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HASTS410 CourseOutline

The HASTS410 course at the University of Zimbabwe focuses on Bioassays and Survival Models, aimed at teaching students methodologies for analyzing binary and survival data. Key objectives include binary data modeling, survival function estimation, and clinical trial design. Assessment consists of tests, assignments, and a final examination, with coursework contributing 25% and the final exam 75% to the overall grade.

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18 views3 pages

HASTS410 CourseOutline

The HASTS410 course at the University of Zimbabwe focuses on Bioassays and Survival Models, aimed at teaching students methodologies for analyzing binary and survival data. Key objectives include binary data modeling, survival function estimation, and clinical trial design. Assessment consists of tests, assignments, and a final examination, with coursework contributing 25% and the final exam 75% to the overall grade.

Uploaded by

blessingmugoni3
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PDF, TXT or read online on Scribd
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HASTS410_Course Outline

University of Zimbabwe
Faculty of Science
Department of Statistics

1. Course Title: Bioassays and Survival Models

2. Course Code: HASTS410

3. BSc Honours in Applied Statistics/Actuarial Science/Data Science and Systems Level


4

4. Semester: 2

5. Course Lecturer: Mr. E Manjoro/ Mr R Moyo

6. Preamble

The course outlines methodologies used in binary and survival data analysis.

7. Aims

7.1 Introduce students to analysis of binary and survival data.

8. Objectives
At the end of this course, students should be able to:
 Binary data modelling
 Compute estimators of survivor/hazard functions
 Understand and use distributions used in survival data analysis
 Model survival data
 Validate fitted survival models
 Fit models with time dependent variables
 Derive sample sizes for clinical trials

9. Content

9.1 Modelling Binary Data


Logistic and probit models for analysis of proportions and percentages: Use of bioassays
including estimation of ED90 and ED50 values, variable selection methods for more
complex logistic models eg. Medical data with binary response.

9.2 Introduction to Survival Analysis


Censored data, Survivor function, hazard function, Kaplan Meier type of estimators,
comparison of two groups of survival data , using Log –rank and Wilcoxon tests.

9.3 Distributions for Survival Times


Distributions of Survival Times: Log Normal, Exponential and Weibull Distributions

9.4 Modelling Survival Data


HASTS410_Course Outline

Proportional hazards, Accelerated Life and Proportional Odds Models. Cox Regression
Model. Fitting these parametric models

9.5 Model Checking/Validation


Cox-Snell, Modifeid Cox-Snell, Martingale, Deviance and Score residuals

9.6 Time Dependent Variables


Fitting the Cox model with time dependent variables

9.7 Design of Clinical Trials


Calculating the required number of patients in clinical trials

10. Methodologies

Teaching will be in the form of lectures and tutorials.

11. Assessment

11.1 Students will write three tests of one hour duration each and one assignment. The
marks from the three tests and one assignment will be averaged to have student’s
coursework.
11.2 Students will write a two-hour final examination consisting of a compulsory section A
worth 40 marks and a choice of two out of three questions in section B worth 60 marks.
11.3 Coursework will constitute 25% of the student final assessment and the final
examination will constitute 75% of the final assessment.

12. References

12.1 Collett D, Binary Data Analysis, Chapman and Hall.

12.2 Collett D, 1994, Modelling Survival Data in Medical Research, Chapman and
Hall.
12.3 Cantor AB. SAS Su on,1994. Survival Analysis Techniques for Medical Research.
Springer Sciences and SAS Institute, Cary, USA, 2003. ISBN: 978-1-59047-135-7
12.4 Dobson, A.J. An Introduction to Generalized Linear Models. 2nd edition. Chapman
and Hall.
12.5 Hosmer DW Jr, Lemeshow S. Applied Survival Analysis: Regression Modeling of
Time to EventData. John Wiley & Sons, Inc, New York, 1999.
12.6 Kalbfleisch, J.D. and Prentice, R.L. The Statistical Analysis of Failure Time Data.
John Wiley
12.7 Machin D, Cheung YB, Parmar MKB. Survival Analysis: A Practical Approach. 2nd
edition. John Wiley and Sons, Ltd. 2006. ISBN: 0-470-87040-0

12.8 McCullagh, P. and Nelder, J.A. Generalized Linear Models. 2nd edition. Chapman
and Hall.
12.9 S. R. Searle , Linear Models
HASTS410_Course Outline

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