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Thyroid Tests Condensed

The document outlines various thyroid function tests, their purposes, detected diseases, and reference values. Key tests include the TRH Stimulation Test, TSH Test, and Radioactive Iodine Uptake, which help differentiate between hyperthyroidism and hypothyroidism. Additional tests like Thyroglobulin Assay and Reverse T3 are used for monitoring thyroid cancer and assessing conflicting lab results.

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4 views3 pages

Thyroid Tests Condensed

The document outlines various thyroid function tests, their purposes, detected diseases, and reference values. Key tests include the TRH Stimulation Test, TSH Test, and Radioactive Iodine Uptake, which help differentiate between hyperthyroidism and hypothyroidism. Additional tests like Thyroglobulin Assay and Reverse T3 are used for monitoring thyroid cancer and assessing conflicting lab results.

Uploaded by

lmvaleroso0672val
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PDF, TXT or read online on Scribd
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TEST COMMENTS DETECTED DISEASE VALUES PARAMETERS

TRH Stimulation Test ●​ Relationship between TRH and ●​ Euthyroid Dose: 500 ug by IV ●​ Inc = Primary
TSH secretion ●​ Grave’s disease Hypothyroidism
●​ Differentiates euthyroid vs. ●​ Dec = Hyperthyroidism
hyperthyroid
●​ Detection of thyroid hormones
resistance syndromes

TSH Test ●​ Best screening test INCREASED RF: 0.5 to 5 μU/mL NA


●​ Most clinically sensitive for ●​ Primary hypothyroidism
primary thyroid disorders ●​ Hashimoto’s
●​ Differentiates primary from ●​ Thyrotoxicosis
secondary hypothyroidism ●​ TSH Ab
●​ Monitoring thyroid ●​ Thyroid Hormone
replacement therapy Resistance

DECREASED
●​ Primary hyperthyroidism
●​ Secondary and Tertiary
hypothyroidism
●​ Treated Grave’s disease
●​ Euthyroid sick disease
●​ Over replacement
hormone

Second-Generation TSH Screen for hyperthyroidism Hyperthyroidism Detection limits of 0.1 mu/L
Immunometric Assays

Third-generation TSH ●​ Monitor and adjust thyroid ●​ Euthyroidism Detection limits of 0.01 mU/L
Chemiluminometric hormone replacement ●​ Hyperthyroidism
assays therapy
●​ Screen both hyperthyroidism
and hypothyroidism

LLMV
Radioactive Iodine ●​ Measure the ability of the Hyperthyroidism NA ●​ High uptake = Active
Uptake (RAIU) thyroid gland to trap iodine hormone production
●​ Establishing the cause of ●​ High uptake + TSH
hyperthyroidism deficiency =
Autonomous thyroid
activity

Thyroglobulin Assay ●​ Postoperative marker of ●​ Thyroid cancer ●​ Adults: 3 to 42 ng/mL or NA


thyroid cancer ug/mL
●​ Metastatic or recurrence of INCREASED ●​ Infants: 38 to 48 ng/mL
thyroid cancer ●​ Untreated and metastatic or ug/mL
●​ Methods: Double antibody RIA, differentiated thyroid
ELISA, IRMA, ICMA cancer
●​ Hyperthyroidism

DECREASED
●​ Infants with goiterous
hypothyroidism
●​ Thyrotoxicosis factitia

Reverse T3 ●​ Assess borderline or conflicting Euthyroid sick syndrome RF: 38 to 44 ng/dL


laboratory results
●​ Formed by removal of one
iodine from the inner ring of T4
and end product of T4
metabolism

Free Thyroxine Index ●​ Also known as FT4I or T7 Euthyroid RF: 1.5 to 4.5 Elevated in hyperthyroidism and
●​ Indirectly assess the level of decreased in hypothyroidism
free T4
●​ Based on equilibrium
relationship of bound T4 and
FT4
●​ Correcting euthyroid individuals
●​ Ref method: Equilibrium
dialysis

LLMV
Total T3 (TT3), FT3 and ●​ Used to differentiate drug ●​ Drug induced TSH NA NA
FT4 induced TSH elevation vs. elevation
hypothyroidism ●​ Hypothyroidism
●​ The value of TT3 or FT3 is in
confirming hyperthyroidism
●​ Direct/reference method:
Equilibrium dialysis (FT4)

T3 Uptake ●​ Number of available binding INCREASED RF: 25 to 35% ●​ Elevated TBG =


sites of the thyroxine-binding ●​ Hyperthyroidism Decrease T3 uptake
proteins ●​ Euthyroid patient ●​ Estrogen increases TBG
●​ Most notably TBG ●​ Chronic liver disease ●​ Androgens depresses
●​ Does not measure the thyroid TBG
hormone levels DECREASED
●​ A known amount of ●​ Hypothyroidism
radiolabeled T3 is added to the ●​ Oral contraceptives
test serum ●​ Pregnancy
●​ Acute hepatitis

Thyroxine Binding ●​ Confirm results of FT3 or FT4 ●​ Hypothyroidism NA NA


Globulin (TBG) test ●​ Abnormalities in the relationship ●​ Euthyroidism
of the total thyroxine (TT4) and
THBR test DECREASED
●​ Hyperthyroidism vs ●​ Anabolic steroids
euthyroidism ●​ Nephrosis
●​ Total Serum T3 and T4 are
dependent on the amount of INCREASED
TBG ●​ Hypothyroidism
●​ Pregnancy
●​ Estrogen

●​ Fine Needle Aspiration - Most accurate tool in the evaluation of thyroid nodules
●​ Recombinant Human TSH - test patients with thyroid cancers residual or recurrent disease
●​ Tanned Erythrocyte Hemagglutination Method - antithyroglobulin antibodies
●​ Serum Calcitonin Test -Tumor marker; Residual thyroid metastasis; Medullary thyroid carcinoma

LLMV

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