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Royal Adelaide Hospital General ICU ECMO Guidelines

General ICU ECMO Guidelines

Authors: Richard Strickland Intensivist Jo Buttery. Nurse Educator

Peter Frantzis. Perfusionist October 2009.
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Royal Adelaide Hospital General ICU ECMO Guidelines

This document describes the standardised management of adult patients receiving

Extracorporeal Membrane Oxygenation (ECMO) in ICU. Although well
established there is very little high grade evidence on which to base
recommendations. The information contained within this document is
predominantly derived from expert opinion. The RAH would like to thank Dr V.
Pelligrino (The Alfred), Mr A Perevolos (The Alfred), Ms E Harris (The Alfred),
The Royal Childrens Hospital Melbourne, Liverpool Hospital Sydney, The
Rikshospitalet Oslo and the Freeman Hospital Newcastle on Tyne.

Contents
1. Introduction

2. Indications and Contraindications

3. Equipment
• Pumps and Circuits
• Cannulation trolley
• Circuit connections

4. Cannulation

5. Maintenance and staffing

• Circuit management
• Respiratory management
• Sedation
• Anticoagulation
• Temperature management
• Ward rounds
• Nursing care
• Weaning

6. Nursing Policies and Procedures

7. Troubleshooting
• V-V ECMO
• V-A ECMO

8. Emergency responses
• V-V ECMO
• V-A ECMO

9. Changing the Circuit

Authors: Richard Strickland Intensivist Jo Buttery. Nurse Educator

Peter Frantzis. Perfusionist October 2009.
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Royal Adelaide Hospital General ICU ECMO Guidelines

1. Introduction
ECMO or Extra Corporeal Membrane Oxygenation is a form of extracorporeal life support where an
external artificial circulation carries venous blood from the patient to a gas exchange device
(oxygenator) where blood becomes enriched with oxygen and has carbon dioxide removed. This blood
then re-enters the patient circulation.

Patients who are hypoxaemic despite maximal conventional ventilatory support, who have significant
ventilator-induced lung injury or who are in reversible cardiogenic shock may be considered for
ECMO support. For respiratory failure, the basic premise is that ECMO will allow the level of
ventilatory support to be reduced, which may allow time for recovery from the underlying pathology
and recovery from ventilator-induced lung injury to occur.

The type of ECMO performed will depend on the patient’s underlying cardiac function. Veno-venous
(V-V) ECMO is usually performed for isolated respiratory failure, whereas veno-arterial (V-A) ECMO
(full cardiopulmonary bypass) is performed for combined cardiac and respiratory failure.
Circuit flow may be achieved using a pump (centrifugal or roller) or by the patients arterio-venous
pressure gradient (pumpless). At The Royal Adelaide Hospital ECMO involves a centrifugal pump to
drive circuit flow.

Veno-venous ECMO involves venous blood from the patient being accessed from the large
central veins (via the “access line”) and returned to the venous system near the right atrium (via the
“return line”) after it has passed through an oxygenator. It provides support for severe respiratory
failure when no major cardiac dysfunction exists. When flow through a single access cannula is
insufficient to support the high ECMO flow rate that may be required in severe respiratory failure, a
second venous access cannula may be required.

Fig. 1. An example of Veno – Venous ECMO

using two access cannulae
Second access (SVC and IVC to right atrium)
cannula (SVC)

Return
cannula
(IVC)

Access cannula
(IVC)

V–V ECMO improves the patient’s oxygenation by reducing the amount of blood that passes through
the lung without being oxygenated and in addition, removes CO2 from the patient’s blood. This allows
the level of ventilatory support to be reduced- which reduces ventilator-induced lung injury.

Authors: Richard Strickland Intensivist Jo Buttery. Nurse Educator

Peter Frantzis. Perfusionist October 2009.
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Royal Adelaide Hospital General ICU ECMO Guidelines
The efficiency of oxygenation by the ECMO circuit depends on the pump flow relative to the patient’s
cardiac output. The patient’s oxygenation should increase with increasing ECMO flow rate, if this does
not occur, recirculation of blood between the inflow and outflow cannulae should be suspected (see
section on instituting ECMO).

V-V ECMO is more efficient at removing CO2 from the blood than delivering oxygen. The amount of
CO2 removal depends on the ECMO flow rate relative to the patient’s cardiac output and also depends
on the oxygen flow rate to the oxygenator. Increasing oxygen flow rate decreases the CO2 in the blood
leaving the oxygenator (analogous to the effect that increasing minute ventilation has on arterial
PCO2). The oxygen flow rate to the oxygenator should be roughly twice the ECMO flow rate. With an
ECMO flow rate of approximately 2/3 the patient’s cardiac output, and an oxygen flow rate of twice
the pump flow, nearly all of the patient’s CO2 production can be removed by the oxygenator.

Veno-arterial ECMO involves venous blood from the patient being accessed from the large
central veins and returned to a major artery after it has passed through the oxygenator. It provides
support for severe cardiac failure, (usually with associated respiratory failure), most commonly after
cardiac surgery

Low flow veno-arterial ECMO is a transitory form of ECMO support in which small cannulae (quicker
to insert) are inserted percutaneously. It is an emergent resuscitative intervention (also known as
ECMO-CPR).

Figure A

Fig 2. Veno – Arterial ECMO

Return Access
cannula cannula

Veno-venous OR Veno-arterial ECMO?

There are several advantages of V-V ECMO compared to V-A ECMO. V-V ECMO avoids the risks of
potentially serious arterial injury and also the consequences of air or clot embolisation from the circuit
are less severe. V-V ECMO is a low-pressure circuit compared to veno-arterial, resulting in less stress
on the circuit tubing and the oxygenator and may thereby improve their longevity. V-V ECMO
produces less haemodynamic disturbance than veno-arterial as blood is withdrawn from, and returned
to the same side of the circulation. For example, increasing V-V ECMO flow will not cause any change
in the CVP, whereas increasing V-A ECMO flow will reduce the CVP (and pulmonary blood flow).
Finally, there is animal evidence that the preservation of pulmonary blood flow that occurs with V-V
ECMO promotes more rapid recovery from pulmonary sepsis than does V-A ECMO.
The major advantages of V-A over V-V ECMO is that it provides complete haemodynamic and
respiratory support. It may be indicated for severe cardiac failure following cardiac surgery either as a
bridge to recovery or to another destination therapy (heart transplant or to another implantable support

Authors: Richard Strickland Intensivist Jo Buttery. Nurse Educator

Peter Frantzis. Perfusionist October 2009.
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Royal Adelaide Hospital General ICU ECMO Guidelines
device). Other indications for V-A ECMO in an adult are cardiogenic shock associated with
myocarditis, poisoning or hypothermia.

2. Indications and Contraindications

ECMO is indicated for potentially reversible, life-threatening forms of respiratory and / or cardiac
failure, which are unresponsive to conventional therapy and it is always applied at the discretion of the
managing intensivist. To be considered for ECMO support a patient must have an established
indication and no contraindications.

Pathological Processes Suitable for V-V ECMO

Common Optimal ventilation (consider
1. Severe pneumonia recruitment, prone, inhaled prostacyclin)
2. ARDS & PaO2 / FiO2 < 60
3. Acute lung (graft) failure following transplant OR
4. Pulmonary contusion PaO2 / FiO2 < 100 and PaCO2 >
Other 100mmHg for > 1hr
1. Alveolar proteinosis
2. Smoke inhalation
3. Status asthmaticus
4. Airway obstruction
5. Aspiration syndromes

Pathological Processes Suitable for V-A ECMO

Common
1. Cardiogenic shock: AMI and complications (including: wall rupture, papillary muscle rupture,
refractory VT / VF) refractory to conventional therapy including IABP
2. Post cardiac surgery: unable to wean safely from cardiopulmonary bypass using conventional
supports
3. Drug overdose with profound cardiac depression
4. Myocarditis
5. Early graft failure: post heart / heart-lung transplant
Other
1. Pulmonary embolism
2. Cardiac or major vessel trauma
3. Massive haemoptysis / pulmonary haemorrhage
4. Pulmonary trauma
5. Acute anaphylaxis
6. Peri-partum cardiomyopathy
7. Sepsis with profound cardiac depression
8. Bridge to transplant

Authors: Richard Strickland Intensivist Jo Buttery. Nurse Educator

Peter Frantzis. Perfusionist October 2009.
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Royal Adelaide Hospital General ICU ECMO Guidelines

Selecting the form of ECMO

1. V-A ECMO: applied for the management of cardio-respiratory failure or cardiac failure where
use of a ventricular assist device (VAD) is deemed inappropriate.
• Central V-A ECMO: In cases where V-A ECMO is required for cardiac support and
where lung function is poor (large shunt) peripheral V-A ECMO should be avoided.
This is because any native cardiac output present will deliver hypoxic blood from the
pulmonary veins preferentially to the cerebral circulation (potentially causing severe
cerebral hypoxia). Central V-A ECMO is most often employed in patients
undergoing cardiac surgery.
• Peripheral V-A ECMO is appropriate when reasonable lung function exists and
cardiac surgery is not required

2. Low-flow V-A ECMO (ECMO-CPR) is used only for initial support and stabilisation in
emergent conditions requiring V-A support

3. V-V ECMO is used for isolated respiratory failure when adequate heart function for the
duration of ECMO is anticipated

4. Hi-flow V-V ECMO is used when circuit flow via a single access cannula is inadequate to
maintain safe oxygenation. This may be required if smaller access cannulae have been placed
percutaneously (although 25FR percuataneous cannulae have recently become available), in
which case a second venous access cannula may be required (eg. from an internal jugular
vein).

Authors: Richard Strickland Intensivist Jo Buttery. Nurse Educator

Peter Frantzis. Perfusionist October 2009.
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Royal Adelaide Hospital General ICU ECMO Guidelines

Contraindications

Absolute Contraindications to all forms of ECMO

• Age > 65yrs
• Non-recoverable cardiac disease
• Non-recoverable respiratory disease
• Non-recoverable neurological disease
• Chronic severe pulmonary hypertension
• Active malignancy, graft vs host disease or significant immunosupression
o Post bone marrow, renal, liver transplant or heart/lung transplant beyond 30
days
• Weight > 140 kg
• Advanced liver disease
• AIDS as defined by:
o Secondary malignancy, prior hepatic or renal (Crt > 250umol/l) impairment
or need for salvage anti-retroviral therapy
• Unwitnessed cardiac arrest or CPR > 60min prior to commencement of
ECMO (this includes set up - cannulation time)

Relative Contraindications to all forms of ECMO

• Trauma with multiple bleeding sites
• Multiple organ failure

Absolute Contraindications to VV ECMO for Respiratory Failure

• Severe pulmonary hypertension (mPAP > 50mmHg)
• Severe right or left heart failure (EF< 25%)
• Cardiac arrest

Absolute Contraindications to VA ECMO

• Aortic dissection
• Severe aortic valve regurgitation

Authors: Richard Strickland Intensivist Jo Buttery. Nurse Educator

Peter Frantzis. Perfusionist October 2009.
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Royal Adelaide Hospital General ICU ECMO Guidelines

3. Equipment
Pumps and Circuits
ECMO pumps are stored in the ICU equipment room. Circuits are not stored in ICU but are
stored by the Perfusion Service in their pump room. The Perfusion Service should be contacted as soon
as possible when a decision is made to initiate ECMO. Out of hours the on call perfusionist should be
contacted, the roster is stored on the ECMO trolley or in CT ICU. The perfusionist is responsible for
obtaining a pump from the ICU equipment room and priming the circuit.

Priming

ECMO circuits are primed by the perfusionist. If using a Maquet Prolonged Life Support (PLS) circuit,
the priming points from the access line are removed and the access line re joined to the pump head. The
excised segment of access line with the priming ports is interposed between the pump head and the
oxygenator and secured with cable ties. This is not necessary if using an ‘Alfred’ circuit. The circuit is
then flushed with CO2 and primed with heparinised saline according to standard perfusion practice. If
time permits the circuit should be coated with albumin.

10cm extension tubing and three way taps will be attached to the access points between the pump and
oxygenator.

Pre and post oxygenator pressure monitoring requires flush type pressure transducers and sampling
manifold be mounted on the arm immediately above the oxygenator and attached via manometer tubing
to the luer connectors on the oxygenator. There should be no other connection in the monitoring system
or circuit.

Authors: Richard Strickland Intensivist Jo Buttery. Nurse Educator

Peter Frantzis. Perfusionist October 2009.
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Royal Adelaide Hospital General ICU ECMO Guidelines

Cannulation Trolley
The cannulation trolley is stored in the Equipment room

The following equipment should be stored on the ECMO trolley.

ITEM STOCK LOCATION

Cannulae: Biomedicus arterial kits 15 – 21 F Special Order
: Biomedicus Single stage venous kits 19 – 23 F
: Maquet / Avalon multiport venous kits 20-24F
Avalon insertion kits 100cm / 210cm guidewire (Order 12100 & 12210) Special Order
Backflow catheter – Super Arrow Flex 8.5 F CVC (REF:CS-13851-E) Special Order
Cook 5 lumen impregnated CVC (Ref: C-UQLM-1001J-ABRM) Special Order
Backflow tubing 30cm (Jostra 4.33x1.3x40cm Ref: BE-S 1270) Perfusionist / CTS
Promedica Angiography minor kit (Product no: 6452) Special Order
Whole Body Drapes x2 ICU
P88 Drapes x2 ICU
Sterile gowns x2 ICU
Mask with visor x4 ICU
Gauze x10 ICU
1 L Sterile jug ICU
50ml catheter tip syringe x 4 ICU
50ml luer lock syringe x2 ICU
Sterile tubing clamps x 10 (4 to remain with patient when on ECMO) ICU / CSSD
Sterile Universal or St Mayo scissors x2 CTS Theatre
2% Chlorhexadine in 70% alcohol ICU

Authors: Richard Strickland Intensivist Jo Buttery. Nurse Educator

Peter Frantzis. Perfusionist October 2009.
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Royal Adelaide Hospital General ICU ECMO Guidelines
Aqueous Povidionine Iodine ICU
10ml syringes x4 ICU
23G needles x4 ICU
1 L sterile saline ICU
Tape to secure cannulae CTS Theatre
1.0 Silk x4 and 2.0 silk x2 ICU
Large opsite x4 ICU
Roll of Hypafix ICU
Duoderm squares x2 ICU
Electric razor with spare heads x3 ICU
3 way tap on 10cm extension line (BD Connecta Ref : 394995) x4 Perfusion
30cm monitoring extension line ICU
Hi flow 3 way tap (Maquet Ref: BE-PLS 2050)) x3 Perfusionist / CTS
3/8 – 3/8 inch connector and Y connector Perfusionist / CTS
B Braun ‘Transofix’ sterile fluid transfer set CTS
Heparin 5000u x 5 ICU
Haemochron ACT machine and Kaolin ACT tubes Special Order
Maquet Rotaflow sensor paste Special order
Perfusion on call roster Perfusionist
Further items that should remain with the patient:
• White board with perfusion and Medical contact numbers
• Spare ECMO circuit
• 2x single transducer kits
• ECMO operating notes, trouble-shooting guide and observation chart
• Rota-flow manual
• 4 tubing clamps
• Rota-flow paste
• ACT machine and tubes
• 30cm monitoring extension lines for use with CVVHD
Circuit Connections
Connections for Backflow cannula
To prevent ischaemia occurring distally to the arterial cannulation site in peripheral V-A ECMO, a
backflow cannula is inserted in the artery distal to the ECMO cannulation site. The backflow cannula is
a wire reinforced 8.5FR catheter. It is connected to the luer connector on the arterial cannula via a piece
of extension tubing and a high flow three way tap. These should be inserted and connected at the time
of cannulation, or as soon as practical later.

Authors: Richard Strickland Intensivist Jo Buttery. Nurse Educator

Peter Frantzis. Perfusionist October 2009.
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Royal Adelaide Hospital General ICU ECMO Guidelines

Tubing to backflow
cannula
Access Cannula
(Venous)

Return Cannula
(Arterial)

Connections for Continuous Renal Replacement Therapy (CRRT or CVVHD)

Ideally, the CVVHD circuit is connected to the ECMO circuit to prevent risk associated with dialysis
catheter (e.g. Vascath) insertion. Connecting the CVVHD circuit to the ECMO circuit is usually
performed by perfusion staff, although it may be performed by an ICU nurse if they have been trained
in this procedure. If the nurse is unsure how to make the connections, they must contact perfusion staff
for assistance (this is a high-pressure circuit, opening the taps to air will result in a spray of blood).

The commonest way to connect the CVVHD circuit to the ECMO circuit is to attach the access and
return lines for CVVHD to the two three-way taps between the outlet of the pump head and the
oxygenator. The return line for the CVVHD circuit is connected to the three –way tap closest to the
oxygenator and the access line for CVVHD goes to the three-way tap closest to the centrifugal pump.
This part of the ECMO circuit (between the pump and the oxygenator) has the highest positive pressure
and may interfere with the functioning of the CVVHD (“PRISMA-FLEX”) circuit:

• High CRRT access pressure: If the pressure within the ECMO circuit causes the access
pressure in the CVVHD circuit to exceed the alarm limits for access pressure, the dialysis
machine (“PRISMA-FLEX”) alarm sounds, and stops CVVHD. To prevent this from
occurring select positive access pressures from the set-up menu, then if needed attach at least
one 30cm monitoring extension line to the access side of the PRISMA-FLEX, this will lower
the pressure and allow the PRISMA-FLEX to function. If the pressure on the access is still too
high a second and even a third extension can be added. This may have implications for
anticoagulation targets.

• High CVVHD return pressure: If the pressure within the ECMO circuit causes the return
pressure in the CVVHD circuit to exceed the alarm limits for return pressure, the dialysis
machine alarm sounds and stops CVVHD. No extension lines should be added to the return
side or the CVVHD circuit (this will only increase return pressures). Options to decrease
pressure on the return side of the CVVHD circuit:
1. If the ECMO circuit has a backflow cannula: this can be accessed as a return site for
the CVVHD circuit. See diagram in section 4.1
2. The CVVHD circuit return blood can be connected to an alternative venous access
(eg: appropriate peripheral IV access)

In central ECMO (no backflow cannula) the return line could be attached to a peripheral line. If this is
not possible, a Perfusionist may be able to reduce the length of the return line by cutting it and
interposing another connector.

If there is no alternative, separate dialysis catheter access may be required.

Authors: Richard Strickland Intensivist Jo Buttery. Nurse Educator

Peter Frantzis. Perfusionist October 2009.
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Royal Adelaide Hospital General ICU ECMO Guidelines
Monitoring of trans-membrane pressures

The trans-membrane pressure is derived by subtracting the post- membrane pressure from the pre-
membrane pressure. The pre-membrane pressure is measured at a connector near the venous inlet of
the oxygenator. The post-membrane pressure is measured at a connector on the oxygenator’s arterial
outlet. These connections will be made by the perfusionist. The pressures are displayed on the ICU
monitor and the pre and post membrane pressure and trans-membrane pressure should be recorded
every 6 hours on the ECMO observation chart.

The trans-membrane pressure gradient should be less than 60mmHg, an increase in the pressure drop
across the membrane oxygenator can indicate the formation of thrombus within the oxygenator. A
steadily increasing trans-membrane pressure without a concomitant increase in the circuit flows is a
sign that the oxygenator may need to be replaced.

Authors: Richard Strickland Intensivist Jo Buttery. Nurse Educator

Peter Frantzis. Perfusionist October 2009.
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Royal Adelaide Hospital General ICU ECMO Guidelines

4. Cannulation

Cannulation should be performed only by medical specialists who are trained in this procedure.

Preparation of the Patient

• New lines should be inserted prior to ECMO cannulation:
o arterial line (preferably right radial for peripheral veno-arterial)
o long term CVC (5 lumen CVC on trolley) and / or pulmonary artery catheter. Note
right femoral vein is preferable to left for ECMO cannulae. Check CVO2 or SVO2.
• A faecal management system should be inserted and sorbitol and flushes charted.
• Hair should be clipped from knees to umbilicus (femoral cannulation) and from neck and
scalp if jugular access is required.
• If indicated chest drains should be inserted prior to ECMO cannulation
• Inotropes and vasopressor infusions made up and connected to patient
• Order red blood cells to ensure a “post connection to circuit” Hb of 100g/L (minimum of 2
units immediately available).
• Adequate sedation and paralysis
• Cannulae selection should be made with the assistance of the cannulae blood flow table. Aim
should be to insert canulae able to capture 70% of cardiac output.
• Vein selection, guidewire placement and cannulae positioning should be assisted by
ultrasound and either transthoraic or transoesophageal echocardiography (TOE).

Cannulae Blood Flow Table

Diameter Arterial Venous

(Fr) Catheter Catheter
15 2.3 1.5
17 3.0 2.0
19 3.9 2.7
21 5.0 3.5
23 6.5 4.5

Flow (l/min water) through a single stage Biomedicus cannulae at a pressure drop of 60mmHg. At a
Hct of 35% blood viscosity is approx 2.7 x that of water, hence pressure drop for blood will be greater
that of water.

Diameter (Fr) Multi-stage

Venous Catheter
19 3.0
20* 3.8
21 4.1
22* 4.7
23 N/A
24* 5.8
25 6.0

Flow (l/min water) through a multi-stage Biomedicus or Avalon* venous catheter at a pressure drop of
60mmHg. At 37 degrees & Hct of 35% blood viscosity is approx 2.7 x that of water, hence pressure
drop for blood will greater than that of water. The risk of haemolysis is thought to increase with
pressures beyond 250mmHg.

Authors: Richard Strickland Intensivist Jo Buttery. Nurse Educator

Peter Frantzis. Perfusionist October 2009.
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Royal Adelaide Hospital General ICU ECMO Guidelines

Cannulation

• Percutaneous cannulation is preferable to cut-down, to minimise bleeding from the

cannulation sites.
• Decide on cannulation sites (femoral is preferable to jugular). Percutaneous subclavian arterial
cannulation (for ECMO) is not performed (but may be performed by surgical cut-down or
with a Gore-Tex graft).
• Wash cannulation site with Chlorhexidine (2.0% in 70% alcohol) and wait until dry.
• Prepare heparin solution (for heparin locking cannulae and cleaning guidewires): 10,000(u) in
one litre of saline. A sterile 1 litre jug is kept on the cannulation trolley
• Move all equipment and monitoring cables so as to allow safe movement of the operator
around the bed.
• Full body drapes must be aseptically applied and when IJ cannulation is planned, the bed head
should be draped to the floor.
• Medtronic cannulae kits contain all equipment required for insertion of cannulae. Avalon
cannulae require an insertion kit supplied on the trolley.
• For peripheral VA ECMO, backflow cannulae should , if possible, be inserted into the femoral
artery percutaneously and heparin-locked prior to ECMO arterial cannula insertion.
o An Arrow 8.5F wire-wound cannula is to be used for backflow cannulation of the
femoral artery. This is kept on the cannulation trolley along with a 30cm connection
line for attachment to the arterial cannula.
• After successful guide-wire insertion for ECMO cannulae a 70 u/kg bolus of heparin should
be given to maintain an ACT of >200. The patient will receive additional heparin as the
cannulae are flushed and from the Bioline circuit, hence it is not usually necessary to give
larger or repeated doses during cannulation.
• Large skin incisions are to be avoided with percutaneous dilation attempts as this weakens the
tightness of the fit around the cannulae once inserted
• In V-A ECMO: the arterial (short) cannula should be fully inserted (to the length of the
cannula)
• In V-V ECMO: the return cannula should be positioned in the right atrium with TOE
guidance.
• In V-V ECMO: the access cannula should be at the level of the diaphragm (femoral insertion)
or in the SVC (internal jugular insertion). Final position will be determined by degree of
recirculation and TOE guidance.
• Heparin- lock cannulae immediately after insertion and clamp. Flush regularly if second
access is delayed.
• In Hi-flow V-V ECMO: Y-connector should be heparin primed and connected

Commencement of ECMO
• Check ACT and ensure >200 seconds
• Ensure oxygen line is connected to oxygenator. Gas flow should be commenced at a rate equal
to or greater than the anticipated circuit blood flow (usually 5-6/min) with 100% O2.
• Clean loop is opened and handed to the cannulating physician
• The circuit is cut between two clamps allowing sufficient length on the access line and return
line to prevent any tension on the circuit. Note the pump trolley is best kept at the “foot” end
of the patient’s bed
• Circuit is connected to cannulae ensuring no air is introduced
• Clamps removed as circuit flows are gradually increased
• Target flow rates are determined by the cannulating Physician
• For V-V ECMO target flows must provide adequate arterial oxygenation
• For V-A ECMO target flows must provide adequate oxygen delivery
• Check patient and circuit arterial blood gases
• Reduce ventilator settings as indicated (see below)
• Establish baseline anticoagulation sampling times.

Authors: Richard Strickland Intensivist Jo Buttery. Nurse Educator

Peter Frantzis. Perfusionist October 2009.
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Royal Adelaide Hospital General ICU ECMO Guidelines

Securing Access and Return lines

• Once cannulae position have been confirmed femoral lines should be secured using a two
stage prep to the patient’s leg and covering with fabric tape or Hypafix provided on the
cannulation trolley as a mesentery dressing. The internal jugular line is directed over the
patient’s head. The loop around the head is immobilised by strapping around the patient’s
forehead. The cannulae are sutured to the dressing.

Positioning the Pump Head and Oxygenator

• The pump head is kept with outlet at “6 o’clock” to limit bubble transfer
• The oxygenator is positioned in the oxygenator arm
• The flow sensor should be appropriately coated with ultrasound paste and once in the pump
head covered with Glad-wrap.
• Flow sensor zeroing should be performed 30-60min after initiation of ECMO. This requires
transient cessation of circuit flow. This should be performed by the cannulation team once the
lines are secure, prior to leaving the patient.

It is the responsibility of the cannulation physician to ensure all cannulae are appropriately positioned
and secured, equipment is set and secured up appropriately, flows are optimized and anticoagulation
orders completed prior to leaving the patient.

Authors: Richard Strickland Intensivist Jo Buttery. Nurse Educator

Peter Frantzis. Perfusionist October 2009.
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Royal Adelaide Hospital General ICU ECMO Guidelines

5. Maintenance of ECMO and Staffing

The ward ICU consultant is the primary Intensivist. The ECMO Intensivist is responsible for all
medical decisions involving ECMO while the patient is in ICU and must also be notified of any
changes. They can be contacted 24 hours.

Whilst on ECMO details of the medical ECMO specialist (Intensivist) and perfusionist on call will be
kept by the patient’s bedside. Both will be present during initiation of ECMO. The perfusionist will
review the patient with the medical team each morning and again before leaving for the evening. The
ECMO Intensivist will review the patient daily and set the ECMO plan in conjunction with the primary
Intensivist.

Circuit Management
In the “ECMO troubleshooting guide” there are algorithms for the management of line problems and
the management of unexpected hypoxia and hypercarbia.

The Jostra Quadrox D oxygenator is remarkably robust and is capable of several weeks of continuous
function. Performance of the oxygenator should be monitored by recording the trans-membrane
pressure gradient (the difference in pressure between the inflow and outflow side of the oxygenator)
and blood gas analysis of the oxygenator outflow every 12 hours. Circuit change-out is indicated if
there is a trend towards increasing transmembrane pressures and / or worsening oxygenator function
(oxygenator outflow PaO2 < 150mmHg). A normal transmembrane pressure gradient is <60mmHg.
There is no absolute transmembrane pressure value that indicates the need for oxygenator replacement
as this value will vary with the flow rate. The decision to change the oxygenator will be based on the
trend of transmembrane pressures and oxygenator performance and should also be considered if the
ECMO circuit is thought to be a source of sepsis.

With V-V ECMO, pre-membrane blood gases may be performed after the initiation of ECMO to
identify recirculation of blood between the access and return cannulae. It is not necessary to perform
pre-membrane blood gases in patients on V-A ECMO.

The Jostra Rotaflow pump is also capable of several weeks of continuous operation. It is important to
ensure that the pump RPM rate is not too high for the maximum flow that can be delivered (“over-
spinning” the pump). When the maximum pump flow rate has been attained (which is determined by
the rate of venous drainage in the access line), increasing the RPM further will increase the negative
pressure in the access line, producing ‘line-shake’ and increasing the risk of haemolysis. “Over-
spinning” of the pump is corrected by dropping the pump RPM until the flow rate starts to drop.
Because the rate of venous drainage in the access line is variable, if the pump RPM is constant and the
venous drainage falls (eg. due to decreased preload), the pump will over-spin and access flow
limitation will start to occur.

Increased noise from the pump head may indicate that it is starting to fail. The other indications for
changing the pump head are the development of haemolysis (producing haematuria and an increased
plasma free haemoglobin) and large thrombus formation within the pump head.

Respiratory management
Once adequate ECMO flows have been established and the patient’s oxygenation has improved, the
level of ventilatory support is reduced. Typical ventilatory goals would be FiO2 <0.7, Pplt < 30cmH2O,
PEEP < 16cmH2O and respiratory rate < 12bpm. In patients on V-V ECMO, reverse diffusion of
oxygen may occur if the oxygen tension in the pulmonary artery (due to ECMO and native blood flow)
exceeds alveolar pO2. As a rule of thumb, maintaining an FiO2 of 0.5 - 0.6 while the patient is on V-V
ECMO should avoid this problem.

The commonest respiratory management problem during V-V ECMO arises from the conflicting goals
of maintaining adequate oxygenation (which may require a high flow rate) and a low CVP (which is
benificial for the lungs, but may cause access limitation of ECMO flow). Hence the goal should be to

Authors: Richard Strickland Intensivist Jo Buttery. Nurse Educator

Peter Frantzis. Perfusionist October 2009.
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Royal Adelaide Hospital General ICU ECMO Guidelines
maintain adequate patient oxygenation at the lowest CVP possible. In practice, an arterial PaO2 of 50-
55mmHg or an oxygenation saturation of 85-90% is acceptable. Pushing fluids to maintain a high
ECMO flow rate and an oxygen saturation of more than 90% may ultimately result in severe fluid
overload. If adequate oxygenation cannot be maintained at a low or normal CVP, a second access line
should be inserted.

Sedation
Deep sedation sufficient to inhibit respiratory movement is required initially. This requires an infusion
of midazolam / fentanyl. Tolerance may develop and high doses may be necessary. Addition of
ketamine or propofol may be required. In some instances thiopentone infusion is needed. In all patients
on high dose opiates a weaning plan should be developed and initiated after cannulae removal.

Muscle relaxation may be necessary.

In some patients on VV ECMO sedation may be lightened to that needed for endotracheal tube
tolerance. This requires an extremely cooperative patient and should only be attempted at the
discression and in the presence of the treating ECMO Intensivist.

Anticoagulation
Although the ECMO circuit has an anticoagulant lining, low-dose heparin is usually administered to
prevent clot formation. The lowest effective level of anticoagulation is not known and heparin may be
avoided altogether if the risks of heparin therapy are considered excessive. Some patients with severe
haemorrhage have safely undergone several days of ECMO without any systemic anticoagulation at all,
although in this situation it would be advisable to avoid prolonged periods of low ECMO flow rates
(less than 2 lpm).

For V-A ECMO following cardiopulmonary bypass, excessive bleeding due to coagulopathy is
managed as usual. A note of caution about the use of rFVIIa in patients on ECMO- it has been
associated with acute generalised intravascular thrombosis, producing acute circuit failure and death.
Following cardiac surgery, heparin is commenced when chest tube drainage is <100ml/h for 2-3hours,
the patient is normothermic and coagulation parameters are acceptable. Heparin should ideally be
commenced within 24 hours postoperatively and this is usually possible within 12 hours. The dose is
titrated to maintain an ACT of 150-180, which should be measured 2nd hourly until it reaches a stable
level. Heparin resistance is usually due to ATIII deficiency – this may be treated with fresh frozen
plasma. Tranexamic acid may be infused whilst on ECMO.

For V-V ECMO, heparin infusion is commenced at 12u/kg/hr once the post cannulation Kaolin ACT
has fallen below 200s. Kaolin ACT should be measured 2 hrly for the first 24hrs and heparin infusion
adjusted as per the table below. The target Kaolin ACT in patients with platelets > 80000 is 150-180
sec. Anticoagulation in patients with platelet counts < 80000 should be discussed with the ICU
consultant, in general heparin would be ceased in these patients. In most instances thrombocytopenia
prolongs the ACT, hence this may still be a suitable marked of anticoagulation in mild to moderate
thrombocytopenia.

ACT Response
< 130 Bolus 1000u and increase infusion 200u/hr.
130 - 150 Increase infusion 100u/hr
150-180 No change
180-200 Decrease infusion 100u/hr
200-250 Decrease infusion 200u/hr
> 250 Cease infusion for 1 hr. Check ACT hourly and
recommence when ACT <200s at 300u/hr less
than the original rate.

After 24 hours the aPTT is used to monitor anticoagulation (target range of 55-75seconds) as in some
patients the aPTT may become excessively prolonged and excessive anticoagulation may occur. aPTT

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Royal Adelaide Hospital General ICU ECMO Guidelines
and ACT should be checked 6 hrly and heparin dose adjusted to the APTT as per the hospital protocol.
Fibrinogen and d-dimer should be checked daily.

Bleeding from around ECMO cannulation sites can be a problem, pressure dressing may be required,
as may be blood or factor transfusion and on occasion, surgical exploration may be necessary. Any
patient on ECMO must have a current Group and X match and 2 units of blood must be immediately
available.

The circuitry must be regularly checked for clot formation, which may develop within the pump head
and on the inflow side of the oxygenator. Flow below 2 lpm. for prolonged periods must be avoided.
Small clots may be seen in the pump head or on the inflow side of the oxygenator. This does not seem
to adversely affect oxygenator function and therefore may not necessarily warrant oxygenator change-
out.

In the past, significant haemolysis occurred due to blood trauma from the centrifugal pump. This
appears to occur much less frequently with the Jostra impeller pump although the absolute incidence is
not known. Rapidly fluctuating pump flow due to inadequate venous drainage (“line shake” of the
access line) may increase the risk of haemolysis, as may the presence of a second access cannula (due
to areas of low flow). Plasma-free haemoglobin should be measured twice daily and when clinically
indicated. Acceptable values are 0.05-0.1g/l, Care must be taken when collecting and transporting the
sample as forceful aspiration of blood or other trauma may produce significant haemolysis. If a valid
plasma-free haemoglobin is >0.1g/l, reasons for haemolysis should be sought and corrected and
consideration given to changing the pump head.

Temperature Management
As a heater-cooler is attached to the oxygenator, the patient’s temperature may be regulated. The aim is
usually to maintain normothermia but where clinically indicated, mild hypothermia (to 35Cº) may be
performed. While the heater cooler is running, the setting on its LED display should be set to about
37C.º The heater-cooler component of the oxygenator may fail after a few days, however this is not
usually an indication for changing out the oxygenator as normothermia should be attainable with
conventional techniques (Bair Hugger). The heater-cooler settings should only be altered by the
perfusion staff unless the nurse has been trained to do this. Should the patient become unexpectedly
hypo- or hyperthermic while on ECMO, the ECMO Intensivist on call must be contacted immediately.

Ward Rounds and Documentation

All ECMO patients should be reviewed on the morning ward round by the primary Intensivist, an
ECMO Intensivist and a Perfusionist. Joint decisions about the management plan for that day will be
made at this round.

• Daily objectives. A list of objectives MUST be detailed on the patient chart by the medical team
each day of ECMO support at each ward round. This specifies
o the times routine blood must be taken
o sets the daily objectives
o the management changes planned
o will form part of the medical record

• ECMO observation chart The paper Nursing ECMO Observation chart must be maintained
and reviewed by the rostered medical Perfusionist. Nursing staff can communicate any
difficulties with observations with the rostered Perfusionist.

Medical management
Investigations required for patients on ECMO include:
• CXR as indicated
• Daily bloods: FBE; Ur, Cr, Elect; Mg; PO4; LFT including LDH, APTT, INR, Fibrinogen

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• APTT is performed 6 hourly as determined by the ECMO Intensivist while the patient is on
ECMO.
• The ACT is usually used to titrate heparin in the first 24 hours and is measured 2 hourly over
the first day. It is performed by the attending nurse, using 2 mls of arterial or venous blood. A
usual target for ACT in the non-bleeding patient with platelet count > 80,000 is 150–180.
• Beyond 24 hours, the APTT performed in the Haematology lab is primarily used to guide
heparin therapy. It is performed 4 times per day and is labelled as urgent to ensure safe
response times. A usual target for APTT in the non -bleeding patient with platelet count >
80,000 is 55-75.
• Plasma free Hb is performed twice daily and when clinically indicated. The safe range for this
is < 0.1g/L. Levels above this MUST be discussed with ECMO Intensivist and Perfusionist.
• Blood cultures daily from the arterial line and as indicated. Do NOT perform venipuncture for
the collection of blood cultures.
• Other cultures as indicated

Doppler examination of the blood flow in the back-flow cannula is indicated if deteriorating leg
perfusion is observed in the cannulated leg.

Antibiotics (vancomycin) to prevent line sepsis are recommended for the duration of ECMO. Other
antibiotics are prescribed as indicated.

Stress ulcer prophylaxis with iv pantoprazole is recommended

No procedure can be performed on a patient on ECMO without the consent of the primary ICU
consultant.

Protamine is contraindicated for patients on ECMO as it can cause serious circuit related thrombosis

Changes to circuit flows are determined by the ECMO Intensivist in discussion with the Perfusionist.

Nursing care
Nursing education available to further knowledge of ECMO care includes
• ECMO Education Program
• Bedside consultation with a medical Perfusionist
Nursing responsibilities are to patient care. Responsibility for technical maintenance of the ECMO
circuit lies with the Perfusionists.

Patient positioning and the safe performance of pressure area care are affected by ECMO support.
• Patients with ECMO support with an “open sternum” may not be rolled and require alternate
means of preventing pressure area care eg: KCI mattress. Patient moves require a Jordan
Frame and the presence of medical staff and/or Perfusionist to ensure no change in circuit
flows result as a consequence of movement.
• Other patients on ECMO support can be log-rolled and moved for chest x-rays. These moves
can be safely performed but require a designated staff member to ensure no tension is
transmitted to the cannulae and the circuit tubing is not kinked. This includes patients with
surgical grafts for femoral artery access but extra care is required to prevent obstruction to
ECMO flow at this site. Moves are scheduled between the hours of 13.00 and 14.00 when
double staffing is available and not during the night (unless there is an urgent patient need).
• No elective changes in patient position are to occur between 18.00 – 08.00hrs
• All moves are to be performed with medical staff knowledgeable in ECMO immediately
available to assess any circuit changes that may occur.

CVVHD connection to the ECMO circuit should be performed by perfusion staff or by a nurse who is
trained in this procedure.

CVVHD disconnection can be performed by nursing staff. The three- way tap is turned off to the
CVVHD circuit and the CVVHD circuit can then be disconnected and a sterile bung applied. The three

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way tap is NOT to be flushed with any solution including normal saline. Betadine solutions must be
used to wipe the connection points when disconnecting the ECMO circuit.
No component of the circuit can be cleaned with alcohol containing solutions, as alcohol may damage
the circuit tubing. If alcohol containing solutions do contact the circuit, the Perfusionist on call must
be immediately notified.

Dressings over the cannulation site should be changed if there is significant accumulation of blood
beneath the dressing or if the dressing is loose. Dressings should be removed in a toe to head direction
to minimize the chance of catheter extraction. Dressing changes should be performed between 08.00
and 18.00hrs.

Perfusionists
Perfusionists are responsible for the technical support required for all phases of ECMO support. They
are in attendance for all cases of ECMO initiation and in the event of patient instability and their
contact details should be available at the patient’s bedside. The Perfusionist should attend the morning
ward round and review the patient prior to leaving the hospital Monday-Friday. The Perfusionist on –
call should also attend the patient Saturday and Sunday, communicating with the primary and ECMO
intensivist, preferably at the morning ward round (08.00 – 09.00hrs)

Circuit blood gases from the post-membrane pressure line should be taken twice a day and additionally
as determined by the Perfusionist.

Transports out of ICU are supervised by the Perfusionist and medical staff. All non-emergent
transports are performed “in hours” (08.00 – 18.00hrs)

Nursing education at scheduled daily visits, to review observations and address nursing concerns
related to ECMO

Weaning ECMO
The decision to wean ECMO is made by the ECMO Intensivist, and in cardio-thoracic patients, it is
made in conjunction with cardiac surgeons.

The principals of V-A ECMO weaning:

• A period of prolonged low flow (~1 lpm.) is advisable while native heart function is carefully
assessed (TOE). As this increases the risk of stasis and clotting within the circuit, additional
heparin is required to increase the ACT of about 400s.
• If respiratory function is a concern, it is possible to turn off gas flow to the oxygenator (only
at circuit flows ≤1.5L/min) and assess oxygenation achieved using the ventilator exclusively.
Note: in this situation the circuit flow acts as a right-to-left shunt. If adequate oxygenation and
CO2 removal can be maintained in the presence of this shunt it is likely that respiratory failure
can be managed without ECMO.

Principals of V-V ECMO weaning:

• Circuit flow need not be reduced at any stage. Full ventilation is re-established, then the
oxygen flow to the oxygenator is turned off and clamped (as oxygen can leak around the
flowmeter even when appears to be off). TOE is not required. No additional heparin is
required. After 6 hrs of stable native ventilation with adequate gas exchange without
oxygenator gas flow consideration may be given to decannulation. Heparin should not be
ceased until decannulation, when a small dose of protamine (50-100mg) may be given if
required.

Removal of cannulae: Removal of arterial ECMO cannulae should always be removed as an “open”
surgical procedure and be accompanied with the vessel wall repair. For removal of venous cannula, a
purse –string suture is inserted around the cannulation site and local pressure then applied for 20
minutes.

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Post-decannulation Doppler: Lower limb venous Doppler studies should be performed following
decannulation as prolonged femoral venous cannulation promotes distal DVT formation.

Nursing Management; ECMO

The patient care nurse should be someone trained or experienced in ECMO management.

Nursing Responsibilities

Prior to cannula insertion

Assist with the insertion of new lines and infusions, CVC, Arterial lines etc.
Remove old lines and non-essential peripheral cannula
Insert FMS
Insert core temp probe
Prepare and position patient
Secure ET so access can be maintained during the procedure
Ensure emergency equipment is in close proximity and supplemental fluid is prepared and
readily available
Configure monitor with 2 extra pressure cables, labelled UVP, pre and UAP, post.

Cannulation
Prepare necessary equipment on ECMO Cannulation trolley as guided by medical staff.
Scrub and assist with cannulation.

Post Cannulation Care

Routine observation and documentation of vital signs

o Systolic BP
o MAP
o Heart Rate
o Sa O2
o Pulsatility V/A ECMO.

Hourly assessment

o Neuro Vascular observations of cannulated limbs

o ET CO2
o Routine ventilation observations
o Urine output.
o Core temperature

Circuit Observations Hourly

o Insertion site/ dressing security

o Integrity of the circuit
o Pump flow (L/min)
o FiO2
o Pump Speed (RPM)
o Fresh Gas Flow
o Functioning of the Heat Exchanger
o Assess access line for movement/kicking
• Colour of access blood in V/V ECMO

Circuit Observations 4 hourly

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Royal Adelaide Hospital General ICU ECMO Guidelines

• Assess for clot formation, lines, pumps and oxygenator, look closely at any
connectors within the circuit.
• Assess and record pre/post oxygenator pressures. Record the gradient. Inform MO if
gradient is > 60mmHg
• Complete the ‘Rotaflow Pump Checklist’ each shift.

Bloods

Pre and post oxygenator bloods will be taken by the Perfusionists. All other bloods should be
taken via the arterial line

Anticoagulation
For the first 12-24 hrs the Kaolin ACT should be checked every 2 hrs. It is important to have
the correct technique when performing this test, if uncertain please ask the Perfusionist for
assistance. In brief:
o The ACT should be promptly undertaken following blood aspiration.
o Fill the ACT with exactly 2mls of blood, mix by turning the tube end to end 6 times.
o Activate machine.
o Insert tube into the appropriate test well. Ensure the machine has detected the
sample, the green detector light is on and the tube is turning. The tube may require
some gentle manipulation for the sample to be detected.

The target ACT is 150 – 180 sec in patients with platelet counts > 80000. Heparin should be
adjusted according to the guidelines in the anticoagulation section. If the platelet count is
<80000 or there are other contraindications to anticoagulation the ECMO Intensivist may alter
the target ACT, change or cease anticoagulation.

After 24 hours and when the ACT is stable anticoagulation is guided by aPTT performed in
the lab. The target aPTT is 55-75 unless altered by the ECMO Intensivist. This should be
checked every 6 hrs.

Plasma Free Hb (green top)

BD with APTT samples, target <0.1 g/L. The blood should be taken through the arterial line.
It should be gently and slowly aspirated to prevent false haemolysis of the sample, do not use
vacuette.
The sample should be gently taken by hand to the laboratory.

Routine Daily Bloods

U&E / Mg/ LFT/
FBC should be taken BD to monitor Hb and platelet counts.

Venopuncture should be avoided at all times.

Blood cultures
Are sent daily from the arterial line, if cultures thorough the circuit are required the
perfusionists will undertake the procedure.

Do not use alcohol on the circuit as it can damage the circuit integrity. Sterilisation of access
points should be undertaken with betadine.

Cross Match the patient should have a current cross match at all times. (cross match lasts for
72 hours).

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Other Care

Patient

Sedation levels, as prescribed. Assessment of sedation requirements should be directed by the

need to maintain cannula and circuit integrity.

3/24 Neurological observations

3/24 CVP

General Nursing Care

Pressure area care is to be undertaken with an extra staff member designated to monitor the
tubing and circuit, ensuring there is no kinking or tension. This should only be undertaken
when medical personnel are readily available to manage circuit/flow or oxygenation problems.
Turning should be timed, where possible, for the early/late shift overlap where double staff are
present to assist. Nocturnal turning, 18.00 – 08.00hrs, should be avoided unless it is essential.

Positioning for the puffy patient

Cannula dressings must be undertaken by 2 nurses with 1 person responsible for cannula
security. This should only be undertaken when there are medical personnel present to manage
accidental cannula dislodgement (between 08.00hrs and 18.00hrs). Always pull the dressing
off towards the insertion site to minimise the risk of cannula displacement

Minimise procedures which may cause bleeding, avoid traumatising tissue during mouth care,
suction, pressure area and hygiene care. Use mouth swabs, or soft toothbrushes, for mouth
care. Do not shave with wet razor. Use electric razor or clippers. Do not dislodge clots on
wounds or cannula insertion sites. Have a supply of haemostatic dressings for use when
required.

Minimise the number of personnel surrounding the patient to those essential for the person’s
care and management.

Ensure there are medical orders for base line rest ventilation and also for rescue ventilation if
ECMO suddenly needs to be abruptly discontinued.

Shift Check

Use Maquet Jostra-Rotaflow Pump Checklist

Position pump, oxygenator and tubing to minimise potential knocks and unintended contact.

Alarms
Low flow set within .5L of current flow
High/Low rev limit set within 500 rpm of current revs

Rev mode
Check battery/ connection to AC power/ red power point with LED on
Check Gas blender is securely connected to gas flow.
Ensure all connection points in the circuit are secure
Re-check the above following patient movement.

ENSURE THERE ARE ALWAYS 4 LARGE TUBING CLAMPS LOCATED WITH NEAR
THE CIRCUIT TO RAPIDLY STOP THE PUMP IN EMERGENCY SITUATIONS.
Hand crank is available
Battery is charging or charged

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Ensure rescue ventilation orders are attached to the ventilator.

CRRT
CRRT can be run through the circuit when the patient’s condition warrants its application.

The CRRT circuit should not added before the pump as this part of the circuit is running under
negative pressure and adding sidelines will increase the risk of introducing air emboli.

Ideally the circuit will be attached between the pump head and the oxygenator through 2
pigtail connectors attached to an inline adaptor, this will be done by the Perfusionist. The
CRRT access cannula should be attached to the connector closest to the Pump head and the
return to the one closet to the oxygenator.

The Prismaflex will be run under positive pressure and the machine must be confirmed that it
is being run in this mode

If access pressures are too positive for the alarms on the Prismaflex the Prefusionists can add
extension tubing to the circuit. This will reduce the pressure and should enable the machine to
run.

If the return pressures are too positive for the alarms on the Prismaflex the Perfusionists may
be able to reduce the length of the tubing and reduce the pressure. If this cannot be done
another venous access is necessary. See notes on CVVHDF section.

There is no need to add the heating line to the Prismaflex as the blood is heated when is passes
through the oxygenator.

Jo Buttery (A) NEF

Authors: Richard Strickland Intensivist Jo Buttery. Nurse Educator

Peter Frantzis. Perfusionist October 2009.
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Royal Adelaide Hospital General ICU ECMO Guidelines

ECMO Troubleshooting
VENO-VENOUS ECMO
Worsening hypoxia
Causes:
• Decreased circuit flows
• Increased Cardiac Output (increasing the shunt from the ECMO circuit)
• Recirculation of returned oxygenated blood into the access line
• Decreased FiO2
• Oxygenator failure
• Gas tubing leak or disconnection
Ensure:
• Pump flow is adequate (> 2/3 cardiac output)
• 100% oxygen is being supplied to the oxygenator
• Oxygenator is functioning correctly (outflow pO2 > 150mmHg)
• Recirculation minimized (see below)
Consider:
Increasing pump flow / increasing ventilation / cooling patient to 35ºC. These changes MUST NOT be
performed without the approval of the ECMO Intensivist or medical Perfusionist on-call.

Worsening hypercarbia
Causes
• Decreased gas flow
• Oxygenator failure
Ensure:
• Pump flow is adequate (>2/3 cardiac output)
• Oxygen flow to oxygenator is at least twice the pump flow rate
Consider:
Increasing ECMO flow rate / increasing ventilation /cooling patient to 35ºC

Low Flows
Causes
• Hypovolaemia (look for a kicking access line)
• Clot in oxygenator (look for increased transmembrane pressures)
• Kinked tubing
• Catheter against vessel wall
• Clot in access line
Action
• Give fluid, monitor CVP
• Reposition tubing
• Assess for clot formation and inform ECMO Intensivist and Perfusionist.

Increasing flow rate does not improve oxygenation

Ensure recirculation is not occurring:

If the access and return cannulae are too close together, recirculation of blood may occur between them
(oxygenated blood is drawn down the access cannula). Hence increasing ECMO flow may not improve
the patient’s oxygenation. To diagnose recirculation, take a blood gas from the venous side of the
oxygenator. This should have a venous pO2. If the pO2 is higher than the patient’s venous pO2,
reposition (withdraw) the access line. Consider adding a second access access line via a Y-connector.

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VENO-ARTERIAL ECMO
Worsening hypoxia
Differential hypoxaemia (lower pO2 in the upper body compared to the lower body) can occur
during peripheral veno-arterial ECMO when there is severe respiratory failure combined with a
high cardiac output. In this situation, the heart is supplying the upper body with de-oxygenated
blood, while the ECMO circuit supplies the lower body with oxygenated blood. To detect this
problem, patient blood gases should be sampled as close to the heart as possible (hence a right
radial arterial line is preferable to a left radial line). Similarly, monitoring of the oxygen saturation
of the upper body should be performed with a pulse oximeter on the right hand or with a
transcutaneous oximeter attached to the patient’s forehead.
To treat differential hypoxaemia, the following steps may be necessary:

• Ensure the oxygenator is functioning correctly (return line pO2 > 150mmHg)
• Ensure the ECMO flow is as high as possible (within constraints of return line pressure)
• Increasing the patient’s ventilation/ PEEP / FiO2
• Consider central cannulation or return via subclavian gortex graft

Worsening hypercarbia

Ensure:
Pump flow is adequate (>2/3 cardiac output)
Oxygen flow to oxygenator is at least twice the pump flow rate

Consider:
Increasing ECMO flow rate / increasing ventilation /cooling patient to 35ºC

VENO-VENOUS AND VENO-ARTERIAL ECMO

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“SIG” alarm on pump console

This alarm may occur on the Jostra pump console. The flow rate indicator on the pump says “SIG”
while the pump is still functioning normally (RPM rate unchanged). The pump continues to function
normally, although flow rate is not displayed. This occurs when the cream that is applied to the flow
sensor (under the black clip at the outlet of the centrifugal Jostra pump) has dried out and needs to be
replaced. This may be prevented by wrapping the flow sensor in cling-wrap whenever the Rotafow
pump is used.

Response: Assess patient saturation and perfusion. If unchanged this is not a critical situation. In hours
contact the Perfusionist or ECMO Intensivist, then if trained in the procedure re-apply ultrasound gel
to the sensor as below:
• Stop pump slowly and clamp inflow and outflow lines to the centrifugal pump.
• Unclip the black clip on the flow sensor and remove the pump head.
• Re-apply silicone cream to flow sensor.
• Unclamp lines and slowly increase flow back to normal level.

After hours defer the re-application of gel to 08.00h

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ECMO Complications
Haemolysis

If haemolysis is suspected while on ECMO, the following steps should be taken:

Plasma free-haemoglobin testing: Samples are taken carefully and very slowly through the shortest
and widest available sampling port (preferably venous). Samples are labelled as urgent and must be
hand delivered to the lab to avoid shaking that will falsely raise the plasma free-haemoglobin. Normal
operating plasma free-haemoglobin level is <0.1 g/L. A confirmed plasma free-haemoglobin at or
above 0.1 or any high reading associated with clinical evidence of intravascular haemolysis (see
below) or circuit malfunction (such as “access insufficiency”) demands a rapid response and must be
communicated to perfusion services and the ICU Consultant urgently.

Elevated plasma free-haemoglobin readings: Any elevated readings should be re-checked

immediately with a repeat sample from a venous port (NOT a stab) and handled meticulously.
Repeatedly high readings are confirmation of intravascular haemolysis. Causes are:
• Clot within the circuit or near the cannulae orifices;
• Inadequate venous return (poor circulation)
• Inappropriate pump speed settings

Signs of haemolysis: Red (or dark brown in extreme cases) urine; high potassium; renal failure;
jaundice (late sign).

Signs of access insufficiency: Access insufficiency occurs when flow into the circuit from the patient
is inadequate for the pump speed settings. This may occur if the venous return is insufficient or there is
obstruction near the inlet of the cannulae. Blood flow into the circuit becomes episodic and pressure
swings can be very large resulting in damage to red blood cells. The access line tubing may visibly
shake or have a palpable “kick”. Continuous, hourly observation of the access line is part of routine
nursing care of a patient on ECMO.

Management of haemolysis may include:

• Increase volume state and review pump settings (if signs of access insufficiency present)
• TOE to ensure cannula not obstructed
• Consider changing the circuit
• Reset anticoagulation targets

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Emergency Complications with ECMO Care

Emergency complications are dramatic, life threatening changes involving the ECMO circuit that
demand immediate responses. They are largely preventable: see accompanying section:

The responses required for a range of possible (but extremely rare) emergency complications in patient
requiring veno- arterial and veno-venous ECMO are given in the accompanying section:
• Emergency ECMO Responses: Veno-venous ECMO
• Emergency ECMO Responses: Veno-arterial ECMO

Emergency ECMO Responses: Veno‐Venous ECMO

Emergency ECMO responses are fortunately rare. In general these

complications are almost entirely preventable.
Possible complications are:

Pump Failure

Decannulation

Circuit Rupture

Air Embolism

Cardiac Arrest

Oxygenator Failure

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Pump failure (Veno – Venous Response)

Definition:
• This is a no flow state due to failure of the electrical pump to drive pump head.
Effects:
• Hypoxia / hypercarbia
• Haemodynamic collapse may occur as a result of severe hypoxia.
Causes:
• Pump head disengagement: eg. accidental contact with pump-head or incorrect initial
placement of pump head or pump head adaptor
• Electrical motor failure
• Battery failure (no AC power connected)
Prevention:
• Always maintain the pump head in a position to minimise the risk of contact especially with
devices such as portable x-ray, haemofilter and Echo
• Minimise time on battery
• Ensure AC “Power Off” alarm is turned on when using wall power
• Console not in use, needs to be plugged into AC power and “on Switch” turned on in order to
recharge battery
Response:
• Re-establish rescue ventilation with 100% oxygen
• Call for help. Contact perfusion services
• Examine circuit: identify pump head disengagement; exclude torsion, kinking or
compression of tubing
• Pump head disengagement
1. Clamp line (anywhere on ECMO circuit) and turn off pump
2. Re-engage pump head
3. Turn pump on to 1000 rpm and remove clamp
4. Gradually increase rpm to previous setting
• Electrical motor failure
1. Clamp line (anywhere on ECMO circuit) and turn off pump
2. Commence manual cranking whilst obtaining spare blood pump (console)
2. Re-engage pump head in new blood pump
3. Turn on blood pump to 1000 rpm and remove clamp
4. Gradually increase revs to previous settings
• Battery failure:
1. Commence manual cranking
2. Re-establish AC power – check
 Wall connection – (UPS source)
 Circuit breaker and plug at base of ECMO trolley
 Power cord connection to pump console
NOTE: If ECMO is off for any period of time, clotting in the circuit is a possibility

Authors: Richard Strickland Intensivist Jo Buttery. Nurse Educator

Peter Frantzis. Perfusionist October 2009.
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Royal Adelaide Hospital General ICU ECMO Guidelines

Decannulation (Veno – Venous Response)

Definition:
• This is the removal of either the access or return cannula
Effect:
• Hypoxaemia
• Haemodynamic collapse and hypoxaemia of varying severity (depending on underlying
cardiac and respiratory reserve)
• In central cannulation, right atrial and vena caval damage resulting in catastrophic blood loss
• In peripheral cannulation, massive blood loss from cannulation site
Causes:
• Extreme tension being placed on tubing and hence cannulae and cannulation sites
Prevention:
• Anchoring the cannulae to the patient
• Use of a spotter to ensure that lines remain free during patient manoeuvres
Response:
• Clamp the circuit proximal to the disconnected cannulae and apply pressure to the cannulation
site
• Call for help
i. Contact ECMO Intensivist, Perfusionist
• Assign roles for concurrent patient and circuit management
Patient Management
• Apply pressure to the cannulation site
• Position patient head down
• Give volume to replace blood loss
• Increase the ventilator settings and inotropes to compensate for loss of support.
Circuit Management
• Turn the pump off

Authors: Richard Strickland Intensivist Jo Buttery. Nurse Educator

Peter Frantzis. Perfusionist October 2009.
 32
Royal Adelaide Hospital General ICU ECMO Guidelines

Circuit Rupture (Veno – Venous Response)

Definition:
• This is the disruption of any part of the circuit
Effects:
• Massive blood loss
• Haemodynamic collapse and hypoxia of varying severity (depending on underlying cardiac
and respiratory reserve)
• Circuit or patient air embolus
Causes:
• Fracture and breakdown of polycarbonate components after being cleaned with alcohol
• Broken three way tap
• Accidental cutting or puncturing of circuit tubing
Prevention:
• Do not allow any part of the circuit to come into contact with alcohol or other organic solvent
such as volatile anaesthetic
• Allocated person to act as “spotter” to ensure that three way taps are not snagged on anything
during patient manoeuvres
• Care with needles and instruments near tubing

Response:
• Clamp the circuit on either side of the circuit disruption
• Call for help.
• Contact Perfusionist and ECMO Intensivist
• Assign roles for concurrent patient and circuit management
• Patient Management
- Establish rescue ventilator settings and increase inotropes to compensate for loss
of support.
- Give volume to replace blood loss
• Circuit Management
- If fractured three way tap: if possible place sterile gloved finger over leak
- Connection change

Authors: Richard Strickland Intensivist Jo Buttery. Nurse Educator

Peter Frantzis. Perfusionist October 2009.
 33
Royal Adelaide Hospital General ICU ECMO Guidelines

Circuit Air Embolism (Veno – Venous Response)

Definition:
• This is the introduction of air into the ECMO circuit.
Effects:
• Introduction of air embolus into the patient
• Massive air embolus into the pump head will de-prime the pump, this will lead to
• Severe hypoxaemia
• Haemodynamic collapse and hypoxaemia of varying severity (depending on underlying
cardiac and respiratory reserve)
Causes:
• Introduction of air into the circuit via a peripheral cannulation site
• Fracture of connector or circuit rupture on the access side of the pump
Prevention:
• Only ECMO trained consultants or cardiac surgeons to perform ECMO cannulation
• Only Perfusionist to manipulate the inlet side of the pump
• Do not allow connectors to come into contact with alcohol or organic solvents
Response:
• Clamp the circuit (anywhere on circuit) and switch off pump to prevent further introduction of
air into the patient
• Call for help.
• Contact Perfusionist and ECMO Intensivist
• Assign roles for concurrent patient and circuit management
Patient Management
• Position patient head down
• Inotropic support to maintain MAP
• Establish rescue ventilation
• Volume load
• For air embolus consider
• aspiration of the right heart using existing lines
• hypothermia to 34°, barbiturates, steroids, mannitol, lignocaine, HBO
Circuit Management (removal of air)
• Clamp arterial return line
• Turn pump off
• Examine circuit for site of air introduction; seal if possible or replace

If no air on the return side of oxygenator:

• Rotate pump head outlet to 12 o’clock.
• Ensure air vent on oxygenator is open and attach a 60 ml luer lock syringe to circuit
venting port distal to oxygenator and aspirate air and blood. If pump head is not
deprimed, slowly turn on pump, using partial clamp release to help control flow; the
air will be vented from the oxygenator provided the flow is low. Aspirate any air
distal to oxygenator using 60ml syringe.
• Return pump head to 6 o’clock position.

Authors: Richard Strickland Intensivist Jo Buttery. Nurse Educator

Peter Frantzis. Perfusionist October 2009.
 34
Royal Adelaide Hospital General ICU ECMO Guidelines
If air on the return side of oxygenator:
• Clamp both the return cannula and access line
• Attach a 60 ml luer lock syringe to the post oxygenator luer conector.
• Whilst aspirating partially release the clamp on the return cannulae to allow blood
flow back down the return line and enable aspiration of air via the luer lock 60ml
syringe.

• Once all air is removed from circuit and the site of air entry fixed, remove clamps and
resume ECMO

Authors: Richard Strickland Intensivist Jo Buttery. Nurse Educator

Peter Frantzis. Perfusionist October 2009.
 35
Royal Adelaide Hospital General ICU ECMO Guidelines

Cardiac Arrest (Veno – Venous Response)

Definition:
• This is the cessation of patient’s circulation. ECMO flow will diminish accordingly
Effects:
• Patient will be in cardiac arrest.
Causes:
• Usual causes of cardiac arrest
Prevention:
• Identify risk factors and treat
Response:
• Call for help
• Commence ACLS
• Notify Primary Intensivist, ECMO Intensivist and Perfusionist
• Continue ECMO although reduce ECMO flows if signs of circuit access insufficiency

Authors: Richard Strickland Intensivist Jo Buttery. Nurse Educator

Peter Frantzis. Perfusionist October 2009.
 36
Royal Adelaide Hospital General ICU ECMO Guidelines

Oxygenator failure (Veno – Venous Response)

Definition:
• Gas transfer failure is a gradual process that is identified through routine blood gas
analysis and requires elective responses by perfusion services.
• Sudden causes of oxygenator failure are :
i. Water leak external (heat exchanger rupture)
ii. Water to blood leak
Effects:
• Heat Exchanger Rupture : Water spraying everywhere, loss of ability to control blood
temperature through oxygenator
• Water to Blood Leak : Massive haemolysis and sepsis
Causes:
• Heat Exchanger Rupture
• Excessive water pressure in heat exchanger
• Tension on heater hoses
• Manufacturing defect
Prevention:
• Ensure that no equipment is rolled over or obstructs the heater hoses attached to the
oxygentaor
Response:
• Heat Exchanger Rupture:
• Turn off Heater Unit
• Contact Perfusionist and ECMO Intensivist
• Use warming blanket to control patient temperature
• Water to blood leak (Evident as massive haemolysis / cardiovascular instability)
• Turn off Heater Unit
• Contact ECMO Intensivist and Perfusion

Authors: Richard Strickland Intensivist Jo Buttery. Nurse Educator

Peter Frantzis. Perfusionist October 2009.
 37
Royal Adelaide Hospital General ICU ECMO Guidelines

Emergency ECMO Responses: Veno-Arterial ECMO

Emergency ECMO responses are fortunately rare. In general these

complications are almost entirely preventable.
Possible complications are:

Pump Failure
Decannulation
Circuit Rupture
Air Embolism
Cardiac Arrest
Oxygenator Failure

Authors: Richard Strickland Intensivist Jo Buttery. Nurse Educator

Peter Frantzis. Perfusionist October 2009.
 38
Royal Adelaide Hospital General ICU ECMO Guidelines

Pump failure (Veno – Arterial Response)

Definition:
• This is a no flow state due to failure of the electrical pump to drive pump head.
Effects:

• If the circulation is mainly mechanically driven: this is associated with haemodynamic

collapse
• If a significant non-mechanical (native) circulation is present: The ECMO circuit becomes a
passive conduit as it contains no valves or occlusive rollers. Hence reversal of blood flow
(from the aorta to the central veins -along its pressure gradient) will occur, which will reduce
the cardiac output and increase the preload to the right heart. The extent of hypotension and
hypoxia that may result will depend on the underlying cardiac function.
Causes:
• Pump head disengagement: eg. accidental contact with pump-head or incorrect initial
placement of pump head or pump head adaptor
• Electrical motor failure
• Battery failure (no AC power connected)
Prevention:
• Always maintain the pump head in a position to minimise the risk of contact especially with
devices such as portable x-ray, haemofilter and TOE
• Minimise time on battery
• Ensure AC “Power Off” alarm is turned on when using wall power
• Console not in use, needs to be plugged into AC power and “on Switch” turned on in order to
recharge battery
Response:
• Clamp lines
• Call for help. Contact Perfusionist and ECMO Intensivist
• Assign roles for concurrent patient and circuit management
Patient Management
• Establish rescue ventilation +/- CPR if haemodynamic collapse
Circuit Management
• Examine circuit: identify power failure, motor failure or pump head disengagement;
exclude torsion, kinking or compression of tubing,
• Pump head disengagement
1. Clamp line (anywhere on ECMO circuit) and turn off pump
2. Re-engage pump head
3. Turn pump on to 1000 rpm and remove clamp
4. Gradually increase rpm to previous setting
• Electrical motor failure
1. Clamp line (anywhere on ECMO circuit) and turn off pump
2. Establish manual cranking whilst obtaining spare blood pump (console)

Authors: Richard Strickland Intensivist Jo Buttery. Nurse Educator

Peter Frantzis. Perfusionist October 2009.
 39
Royal Adelaide Hospital General ICU ECMO Guidelines
3. Re-engage pump head in new blood pump
4. Turn on blood pump to 1000 rpm and remove clamp.
5. Gradually increase revs to previous settings
• Battery failure:
3. Commence manual cranking
4. Re-establish AC power – check
 Wall connection – (UPS source)
 Circuit breaker and plug at base of ECMO trolley
 Power cord connection to pump console
NOTE: If ECMO is off for any period of time, clotting in the circuit is a possibility

Authors: Richard Strickland Intensivist Jo Buttery. Nurse Educator

Peter Frantzis. Perfusionist October 2009.
 40
Royal Adelaide Hospital General ICU ECMO Guidelines

Decannulation (Veno – Arterial Response)

Definition:
• This is the removal of either the access or return cannula
Effect:
1. Haemodynamic collapse and hypoxia of varying severity (depending on underlying cardiac
and respiratory reserve)
2. In centrally cannulated, immediate loss of ECMO support and:
a. if arterial, cannula would be pulled out of or torn off Aorta resulting in catastrophic
blood loss
b. if venous, cannula would be pulled out of Right Atrium.
3. In peripherally cannulated, massive blood loss from cannulation site (may be controllable)
4. Possible introduction of air into ECMO circuit and patient
Causes:
• Extreme tension being placed on tubing and hence cannulae and cannulation sites
Prevention:
• Anchoring the cannulae to the patient
• Use of a spotter to ensure that lines remain free during patient manoeuvres
Response:
• Clamp the circuit
• Call for help. Contact ECMO Intensivist, Perfusionist and Cardiothoraic surgeon.
• Assign roles for concurrent patient and circuit management
Patient Management
• If peripheral cannulation apply pressure to the cannula site
• Position patient head down
• Give volume to replace blood loss
• Increase the ventilator settings and inotropes to compensate for loss of support.
• If central cannulation
i. prepare for chest opening in ICU
ii. Give fentanyl 500ug iv
Circuit Management
• Turn the pump off

Authors: Richard Strickland Intensivist Jo Buttery. Nurse Educator

Peter Frantzis. Perfusionist October 2009.
 41
Royal Adelaide Hospital General ICU ECMO Guidelines

Circuit Rupture (Veno – Arterial Response)

Definition:
• This is the disruption of any part of the circuit
Effects:
• Massive blood loss
• Haemodynamic collapse and hypoxaemia of varying severity (depending on underlying cardiac
and respiratory reserve)
• Circuit or patient air embolus
Causes:
• Fracture and breakdown of polycarbonate components after being cleaned with alcohol
• Broken three way tap
• Accidental cutting or puncturing of circuit tubing
Prevention:
• Do not allow any part of the circuit to come into contact with alcohol or other organic solvent
such as volatile anaesthetic
• Allocated person to act as “spotter” to ensure that three way taps are not snagged on anything
during patient manoeuvres
• Care with needles and instruments near tubing
Response:
• Clamp the circuit on either side of the circuit disruption
• Call for help. Contact Perfusionist and ECMO Intensivist
• Assign roles for concurrent patient and circuit management
Patient Management:
• Increase the ventilator settings and inotropes to compensate for loss of support.
• Give volume to replace blood loss
Circuit Management:
• If fractured three way tap: if possible place sterile gloved finger over leak
- Connection change

Authors: Richard Strickland Intensivist Jo Buttery. Nurse Educator

Peter Frantzis. Perfusionist October 2009.
 42
Royal Adelaide Hospital General ICU ECMO Guidelines

Circuit Air Embolism (Veno – Arterial Response)

Definition:
• This is the introduction of air into the ECMO circuit.
Effects:
1. Massive air embolus into the pump head will deprime the pump and stop it pumping
leading to haemodynamic collapse and hypoxaemia of varying severity (depending on
underlying cardiac and respiratory reserve)
2. Possible introduction of air embolus into the patient
Causes:
• Introduction of air into the circuit via a peripheral cannulation site
• Fracture of connector on the inlet side of the pump (Vent port on arterial cannulae or Y connector if on
Hi-flow VV)
Prevention:
• Only ECMO trained consultants to perform cannulae insertion
• Only perfusionist to manipulate the inlet side of the pump
• Do not allow connectors to come into contact with alcohol or organic solvent
Response:
• Clamp the circuit (anywhere on circuit)
• Switch off pump to prevent further introduction of air into the patient
• Call for help. Contact Perfusionist and ECMO Intensivist
• Assign roles for concurrent patient and circuit management
• Patient Management
• Position patient head down
• Inotropic support to maintain MAP
• Establish rescue ventilation
• Volume load
• For patient air embouls
• Consider aspiration of the right heart using existing lines (if venous air
embolus via access cannulae. This is unlikley)
• Consider hypothermia to 34°, barbiturates, steroids, mannitol, iv
lignocaine, HBO for air embolus
• Circuit Management (removal of air)
• Clamp arterial return line
• Turn pump off
• Examine circuit for site of air introduction; seal if possible or replace

If no air on the return side of oxygenator:

• Rotate pump head outlet to 12 o’clock.
• Ensure air vent on oxygenator is open and attach a 60 ml luer lock syringe to circuit
venting port distal to oxygenator and aspirate air and blood. If pump head is not
deprimed, slowly turn on pump, using partial clamp release to help control flow; the
air will be vented from the oxygenator provided the flow is low. Aspirate any air
distal to oxygenator using 60ml syringe.

Authors: Richard Strickland Intensivist Jo Buttery. Nurse Educator

Peter Frantzis. Perfusionist October 2009.
 43
Royal Adelaide Hospital General ICU ECMO Guidelines
• Return pump head to 6 o’clock position.

If air on the return side of oxygenator:

• Clamp the arterial return cannula on the patient side of the luer lock port; remove
first clamp.
• Attach a 60 ml luer lock syringe to the luer lock port and aspirate air and blood.

• Once all air is removed from circuit, remove clamps and resume ECMO

Authors: Richard Strickland Intensivist Jo Buttery. Nurse Educator

Peter Frantzis. Perfusionist October 2009.
 44
Royal Adelaide Hospital General ICU ECMO Guidelines

Cardiac Arrest (Veno – Arterial Response)

Definition:
• This is the cessation of native cardiac function. Pulseless circulation
Effects:
• Little haemodynamic effect if circuit flow is above 4 L/min
Causes:
• Cardiac stunning
• Hyperkalaemia
• Arrhythmia ie: VF
Prevention:
• Need to exclude reversible factors
Response:
• Establish adequate circuit flow
• Notify Primary and ECMO Itensivist and Perfusionists
• Address reversible factors
• Defibrilate if indicated / consider antiarryhthmics
• Vasopressor if indicated

Authors: Richard Strickland Intensivist Jo Buttery. Nurse Educator

Peter Frantzis. Perfusionist October 2009.
 45
Royal Adelaide Hospital General ICU ECMO Guidelines

Oxygenator failure (Veno – Arterial Response)

Definition:
• Gas transfer failure is a gradual process that is identified by worsening pO2 values in the
post-membrane blood gases or by an increasing trans-membrane pressure gradient. It
requires an elective response by perfusion services.
• Sudden causes of oxygenator failure are:
• Water leak external (heat exchanger rupture)
• Water to blood leak
Effects:
• Heat Exchanger Rupture: Water spraying everywhere, loss of ability to control blood
temperature through oxygenator
• Water to Blood Leak: Massive haemolysis and sepsis
Causes:
• Heat Exchanger Rupture:
• Excessive water pressure in heat exchanger
• Excess tension on heater hoses
• Manufacturing defect
Prevention:
• Ensure that no equipment is rolled over or obstructs the heater hoses attached to the
oxygentaor
• Avoid excess traction on the heater hoses
Response:
• Heat Exchanger Rupture:
• Turn off Heater Unit
• Contact Perfusionist and ECMO Intensivist
• Use warming blanket to control patient temperature
• Water to blood leak (Evident as massive haemolysis / cardiovascular instability)
• Turn off Heater Unit
• Contact ECMO Intensivist and Perfusion

Authors: Richard Strickland Intensivist Jo Buttery. Nurse Educator

Peter Frantzis. Perfusionist October 2009.
 46
Royal Adelaide Hospital General ICU ECMO Guidelines

Changing the circuit

Change the whole circuit in the event of either an oxygenator or pump failure.
It should take less than 60 seconds to cut and change the tubing. This will usually be performed by
the Perfusionist with assistance from ICU.

Indications
• Increasing transmembrane pressure gradient; it should be <50 mmHg
• Oxygenator outflow PaO2 <150 mmHg
• Heat exchanger rupture
• Increased noise from pump head
• Large thrombus formation within pump head
• Development of haemolysis

Method
• Re-establish full ventilation.
• Apply defib pads - (as some patients will arrest due to hypoxia - especially respiratory cases).
• Prime the new ECMO circuit, as per the above guidelines in a second pump.
• If the new circuit has been primed in the hand crank, remove the pump head from the hand
crank.

• Use a four person technique with appropriate PPE and sterile field, scissors and gloves. Prep
the circuit with aqueous betadine, not alcohol.
• Position two people on each side, one to cut and change the tubing and one with a 1 L jug of
sterile saline and 4 filled 60ml catheter tipped syringes to fill the circuit as required.
• Double-clamp the new patient loop, divide it between the connectors, remove the interposing
tubing to expose the straight ⅜” connectors and prime the connectors with a syringe of saline.
• Stop the old pump slowly and double clamp the arterial return and venous access lines close to
the patient (clamp on the coloured tapes, cut between the tapes)
• Divide the lines close to the clamps on the side of the clamps away from the patient and prime
their ends using a syringe of saline.
• Connect the new lines to the ends of the old lines.

If using the same pump,

• Disconnect the heater-cooler tubing from the old oxygenator.
• Disconnect the fresh gas line from the old oxygenator.
whilst the new connections are being made
• Remove the old pump head from the pump and insert the new pump head
• Connect the fresh gas line to the new oxygenator.
• Connect the heater-cooler tubing to the new oxygenator.

• Unclamp the lines and slowly increase flow back to normal level.
• Apply gun-ties to the new connections in the lines.

The blood remaining in the old circuit may be drained into citrate bags for re-infusion, unless there
is thrombus in the circuit.

Authors: Richard Strickland Intensivist Jo Buttery. Nurse Educator

Peter Frantzis. Perfusionist October 2009.
 47
Royal Adelaide Hospital General ICU ECMO Guidelines

Authors: Richard Strickland Intensivist Jo Buttery. Nurse Educator

Peter Frantzis. Perfusionist October 2009.