Advanced Physiology and Pathophysiology

Essentials for Clinical Practice

Nancy C. Tkacs PhD, RN

Linda L. Herrmann PhD, RN, ACHPN, AGACNP-BC, GNP-BC, FAANP
Randall L. Johnson PhD, RN

Specifically designed for future healthcare

providers who will diagnose, manage, and
prescribe.

This advanced physiology and pathophysiology

text is designed to address the specific learning
needs of future nurse practitioners, physician
assistants, and other advanced healthcare
providers caring for patients across the life span.

Focusing on practical applications of physiology,

it facilitates in-depth understanding of important
pathophysiological concepts as they relate
to major disorders commonly seen in clinical
practice and includes comprehensive pediatric
and geriatric considerations. This knowledge is
crucial to providing the foundation required to be
an informed and confident clinical decision maker.

www.springerpub.com/3P
March 2020 | 9780826162496
840 pp | Paperback
 MEET THE EDITORS

Nancy C. Tkacs Linda L. Herrmann Randall L. Johnson

PhD, RN PhD, RN, ACHPN, AGACNP-BC, GNP-BC, PhD, RN
Dr. Tkacs has been teaching FAANP Dr. Johnson is an associate
pathophysiology for advanced Dr. Hermann is a clinical assistant professor of nursing at the
nursing practice for over 25 years, professor at New York University University of Tennessee Health
drawing on her knowledge of Rory Meyers College of Nursing and Science Center. He is also a
organ systems physiology and nurse practitioner with expertise pediatric critical care nurse
pathophysiology to provide a in gerontology, neuroscience, practitioner and has taught
strong basic science foundation for and palliative care. She teaches pathophysiology in both
advanced nursing practice. She has advanced pathophysiology and undergraduate and graduate
taught the course most recently at aging at the graduate level. degree programs.
the University of Pennsylvania and
University of Southern California.

“We dedicate the book to our students who have asked such great questions through the years.
You inspire us to do all we can to provide detailed, yet understandable explanations of the
pathophysiological phenomena underlying advanced clinical practice.”

Empowers Prepares
Focuses on core
students to think students
concepts to provide a
critically and prepares with concepts and
flexible foundation to
them for pharmacology vocabulary to learn
adapt for instructor/ Bridges science
and future clinical how to learn about
program needs Addresses WHY to clinical practice, &
courses new diseases
patients present with includes robust pediatric
symptoms and gerontological
considerations
 ENHANCED LEARNING FEATURES

Case Studies throughout provide real-life Pediatric and Gerontological

scenarios to help connect pathophysiological Considerations provide essential
concepts to clinical presentations life span coverage.

Richly illustrated
to demonstrate
principles of health
and disease

Connect with your regional sales rep at textbook@springerpub.com springerpub.com/3p

BONUS FEATURES
This text is accompanied by an Instructor’s Manual
and comprehensive bonus resources, including: Answers
to Case
PowerPoint
Study and
Lectures
Thought Assignment
Connecting Questions Suggestions
the Dots Test Bank
and Discussion
Teaching Tips
Questions
Chapter Learning
Image Bank
Summaries Objectives

Thought Questions require

students to reflect on the section
they have just read, recall facts,
and use higher-level thinking to
apply what they have learned.

Bridge to Clinical
Practice sections link
pathophysiological
concepts to clinical
practices of assessment
and management.
Visit
springerpub.com/MORE3P
for the full list of disorders
and our How to Use This
Book section
 TABLE OF CONTENTS

1. THE FOUNDATIONAL CONCEPTS OF CLINICAL 9. CIRCULATION

PRACTICE Fruzsina K. Johnson, Robert A. Johnson, and Spencer A. Rhodes
Nancy C. Tkacs, Linda L. Herrmann, Randall L. Johnson, and 10. HEART
Loretta A. Sernekos Fruzsina K. Johnson, Robert A. Johnson, and Spencer A. Rhodes
2. CHEMICAL AND BIOCHEMICAL FOUNDATIONS 11. LUNGS
Gioia Petrighi Polidori Nancy C. Tkacs, Charrell S. Porter, and Nicholas A. Barker
3. MOLECULAR BIOLOGY, GENETICS, AND GENETIC 12. KIDNEYS
DISEASES Connie B. Scanga and Nancy C. Tkacs
Sheila A. Alexander and Michael J. Groves
13. GASTROINTESTINAL TRACT
4. CELL PHYSIOLOGY AND PATHOPHYSIOLOGY Wilson Crone
Nancy C. Tkacs, Fruzsina K. Johnson, Robert A. Johnson,and
Spencer A. Rhodes 14. LIVER
Jennifer Andres, Adam Diamond, Kimberly A. Miller, Nicole E.
5. INFECTIOUS DISEASE Omecene, and Dusty Lisi
Ross S. Johnson, Jennifer Bailey, and Roseann Velez
15. NERVOUS SYSTEM
6. THE IMMUNE SYSTEM AND LEUKOCYTE FUNCTION Nancy C. Tkacs, Peggy A. Compton, and Kara Pavone
Jo Kirman and Raffaella Ghittoni
16. MUSCULOSKELETAL SYSTEM
7. NEOPLASIA Connie B. Scanga and Joseph J. Curci
Kolbrun (Kolla) Kristjansdottir, Thomas M. Bodenstine, and
Sandhya Noronha 17. ENDOCRINE SYSTEM
Christine Yedinak, Carolina R. Hurtado, Angela M. Leung,
8. BLOOD AND CLOTTING Meredith Annon, Hanne S. Harbison, Diane L. Spatz, Gioia
Allison Rusgo, Megan E. Schneider, Daniela Livingston, and Petrighi Polidori, and Victoria Fischer
Patrick C. Auth

Nearly 30
500+ Images
Case Studies
Key Points at
200+ Thought
the End of Each
Questions
Chapter

70+ Tables
 POWER THROUGH THE 3PS
visit www.springerpub.com/3P

Evidence-Based Physical Advanced Health Assessment and

Examination Advanced Pharmacology for
Differential Diagnosis
Best Practices for Health and Prescribers
Well-Being Assessment Essentials for Clinical Practice
EDITORS: EDITORS: EDITORS:
Kate Sustersic Gawlik DNP, APRN-CNP, FAANP Karen Myrick DNP, APRN, FNP-BC, ANP-BC Brent Luu PharmD, BCPS, BCACP
Bernadette Mazurek Melnyk PhD, RN, APRN- Laima Karosas PhD, APRN, FNP-BC, ANP-BC Gerald Kayingo PhD, PA-C
CNP, FAANP, FNAP, FAAN Suzanne Smeltzer EdD, RN, ANEF, FAAN Virginia McCoy Hass DNP, MSN,RN, FNP-C,
Alice M. Teall DNP, APRN-CNP, FAANP (Expert Consultant) PA-C
The first book to teach physical The first textbook to specifically Delivers the critical information
assessment techniques based on target the scope of practice for clinicians need to be thoroughly
evidence and clinical relevance. advanced practice providers. informed prescribers.
Grounded in an empirical approach With a focus on promoting sound This unique resource—an
to history-taking and physical clinical decision-making and a evidence-based pharmacology
assessment techniques, this text for streamlined and highly accessible text and reference for advanced
advanced practice clinicians and approach, this text for advanced practice students and clinicians—
students focuses on patient well- practice nurses and physician guides users in analyzing the
being and health promotion. It is assistants delivers up-to-date pharmacological foundations
based on analysis of current primary care health assessment of drug therapy and fosters the
evidence and up-to-date techniques for individuals development of sound clinical
guidelines and recommendations throughout the life span. Each judgment in determining the
and underscores the evidence, chapter offers a concise overview appropriate medication for every
acceptability, and clinical relevance of anatomy and physiology and patient across the life span.
behind physical assessment an in-depth review of normal and
techniques. abnormal findings.