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Hanta Vi Ru S Inf Ection S

Hanta virus infection are Rodent born viral infection prevalent in several regions of the world, High leverl of clinical suspicion helps in diagnosis and effective clinical management.

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tummalapalli venkateswara rao
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714 views20 pages

Hanta Vi Ru S Inf Ection S

Hanta virus infection are Rodent born viral infection prevalent in several regions of the world, High leverl of clinical suspicion helps in diagnosis and effective clinical management.

Uploaded by

tummalapalli venkateswara rao
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PPT, PDF, TXT or read online on Scribd
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HANTA VI RU S

Inf ection s
Dr.T.V.Rao MD
Hanta Viruses

 Hanta virus belong to family


- Bunyaviridae
 Found Globally
 Causes serious diseases, can
be fatal
 It is estimated there are
100,000 to 200,000
infections occur worldwide.
Dr.T.V.Rao MD
Hanta Virus diseases
 Hantavirus infections are caused by a group of
viruses known as hantaviruses. These viruses
cause two serious illnesses in humans. They
are hemorrhagic (pronounced heh-meh-RA-
jik) fever with renal syndrome (HFRS) and
hantavirus pulmonary syndrome (HPS).

Dr.T.V.Rao MD
Hanta virus
Source of Hanta Virus Infections

There are several distinct


Hanta viruses, each
associated with specific
Rodent Host
The Infection in Rodents are
life long without deleterious
effects.
Humans get infected by
inhaling aerosols of Rodent
excreta.
( Urine, Feces, Saliva )
Spread of Hanta Virus Infections
Breeding of Rodents have
relation to spread of
Infection
Diseases produced by Hanta
virus Infections

 1 Hemorrhagic fever with Renal Syndrome


( HFR )
 2 Hanta virus pulmonary Syndrome ( HPS )

Infection with Hanta virus is associated with


Geographic distribution of Rodents and nature
of the Virus.
Hemorrhagic Fever with Renal
Syndrome
 The virus were first isolated
in 1976 in Korea from a
Rodent Apodemus Agraris
 Urban Rats are to be
persistently infected with
Hanta virus
 Rats migrate on trading
ships and disperse the virus
world wide
 Hanta virus infection has
occurred in persons whose
occupations place them in
contact with Rats
Hemorrhagic Fever – Renal syndrome

 Acute Hanta viral infection causes a Interstitial


nephritis
 Lead to acute renal insufficiency and renal
failure in severe form
 Generalized hemorrhage and shock may occur
with case fatalities upto 5 – 15 %

Dr.T.V.Rao MD
Man ge me nt

 Hemorrhagic fever, and


renal failure are managed
with supportive treatment.
 Rodent control
 Protection from exposure to
rodent droppings and
contaminated material.
Hanta virus – Pulmonary syndrome
 Caused by novel Hanta virus
( Sin Nombre virus )
First case was reported from North
America
Primarily an adult respiratory
disease syndrome
The deer mouse ( Peromyscus
maniculats) is the primary rodent
for Sin Nombre virus
10 % of the deer mouse are infected.
Other viruses resembling novel
Hantavirus can cause Hanta viral
pulmonary syndrome

Dr.T.V.Rao
Other viruses causing HPS

 New York virus


 Black Creek canal virus

 Bayou virus

and each type of virus


has a different Rodent
host
Clinical Manifestations
 Infections and subclinical infections are not common.
 Hantavirus pulmonary syndrome is generally severe with
reported mortality rate of > 30 % or greater.
 Present with
Fever, Headache,Myalgia
Prolonged pulmonary edema
Leading to respiratory compromise
No signs of hemorrhage

Dr.T.V.Rao MD
Pathogenesis
 Hanta viral antigens are found in endothelial
cells.
In macrophages in lung, heart,
Spleen,Lymphnodes
Leads to functional impairment of vascular
endothelium
Person to person transmission is rare
Laboratory Diagnosis
 Detection of antigens by immuno
histochemistry,
 RT – PCR for viral antigen detection
 Specific antibodies by recombinant proteins
 A four fold rise of IgM antibody titer between
acute and convalescent serum is diagnostic
Dr.T.V.Rao MD
Management

 Maintenance of adequate O2
 Supporting homodynamic
functioning
 Antiviral drug Ribavirin is
some benefit

Dr.T.V.Rao MD
Control and Prevention

 Rodent control
 Avoiding control of Rodents
and Rodent droppings
 Care must be taken to avoid
inhaling aerolized dried
excreta when cleaning
Rodent infected structures.

Dr.T.V.Rao MD
Created for benefit of
Health Care Workers
Dr.T.V.Rao MD
Email
doctortvrao@gmail.com

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