Chemotherapy

Classification of Drugs

Anti-Biotics
Cell Wall Inhibitors
Penicillins ( ADRs : Hypersensitivity ,Dirrhea , Nephritis, Neuro-toxicity, Hematological Toxicity )

Natural Penicillins Anti-Staphylococcal Extended Spectrum Anti-Pseudomonal (G –ive)

Penicillin V ( Oral ) Cloxacillin Ampicillin Ticarcillin
Penicillin G ( IV) Dicloxacillin Amoxicillin Piparacillin
Procain Penicillin G Oxacillin Flucloxacillin Carbenicillin
Benzathine Penicillin G Methicillin ( nephritis)
G +ive, G –ive Cocci Nafcillin
Cephalosporins

1st Generation 2nd Generation 3rd Generation 4th Generation ( IV)

Cephradine Cefaclor Oral Cefixime Cefepime
Cefadroxil Oral Cefuroxime axetil Cefdinir Oral Cefpirome
Cephalexin Cefprozil Ceftriaxone
Cephapirin Cefuroxime Ceftazidine Parentral
Cephalothin Cefotetan Parentral Cefotaxime
Cefoxitin Cefoperazone
Cefazolin ( IV Only ) Cefmetazole

Monobactums Aerobic G–ive rods Carbapenems : IV Others :

Imipenem Vancomycin
Aztreonam (IV) Doripenem Fosfomycin
Meropenem Daptomycin
Ertapenem Bacitricin
Protein Synthesis Inhibitors
Aminoglycosides : (Only Parentral 30-60 mint infusion, No Oral available) No metabolism in host,
Common ADRs : Ototoxicity ( Vertigo,Tinnitus,Hearing loss, Dysequilibriuam ) Nephrotoxicity
Derived from Streptomyces Derived from Micromonospora
Streptomycin Amikacin
Neomycin Gentamicin
Tobramycin Sisomicin
Kanamycin Netilmicin
Tetracyclins : ( Tooth enemal dysplasia,Decr. Bone growth in Children, Pseudotumor cerebri )
DOC : Rickettsia
Short Acting (6-8 hours) Intermediate Acting (12h) Long Acting (12-18 hrs)
Tetracyclins Demeclocycline Doxycycline
Chlortetracyclin Methacycline Minocycline
Oxytetracyclin
Macrolides and Ketolides Others:
Erythromycin ( Proto-type Drug) Chloramphenicol
Clarithromycin Clindamycin
Azithromycin Oxazolidinones ( Linezolid & Tedizolid )
 Telithromycin ( 1st Ketolide Drug)
DNA Synthesis Inhibitors
Fluoroquinolones : Nausea , vomiting,Diarrhea, Headache , insomnia,Skin rashes
st
1 Generation 2nd Generation 3rd Generation 4th Generation
Nalidixic Acid Ciprofloxacin Levofloxacin Moxifloxacin
Cinoxacin Ofloxacin Gatifloxacin ( Hyperglycemia) Trovafloxacin
Lomefloxacin Sparfloxacin
Enoxacin
Norfloxacin
Pefloxacin
Folate Reductase Inhibitors :
 Trimethoprim
 Pyrimethamine
 Sulphonamides ( Sulfisoxazole, Sulfadiazine,Sulfadoxine)

Anti Mycobacterial Drugs

1st Line Drugs 2nd Line Drugs 3rd Line Drugs Acc. To WHO
Isoniazid ( Vit.B6 deficincy Amikacin Linezolid
Ethambutol ( red-green blindness Kanamycin Clarithromycin
Pyrazinamide Cepreomycin Bedaquiline
Rifampin (orange color in urine) Ceprofloxacin Rifabutin
Streptomycin Levofloxacin
Moxifloxacin
Ethionamide (only oral)
Drugs used to treat Leprosy :
 Rifampin ( 600mg, Daily/ twice weekly)
 Dapsone ( inhibit folate synthesis , retained in skin , muscle ,liver , kidney )
 Clofazimine ( Discoloration of skin )

Anti-Fungal Drugs
Polyene Antibiotics Azole Derivatives Allyl Amines Echinocandins Others
Amphotericin B Voriconazole Fluoconazole Terbinafine Caspofungin Griseofalvin
Nystatin ( Topically ) Clotrimazole Ketoconazole Butenafine Anidula fungin Ciclopirax
Natamycin Teraconazole Miconazole Naftifine Mica fungin Flucytosine
Efinaconazole Econazole (All IV Only) Tolnaflate
Itraconazole
Posaconazole
Anti-Parasite Drugs
Anti-Protozoal Drugs :
Anti- Malarial Drugs :
st
1 Line Drugs 2nd Line Drugs
Quinine / Quinidine Artemesinin Derivatives : Halofautrine
Primaquine Lumefentrine
( Etaquine,Tafenoquine Artemisin
Chloroquine Artesunate Inhibitors of folate synthesis:
Amodiaquine Artemether  Pyrimethamine ( 1-week)
Piperaquine Dihydroartemesinin  Proguanil (Daily)
Mefloquine  Bignamide
 Anti-Helminthic Drugs :
For Treatment of Round Worm, Hook Worm, Pin Worm :
Albendazole , Mebendazole , Pyrantel pamoate , Piperazine , Levamisole
For Treatment of Whip Worm, Trichinella Spirelis :
Albendazole , Mebendazole
For Treatment of Tape Worm:
Albendazole , Niclosamide (2g, 2nd line) , Praziquantal
For Treatment of Hydatid Disease :
Albendzole , Mebendazole
For Treatment of Thread Worm :
Albendazole , Ivermectin
For Treatment of Filarasis :
Albandazole , Diethyl Carbamazine , Ivermectin ( DOC : Strongyloidiasis, Onchocerciasis )

Amoebicidal Drugs
1. Luminal Amoebicidal
2. Extra-Intestinal Amoebicides
3. Mixed Action
Tissue Amoebicides Luminal Amoebicides
Nitro-imidazole ( Metronidazole, Tinidazole) Amides (Diloxanide furoate)
Alkaloids (Emetine, Dihydroemetine ) 8-Hydroxyquinolines (Iodoquinol )
4-Aminoquinoline ( Chloroquine) Anti-Biotics Paromomycin sulphate , tetracyclines

Leishmaniasis Chemotherapy
1. Pentavalent Anti-Monials ( Sodium Stibogluconate,Meglumine anti-monials )
2. Pentamidine ( IV ) Used for visceral
3. Amphotericin B Used for visceral
4. Miltefosine ( 1st effective oral drug for visceral leish… 28days 2.5mg/kg/d)
5. Paromomycin ( IV for Visceral inf. , Oral for Luminal )
Anti-Viral Drugs
Acquired Immuno-Deficiency Syndrome ( AIDs)
Protease Inhibitors Reverse Transcriptase Inhibitors Integrase Fusion Peptide
Inhibitors Inhibitors
Amprenavir Nelfinavir NRTIs NTRTIs NNRTIs 1st Albuvirtide
( 1st Gene..) Generation
Atazanavir Saquinavir Abacavir Tenofovir Delavirdine Elvitegravir Enfuvirtide
(Subcutaneous)
Darunavir Tipranavir Didanosine Nevirapine Ealtgeravir Attachment
Inhibitors
Fosamprenavir Emtricitabine Efavirenz 2nd Fostemsavir
(once daily) Generation
Indinavir Lamivadine 2nd Gene. Bictegravir Maraviroc
Iopinavir Stavudine Etravirine Dolutegravir
Ritonavir Zidovudine Rilpivirine
Hepatitis C Virus :
NS ¾ Protease Inhibitors NS5A Phosphoprotein Inhibitors NS5B Polymerase Inhibitors
Boceprevir Daclactasvir (Very imp drug class)
Simeprevir ( once daily) Ledipasvir Sofosbuvir
 Telaprevir Ombitasvir Dasabuvir
(All drugs take with food inc. abs) Elbasvir
Velpatasvir
Pibrentasvir
Hepatitis B Virus :
DNA Polymerase Inhibitors Injectable Interferon Drugs
Adefovir Dipivoxil Entecavir Interferon alpha 2-b
Besifovir Telbivudine Pegylated interferon alpha 2a
Clevudine Tenofir
Human Influenza Virus :

RNA Polymerase Inhibitors Neuraminidase Inhibitors Matrix protein Inhibitors

Baloxavir Laninamivir Amantadine
Favipravir Oseltamivir ( oral ) Rimantadine
Permavir
Zanamivir (Directly inhalation)
Respiratory Synctial Inhibtors :

RNA Polymerase Inhibitors Fusion Glycoprotein Inhibitors

Ribavirin Pavlizumab
Herpes Simplex Virus :

DNA Polymerase Inhibitors Envelope Protein Inhibitors

Aciclovir Idoxuridine Docosanol
Valacyclovir Penciclovir
Famciclovir Trifluridine
Foscarnet ( IV Only) Valaciclovir
Human Cytomegalo Virus :

DNA Polymerase Inhibitors Terminase Inhibitors

Ciclofovir Ganciclovir (IV ,Oral) Letermovir
Fomivirsen Valganciclovir ( Oral)
Foscarnet ( IV)
Vericella Boster Virus :
DNA Polymerase Inhibitors : Acyclovir, Brivudine , Famcyclovir, Vidarabine
Human Small Pox Virus :
Envelope Wrapping Protein Inhibitor Tecovirimat

Classification Of Anti-Cancerous Drugs

Alkylating Agents :
Nitroso Urease Nitrogen Mustard IV Platinum Compound Others
Carmustine Cyclophosphamide Cisplatin Busulfanare
Lomustine ( oral) Ifosfamide Carboplastin Thiotepa
Nimustine Chlorambucil Oxaliplastin Procarbazine
Mechlorethamine Temozolamide
Anti-Metabolites :

Folate Antagonists Purine Inhibitors Pyrimidine Inhibitors

Methotrexate Clofarabine Azacitidine
Trimethrexed Fludarabine Capecitabine
Pemetrexed 6-Mercaptopurine Tegafur
Thioguanine 5-Fluorouracil IV , Topical
Cytarabine IV
Plants Derivatives :

Taxans Vina Alkaloids Camptothecins Others

Paclitaxel Vincristine Topotecan Toposide
Docetaxel Vinblastine Irinotecan Etoposide
Toxal Vinorelbine Bolotecan Teniposide
Vindesine
Cytotoxic Anti-Biotics :

Anthracyclines IV Others
Doxarubicin Bleomycin ( IV,IM Subcutaneous, Intra-cavitary)
Daunorubicin Mitomycin
Idarubicin Dactinomycin IV
Epirubicin
Hormones Antagonists :

Hormones Analogue Antagonists Protamase Inhibitors

Buserelin Bicultamide Anastrozole
Diethylstilblesterol Flutamide Exemastane
Ethinylestradiol Cyproterone Letrozole
Goserelin Tamoxifen
Mitotane
Protein Kinase Inhibitors :

Tyrosine Kinase Inhibitors Pan Kinase Inhibitors

Axitinib Sonitinib Enverolins
Imatinib Dasatinib Sorafinib
Nilotinib Temisirolimus
Mono-Clonal Anti-Bodies :

Anti-EGF/EGF2 Anti-CD 20/30/52 Anti- PD1 /PDL1 Anti-VEGP

Panitumumab Brentuximab Nivalumab
Trastuzumab Ofatumumab Penbroliximab Bevacizumab
Lituximab
Miscellaneous Drugs

Retimoid X-receptor Proteosome Inhibitors Enzymes Photoactivated-

Antagonists Cytotoxins
Bexarotene Bortezomib Cristantaspase Porfiner
Temoporfin