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1 Neural Simulator

The document contains a series of questions related to the Nernst and Goldman equations, membrane potentials, and the effects of various ions and toxins on neuronal activity. It covers topics such as the impact of ion concentrations on membrane potential, the behavior of sodium and potassium during action potentials, and the effects of certain venoms on neurotransmitter receptors and ion channels. The questions are designed to test understanding of physiological concepts in neurobiology.

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Najam
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10 views2 pages

1 Neural Simulator

The document contains a series of questions related to the Nernst and Goldman equations, membrane potentials, and the effects of various ions and toxins on neuronal activity. It covers topics such as the impact of ion concentrations on membrane potential, the behavior of sodium and potassium during action potentials, and the effects of certain venoms on neurotransmitter receptors and ion channels. The questions are designed to test understanding of physiological concepts in neurobiology.

Uploaded by

Najam
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
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Test Content

Question 1
Using the Nernst Equation: Increasing the potassium concentration outside the cell makes the membrane potential more
negative.
True
False
Clear selection

Question 2
Use the Nernst simulator for Na+. The membrane potential can be made negative by (more than one answer may be correct):
Increasing the temperature
Increasing the intracellular Na+ concentration
Increasing the extracellular Na+ concentration
Decreasing the extracellular Na+ concentration

Question 3
Uisng the Goldman Equation: The membrane permeability for Sodium suddenly increases. This means that
The membrane potential may become positive.
Sodium can no longer enter or exit the cell.
Potassium can no longer enter or exit the cell.
Potassium can no longer enter or exit the cell.

Question 4
Using the Nernst equation, what is the value for the Membrane potential in mV at 37° C when the intracellular concentration of
K+ is 100 mM and the extracellular concentration is 20 mM? 1
-43mV

Question 5
Using the Nernst Equation: What is the change in the membrane potential (in mV) at 37° C if the intracellular concentration of
Sodium is doubled? (answer may be negative) 1
-18.5mV

Question 6
Using the default settings for the squid axon in the Nernst Equation the membrane potential for chloride is negative because:
chloride is positively charged and the concentration of chloride ions is larger outside the cell than inside the cell.
chloride is negatively charged and the concentration of chloride ions is larger outside the cell than inside the cell.
chloride is positively charged and the concentration of chloride ions is larger inside the cell than outside the cell.
chloride is negatively charged and the concentration of chloride ions is larger inside the cell than outside the cell.

Question 7
Using the Goldman Equation: Increasing the permeability for Na ion (PNa+)
Brings the membrane potential closer to the equilibrium potential for that ion.
Always decreases the membrane potential.
Always increases the membrane potential.
Does not affect the membrane potential.

Question 8
Using the Goldman Equation: Decreasing the temperature from 40° C to 20° C
Doubles the membrane potential.
Halves the membrane potential.
Does not affect the membrane potential.
Brings the membrane potential closer to zero.

Question 9
The action potential simulator at http://www.cs.sunysb.edu/~grosu/simulation/HHModel.htm shows that the
Sodium and Potassium currents are in opposite directions. Why is this the case?
Because Na+ enters the cell and K+ exits the cell.
Because Na+ enters the cell first and K+ enters the cell later.
Because the charge of Na+ is different from the charge of K+
Because the simulator does not work.
Question 10
Acetyl choline is released when the action potential reaches the end plate of a motor neuron. This triggers an action potential in
a muscle cell.
True
False
Clear selection

Question 11
Spider venom blocks the acetyl choline receptors.
True
False
Clear selection

Question 12
Pufferfish venom blocks the sodium channels so there is no propagation of the action potential.
True
False
Clear selection

Question 13
The venom of a snake acts in the same way as the venom of a pufferfish.
True
False
Clear selection

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