The

RMBC Method
for Writing
Winning
Sales
Letters
by Stefan Georgi

TRANSCRIPTS
Bonus 4
Visit Me At:
stefanpaulgeorgi.com
 TRANSCRIPTS

Coming Up

4
With the
Mechanism
for Health
Offers
VIDEO 1
Health Offer
Mechanism

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Coming Up With the

Mechanism for Health Offers
VIDEO 1
Health Offer Mechanism

(00:00:02)
Yo! Okay. So I’m going to talk about how to come with a unique mechanism
for a health offer and we’re going to pick a memory or brain offer; depending
on when this video started recording, you may have seen the Amazon up there
so I was thinking about if I wanted to do it for a preexisting supplement, but
I don’t. I think what I want to do is find the unique mechanism where we
would be creating the product and the product could either be, in this case,
a nutritional guide which is going to have you eating for a healthier brain or
it could be a supplement so a product supplement or nutritional guide and
basically, you could actually have this work either way. So let’s go for category
brain/memory. Sweet.

(00:01:07)
So really, I mean, to be completely honest with you, here’s what I would do. I’ll
go to ScienceDaily. If I’m on ScienceDaily, I’m actually going to move this over
here because it’s more natural for me. Let’s start here. I love ScienceDaily. It’s
basically got all interesting new discoveries and findings and things like that.
Right now of course, lots of COVID stuff going on. To be completely honest
with you - this is interesting. Open a new tab here, “Where in the brain does
creativity come from?”

(00:02:01)
Just looking through anything else that might be interesting. Brain research
seems interesting. I’m just curious about this real quick, this “Treatment
relieves depression in 90% of the cases,” interesting. Mind and brain, whole
category. You already know “amyloid as a target for prevention of Alzheimer’s,”
which makes sense. But now really at that point, let’s go like this. I was going
to search memory and we’re going to get a bunch of interesting articles and
then I’m going to open those all as new tabs, too basically.

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(00:03:08)
“Good blood supply is good for memory.” This looks something I’m not going
to interested in that cereal consumption helps to prevent memory loss.
This would be interesting for a self-help thing, “In a new study, researchers
report they can manipulate how the brain encodes and retains emotional
memories.” “Brain’s astrocytes play starring role in long-term memory,” this is
very interesting because I don’t know what astrocytes are. “Exercise boosts
memory” is interesting but probably not going to go too deep on that. This idea
of a genetic switch boosting hardwired memories s interesting, open a tab to
that. Sleep improves your memory is interesting but I’m going to skip that.
“How the brain’s immune system could be harnessed to improve memory,”
very interesting. Interesting, “Monitor brains replaying memories in real time.”
This vitamin D one is a little interesting. “Tickling the brain with electrical
stimulation improves memory,” interesting. This is very interesting, “Hot flashes
impair memory performance.” If I was targeting that demographic, which is a
good demographic, be interested in that. Interesting, “Chimpanzees’ working
memory is similar to ours.” That’s very interesting, memory is transferred
between organisms. I don’t know if that’s going to work for a supplement but
I got to open it because it’s just interesting to me. Let’s just start with that. I
have a bunch of articles, obviously. What am I doing here?

(00:05:26)
This is the one I opened randomly, “Where in the brain does creativity come
from? Evidence from jazz musicians.” What I love about it - okay, the date is
very new. Drexel University. I’m filming this on April 7th, this is March 31st;
this came out. “A new brain imaging study has studied the brain activity of jazz
guitarists during improvisation to show that creativity is in fact, driven primarily
by the right hemisphere in musicians who are comparatively inexperienced
at improvisation. However, musicians who are highly experienced at
improvisation rely primarily on the left hemisphere.” This is interesting, but
I don’t think it’s going to be the mechanism for a supplement or health offer.

(00:06:35)
This is also interesting, it’s from Stanford. This idea of observing a ton of a
brain activity in real time. However, not actually specifically relevant right now.
This one I just wanted to open it because I was curious but again, Stanford’s
always good. This is really interesting. I wouldn’t be doing this for a brain
supplement, but the fact that Stanford is having a lot of success treating
depression would be something I would probably save if I ever wanted to do

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something around that.

(00:07:35)
We’ve always heard that amyloid levels or not always, but it’s common
knowledge that amyloid levels are associated with Alzheimer’s at some
NIH, National Institute of Aging. I probably wouldn’t touch this for a brain
supplement, though just because amyloids are so closely associated with
Alzheimer’s and we don’t want to make any claims about curing or treating
diseases or anything like that. So I probably wouldn’t touch this one even
though it is interesting to me. One second here. Yeah. I mean this is definitely
a big study and these amyloid levels. I’m going to keep that one open but not,
we’ll come back to it.

(00:08:30)
“Lifestyle changes could delay memory problems in old age, depending on our
genes.” This one’s looking interesting. “Researchers have shown that how we
respond to changes in nutrients at a molecular level plays an important role
in the aging process and this is directed by some key genetic mechanisms.”
“Study explored the molecular interactions that occur in our response to
varying levels of nutrients, otherwise known as nutrient-sensing pathways as
we grow older.” This one I would take and put the link here and I basically just
start copy/pasting and stuff like this what I think is an interesting potential
mechanism.

(00:09:29)
So here we’ve got, “Using a combination of laboratory-based techniques and
analysis...” Basically, they identified genes that are active in nutrient-sensing
pathways and demonstrated that these genes also show associations to
performance on memory tasks and data of over 2,000 individuals. The study
identified that the genes ABTB1 and GRB10” as both influential in nutrient-
sensing pathways and showed association to memory.” Copy/paste that into
here, too.

(00:10:16)
“Previous studies have indicated that neural stem cells and the hippocampal
part of the brain play an important role in the decline of our thought process
and memory over time. NSCs AKA neural stem cells are cells that keep
dividing as long as they’re alive and either make more NSCS or cells that have
a special function in the brain. The maintenance of these NSCs is important in

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memory and is affected by environmental factors such as diet and exercise.”

So the reason that’s interesting is because I mean one potential mechanism
here could be nutrients that support neural stem cells. I mean that alone is
not - frankly, it’s pretty easy so I’m going to put a note for myself like “SPG
note: could be looking for nutrients that support neural stem cells.” and we’re
going to do that. The next steps would be to “get a little more information on
neural stem cells.” Then “look at nutrients/ingredients that have been shown
to support them.” I mean frankly, I probably am going to do this one because
it’s frankly easy but.

(00:11:51)
I’ll read the rest of this real quick here. “Nutrient-sensing pathways can
provide...” I guess helpless stem cell maintenance. Because there was a study
that was talking about genes being a part of this so you can find something
that maybe supports these genes and I mean I’d probably highlight that as a
note for myself, too. But honestly, from a mechanism standpoint, you could
potentially just do the neural stem cells and I’m willing to talk about the genes
or - sorry, it’s 6:30 in the morning so deal with it. You may just be able to do
that without having to talk about the genes or the nutrients had the same
pathways really because our goal at the end of the day is to get people to
understand that this is the key. You could go deeper with genetic stuff here,
but I don’t think you really need you. For now, I’m going to just save this and
come back to it and look at a few more mechanism options and I’m going to
give this Alzheimer’s one because I like this more.

(00:13:02)
“A good blood supply is good for memory.” “Memory performance and other
cognitive abilities benefit from a good blood supply to the brain. This applies
in particular to people affected by a condition known as sporadic cerebral
small vessel disease. Researchers suggest that blood profusion of the so-
called hippocampus can play a key role in age- and disease-related memory
problems.” Let’s see.

(00:14:38)
I mean, this is an interesting mechanism, too. I wouldn’t touch disease, but
this idea that basically blood flow to the brain is important. So I would do it
again, copy/pasting these here. I’m taking the parts that I think are interesting.
Actually, I got a whole part here. This is the big takeaway. I don’t know why
that’s how it is, that’s what happens. Okay, cool. Yeah, so I mean and I guess

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since we’re talking about hippocampus and cognitive performance here, then
maybe up to how big the hippocampus is and then what does this mean? Well,
I’m making notes, too. RMBC Bonus health mechanism.

(00:16:19)
I would even make up a term here talking about circulation and for the brain.
Well, because we’re talking about blood flow, but if you’re talking about hey, this
product could increase blood flow to the brain that sounds kind of creepy, but if
you’re talking about circulation, I almost called it “Make up a term like cognitive
circulation” or something like that. But mechanism “would be basically something
like increased blood flow to the brain AKA cognitive circulation supports better
memory.” My next steps would be “prove that’s true that increased blood flow
improves memory and find nutrients that increase blood flow to the brain.” That
would be the next steps for that here. So now we’ve got two different options.
There’s this one. This one I’m actually make that a little clearer. All right, so that
was interesting. I’ll keep that open for now, too.

(00:18:08)
“Memory games: Eating well to remember.” Let me just sum that here. All
right, so this is interesting that older people eating cereals helps with memory
loss, but I just sort of, I don’t know, that one’s not exciting to me. One thing to
note, though by the way with these because this is not an academic source
but what you’ll find is if you come down, you’ll get a link to the actual study so
you’ll just click that, then you’ll get these actual studies. So then if you want to
cite that in the sales letter or something, you can just do it by clicking that link
that was down here right here. I don’t care about that one that much.

(00:19:14)
“Brain’s astrocytes play starring role in long-term memory.” “Scientists
discover that astrocytes, long considered sideline players in the brain, are
required to establish long-lasting memories in mice.” Now it’s an animal
study, but it’s interesting. It’s from the Salk Institute. “Star-shaped cells called
astrocytes help the brain establish long-lasting memories. The work could
inform therapies for disorders in which long-term memory is impaired.” It’s
interesting. This is a repeat of that but we’ll copy/paste anyway because
this one is interesting to me because it’s like these astrocytes. So what’s
interesting? Well, this is interesting, “Merely supportive calls in the brain may
have more of a leading role,” this is really interesting. I probably would take
this because it’s a good quote.

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(00:20:29)
“The brain’s neurons rely on speedy electrical signals to communicate
throughout the brain and releases neurotransmitters, but astrocytes
instead generate signals of calcium and release substances known as
gliotransmitters, some of them chemically similar to neurotransmitters. The
classical view was that astrocytes’ function was mostly to provide support
to the more active neurons, helping transport nutrients, clean up molecular
debris and hold neurons in place. Only more recently, researchers have found
that they might play other, more active, roles in the brain through the release
of gliotransmitters, but these remain largely mysterious.” Let’s go and copy/
paste that in, too. What’s interesting to me, gliotransmitters that are chemically
similar to neurotransmitters. I’m not going to make the note here. I’ll come
back to this but what are gliotransmitters, a question I ask after that.

(00:21:23)
Interesting, too. In 2014, basically they disabled the release of gliotransmitters
and astrocytes. Now the issue here with this one is it’s a little complex because
if we look at how easy it was to be like neural stem cells. That was pretty easy;
the secret to memory is supporting neural stem cells. These nutrients help
to support them, here’s what happened. That’s very basic, it’s not the sexiest
mechanism, but if you’re trying to just quicker and dirty, I still think this is
the easiest one. But I think this one is very interesting. Poor little mice but
this is interesting so I’d be like, I guess I follow the same format I’m doing.
Next steps would be “more on astrocytes and gliotransmitters, confirm their
importance for memory, find nutrients that support both.” That would be the
next steps for that one.

(00:23:44)
Now the one cool thing, by the way of doing this research I mean, how long
have they actually been going? I’m not 100% sure, but maybe like 20 minutes
here and we already have a bunch of potential mechanisms. What’s cool is
even you pick one for now, you still have these. If you’re smart, you’ll save all
these other ones. So the next time you have to do a memory offer or you want
to do a memory offer, you already have a bunch of the resources and you
already have research for the mechanism and you can potentially shortcut
a lot of time because now you have to - this is going to save you a bunch of
time. I’m going to go ahead and pause this. I’m going to adjust the thermostat
real quick in my offices. Honestly, heat is pumping in and I don’t want to pass
out so give me a second.

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(00:24:27)
All right. We that one here. I’m going to keep it open for now.

(00:24:36)
“Long-term memory performance depends upon gating system.” I liked
that they started with a paradoxical question, “Why do we remember some
experiences for our entire lives but quickly forget others?” It’s from Scripps
Research Institute which is a good institute, very recent. Drosophila, I think it’s
a fruit fly, isn’t it? Yeah. Look at that, look at me knowing shit.

(00:25:48)
So this is really interesting to me, but I think for me this is too complicated.
While it’s really interesting and especially again, genetic stuff and things
like that, I just sort of feel like... I’m sorry, I’m reading about this protein
synthesis dependent in long-term memory. I mean what I would do, I think
this is interesting, but I’m going to save it for like later because I just feel
like - I’ll make a note real quick, “Interesting, good paradoxical question, but
a little complicated plus talking about genetic factors” because I think it’s
hard to say. You can’t really sell a supplement that’s like altering your genes.
Generally, I don’t think the FDA is going to like you doing that but for a product
it can work still potentially for just teaching this system, but even beyond that,
I don’t know. I do think it’s interesting so I was still saving because again, who
knows, maybe down the road I may come back to this and have a really clear
head and read it again and it’s like oh crap, that actually totally works and it’s
great. For now, though I’m going to close it because I already have other ones
that are much easier.

(00:27:13)
Obviously, I love this already, although immune system certainly is on my mind
because of just what’s going on with coronavirus or anything like that but
“How the brain’s immune system could be harnessed to improve memory.”
I mean, I don’t know if I’m going to do this as my mechanism. I have to read
about it, but I think that’s a very interesting concept.

(00:27:43)
“Inflammation can send the brain’s immune cells into damaging hyperdrive,
an effect that has been linked to neurodegenerative diseases that affect
memory, like dementia. A new study finds these same immune cells can
also be activated to have the reverse effect, powering memory and learning.”

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I mean oh God, this is a really good one already. Interesting that “When it
comes to memory, immune cells are known as the “bad cops” of the brain.
But new research shows they could also be turned into “good cops” to power
memory and learning.” They’re called microglia so that’s interesting. This
is really interesting. Microglia, when they’re altered.... This is a good quote,
“Chief investigator and senior author.” We want to have the person’s name in
case we want to quote them in the sales copy.

(00:29:13)
What I’m doing, the cognitive the client, I’m won’t talk about treatments
or preventing things, but this idea that “optimizing how well we learn and
remember can give us a substantial performance edge at work and socially.
Our study has for the first time showed a link between changes in the immune
cells of healthy brains and improved cognitive function.” How do they do it?
It’s interesting to say, looked at how rats do tasks when their microglia or
whatever and were knocked out, made no difference but when the microglia
were regenerated, this led to astounding result, same memory tests on the
rats and they performed 25 to 50% better than normal rats. Regenerated ones
were a different similar to the “activated” shape that these cells have when
dealing with inflammation. To me, this is interesting.

(00:30:33)
“Brain’s immune system. Also, microglia in the brain being activated and that
increasing memory.” So I would look at “activating microglia, what happens,
memory, what they are, et cetera. Does this support short term memory
improvements and then nutrients that help activate microglia.”

(00:31:37)
All right. I’ll be honest with you, we probably aren’t going to use this one, but
just highlight it. I have a couple more to go through here and again, I’m probably
going to stick with that first one, the neural stem cells. Just for this example
for simplicity’s sake. But it is interesting to know that you have all this other
stuff here. So NIH, which is cool. “Monitor brains replaying memories in real
time.” “Our brains use distinct firing patterns to store and replay memories.”
This one is interesting now that it’s going to lend itself to a nutrient offer
necessarily, but just some interesting stuff about how memory works.

(00:33:26)
“More vitamin D may improve memory but too much may slow reaction time.”

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It’s interesting. More vitamin D can improve boost memory, but potentially slow
reaction time. Well, this is interesting to me is because I’m pretty positive that
you’re going to find the vitamin D if we do the neural stem cell thing. Neural
stem cell, what. Check this out. Neural stem cells, vitamin D. So watch. “D3
enhances neural stem cell proliferation.” Well, remember neural stem cells
“play an important role in the decline of our thought process and memory
over time.” They were are really good, maybe this is important for memory.
Well, guess what D3 enhances neural stem cell proliferation. There you go,
this is one of the potential ingredients to produce mechanisms, it’s one of
the reasons I would probably do this mechanism at least for this example
because it’s the fastest and easiest one.

(00:34:52)
Here’s another one. This is not from an academic source, though so I would
just skip that. Although, there’s some more things about vitamin D3. What I
would actually do, just to jump ahead here, let’s go to NCBI because NCBI is a
national health - the National Institute of Health’s website. Here’s a bunch of
stuff. Okay, we looked at this one already. That one academic. “Role of vitamin
D in regulating the neural stem cells of mouse model with MS.” Basically,
“vitamin D has the ability to trigger neural stem cells and thereby, in this case,
it’s helping fight MS.” We’re not trying to do an MS product, but again, that’s
really interesting. “Improves the differentiation of neural stem cells.”

(00:36:11)
Anyway, so the point is I’m [inaudible 00:36:12] securing that stuff for now, but
going back to “More vitamin D may improve memory but too much may slow
reaction time.” Obviously, it’s a fine line, but again, then you’re us interesting
it makes sense because NSCs are important for the brain, vitamin D supports
those things and a new study shows that more vitamin D improves memory.
Again, vitamin D is not really your star ingredient for a supplement, but this is
worth mentioning or saving. It’d be like, “SPG note, remember that remedy” -
and again, I happen to just know this about vitamin D - “helps support, neural
stem cells. So interesting that it also supports memory. Makes sense.” I
mean, it’s not the best note in the world. I’m curious if they mentioned stem
cells here, but what’s nice about this is it’s a huge human or not huge but
look at how many people that were. But this is a good human study, too. But
again, looks like you need to be careful of the dosage, to get the right amount
if you’re older especially and then here’s the study. This study I’m going to
save because since I might have, I haven’t deemed my formulation. “Study

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reference.” I’m curious how many women there were, but [inaudible 00:38:31]
says it here. Anyway, very interesting. So okay.

(00:38:51)
Seems like they have really interesting ones. “Electrical simulation improves
memory,” which is interesting because this is Mayo Clinic and Stanford found
the same thing. But of course, we’re not selling a product that stimulates the
brain so just save this one for now and then I’ll come back to this in just a
minute here. All right, so electrical stimulation stuff, Mayo clinic. Interesting,
but not relevant for us. Maybe I don’t want to just save. “Just interesting
because another thing about electrical simulation, similar to Stanford study
viewed earlier. This one from the Mayo Clinic.” Chimpanzee thing is interesting
but not really that interesting.

(00:40:18)
This is just super fucking interesting. I’m not going to - it’s not part of our
product, but I mean this idea that memories can be transferred. I’m just going
to have to save that whole thing because this is super interesting. Memories
can be transferred between animals by basically literally injecting memories
from one animal to another. I mean that’s fascinating, but not really for us.

(00:40:41)
So all right. Honestly, with all of these, there’s a bunch of interesting
mechanisms to pursue, but - so annoying when that comes up, there you go.
Okay. I think what makes the most sense by far, especially for this example,
is probably focusing on neural stem cells. So I’m going to take this. Why am
I choosing this one? Again, this is simplest, easy to understand, all that stuff.
Let’s do a page break here. Okay. So neural stem cells, let’s put On: Neural
stem cells.

(00:41:46)
Oh, ScienceDaily came up again, but come back to that. I didn’t mean to
click on that, let’s go back, let’s open the link, here you go. I can’t right click
right now. Very annoying, sorry about that guys. I’m opening a bunch of stuff
because I just want to get some basic things about it which Scientific America
is I know going to be reputable; this isn’t like a citation, but it’d be something
good, well-written, well-researched, legit but then it’s also probably hopefully
be written in a way I can understand. So let’s go and just take that. Frank
LaFerla, who’s from Irvine, his colleagues “showed that neural stem cells can

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reverse memory loss.” “Mice injected with stem cells developed far greater
number of synapses or connections between neurons at the damaged site
than control mice.” Not sure I’m going to do that. Eh, it was a little helpful. It’s
a little bit too complex.

(00:44:12)
“Neural stem cells largely undifferentiated cell originating in the central nervous
system. Neural stem cells have the potential to give rise to offspring cells
that grow and differentiate into neural and glial cells, non-neuronal cells that
insulate neurons and enhances the speed at which neurons send signals.” It’s
interesting. Scientists thought that the brain couldn’t generate new cells like
other parts of the body could, the generation of new brain cells in the adult brain
was thought to be impossible, but then in 1998, no stem cells were discovered
in humans, found in the hippocampus which we keep seeing come up.

(00:45:29)
Sure, let’s do all that from here. Let’s all do this here, undifferentiated stem
cells, great. Gives us everything we need, frankly. So really, what is it like
“undifferentiated cells in the central nervous system that can become new
types of brain cells that support memory.” Here’s an easy hack or a trick or
whatever, so that’s the case. “Studies showing that no stem cells support
memory,” which I know we have several, but basically as far as this goes, if
we can basically find that do NSCs decline with age because if we can and we
can find that there’s ingredients that activate those, then we can be in good
shape here. So this was that I just had from Britannica. We know that stem
cell, when it’s transplanted, improves cognition. “When transplanted into an
animal model or improves cognition animal study, but just to save that.

(00:47:35)
“Adult neural stem cells in the mammalian central nervous system.” “Neural
stem cells are present not only during the embryonic development but also in
adult brain of all mammalian species including humans.” So this is similar to
what we already know, but I’m curious if we were talking about NSCs how they
basically decline with age potentially. It goes into plasticity and neuroplasticity
which was just even 10 years ago, people would like scoff at neuroplasticity
and now it’s saying that yeah, actually you can. Again, we know that there. I
can put this back up here. It’s a good breakdown of them. Self-renewing and
then the hippocampus again. It’s gets a little complicated. I won’t worry about
too much, just where they’re located. All I’m looking for right now is to find
something to talk about how we lose them with age.

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(00:50:14)
I know I’m scanning, but I’m really just trying to find stuff about how they
probably may go down. I’m just really going to put “neural stem cells decline
age NCBI.” This is interesting, by the way, “Calorie restriction protects neural
stem cells from age-related decline.” By the way, one thing you find when you
do a lot of this health stuff is basically intermittent fasting and it’s basically
the healthiest thing you could possibly do and all of your cells regenerate and
all of this stuff, which by the way, I don’t really do that much, but frankly really
should because it’s just everything is better when you do that.

(00:51:33)
“Effects of aging on stem cells,” just search for neural because that’s what
we’re interested in. Nothing but neural stem cells here. “There is now strong
evidence for the aging-associated cognitive deficits, spatial memory deficits,
neurogenic disorders caused by deterioration of NSC proliferation and
differentiation enhancement.” Okay, perfect so we’ve got that. Let me put this
link up here because this is really important, the deterioration of proliferation.
The reason that’s important is because remember, we wrote down if vitamin
D up here somewhere. Yes, I closed it. Did I? Well, whatever, I’ll come back
to that. But basically, we had all that stuff saying that vitamin D helps with
proliferation, of NSC proliferation and now this is what we were just looking
at. 27, 28 so let’s see here. “Aging results in reduced epidermal growth factor”
blah, blah, blah. Let’s just open that one in a new tab and then 28. Either way,
we have this that we can now cite and that’s really all we need for this one.

(00:53:05)
Let’s see what it says about NSCs here. Eh, it doesn’t do a ton for me. It doesn’t
do ton for me either but let’s keep going. Well, “studies suggest that increasing
in adult neurogenesis has beneficial,” which is a creation of differentiation
of neural stem cells, “beneficial effects. The observation that aging has a
negative effect on the proliferation of neural stem cells has prompted several
laboratories to investigate” ways of increasing neurogenesis. Okay, great.

(00:54:20)
Let’s look this real quick. Basically, this is really interesting to me. Essentially,
it’s showing how when you’re young, you have all this differentiation happening
and as you get older, it stops happening and depletion due to death of the
neural stem cells and now you’re seeing more of them dying and then they
eventually all die and your brain goes to shit, your neuronal death. So this is

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really something I would probably want to save to put in my mechanism. Hold

on a second, let’s do it like this actually.

(00:56:01)
Excuse me, the screen capture tool. That’s just a great visual representation
of that. Perfect. All right.

(00:56:20)
When stem cells grow old, does it get neural ones again? Like satellite cells,
they decrease in numbers of age, which again, because there’s a decrease
in neurogenesis. Let’s just get a really good definition of neurogenesis.
“Neurogenesis is a process by which nervous system cells are produced by
neural stem cells.” Got it and that was from this one. Neurogenesis equals,
what did we say it did? It’s not bad.

(00:57:41)
Cool, interesting. I’m finding the same thing which is neural. All right, whatever
we also need declining so we get it but I think at that point, we have enough
research showing that they decline with age. “With increasing age the niche
begins to deteriorate, compromising these functions” of memory. So, okay.
Save that one. “Just another saying that with increased age NSCs decline in
memory gets worse.”

(00:59:18)
Just one more. Perfect. That’s just interesting, but not for now.

(00:59:41)
All right, perfect. So we knew vitamin D - basically, what do we have here? So
basically, we have that NSCs support memory. Let’s actually do one more thing
here. Neural stem cells, memory support. A quick one here, open this up. It’s
different than that one, right? Yeah, basically... Memory, crucial for spatial learning
and memory, contributing to new memory formation, alleviating depression
which I won’t say that, probably supporting mood. Okay, good enough.

(01:01:29)
So basically, here’s your mechanism of the problem, “The way your brain
supports itself and regenerates is through adult neural stem cells. These are
stem cells that come from your central nervous system and are found in the
hippocampus of your brain. The hippocampus is the place - is highly associated

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with mental performance and memory. The ongoing creation AKA proliferation
of adult neural stem cells has been shown to support working memory, spatial
learning and the formation of new memories. However, as we age, there is
significant evidence suggesting that the creation AKA proliferation of NSCs
decreases and that with the less NSCs and slowed down activity, brain activity
also slows down and memory suffers. The mechanism of the solution is to
support the ongoing creation AKA proliferation of NSCs in the brain.”

(01:04:05)
Now at this point, if you’re doing info products, you find ingredients in the
diet that does that or you can get those ingredients and turn them into a
supplement. “Specifically, here are ingredients that help to support memory
or support the proliferation of NSCs and memory.”

(01:04:31)
Let’s do something. New line. All right now, we already know vitamin D is going
to be one. Vitamin D3. Why do we know that? Remember, we had before?
Vitamin D3, what was the association? Neural stem cells, vitamin D. Oh, NCBI.
Actually, let’s not - yeah, NCBI works. Okay, we have this one, this one, this is the
same study, but actually maybe it’s not. Not it’s different, actually. No, they’re
not. They were just published at different times. Sorry about that. There we go.

(01:05:43)
There’s this one basically. Again, this is about MS, but this is for now, let’s just
save that. Another one. This vitamin “significantly enhances proliferation of
NSCs, enhances the differentiation in neurons” and blah, blah, blah. Astrocytes,
which is interesting.

(01:06:32)
This one enhances neural stem cell proliferation. Interesting, I keep saying it in
the context of MS which is funny but. Not funny but interesting. Basically, I’m
not doing this whole thing, but just like I know what’s it’s going to say is that
going to say vitamin - I mean that’s just the title of it, “Vitamin D3 enhances
neural stem cell proliferation.”

(01:07:41)
This one. For now, it’s just the same idea. “Improves the differentiation of
neural stem cells.” Great. A mouse model. So enough of that. Great. Now I’m
basically going to Google shit. Oh, one another thing actually before we get

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to that. Remember we talked about vitamin D? Remember this study? The

study tells us well, “vitamin D and NSCs proliferation.” There is this study.
“Showing that vitamin D supports memory.” Now the reason behind that is
because while it’s important that like vitamin D - the solution is to support the
proliferation of stem cells.

(01:09:49)
But beyond that, there’s the whole factor of just then be like, “Okay, well what
does that mean?” “It helps with these stem cells!” “But that’s not really to
support memory” and it’s like it does because guess what and then you’re like
okay, vitamin D3 memory. Forgot to put NCBI. I’ll write this like, “Vitamin D3 and
memory.” We know this one, “Deficiency equals worse memory.” “Population-
based prospective studies.” Same thing, “same as above.” Partially, it’s about
efficiency. Randomized trial in healthy adults of D supplementation, 4,000 IU/
ds, it’s from 2017. Nonverbal visual memory benefits from higher doses of
D3, are consistent with what other studies have found. Higher D is critically
important for higher levels of cognitive functioning, specifically nonverbal.
Great. That’s excellent and they find out what was the dosages, let’s see.
You have to translate this, the IU/ds if you’re going to be doing the actual
formulation, but perfect. Good enough.

(01:12:14)
Now let’s go back to neural stem cells. Natural ingredients that support neural
stem cell growth. Showing me NCBI right now, honestly. Okay, well, let’s see
here. “Chinese herbs and their active ingredients for activating blood promoted
proliferation and differentiation of neural stem cells.” It’s of course from
Chinese Medicine. Here’s what I would take this one that other ingredients
that support growth of neural stem cells.” So this basically says... Basically, I
just copy and paste all this stuff.

(01:14:10)
So let’s see, Rhodiola is a great ingredient in general. I don’t know what this
one is. Ginsenoside Rg 1 is going to be part of I think, ginger. We’ll find out.
Astragalus, Safflower, Muck, blah, blah, blah, blah. Panax. Just looking at this
stuff, so what have I got here? I’ve got Rhodiola, Panax Ginseng, Astragaloside,
which I believe is... I forgot what that is, but I think it’s some - well, we’ll look at it
in a minute. Ginkgolide which I’m assuming is part of ginkgobaum. Safflower.
Gardenia. Ginsenoside.

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(01:15:37)
Let’s start with that, okay. So why and it may be that there’s actual studies in
here on these ingredients, but you don’t get a bunch of answers with these
ingredients in here actually. Yeah, you do. Yeah, perfect, look at this. I don’t
know what this one is. I’m not exactly sure. What’s Angelica, I wonder. Rhodiola,
interesting. Ganoderma.

(01:17:02)
They’re mostly animal studies, but it’s really interesting. I can basically pull
a bunch of these studies with this, but just for simplicity’s sake. What is
Angelica? Wild celery, okay. So Angelica, wild celery. Angelica neural stem
cells NCBI. All right, let’s see. Angelica, I saw ASP mentioned somewhere. I’m
assuming that is for Angelica polysaccharide. “ASP can delay aging speed
protecting neural stem cells and promote neurogenesis.” Now again, animal
study, but pretty dope. Good. Angelica should be in our formulation. Well, I
don’t know it should be, but maybe or again, same thing that we add to our
guide if we’re doing an info product.

(01:18:51)
What about this one? Here we go. I’ve got another one. “Alleviate hypoxia-
introduced NSC by maintaining cell viability, blocking apoptosis” which is death
and autophagy which is basically supporting the health of and well, recycling
the cell and self-cleaning. So sweet, another one right there. This one this
longer, whatever. Scanning for neural stem cells, whatevs. Let’s see here. This
we can induce “stem cell differentiation into neuron-like cells and produce less
cytotoxicity,” which is cool so I’ll save that one, too. All right, cool.

(01:20:20)
Now again, what about memory? Does it really help with memory? Angelica,
memory NCBI. Let’s see what we get here and close some of these ones
because we actually have a good list of leads here. All right, so check this out.
Reduced Alzheimer’s type of memory impairment in rats so again, we’re not
going to talk about Alzheimer’s but cool.

(01:21:21)
Well, this one. Put something like Angelica memory. There you go, “Mild
cognitive impairments.” Again, these are all animal studies but pretty
interesting. Now one thing I might do - it’s another one. One thing I might do
is try and find the human study. Just another and another and another one.

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Let’s see if there’s any human studies. All right, I read that one already. Rat
model again, mice, mice. Might as well give you a little box to show you human
studies and then we have it here. Let’s search human. It’s one. All right, now
it’s about the human studies but still interesting so that’s one.

(01:23:42)
Now basically, look, here’s what I’m going to wrap up here, let me just show
you a few more things. So that was all with Angelica and so - I just realized,
I’m sorry, I would have this on the other page for a minute, but basically we’re
copy/pasting all of this stuff. I went to actual work mode of what I would be
actually doing, so I apologize, but all right. But again, Angelica, wild celery.
We know Angelica, we know we have vitamin D. Okay, what about Rhodiola?
Rhodiola neural stem cells NCBI. I’m going to close a bunch of this other
shit for now. “Enhancement of neural stem cells after induction of depression
in male albino rats.” They received Rhodiola extract. Rhodiola increased
undamaged neurons, blah, blah, blah. Looks like it helps in the improvement
and in the stimulation of NSC proliferation.

(01:25:19)
Again, these are animal studies, but there are great human studies on Rhodiola
memory as you’re going to see. This is another one, “May enhance the level
5-HT and promote the proliferation and differentiation of neural stem cells in
hippocampus of depressed rats.” Cool. Protective effect of Rhodiola extract
on hippocampal neurogenesis. This is one of the main ingredients in Rhodiola.
Reduction of ROS level which is part of free radicals and inflammation stuff,
but NSC death increasing perforation and differentiation. Hippocampal again,
boom. Okay, sweet and last one here for Rhodiola. More depressed rats, but
results demonstrated that could help with this could induce neural stem cell
proliferation. Great. So again, we’re not going to say this is the magical cure,
but it can help support these things.

(01:26:52)
Now what about Rhodiola memory humans NCBI? Let’s see, preclinical
evidence. These are animal studies. Do we have any human studies? Animals
not humans, so no. Not good for me. This one helps a little bit. This is about
physical performance, but basically this is going to, I think reference some
of the studies. A double-blind random control trial, 36 male and female non-
smokers, 21 and 24, exercise, late exhaustion, higher blood lactate, muscle,
mental performance. Cool. Double-blind random control trial, 2008, 60 males

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and females between 20 to 55, fatigue, took Rhodiola 144 milligrams so

actually took four of those a day. Significant improvement in fatigue, scores
and all that stuff. I’ll pop this in here. Human trials.

(01:28:41)
I can reference these later but basically, there’s another one. 56 males and
females, significant improvement in total fatigue, mental fatigue was lower.
Statistically significant, beneficial physiological effect, non-significant
improvement but significant to prevent general wellbeing and mental fatigue.
So very interesting, has a bunch of good stuff there. This is the last one. Does
it say human study? No, but that one reference those in there from that study
we just looked at. We could define the citations for those studies in here and
there you go, here’s some double-blind studies and then we can put them
here. So that was just Rhodiola. Now again, I’m going to stop here basically
but what about “on Rhodiola memory.”

(01:29:36)
Let’s do one more Panax ginseng neural stem cells NCBI and basically, what
you’re going to find is oh, look at that it helps with neural stem cells, too. So
again, we would do that for the rest of these ingredients where you come
across some other ones. Now you have your formulation. Honestly, you have
to find out the right dosages that are safe and nontoxic and that work together
and all that stuff or if it was an info product, this would just be ingredients that
are sharing as part of your info product.

(01:30:23)
But going back to your mechanism, basically adult neural stem cells are
important for your brain and your memory and all that stuff and ongoing
creation of them helps with these things as we age but as we get older, the
creation of them decreases and when those slow down, your memory suffers
as well. So we want to support the ongoing creation of neural stem cells in
the brain “and protect the ones that we already have. Doing so can support
memory and mood and cognition, et cetera” and then we’d go like, “Here are
the ingredients” so we have again, vitamin D3, we have Rhodiola.

(01:31:18)
We’d have these other ones we could mess with like Panax we have Angelica
wild celery, so we would just do the same way we did for these, for these
ones. We’d have our formulation, we’d have our mechanism and we’d be all

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good with that. We’ve already done our research, so we know the pain points
of the market. Obviously, you’d ideally have your spokesperson, your story,
you’d have the brief or you’d get it but yeah, hopefully that helps. I think this
is fucking awesome and excited and I pray to God that Zuma or Loom saves
this correctly.

Stefan Georgi 21
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