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4 - 21RA42 Module 3 Blood Analyzer

The document outlines the syllabus for the 18RA42 Measurement Systems course, focusing on micro and smart devices, sensors, actuators, and systems. It details various types of sensors and actuators, including blood analyzers and their operational principles such as impedance changes and light scattering techniques. The pedagogical approach includes MATLAB demonstrations and numerical problem-solving to enhance understanding of the material.

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Arjun Arjun
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17 views5 pages

4 - 21RA42 Module 3 Blood Analyzer

The document outlines the syllabus for the 18RA42 Measurement Systems course, focusing on micro and smart devices, sensors, actuators, and systems. It details various types of sensors and actuators, including blood analyzers and their operational principles such as impedance changes and light scattering techniques. The pedagogical approach includes MATLAB demonstrations and numerical problem-solving to enhance understanding of the material.

Uploaded by

Arjun Arjun
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
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Syllabus 18RA42 Measurement Systems

Dr.M.Karthikeyan
Professor and Head
Dept. of Robotics and Automation, RRCE
Dr. M K, Professor and Head, Dept. of Robotics and Automation, RRCE 1
Module 3 18RA42 Measurement Systems
Micro And Smart Devices And Systems: Principles And
Materials: Definitions and salient features of sensors, actuators,
and systems.
Sensors: silicon capacitive accelerometer, piezo-resistive
pressure sensor, blood analyzer, conductometric gas sensor,
fiber-optic gyroscope, and surface-acoustic-wave based wireless
strain sensor.
Actuators: silicon micro-mirror arrays, piezo-electric based inkjet
print-head, electrostatic comb-drive and micromotor, magnetic
micro relay, shape- memory-alloy based actuator, electro-
thermal actuator.
Systems: micro gas turbine, portable clinical analyzer, active
noise control in a helicopter cabin.
Pedagogy Demonstrating image classification using MATLAB
Power point presentation along with solving numerical using
chalk and board
Dr. M K, Professor and Head, Dept. of Robotics and Automation, RRCE 2
Module 3 18RA42 Measurement Systems
Blood analyzer
• Whole blood is passed between two electrodes through an aperture so narrow that
only one cell can pass through at a time.

• The impedance changes as a cell passes through.

• The change in impedance is proportional to cell volume, resulting in a cell count and
measure of volume.

• Principles of flow cytometry and light scattering blood cell testing: Individual cells
are refracted, diffracted, and scattered as the sheath fluid with fluid power
aggregation passes through the laser irradiated detection area, and the scattered
light is received by the light detector and produces a pulse.

Blood analyzer
•Electrical impedance
•Light scatter
•Fluorescence
•Light absorption
•Electrical conductivity.

Dr. M K, Professor and Head, Dept. of Robotics and Automation, RRCE 3


Module 3 18RA42 Measurement Systems
Blood analyzer

Light scatter technology:

(A) schematic illustrating the light-scatter method of cell counting;

(B) schematic of sheath flow, used to focus the cells hydrodynamically

Dr. M K, Professor and Head, Dept. of Robotics and Automation, RRCE 4


Module 3 18RA42 Measurement Systems
Blood analyzer
• A tiny channel in a machine called a light-scatter cell counter guides blood cells in a
single line.
• A laser or light beam shines on them, and when a cell is hit by the light, it scatters in
different directions depending on what kind of cell it is.

• This is because of something called the cell refractive index, which is based on the
cell’s shape and size.

• The machine measures how much light the cell absorbs and scatters to determine the
type of cell.

• The laser light employed in light-scatter cell counts is unique in that it has just one
wavelength and so travels in a straight line.

• As a result, it is more exact than other forms of light, such as tungsten halogen light
beams.
• The laser beam is very effective in diagnostic hematology because it may produce
highly accurate scatter patterns that can be utilized to distinguish various types of
blood cells.

Dr. M K, Professor and Head, Dept. of Robotics and Automation, RRCE 5

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