. Errors

Errors in quantitative analysis, classification of errors, concept of accuracy and precision, treatment
of analytical results.

2. Volumetric analysis

Principle of volumetric analysis, different methods of analysis, different methods for expressing
concentrations of solutions, primary and secondary standards.

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3. Acid-base titrations

Acid- base concepts, relative strength of acids and bases, law of mass action, common ion effect,
ionic product of water, Henderson-Hasselbalch equation, buffer solutions, theory of indicators,
neutralization curves, choice of indicators, mixed and universal indicators.

4. Redox titrations

Concepts of oxidation–reduction reactions, redox reactions, theory of redox titrations, redox

indicators, iodometry and iodimetry, titrations involving cerric sulphate, potassium iodate,
potassium bromate, potassium permanganate, titanous chloride.

5. Non aqueous titration

Theoretical basis, types of solvents, preparations and standardization of titrant solutions, titration
of weak acid, weak bases and indicators. standardisation of perchloric acid, lithium and sodium
methoxide, tetra butyl ammonium hydroxide.

6. Precipitation titrations

Introduction, types of precipitation titrations, end point detection.

7. Complexometric titrations

Introduction, principle, types of titrations, endpoint detection.

8. Theory of Indicators

9. Gravimetry

Basic concepts, Precipitation techniques, co-precipitation, post–precipitation, various steps

involved in gravimetric analysis, pharmaceutical applications.

10. Limit tests

Definition, importance, general procedure for limit test for chlorides, sulphates, iron, arsenic, lead
and heavy metals.

11.Medicinal Gases

Preparation and uses of the following Oxygen, Carbon dioxide, Helium, Nitrogen and Nitrous
Oxide.

Method of preparation, assay, storage conditions and uses of inorganic compounds listed in I.P
belonging to the following categories.

12. Acidifiers

Dilute hydrochloric acid, Sodium phosphate, Ammonium chloride.

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13. Antacids

Classification, Qualities of an ideal antacid, side effects, advantages, combination therapy, acid
neutralizing capacity, Sodium bicarbonate, Potassium citrate, Aluminium hydroxide gel, Dried
aluminium hydroxide gel, Magnesium hydroxide, Light and heavy magnesium trisilicate, light and
heavy magnesium carbonate, Calcium carbonate, Magaldrate and Bismuth carbonate.

14. Cathartics

Magnesium hydroxide, Magnesium sulphate, Magnesium carbonate and Sodium phosphate.

15. Electrolyte replenisher

Electrolytes used for replacement therapy: Sodium chloride, Potassium chloride, Calcium chloride,
Calcium gluconate,

Electrolytes used in the acid-base therapy : Sodium acetate, Potassium acetate, Sodium
bicarbonate, Potassium bicarbonate, Sodium citrate, Sodium lactate, Ammonium chloride.
Electrolyte combination therapy, Compound sodium chloride solution, Sodium chloride injection
and Oral rehydration salt.

16. Essential Trace elements

Definition, Physiological role of Iron, Copper, Zinc,

Chromium, Manganese, Molybdenum, Selenium, Sulphur and Iodine.

17. Antimicrobials

Hydrogen Peroxide, Potassium Permanganate, Chlorinated Lime, Iodine, Boric Acid, Silver
Nitrate, Selenium Sulphide.

18. Pharmaceutical Aids: Sodium bisulphite, sodium metabisulphite, bentonite, magnesium

stearate, zinc stearate, aluminium sulphate, sodium carboxy methyl cellulose, purified water, water
for injection and sterile water for injection.

19. Dental products

Anti-caries Agents: Role of Fluorides as anti-caries agents, Sodium fluoride.

Dentifrices: Calcium carbonate, dibasic calcium phosphate, Zinc chloride.

20. Miscellaneous compounds.

Sclerosing agents: Hypertonic saline, Sodium tetra decyl sulphate.

Expectorants: Potassium citrate and Potassium iodide.

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Sedative: Potassium bromide.

Antidotes: Sodium nitrite, Sodium thiosulphate and Charcoal

Respiratory stimulant: Ammonium carbonate.

21. Radiopharmaceuticals.

Introduction, measurement of radioactivity, clinical applications and dosage, hazards and

precautions.