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Akansha D

The document discusses the transformative role of biodegradable biopolymeric nanoparticles in sustainable healthcare, highlighting their advantages over metal-based nanoparticles, such as biodegradability and non-toxicity. It provides an analysis of their applications in drug delivery, particularly in antimicrobial and anticancer therapies, and classifies them into protein-based and polysaccharide-based systems. The study emphasizes the importance of ongoing research to maximize their potential in addressing global health challenges.

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Kasha Sam
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1 views2 pages

Akansha D

The document discusses the transformative role of biodegradable biopolymeric nanoparticles in sustainable healthcare, highlighting their advantages over metal-based nanoparticles, such as biodegradability and non-toxicity. It provides an analysis of their applications in drug delivery, particularly in antimicrobial and anticancer therapies, and classifies them into protein-based and polysaccharide-based systems. The study emphasizes the importance of ongoing research to maximize their potential in addressing global health challenges.

Uploaded by

Kasha Sam
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
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Biodegradable Biopolymer- Based Nanoparticles for Sustainable Healthcare

Akansha Dobhal1, Preeti Sharma1*

1
Department Of Pharmacology, Centre Of Excellence in Pharmaceutical Sciences, Guru
Gobind Singh Indraprastha University, Sector 16c, Dwarka, New Delhi-110078

Correspondence:

Email: ppreetisharma22@gmail.com

ABSTRACT

Background: Biopolymeric nanoparticles are transforming biomedical applications and


medication delivery. In contrast to metal-based nanoparticles, they originate from natural
sources and possess properties of biodegradability, biocompatibility, and non-toxicity,
rendering them sustainable and safer alternatives. These nanoparticles provide the regulated
and prolonged administration of therapeutic drugs to specific target locations, thereby
improving treatment effectiveness and minimizing adverse effects. Their considerable potential
in antimicrobial and anticancer drugs underscores their significance in advancing healthcare
solutions.

Aim
The study aims to provide an extensive analysis of biopolymeric nanoparticles as sustainable
drugs delivery systems. It emphasizes their biological origins, encapsulating capacity for
diverse medicinal substances, and their applications in healthcare, especially in antimicrobial
and anticancer therapies. The study aims to classify these nanoparticles into protein-based and
polysaccharide-based systems to facilitate the selection of the most suitable carrier for
particular therapeutic applications.

Material and Method

The study analyzes biopolymeric nanoparticles originating from animal, plant, algal, fungal,
and bacterial sources. These are classified according to their biological origin into protein-
based and polysaccharide-based systems. The encapsulation of therapeutic agents such as
pharmaceutical drugs, bioactive compounds, antibiotics, plant extracts, and essential oils is
discussed, emphasizing advancements in nanoparticle design and production over the past five
years. The materials and methods for nanoparticle manufacturing and their therapeutic
effectiveness in delivering these medicines are analyzed.

Results: Biopolymeric nanoparticles have shown considerable potential in healthcare,


especially as nanocarriers for targeted and regulated drug delivery. Protein-based systems,
including casein and gelatin, as well as polysaccharide-based systems like chitosan and
alginate, exhibit significant encapsulation efficiency and stability. These methods augment the
therapeutic efficacy of encapsulated drugs, especially in antimicrobial and anticancer
treatments, by improving bioavailability and minimizing toxicity. Recent breakthroughs
involve improving nanoparticle manufacturing to enhance therapeutic efficacy and durability,
rendering them viable alternatives to synthetic carriers.

Conclusion: Biopolymeric nanoparticles are an innovative method for drug delivery, providing
sustainability, biocompatibility, and improved therapeutic results. Their capacity to contain
various therapeutic substances and target specific disease locations underscores their
importance in contemporary healthcare. Ongoing research and development in this domain are
crucial to realize their complete potential in addressing global health concerns, especially in
antimicrobial and cancer treatments.

Keywords: Biopolymers, nanoparticles, drug delivery, biocompatibility, biomedical


applications, therapeutic agents, healthcare solutions.

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