Glycerin

Suppositories
GROUP 4
  Defined as a small plug of medication
 Dissolve at body temperature, typically the rectum
or vagina
 Latin word  suppositus meaning to put something
Suppositories under
 Vaginal Suppositories  pessary
 Urethral Suppositories  bougies
 First suppository base  Cocoa Butter
ROUTE OF ADMINISTRATION
 Two types of action

Local Action
 Systemic Action
Distribute therapeutic effect to the
tissues of the region
 Mucous membranes permit the absorption of many
soluble drugs
 Systemic absorption (rectum)
 LocalAction-

RECTUM
Relieve constipation, pain,
irritation, itching and
inflammation associated with
hemorrhoids and anorectal
conditions
 Local anesthetic,
vasoconstrictors, astringents,
analgesics, soothing emollients
and protective agents
 Glycerin Suppository- a popular
laxative, promote local
irritation, dehydrate mucous
membranes
 ‘Suppositoria Glycerini’
 VAGINA URETHRAL
Local Action
 Contraceptives, antiseptics in feminine  Antibacterial or local anesthetic
hygiene and as specific agents to preparative for urethral examination
combat an invading pathogen
(vaginitis)
Ideal Suppository Vehicle

DOES NOT INTERACT WITH SOLID AT ROOM DISSOLVES AT BODY STABLE UNDER AMBIENT PROMOTES RELEASE AND
OR DEGRADE THE ACTIVE TEMPERATURE TEMPERATURE STORAGE CONDITIONS ABSORPTION OF THE
INGREDIENTS ACTIVE CONSTITUENTS
Glycerin Suppositories
 Theoretical Adjusted
Ingredients
amount Amount
Glycerin 91 g 13 g
Sodium
9g 1.29 g
Stearate

Purified Water 5g 0.71 g

Total Amount 105 g 15 g

 Physical and
Ingredient Functional Container
Chemical Methods used
s Category used
Properties

Water-soluble,
clear, almost
colorless,
Glycerin odorless, API
hygroscopic
MP: 17.8 ℃
BP:290℃
M
The sodium salt of O
stearic acid, white
solid (common to Inactive L Tightly
Sodium soap); found in
solid deodorants,
ingredient: D closed
Stearate rubbers, latex Solidifying I container
paints and inks. Agent
MP:245-255 ℃ N
BP:360 ℃
G
Inactive
METHODS AND PROCEDURE
 Two methos in preparing
suppositories
1.Molding
2.Hand rolling and shaping
  Hand Rolling is the oldest and simplest method of
suppository preparation and may be used when only a
few suppositories are to be prepared in a cocoa butter
base.

Hand Rolling
  involves first melting the suppository base, and then
dispersing or dissolving the drug in the melted base.
The mixture is removed from the heat and poured into a
suppository mold. When the mixture has congealed, the
suppositories are removed from the mold.

Molding
 Weigh the Ingredients:
Glycerin= In a beaker, heat the Clean the metal mold
Sodium Stearate= glycerin to about 50℃
Purified Water=

Dissolve Sodium Stearate Prepare the metal mold

Remove from heat then
in glycerin with continuous by heating it
add water
stirring.

Let it cool for a few

Remove the excess
Immediately pour into the minutes. Refrigerate for 2
amount of the mixture
metal mold minutes to ensure that it
from the metal mold
solidified.

Store in a tightly closed Remove from the mold

container at temperatures and pack each
below 25 ℃ suppository using foil
 RESULTS:
Weights
0.84 0.94 1.05 0.96
0.88 0.95 0.95 0.97
0.90 0.96 0.94 0.97
Conclusion:
 Learning
Evaluation
 1. False
TRUE OR FALSE
Explanation:
Cocoa
butter
contains
emulsifiers.
 2. False TRUE OR FALSE
One advantage Explanation:
of cocoa butter as
a suppository base
is that it can exist
as several
polymorphic
forms.
 3. FalseTRUE OR FALSE
PEG bases Explanation:

are
formulated to
melt at body
temperature.
 TRUE OR FALSE
4. True Explanation:
PEG bases are
formulated to
dissolve in body
fluids rather than
melt at body
temperature.
 TRUE OR FALSE

5. True Explanation:

It is best to
moisten PEG
suppositories
prior to
insertion.
1. What are the different suppositories
and where are they used?

Rectal Urethral Vaginal

Go into your Size of a grain Oval shape
bottom or of rice Can be used
rectum. Used in men for bacterial
Used as a with erection or fungal
laxative problems infections
What are Alprostadil
A SINGLE-USE MEDICATED
pellets and where are TRANSURETHRAL SYSTEM
they used? FOR DELIVERY OF
ALPROSTADIL DRUG TO THE
MALE URETHRA.

USED AS A TREATMENT OF
ERECTILE DYSFUNCTION
AND ALSO USED TO
IMPROVE BLOOD FLOW IN
NEWBORN BABIES WITH
HEART PROBLEM
What is PEG and why PEG IS A POLYETHYLENE
are they used in GLYCOL USED IN
VAGINAL SUPPOSITORIES
vaginal and urethral WITH WHICH PROLONGED
suppositories? ACTION OF THE
MEDICINAL AGENT IS
ACCOMPLISHED.

IT IS ALSO COMPATIBLE
WITH MANY DRUGS SUCH
AS IN URETHRAL
SUPPOSITORIES
 PROVIDES FAST RELIEF FOR
OCCASIONAL CONSTIPATION
WITH A NO MESS APPLICATOR
, LUBRICATED GENTLE GLIDE
TIP AND NO NEED TO WAIT
FOR THE SUPPOSITORY TO
DISSOLVE SINCE IT’S ALREADY
4. What are IN LIQUID FORM.
liquid
suppositories? DOCTOR RECOMMENDED
GLYCERIN WORKS BY
ATTRACTING WATER INTO
STOOL TO PROMOTE BOWEL
MOVEMENT
  HARDNESS: PROPER
HANDLING AND
DELIVERY
 SHAPE: COMFORTABLE
5. What are the INSERTION AND
most important RETENTION
requirements for  SOLUBILIZATION OF
DRUGS IN
a suppository? SUPPOSITORY MATRIX
 RAPID MELTING AFTER
INSERTION