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Granulation by Single Pot

The document discusses single pot processing (SPP), which combines multiple unit operations like mixing, wet granulation, and drying into a single machine. SPP allows for continuous processing with fewer processing steps. It monitors process variables and has advantages like reduced costs, time, and space compared to conventional batch processing. The document describes the steps, instrumentation, advantages, and applications of SPP.

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Chairman Pharmaceutical Sciences
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158 views15 pages

Granulation by Single Pot

The document discusses single pot processing (SPP), which combines multiple unit operations like mixing, wet granulation, and drying into a single machine. SPP allows for continuous processing with fewer processing steps. It monitors process variables and has advantages like reduced costs, time, and space compared to conventional batch processing. The document describes the steps, instrumentation, advantages, and applications of SPP.

Uploaded by

Chairman Pharmaceutical Sciences
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPTX, PDF, TXT or read online on Scribd
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3

Instrumentation

2 4

Steps of SPP Advantages of SPP

Granulation by

1 single pot 5

INTRODUCTION Applications of SPP


introduction Steps Instrumentation Advantages of SPP Application of SPP

Wet granulation
Single machine
Multiple process
introduction Steps Instrumentation Advantages of SPP Application of SPP

Dry mixing Drying

Multiple phase process.


Combine different unit
Operations. Addition of
Sizing and
binder
lubrication
solution

Wet massing
introduction Steps Instrumentation Advantages of SPP Application of SPP

Dry mixing:
Powder loaded manually.
By conveying system.

Process variables:
Batch Size, Impeller speed, Mixing time
introduction Steps Instrumentation Advantages of SPP Application of SPP

Addition of binder solution:


By spray lance
Variables:
Rate of binder action
Droplet size
Spray pattern
introduction Steps Instrumentation Advantages of SPP Application of SPP

Wet massing:
By binder addition
Variables:
Speed of main impeller
Wet massing time
Jacket temperature
introduction Steps Instrumentation Advantages of SPP Application of SPP

Drying:
Vacuum drying
Gas assisted vacuum drying Sizing and lubrication:
Microwave vacuum drying By discharging material through an in line
mill into receiving vessel
Variables: Blending with remaining excipients
Level of vacuum in bowl,
Jacket temperature
introduction Steps Instrumentation Advantages of SPP Application of SPP

Feeder

Condenser
Heating unit
Filter

Spray nozzle Vacuum pump

Heated jacket

Rotating blades

Receiving vessel
introduction Steps Instrumentation Advantages of SPP Application of SPP

1. Process variable decreased


2. Cost effectiveness
3. Reduce floor space
4. Number of material handling steps minimize
5. Shorter processing time
Dry mixer + Wet granulator + Vacuum dryer = SPP
Applications of
introduction Steps Instrumentation Advantages of SPP
SPP

1. Effervescent production
2. Pellet production
3. Melt granulation
4. Wet granulation
5. Vacuum drying

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