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Ogrania: Pregabalin 75 MG Capsules

Pregabalin is a GABA analogue used to treat neuropathic pain associated with conditions like diabetic neuropathy and post-herpetic neuralgia. It is also used as an adjunctive therapy for epilepsy and fibromyalgia. Pregabalin has higher potency and bioavailability than gabapentin, allowing lower doses to be used. It has distinct pharmacokinetic advantages over gabapentin and provides equivalent efficacy at much lower doses. The maximum recommended dose of pregabalin is 300mg per day.

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305 views9 pages

Ogrania: Pregabalin 75 MG Capsules

Pregabalin is a GABA analogue used to treat neuropathic pain associated with conditions like diabetic neuropathy and post-herpetic neuralgia. It is also used as an adjunctive therapy for epilepsy and fibromyalgia. Pregabalin has higher potency and bioavailability than gabapentin, allowing lower doses to be used. It has distinct pharmacokinetic advantages over gabapentin and provides equivalent efficacy at much lower doses. The maximum recommended dose of pregabalin is 300mg per day.

Uploaded by

مصطفى الجبوري
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© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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OGRANIA

Pregabalin 75 mg capsules
 Pregabalin is a GABAergic anticonvulsant and
depressant of the central nervous system (CNS).
 It is classified as a GABA analogue and gabapentinoid.

 It is a close analogue of the inhibitory neurotransmitter


γ-aminobutyric acid (GABA).
 Although pregabalin is an analogue of GABA, it does
not bind directly to GABAA, GABAB, GABAϱ, or
benzodiazepine receptors. Nor does it block sodium
channels and is not active at opioid receptors.
 Gabapentinoids, such as pregabalin, are α2δ subunit
modifiers that affect GABA.
 In contrast to the distribution of α2δ-1 and α2δ-2
subunits binding correlates partially with GABAergic
neurons.
INDICATIONS
 Management of neuropathic pain associated with
diabetic peripheral neuropathy.
 Management of post-herpetic neuralgia.

 Adjunctive therapy for adult patients with partial onset


seizures.
 Management of fibromyalgia.

 Management of neuropathic pain associated with spinal


cord injury( ex. Sciatica)
POTENCY
 When studied in non-humans pregabalin appears to be 3
to 10 times more potent as an anticonvulsant than
gabapentin.
 Pregabalin is 2 to 4 times more potent as an analgesic
than gabapentin.
 Pregabalin is 6 times more potent than gabapentin in
binding affinity.
COMPARISON WITH GABAPENTIN
 Pregabalin has been shown in studies to provide
equivalent efficacy to gabapentin, however, at much
lower doses.
 Because lower dosages can be used to treat neuropathic
pain, it is likely that pregabalin will be associated with
fewer dose-related adverse events.
 Part of the reason why pregabalin requires lower dosages
is that it has a much higher bioavailability (90% versus
33-66%) and is rapidly absorbed (peak: 1 hr).
 Also, plasma concentrations increase linearly with
increasing dose.
 This is not true with gabapentin.

 Gabapentin is slowly absorbed (peak: 3 to 4 hours post-


dose) and more importantly, plasma concentrations have
been found to have a non-linear relationship to
increasing doses.
 Pregabalin has been found to have distinct
pharmacokinetic advantages over gabapentin.
DOSE
 Maximum dose in patients with normal creatinine
clearance, is 600 mg/day in divided doses, but because of
dose related adverse events and no added benefit, doses
above 300 mg are not recommended.
 The usual starting dose is 75 mg once or twice daily and
increasing gradually, and when discontinued, tapered
gradually over a minimum of 1 week.
OGRANIA
 Target Doctor: Neurologist, Internist, Neurosurgeon,
Orthopedist.
 Dose and indications :mentioned

 Message: Ogrania provides as high quality pregabalin,


with a cost-effective course when compared with other
competitors in the market.

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