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Biological Information On Artificial Intelligence

The document outlines an introductory course on bioinformatics, emphasizing its integration of biotechnology and computer science for analyzing biological data. It discusses various biological databases such as GenBank, SWISS-PROT, and DDBJ, highlighting their roles in storing and providing access to genetic and protein sequence information. Additionally, it covers the distinction between primary and secondary databases and their importance in research and scientific discovery.

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21 views20 pages

Biological Information On Artificial Intelligence

The document outlines an introductory course on bioinformatics, emphasizing its integration of biotechnology and computer science for analyzing biological data. It discusses various biological databases such as GenBank, SWISS-PROT, and DDBJ, highlighting their roles in storing and providing access to genetic and protein sequence information. Additionally, it covers the distinction between primary and secondary databases and their importance in research and scientific discovery.

Uploaded by

4ytghtdfkt
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PDF, TXT or read online on Scribd
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Course Title:

Introduction to
Bioinformatics
COURSE INSTRUCTOR:
SALMAN SAEED

Botany Department
University College of Management &
Sciences, Khanewal, Pakistan
Allcih fG\X/’TJ never ch‹:snșjes
the conOi“ti‹:zri mȚci ¡seaple unlezs
thejz strive to «honțje therrinelven
Surah Ar-Ra’ctf>3:*>)
hat is ioinfor a
• The newesi, fastest growing specialty
in the li li sciences that integrates
biñtecbnology and computer sci*nce.

• Computers aid to collect.. nnslyze,


and interpret biological inf mation

• Bioinfntmatics encompasses a.at nf

funcli•nai analysis
of genes & genomes and ihcir
cnrresponding products
• Data is raw, unorganizedfacts need to be
process«d.
• Example: Each students test score is one piece of
data.

• When data is processed, organized structured or


presented in a given context so as to make it useful it
is called i y»rmation.
are Databasen??

Fealures01BiOIOgiczI
B0l0 aIDai| e
Databases

• S u i t ñ0Ii¡; M Edit int#nÍfifiii


l0fKl.
i Data ÍfiÍ8gfát0fl

J›alzfili|y 0Tfi0@C0I 68|z


On the basis of nature of data.
Blologi< al Databases

Sequent e
Struclure Olher

• PDB SWiS8-PrOt • GenBank • REL IBASE


• PIR • DDBJ • REBASE
• T EMB • EMBL • GGC B
- SCOP
• CATH • PROSITE
PFAM
• On the basis of source:
Daobasez
• They contains biomolecular data in its oripino//arm.

• Experimental results are submitted directly into the database


by researchers, and the data are essentially archival in nature.
• Once a database accession no. is given to an kind of data in
primary database then that data can't be changed further
• Examples : GenBank, EMBL, DDBJ for DNA/RNA sequences.
SWISS —PROT and PIR for protein sequeces.
CenBanL:
• It is a database/rom N6BI, includes sequencesfrom
publically availableresources.
• GenBank is the genetic sequence database, an annoted
collection of all publically available DNA sequences.
• GenBank is the part of the International Nucleotide
Saguance Database Collaboration.

G e n E ars£c €¥v'ezvte›w
• European Molecular Biological Laboratory. It is an Nucleic acid
Porobose that comes under EBI ( European Bioinformatics institutes.
• It was Established in collaboration with DDBJ and Gen8ank.

databanks in molecular biology, integrating and linking the main


• The ONA Oato Bank oflapan is a biological database that effects
OhlA Sequences.
• It is located at the National Institute of Genetics in the ñhizuoka
Prefecture of Japan.
• It is also a member oJ the Int:emotional Nucleotide Sequence
OotoboSe tollabomtion or IN5DC.
DDBJ HOME PAOE AT :
SWISS - PROT
SWISS PROT is a curoted protein sequence datobase which strikes
to provide a high level of annotatian (such as description of the
function of proteins, Its domains structure, post translational
The Protein Information Resources (PART is an rnregrored public
resource of protein Informatics that supports genomic and
proteomic research and scientific discovery.
FORmaintains the Protein Sequence Database (PSD), on annoted
protein database containing over 2B3000 sequences covering the
Seconda Dambase
• It contains Data derived from results of analysed primary data.
• The dota in secondarydotabose /seither manually created or
generated automatically.
• It contains some valuable infbmation such as about mutâtions or
evolutionary elationship.
PR SITE is a protein do tabase. It consist of entri'es describi'ng the

acid patterns and profiles in them


They ore monually curated by a team of the Swiss /nsti’tute of
• Pfam is adatabase of protein families that includes their
annotations and mutiple alignments generated using hidden
markov models.
• The general purpose of the pfam database is to provide acomplete
and accurate classification of protI^in families and domains.
Some Stmozaldaobaze
• PDB ( protein dato banal.
Comprises of: . PDBe (PDB of Europe)
2. PDBj (PD oJ*•Ran )

• SCOPE. Structural classificâtion af protein

• CATH .' Class ArcheitectureTopology Hâmology

•They all contains information generated from X- Crystallgraphy


and NMR Experiments.
Other S ecialised databases
• MACRO: Human gene mutation database

• OJLffM: Online mutation inheritance in man (Disease database)

• Tf4AfSFA6: Trancription Factors database (Eukaryotic TF database)

• PFAM' RNA family Database.


• The of these database thot they can be
sharable wide.

• The contains information about genome and protein of every


species..

• The primarydatabase provide natural Colm oof data so


initial or begning point in and research.

• They also contains information of mutations and evolutionary


relationships.

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