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2024 - Granactive Retinod Pro+

Granactive Retinoid Pro+ is a concentrated, anhydrous powder containing Hydroxypinacolone Retinoate, designed to promote anti-aging and anti-acne benefits with reduced irritation. It features advanced encapsulation technology for enhanced stability and versatility in various cosmetic formulations. The product is compliant with sustainability standards and provides effective delivery of Vitamin A derivatives while minimizing oxidative stress.

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Sofia Vallin
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19 views2 pages

2024 - Granactive Retinod Pro+

Granactive Retinoid Pro+ is a concentrated, anhydrous powder containing Hydroxypinacolone Retinoate, designed to promote anti-aging and anti-acne benefits with reduced irritation. It features advanced encapsulation technology for enhanced stability and versatility in various cosmetic formulations. The product is compliant with sustainability standards and provides effective delivery of Vitamin A derivatives while minimizing oxidative stress.

Uploaded by

Sofia Vallin
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
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GRANACTIVE

RETINOID PRO+ TM

TARGETED RETINOID
INCI
Cyclodextrin (and) Hydroxypinacolone

RESPONSE COMPLEX
Retinoate (and) Glucosylrutin

BENEFITS

Recharge and invigorate the skin’s biological A concentrated and easily formulated anhydrous powder containing
processes to promote anti-aging activity Hydroxypinacolone Retinoate encapsulated and stabilized in Gamma-
Cyclodextrin with Alpha-Glucosylrutin
Superior formulation versatility such as One of the most bio-available, non-prescription forms of Vitamin-A sold in
powders and water-based gels cosmetics

Reduce oxidative stress due to daily wear Intended for use in anti-aging and anti-acne beauty treatments; provides
low irritating, effective active delivery in daily maintenance applications
and photo-aging
Vitamin A, also known as All-Trans Retinoic Acid (ATRA), is the only FDA-
Enhanced stability compared to other approved compound for treating photoaging of the skin. Hydroxypinacolone
Vitamin A Derivatives Retinoate is a cosmetic ester of ATRA and has the same oxidation form

Reduced Irritation Profile: features an

FORMULATION
advanced encapsulation technology

SUSTAINABILITY
Can be added into the water phase of all types of emulsions, pressed
Naturality Profile powders, and other formula types
ISO 16128: Nat. Origin Index = 0.98
It’s recommended to formulate this product in a manner that avoids
Non-GMO infusing air/oxygen into the final cosmetic product. Like all retinoids, the
REACH compliant highly specific set of conjugated double bonds are susceptible to oxidation

Palm Oil Free Applications include (but are not limited to) skincare, suncare, color
cosmetic and body care formulations

For acne claims product must be co-formulated with


Technical Support? an approved anti-acne active as subject to regional laws
formula@grantinc.com
Typical use level: 2-6%
www.grantinc.com
GRANACTIVE RETINOID PRO+ COMPOSITION

Gamma-Cyclodextrin HPR Encapsulated in Cyclodextrin Alpha-Glucosylrutin


The most water-dispersible of the As the star of the show, HPR AGR is a potent water-soluble
three parent cyclodextrin molecules, performance is maximized for a antioxidant that quenches
containing eight glucose units targeted retinoid response with skin-damaging free radicals
enhanced stability

IMPROVED RETINOID RESPONSE ACTIVITY

Granactive RetinoidTM Pro+

Boosted retinoid signaling activity


Led to an efficient transcriptional response
(>2x) at lower use concentrations

Gamma-Cyclodextrin provided HPR delivery with


Granactive RetinoidTM Pro+

Alpha-Glucosylrutin supports prolonged and increased


skin care benefits by optimizing stability and potency

GRANACTIVE RETINOID PRO+ STABILITY & ACTIVITY


PROTOCOL:
Hydroxypinacolone Retinoate,
Retinol, Retinaldehyde, and Retinyl
Palmitate were encapsulated in
Cyclodextrin using the same protocol
as Granactive RetinoidTM Pro+

Samples were kept at 50°C for 4


weeks and a R.A.R.E. assay was
conducted to determine their stability

Granactive CD + Retinyl
CD + Retinol CD + Retinaldehyde Palmitate
RetinoidTM Pro+
Remained stable It overloaded and It overloaded and was Retained steady
and kept the highest was initially cytotoxic initially cytotoxic to cells, activity but is less
and most consistent to cells, then fell into then fell into optimal efficacious than
R.A.R.E. activity
optimal concentration concentration with higher Granactive Retinoid
with higher activity activity because of poor Pro+ at the same
because of poor stability concentrations
stability

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